Marinobufagin (BioDeep_00000013217)

 

Secondary id: BioDeep_00001868439


代谢物信息卡片


3-.beta.,5-Dihydroxy-14,15-.beta.-epoxy-5-.beta.-bufa-20,22-dienolide

化学式: C24H32O5 (400.225)
中文名称: 海蟾蜍毒素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CCC(CC1(CCC3C2CCC4(C35C(O5)CC4C6=COC(=O)C=C6)C)O)O
InChI: InChI=1S/C24H32O5/c1-21-8-5-15(25)12-23(21,27)10-7-17-16(21)6-9-22(2)18(11-19-24(17,22)29-19)14-3-4-20(26)28-13-14/h3-4,13,15-19,25,27H,5-12H2,1-2H3/t15-,16-,17+,18+,19+,21+,22+,23-,24+/m0/s1

描述信息

D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002018 - Bufanolides
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
D004791 - Enzyme Inhibitors

同义名列表

4 个代谢物同义名

3-.beta.,5-Dihydroxy-14,15-.beta.-epoxy-5-.beta.-bufa-20,22-dienolide; Marinobufogenin; Marinobufagenin; Marinobufagin



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yulia N Grigorova, Ondrej Juhasz, Jeffrey M Long, Valentina I Zernetkina, Mikayla L Hall, Wen Wei, Christopher H Morrell, Natalia Petrashevskaya, Audrey Morrow, Katherine H LaNasa, Alexei Y Bagrov, Peter R Rapp, Edward G Lakatta, Olga V Fedorova. Effect of Cardiotonic Steroid Marinobufagenin on Vascular Remodeling and Cognitive Impairment in Young Dahl-S Rats. International journal of molecular sciences. 2022 Apr; 23(9):. doi: 10.3390/ijms23094563. [PMID: 35562955]
  • Natalia I Agalakova, Yulia N Grigorova, Ivan A Ershov, Vitaly A Reznik, Elena V Mikhailova, Olga V Nadei, Leticia Samuilovskaya, Larisa A Romanova, C David Adair, Irina V Romanova, Alexei Y Bagrov. Canrenone Restores Vasorelaxation Impaired by Marinobufagenin in Human Preeclampsia. International journal of molecular sciences. 2022 Mar; 23(6):. doi: 10.3390/ijms23063336. [PMID: 35328757]
  • Davide Bolignano, Marta Greco, Pierangela Presta, Giuseppina Crugliano, Jolanda Sabatino, Nazareno Carullo, Roberta Arena, Isabella Leo, Alessandro Comi, Michele Andreucci, Francesco Dragone, Antonio Strangio, Ciro Indolfi, Daniela Patrizia Foti, Salvatore De Rosa, Giuseppe Coppolino. Altered circulating marinobufagenin levels and recurrent intradialytic hypotensive episodes in chronic hemodialysis patients: a pilot, prospective study. Reviews in cardiovascular medicine. 2021 Dec; 22(4):1577-1587. doi: 10.31083/j.rcm2204163. [PMID: 34957798]
  • Artem M Tverskoi, Yuri M Poluektov, Elizaveta A Klimanova, Vladimir A Mitkevich, Alexander A Makarov, Sergei N Orlov, Irina Yu Petrushanko, Olga D Lopina. Depth of the Steroid Core Location Determines the Mode of Na,K-ATPase Inhibition by Cardiotonic Steroids. International journal of molecular sciences. 2021 Dec; 22(24):. doi: 10.3390/ijms222413268. [PMID: 34948068]
  • Katarzyna Łabno-Kirszniok, Agata Kujawa-Szewieczek, Andrzej Wiecek, Grzegorz Piecha. The Effects of Short-Term Changes in Sodium Intake on Plasma Marinobufagenin Levels in Patients with Primary Salt-Sensitive and Salt-Insensitive Hypertension. Nutrients. 2021 Apr; 13(5):. doi: 10.3390/nu13051502. [PMID: 33946894]
  • Michél Strauss-Kruger, Ruan Kruger, Wayne Smith, Lebo F Gafane-Matemane, Gontse Mokwatsi, Wen Wei, Olga V Fedorova, Aletta E Schutte. The Cardiotonic Steroid Marinobufagenin Is a Predictor of Increased Left Ventricular Mass in Obesity: The African-PREDICT Study. Nutrients. 2020 Oct; 12(10):. doi: 10.3390/nu12103185. [PMID: 33081045]
  • Maryam Jameelah Md Hassan, Nor Salmah Bakar, Mardiana Abdul Aziz, Norizan Kamal Basah, Harbindar Jeet Singh. Leptin-induced increase in blood pressure and markers of endothelial activation during pregnancy in Sprague Dawley rats is prevented by resibufogenin, a marinobufagenin antagonist. Reproductive biology. 2020 Jun; 20(2):184-190. doi: 10.1016/j.repbio.2020.03.004. [PMID: 32253169]
