Sennidin B (BioDeep_00000022842)

 

Secondary id: BioDeep_00000321345, BioDeep_00000396850, BioDeep_00000569113

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(9S)-9-[(9R)-2-carboxy-4,5-dihydroxy-10-oxo-9,10-dihydroanthracen-9-yl]-4,5-dihydroxy-10-oxo-9,10-dihydroanthracene-2-carboxylic acid

化学式: C30H18O10 (538.0899928)
中文名称: 番泻苷元B
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC2=C(C(=C1)O)C(=O)C3=C(C2C4C5=C(C(=CC=C5)O)C(=O)C6=C4C=C(C=C6O)C(=O)O)C=C(C=C3O)C(=O)O
InChI: InChI=1S/C30H18O10/c31-17-5-1-3-13-21(15-7-11(29(37)38)9-19(33)25(15)27(35)23(13)17)22-14-4-2-6-18(32)24(14)28(36)26-16(22)8-12(30(39)40)10-20(26)34/h1-10,21-22,31-34H,(H,37,38)(H,39,40)/t21-,22+

描述信息

Anthraquinone derivative, a stereoisomer of sennidin A, stimulates glucose incoporation into adipocytes in rats, but the activity of sennidin B is lower than sennidin A. [HMDB]
Anthraquinone derivative, a stereoisomer of sennidin A, stimulates glucose incoporation into adipocytes in rats, but the activity of sennidin B is lower than sennidin A.

同义名列表

8 个代谢物同义名

(9S)-9-[(9R)-2-carboxy-4,5-dihydroxy-10-oxo-9,10-dihydroanthracen-9-yl]-4,5-dihydroxy-10-oxo-9,10-dihydroanthracene-2-carboxylic acid; (9R,9s)-4,4,5,5-Tetrahydroxy-10,10-dioxo-9H,9H,10H,10H-[9,9-bianthracene]-2,2-dicarboxylate; dihydroxydianthrone, (R*,S*)-isomer; dihydroxydianthrone; Sennidine b; sennidine A; Sennidin A; sennidin B



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cuihua Jiang, Meng Gao, Yue Li, Dejian Huang, Nan Yao, Yun Ji, Xuejiao Liu, Dongjian Zhang, Xiaoning Wang, Zhiqi Yin, Su Jing, Yicheng Ni, Jian Zhang. Exploring diagnostic potentials of radioiodinated sennidin A in rat model of reperfused myocardial infarction. International journal of pharmaceutics. 2015 Nov; 495(1):31-40. doi: 10.1016/j.ijpharm.2015.08.046. [PMID: 26302863]
  • Yun Ji, Cuihua Jiang, Xueli Zhang, Wei Liu, Meng Gao, Yue Li, Junhu Wang, Qingqing Wang, Ziping Sun, Xiao Jiang, Nan Yao, Xiaoning Wang, Zhijun Fang, Zhiqi Yin, Yicheng Ni, Jian Zhang. Necrosis targeted combinational theragnostic approach using radioiodinated Sennidin A in rodent tumor models. Oncotarget. 2014 May; 5(10):2934-46. doi: 10.18632/oncotarget.1728. [PMID: 24931286]
  • Tatsuya Higashi, Katsumi Kawasaki, Nagisa Matsumoto, Shoujiro Ogawa, Kuniko Mitamura, Shigeo Ikegawa. LC/MS/MS of steroids having vicinal diol as electrospray-active boronates. Chemical & pharmaceutical bulletin. 2013; 61(3):326-32. doi: 10.1248/cpb.c12-00979. [PMID: 23449202]
  • B Waltenberger, B Avula, M Ganzera, I A Khan, H Stuppner, S I Khan. Transport of sennosides and sennidines from Cassia angustifolia and Cassia senna across Caco-2 monolayers--an in vitro model for intestinal absorption. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008 May; 15(5):373-7. doi: 10.1016/j.phymed.2007.03.008. [PMID: 17481875]
  • T Akao, Q M Che, K Kobashi, L Yang, M Hattori, T Namba. Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins. Applied and environmental microbiology. 1994 Mar; 60(3):1041-3. doi: 10.1128/aem.60.3.1041-1043.1994. [PMID: 8161172]