  • Natalia I Agalakova, Vitaly A Reznik, Olga V Nadei, Ivan A Ershov, Olga S Rassokha, Marina L Vasyutina, Dmitry O Ivanov, C David Adair, Michael M Galagudza, Alexei Y Bagrov. Antibody against Na/K-ATPase Inhibitor Lowers Blood Pressure and Increases Vascular Fli1 in Experimental Preeclampsia. American journal of hypertension. 2020 05; 33(6):514-519. doi: 10.1093/ajh/hpz180. [PMID: 31713584]
  • E A Klimanova, D A Fedorov, S V Sidorenko, P A Abramicheva, O D Lopina, S N Orlov. Ouabain and Marinobufagenin: Physiological Effects on Human Epithelial and Endothelial Cells. Biochemistry. Biokhimiia. 2020 Apr; 85(4):507-515. doi: 10.1134/s0006297920040112. [PMID: 32569558]
  • Olga V Fedorova, Artem V Fadeev, Yulia N Grigorova, Courtney A Marshall, Valentina Zernetkina, Nikolai I Kolodkin, Natalia I Agalakova, Alexandra O Konradi, Edward G Lakatta, Alexei Y Bagrov. Cardiotonic Steroids Induce Vascular Fibrosis Via Pressure-Independent Mechanism in NaCl-Loaded Diabetic Rats. Journal of cardiovascular pharmacology. 2019 11; 74(5):436-442. doi: 10.1097/fjc.0000000000000730. [PMID: 31415452]
  • Yongqing Zhang, Wen Wei, Victoria Shilova, Natalia N Petrashevskaya, Valentina I Zernetkina, Yulia N Grigorova, Courtney A Marshall, Rachel C Fenner, Elin Lehrmann, William H Wood, Kevin G Becker, Edward G Lakatta, Alexei Y Bagrov, Olga V Fedorova. Monoclonal Antibody to Marinobufagenin Downregulates TGFβ Profibrotic Signaling in Left Ventricle and Kidney and Reduces Tissue Remodeling in Salt-Sensitive Hypertension. Journal of the American Heart Association. 2019 10; 8(20):e012138. doi: 10.1161/jaha.119.012138. [PMID: 31576777]
  • Michél Strauss, Wayne Smith, Olga V Fedorova, Aletta E Schutte. The Na+K+-ATPase Inhibitor Marinobufagenin and Early Cardiovascular Risk in Humans: a Review of Recent Evidence. Current hypertension reports. 2019 04; 21(5):38. doi: 10.1007/s11906-019-0942-y. [PMID: 30980225]
  • Martin H Keppel, Grzegorz Piecha, Winfried März, Janne Cadamuro, Simon Auer, Thomas K Felder, Cornelia Mrazek, Hannes Oberkofler, Christian Trummer, Martin R Grübler, Verena Schwetz, Nicolas Verheyen, Marlene Pandis, Valentin Borzan, Elisabeth Haschke-Becher, Andreas Tomaschitz, Stefan Pilz. The endogenous cardiotonic steroid Marinobufagenin and decline in estimated glomerular filtration rate at follow-up in patients with arterial hypertension. PloS one. 2019; 14(2):e0212973. doi: 10.1371/journal.pone.0212973. [PMID: 30817774]
  • Igor V Emelyanov, Alexandra O Konradi, Edward G Lakatta, Olga V Fedorova, Alexei Y Bagrov. Acute salt loading and cardiotonic steroids in resistant hypertension. Current topics in membranes. 2019; 83(?):1-13. doi: 10.1016/bs.ctm.2019.01.005. [PMID: 31196601]
  • Michél Strauss, Wayne Smith, Wen Wei, Alexei Y Bagrov, Olga V Fedorova, Aletta E Schutte. Large artery stiffness is associated with marinobufagenin in young adults: the African-PREDICT study. Journal of hypertension. 2018 12; 36(12):2333-2339. doi: 10.1097/hjh.0000000000001866. [PMID: 30382957]
  • Michél Strauss, Wayne Smith, Ruan Kruger, Wen Wei, Olga V Fedorova, Aletta E Schutte. Marinobufagenin and left ventricular mass in young adults: The African-PREDICT study. European journal of preventive cardiology. 2018 10; 25(15):1587-1595. doi: 10.1177/2047487318788140. [PMID: 29993282]
  • Luciana S Amaral, Jainne Martins Ferreira, Danilo Predes, José Garcia Abreu, François Noël, Luis Eduardo M Quintas. Telocinobufagin and Marinobufagin Produce Different Effects in LLC-PK1 Cells: A Case of Functional Selectivity of Bufadienolides. International journal of molecular sciences. 2018 Sep; 19(9):. doi: 10.3390/ijms19092769. [PMID: 30223494]
  • Charline Lenaerts, Liz Bond, Robin Tuytten, Bertrand Blankert. Revealing of endogenous Marinobufagin by an ultra-specific and sensitive UHPLC-MS/MS assay in pregnant women. Talanta. 2018 Sep; 187(?):193-199. doi: 10.1016/j.talanta.2018.05.020. [PMID: 29853035]
  • Grzegorz Piecha, Agata Kujawa-Szewieczek, Piotr Kuczera, Katarzyna Skiba, Ewelina Sikora-Grabka, Andrzej Więcek. Plasma marinobufagenin immunoreactivity in patients with chronic kidney disease: a case control study. American journal of physiology. Renal physiology. 2018 09; 315(3):F637-F643. doi: 10.1152/ajprenal.00046.2018. [PMID: 30043626]
  • David J Kennedy, Fatimah K Khalaf, Brendan Sheehy, Malory E Weber, Brendan Agatisa-Boyle, Julijana Conic, Kayla Hauser, Charles M Medert, Kristen Westfall, Philip Bucur, Olga V Fedorova, Alexei Y Bagrov, W H Wilson Tang. Telocinobufagin, a Novel Cardiotonic Steroid, Promotes Renal Fibrosis via Na⁺/K⁺-ATPase Profibrotic Signaling Pathways. International journal of molecular sciences. 2018 Aug; 19(9):. doi: 10.3390/ijms19092566. [PMID: 30158457]
  • Olga V Fedorova, Valentina V Ishkaraeva, Yulia N Grigorova, Vitaly A Reznik, Nikolai I Kolodkin, Irina E Zazerskaya, Valentina Zernetkina, Natalia I Agalakova, Natalia I Tapilskaya, C David Adair, Edward G Lakatta, Alexei Y Bagrov. Antibody to Marinobufagenin Reverses Placenta-Induced Fibrosis of Umbilical Arteries in Preeclampsia. International journal of molecular sciences. 2018 Aug; 19(8):. doi: 10.3390/ijms19082377. [PMID: 30104471]
  • Michél Strauss, Wayne Smith, Wen Wei, Olga V Fedorova, Aletta E Schutte. Marinobufagenin is related to elevated central and 24-h systolic blood pressures in young black women: the African-PREDICT Study. Hypertension research : official journal of the Japanese Society of Hypertension. 2018 Mar; 41(3):183-192. doi: 10.1038/s41440-017-0009-x. [PMID: 29335615]
  • Vladimir A Kashkin, Elena V Shekunova, Alexei Y Egorov, Alexei Y Bagrov. Marinobufagenin in Urine: A Potential Marker of Predisposition to Ethanol and a Target for Spironolactone. Current hypertension reviews. 2018; 14(1):35-38. doi: 10.2174/1573402114666180212115518. [PMID: 29437012]
  • Renata I Dmitrieva, Stacy M Cranford, Peter A Doris. Genetic Control of Serum Marinobufagenin in the Spontaneously Hypertensive Rat and the Relationship to Blood Pressure. Journal of the American Heart Association. 2017 Oct; 6(10):. doi: 10.1161/jaha.117.006704. [PMID: 28982675]
  • Alana N Godinho, Graciana T Costa, Nádia O Oliveira, Bruno A Cardi, Daniel Esdras A Uchoa, Edilberto R Silveira, Luis Eduardo M Quintas, François G Noël, Manassés C Fonteles, Krishnamurti M Carvalho, Cláudia F Santos, Lucília M A Lessa, Nilberto R F do Nascimento. Effects of cardiotonic steroids on isolated perfused kidney and NHE3 activity in renal proximal tubules. Biochimica et biophysica acta. General subjects. 2017 Aug; 1861(8):1943-1950. doi: 10.1016/j.bbagen.2017.05.012. [PMID: 28506883]
  • Mir M K Abbas, B Patel, Q Chen, W Jiang, B Moorthy, R Barrios, J B Puschett. Involvement of the Bufadienolides in the Detection and Therapy of the Acute Respiratory Distress Syndrome. Lung. 2017 06; 195(3):323-332. doi: 10.1007/s00408-017-9989-1. [PMID: 28260175]
  • Darpan Chakraborty, Olga V Fedorova, Alexei Y Bagrov, Hanoch Kaphzan. Selective ligands for Na+/K+-ATPase α isoforms differentially and cooperatively regulate excitability of pyramidal neurons in distinct brain regions. Neuropharmacology. 2017 05; 117(?):338-351. doi: 10.1016/j.neuropharm.2017.02.016. [PMID: 28232062]
  • Steven T Haller, Yanling Yan, Christopher A Drummond, Joe Xie, Jiang Tian, David J Kennedy, Victoria Y Shilova, Zijian Xie, Jiang Liu, Christopher J Cooper, Deepak Malhotra, Joseph I Shapiro, Olga V Fedorova, Alexei Y Bagrov. Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro-Fibrotic Signaling. Journal of the American Heart Association. 2016 09; 5(10):. doi: 10.1161/jaha.116.004106. [PMID: 27694325]
  • N Kantaria, I Pantsulaia, I Andronikashvili, G Simonia. ASSOSIATION OF ENDOGENOUS CARDIOTONIC STEROIDS WITH SALT-SENSITIVITY OF BLOOD PRESSURE IN GEORGIAN POPULATION. Georgian medical news. 2016 Sep; ?(258):33-37. doi: NULL. [PMID: 27770524]
  • Yulia N Grigorova, Ondrej Juhasz, Valentina Zernetkina, Kenneth W Fishbein, Edward G Lakatta, Olga V Fedorova, Alexei Y Bagrov. Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, is Reduced by a Monoclonal Antibody to Marinobufagenin. American journal of hypertension. 2016 May; 29(5):641-6. doi: 10.1093/ajh/hpv155. [PMID: 26350300]
  • Aneta Paczula, Andrzej Więcek, Grzegorz Piecha. The role of endogenous cardiotonic steroids in pathogenesis of cardiovascular and renal complications of arterial hypertension. Postepy higieny i medycyny doswiadczalnej (Online). 2016 Mar; 70(?):243-50. doi: 10.5604/17322693.1197486. [PMID: 27117099]
  • Christopher A Drummond, Michael C Hill, Huilin Shi, Xiaoming Fan, Jeffrey X Xie, Steven T Haller, David J Kennedy, Jiang Liu, Michael R Garrett, Zijian Xie, Christopher J Cooper, Joseph I Shapiro, Jiang Tian. Na/K-ATPase signaling regulates collagen synthesis through microRNA-29b-3p in cardiac fibroblasts. Physiological genomics. 2016 Mar; 48(3):220-9. doi: 10.1152/physiolgenomics.00116.2015. [PMID: 26702050]
  • David J Kennedy, Kevin Shrestha, Brendan Sheehey, Xinmin S Li, Anuradha Guggilam, Yuping Wu, Michael Finucan, Alaa Gabi, Charles M Medert, Kristen Westfall, Allen Borowski, Olga Fedorova, Alexei Y Bagrov, W H Wilson Tang. Elevated Plasma Marinobufagenin, An Endogenous Cardiotonic Steroid, Is Associated With Right Ventricular Dysfunction and Nitrative Stress in Heart Failure. Circulation. Heart failure. 2015 Nov; 8(6):1068-76. doi: 10.1161/circheartfailure.114.001976. [PMID: 26276886]
  • Olga V Fedorova, Valentina I Zernetkina, Victoria Y Shilova, Yulia N Grigorova, Ondrej Juhasz, Wen Wei, Courtney A Marshall, Edward G Lakatta, Alexei Y Bagrov. Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway. Circulation. Cardiovascular genetics. 2015 Oct; 8(5):736-45. doi: 10.1161/circgenetics.115.001217. [PMID: 26374826]
  • Olga V Fedorova, Igor V Emelianov, Konstantin A Bagrov, Yulia N Grigorova, Wen Wei, Ondrej Juhasz, Elena V Frolova, Courtney A Marshall, Edward G Lakatta, Alexandra O Konradi, Alexei Y Bagrov. Marinobufagenin-induced vascular fibrosis is a likely target for mineralocorticoid antagonists. Journal of hypertension. 2015 Aug; 33(8):1602-10. doi: 10.1097/hjh.0000000000000591. [PMID: 26136067]
  • John M Hamlyn, Paolo Manunta. Endogenous cardiotonic steroids in kidney failure: a review and an hypothesis. Advances in chronic kidney disease. 2015 May; 22(3):232-44. doi: 10.1053/j.ackd.2014.12.005. [PMID: 25908473]
  • Jing Ning, Zhen-Long Yu, Liang-Hai Hu, Chao Wang, Xiao-Kui Huo, Sa Deng, Jie Hou, Jing-Jing Wu, Guang-Bo Ge, Xiao-Chi Ma, Ling Yang. Characterization of phase I metabolism of resibufogenin and evaluation of the metabolic effects on its antitumor activity and toxicity. Drug metabolism and disposition: the biological fate of chemicals. 2015 Mar; 43(3):299-308. doi: 10.1124/dmd.114.060996. [PMID: 25504504]
  • Olga V Fedorova, Edward G Lakatta, Alexei Y Bagrov, Olle Melander. Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men. Journal of hypertension. 2015 Mar; 33(3):534-41; discussion 541. doi: 10.1097/hjh.0000000000000437. [PMID: 25479026]
  • Andreas Tomaschitz, Grzegorz Piecha, Eberhard Ritz, Andreas Meinitzer, Josef Haas, Burkert Pieske, Andrzej Wiecek, Jutta Rus-Machan, Hermann Toplak, Winfried März, Nicolas Verheyen, Martin Gaksch, Karin Amrein, Elisabeth Kraigher-Krainer, Astrid Fahrleitner-Pammer, Stefan Pilz. Marinobufagenin in essential hypertension and primary aldosteronism: a cardiotonic steroid with clinical and diagnostic implications. Clinical and experimental hypertension (New York, N.Y. : 1993). 2015; 37(2):108-15. doi: 10.3109/10641963.2014.913604. [PMID: 24785704]
  • Moustafa Sayed, Christopher A Drummond, Kaleigh L Evans, Steven T Haller, Jiang Liu, Zijian Xie, Jiang Tian. Effects of Na/K-ATPase and its ligands on bone marrow stromal cell differentiation. Stem cell research. 2014 Jul; 13(1):12-23. doi: 10.1016/j.scr.2014.04.002. [PMID: 24793006]
  • Steven T Haller, Christopher A Drummond, Yanling Yan, Jiang Liu, Jiang Tian, Deepak Malhotra, Joseph I Shapiro. Passive immunization against marinobufagenin attenuates renal fibrosis and improves renal function in experimental renal disease. American journal of hypertension. 2014 Apr; 27(4):603-9. doi: 10.1093/ajh/hpt169. [PMID: 24014658]
  • Irina E Zazerskaya, Valentina V Ishkaraeva, Elena V Frolova, Nelly G Solodovnikova, Yulia N Grigorova, C David Adair, Olga V Fedorova, Alexei Y Bagrov. Magnesium sulfate potentiates effect of DigiFab on marinobufagenin-induced Na/K-ATPase inhibition. American journal of hypertension. 2013 Nov; 26(11):1269-72. doi: 10.1093/ajh/hpt117. [PMID: 23878005]
  • Kristen L Jablonski, Olga V Fedorova, Matthew L Racine, Candace J Geolfos, Phillip E Gates, Michel Chonchol, Bradley S Fleenor, Edward G Lakatta, Alexei Y Bagrov, Douglas R Seals. Dietary sodium restriction and association with urinary marinobufagenin, blood pressure, and aortic stiffness. Clinical journal of the American Society of Nephrology : CJASN. 2013 Nov; 8(11):1952-9. doi: 10.2215/cjn.00900113. [PMID: 23929930]
  • Valentina V Ishkaraeva-Yakovleva, Olga V Fedorova, Nelly G Solodovnikova, Elena V Frolova, Anton M Bzhelyansky, Igor V Emelyanov, C David Adair, Irina E Zazerskaya, Alexei Y Bagrov. DigiFab interacts with endogenous cardiotonic steroids and reverses preeclampsia-induced Na/K-ATPase inhibition. Reproductive sciences (Thousand Oaks, Calif.). 2012 Dec; 19(12):1260-7. doi: 10.1177/1933719112447124. [PMID: 22649120]
  • Jules B Puschett. Marinobufagenin predicts and resibufogenin prevents preeclampsia: a review of the evidence. American journal of perinatology. 2012 Nov; 29(10):777-85. doi: 10.1055/s-0032-1316447. [PMID: 22814872]
  • Olga V Fedorova, Vladimir A Kashkin, Irina O Zakharova, Edward G Lakatta, Alexei Y Bagrov. Age-associated increase in salt sensitivity is accompanied by a shift in the atrial natriuretic peptide modulation of the effect of marinobufagenin on renal and vascular sodium pump. Journal of hypertension. 2012 Sep; 30(9):1817-26. doi: 10.1097/hjh.0b013e328356399b. [PMID: 22796708]
  • Steven T Haller, David J Kennedy, Amjad Shidyak, George V Budny, Deepak Malhotra, Olga V Fedorova, Joseph I Shapiro, Alexei Y Bagrov. Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure. American journal of hypertension. 2012 Jun; 25(6):690-6. doi: 10.1038/ajh.2012.17. [PMID: 22378033]
  • Christopher Hauck, William H Frishman. Systemic hypertension: the roles of salt, vascular Na+/K+ ATPase and the endogenous glycosides, ouabain and marinobufagenin. Cardiology in review. 2012 May; 20(3):130-8. doi: 10.1097/crd.0b013e31823c835c. [PMID: 22183064]
  • John N Lorenz, Naomi Oshiro, Elizabeth L Loreaux, Jerry B Lingrel. DOCA-salt hypertension does not require the ouabain-sensitive binding site of the α2 Na,K-ATPase. American journal of hypertension. 2012 Apr; 25(4):421-9. doi: 10.1038/ajh.2011.255. [PMID: 22258333]
  • Mark F McCarty. Marinobufagenin and cyclic strain may activate endothelial NADPH oxidase, contributing to the adverse impact of salty diets on vascular and cerebral health. Medical hypotheses. 2012 Feb; 78(2):191-6. doi: 10.1016/j.mehy.2011.09.028. [PMID: 21968275]
  • Elena V Kolmakova, Steven T Haller, David J Kennedy, Alina N Isachkina, George V Budny, Elena V Frolova, Grzegorz Piecha, Elena R Nikitina, Deepak Malhotra, Olga V Fedorova, Joseph I Shapiro, Alexei Y Bagrov. Endogenous cardiotonic steroids in chronic renal failure. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2011 Sep; 26(9):2912-9. doi: 10.1093/ndt/gfq772. [PMID: 21292813]
  • Nadezda Koleganova, Grzegorz Piecha, Eberhard Ritz, Luis Eduardo Becker, Annett Müller, Monika Weckbach, Jens Randel Nyengaard, Peter Schirmacher, Marie-Luise Gross-Weissmann. Both high and low maternal salt intake in pregnancy alter kidney development in the offspring. American journal of physiology. Renal physiology. 2011 Aug; 301(2):F344-54. doi: 10.1152/ajprenal.00626.2010. [PMID: 21593188]
  • Enoch Agunanne, Darijana Horvat, Recherael Harrison, M Nasir Uddin, Richard Jones, Thomas J Kuehl, Daad Abi Ghanem, Luc R Berghman, Xinzhong Lai, Jing Li, Daniel Romo, Jules B Puschett. Marinobufagenin levels in preeclamptic patients: a preliminary report. American journal of perinatology. 2011 Aug; 28(7):509-14. doi: 10.1055/s-0031-1272965. [PMID: 21380994]
  • Natália Araújo Touza, Elisa Suzana Carneiro Pôças, Luis Eduardo M Quintas, Geraldino Cunha-Filho, Maria Lucília Santos, François Noël. Inhibitory effect of combinations of digoxin and endogenous cardiotonic steroids on Na+/K+-ATPase activity in human kidney membrane preparation. Life sciences. 2011 Jan; 88(1-2):39-42. doi: 10.1016/j.lfs.2010.10.027. [PMID: 21047518]
  • Daad Abi-Ghanem, Xinzhong Lai, Luc R Berghman, Darijana Horvat, Jing Li, Daniel Romo, Mohammad N Uddin, Yoshiaki Kamano, Toshihiko Nogawa, Jun-Ping Xu, George R Pettit, Jules B Puschett. A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids. Journal of immunoassay & immunochemistry. 2011; 32(1):31-46. doi: 10.1080/15321819.2010.538107. [PMID: 21253968]
  • Jiang Liu, Zi-Jian Xie. The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking. Biochimica et biophysica acta. 2010 Dec; 1802(12):1237-45. doi: 10.1016/j.bbadis.2010.01.013. [PMID: 20144708]
  • Jiang Tian, Steven Haller, Sankaridrug Periyasamy, Pamela Brewster, Haifeng Zhang, Satjit Adlakha, Olga V Fedorova, Zi-Jian Xie, Alexei Y Bagrov, Joseph I Shapiro, Christopher J Cooper. Renal ischemia regulates marinobufagenin release in humans. Hypertension (Dallas, Tex. : 1979). 2010 Nov; 56(5):914-9. doi: 10.1161/hypertensionaha.110.155564. [PMID: 20823380]
  • Jules B Puschett, Enoch Agunanne, Mohammad N Uddin. Emerging role of the bufadienolides in cardiovascular and kidney diseases. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2010 Aug; 56(2):359-70. doi: 10.1053/j.ajkd.2010.01.023. [PMID: 20417001]
  • Olga V Fedorova, Natalia I Tapilskaya, Anton M Bzhelyansky, Elena V Frolova, Elena R Nikitina, Vitaly A Reznik, Vladimir A Kashkin, Alexei Y Bagrov. Interaction of Digibind with endogenous cardiotonic steroids from preeclamptic placentae. Journal of hypertension. 2010 Feb; 28(2):361-6. doi: 10.1097/hjh.0b013e328333226c. [PMID: 19927009]
  • E E Agunanne, M N Uddin, D Horvat, J B Puschett. Contribution of angiogenic factors in a rat model of pre-eclampsia. American journal of nephrology. 2010; 32(4):332-9. doi: 10.1159/000319463. [PMID: 20720407]
  • Mohammad N Uddin, Darijana Horvat, Ed W Childs, Jules B Puschett. Marinobufagenin causes endothelial cell monolayer hyperpermeability by altering apoptotic signaling. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 Jun; 296(6):R1726-34. doi: 10.1152/ajpregu.90963.2008. [PMID: 19386984]
  • Alexei Y Bagrov, Natalia I Agalakova, Vladimir A Kashkin, Olga V Fedorova. Endogenous cardiotonic steroids and differential patterns of sodium pump inhibition in NaCl-loaded salt-sensitive and normotensive rats. American journal of hypertension. 2009 May; 22(5):559-63. doi: 10.1038/ajh.2009.22. [PMID: 19229192]
  • Larisa V Fedorova, Vanamala Raju, Nasser El-Okdi, Amjad Shidyak, David J Kennedy, Sandeep Vetteth, David R Giovannucci, Alexei Y Bagrov, Olga V Fedorova, Joseph I Shapiro, Deepak Malhotra. The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition. American journal of physiology. Renal physiology. 2009 Apr; 296(4):F922-34. doi: 10.1152/ajprenal.90605.2008. [PMID: 19176701]
  • Olga V Fedorova, Andrey S Simbirtsev, Nikolai I Kolodkin, Alexander Y Kotov, Natalia I Agalakova, Vladimir A Kashkin, Natalia I Tapilskaya, Anton Bzhelyansky, Vitaly A Reznik, Elena V Frolova, Elena R Nikitina, Georgy V Budny, Dan L Longo, Edward G Lakatta, Alexei Y Bagrov. Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension. Journal of hypertension. 2008 Dec; 26(12):2414-25. doi: 10.1097/hjh.0b013e328312c86a. [PMID: 19008721]
  • Wilhelm Schoner, Georgios Scheiner-Bobis. Role of endogenous cardiotonic steroids in sodium homeostasis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2008 Sep; 23(9):2723-9. doi: 10.1093/ndt/gfn325. [PMID: 18556748]
  • Mohammad N Uddin, Darijana Horvat, Shannon S Glaser, Brett M Mitchell, Jules B Puschett. Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblast function. The Journal of biological chemistry. 2008 Jun; 283(26):17946-53. doi: 10.1074/jbc.m800958200. [PMID: 18434301]
  • Olga A Akimova, Monique Poirier, Sergei V Kotelevtsev, Pavel Hamet, Sergei N Orlov. The death of ouabain-treated renal epithelial cells: evidence against anoikis occurrence. Apoptosis : an international journal on programmed cell death. 2008 May; 13(5):670-80. doi: 10.1007/s10495-008-0204-y. [PMID: 18392681]
  • David E Anderson, Olga V Fedorova, Christopher H Morrell, Dan L Longo, Vladimir A Kashkin, Jessica D Metzler, Alexei Y Bagrov, Edward G Lakatta. Endogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensives. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 Apr; 294(4):R1248-54. doi: 10.1152/ajpregu.00782.2007. [PMID: 18287222]
  • M N Uddin, D Horvat, S S Glaser, S Danchuk, B M Mitchell, D E Sullivan, C A Morris, J B Puschett. Marinobufagenin inhibits proliferation and migration of cytotrophoblast and CHO cells. Placenta. 2008 Mar; 29(3):266-73. doi: 10.1016/j.placenta.2007.12.009. [PMID: 18279954]
  • David J Kennedy, Jihad Elkareh, Amjad Shidyak, Anna P Shapiro, Sleiman Smaili, Krishna Mutgi, Shalini Gupta, Jiang Tian, Eric Morgan, Samer Khouri, Christopher J Cooper, Sankaridrug M Periyasamy, Zijian Xie, Deepak Malhotra, Olga V Fedorova, Alexei Y Bagrov, Joseph I Shapiro. Partial nephrectomy as a model for uremic cardiomyopathy in the mouse. American journal of physiology. Renal physiology. 2008 Feb; 294(2):F450-4. doi: 10.1152/ajprenal.00472.2007. [PMID: 18032546]
  • S Danchuk, S Sukhanov, D Horvat, M N Uddin, J B Puschett. Effects of resibufogenin in experimental hypertension. American journal of nephrology. 2008; 28(1):8-13. doi: 10.1159/000108756. [PMID: 17890853]
  • Vladimir A Kashkin, Edwin E Zvartau, Olga V Fedorova, Yakov Y Bagrov, Edward G Lakatta, Alexei Y Bagrov. Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2008 Jan; 18(1):74-7. doi: 10.1016/j.euroneuro.2007.05.006. [PMID: 17683916]
  • Jules B Puschett. Vascular effects of the bufodienolides. Transactions of the American Clinical and Climatological Association. 2008; 119(?):103-12; discussion 112. doi: NULL. [PMID: 18596850]
  • Wilhelm Schoner, Georgios Scheiner-Bobis. Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth. American journal of physiology. Cell physiology. 2007 Aug; 293(2):C509-36. doi: 10.1152/ajpcell.00098.2007. [PMID: 17494630]
  • Masamichi Yoshika, Yutaka Komiyama, Motomi Konishi, Toshifumi Akizawa, Takahisa Kobayashi, Mutsuhiro Date, Shinzo Kobatake, Midori Masuda, Hiroya Masaki, Hakuo Takahashi. Novel digitalis-like factor, marinobufotoxin, isolated from cultured Y-1 cells, and its hypertensive effect in rats. Hypertension (Dallas, Tex. : 1979). 2007 Jan; 49(1):209-14. doi: 10.1161/01.hyp.0000250433.64202.78. [PMID: 17116763]
  • I V Averina, N I Tapilskaya, V A Reznik, E V Frolova, O V Fedorova, E G Lakatta, A Y Bagrov. Endogenous Na/K-ATPase inhibitors in patients with preeclampsia. Cellular and molecular biology (Noisy-le-Grand, France). 2006 Dec; 52(8):19-23. doi: NULL. [PMID: 17535731]
  • N E Zvartau, A O Conrady, Y V Sviryaev, O P Rotari, N K Merkulova, A L Kalinkin, E V Shlyakhto, A Y Bagrov. Marinobufagenin in hypertensive patients with obstructive sleep apnea. Cellular and molecular biology (Noisy-le-Grand, France). 2006 Dec; 52(8):24-7. doi: NULL. [PMID: 17535732]
  • Vardaman M Buckalew. Atrial peptides modify the effect of marinobufagenin on sodium pumps: implications for blood pressure control. Hypertension (Dallas, Tex. : 1979). 2006 Dec; 48(6):1029-30. doi: 10.1161/01.hyp.0000248119.54493.18. [PMID: 17043156]
  • Olga V Fedorova, Natalia I Agalakova, Christopher H Morrell, Edward G Lakatta, Alexei Y Bagrov. ANP differentially modulates marinobufagenin-induced sodium pump inhibition in kidney and aorta. Hypertension (Dallas, Tex. : 1979). 2006 Dec; 48(6):1160-8. doi: 10.1161/01.hyp.0000248129.20524.d0. [PMID: 17043158]
  • H L LaMarca, C A Morris, G R Pettit, T Nagowa, J B Puschett. Marinobufagenin impairs first trimester cytotrophoblast differentiation. Placenta. 2006 Sep; 27(9-10):984-8. doi: 10.1016/j.placenta.2005.12.004. [PMID: 16458353]
  • Bing S Huang, Md Shahrier Amin, Frans H H Leenen. The central role of the brain in salt-sensitive hypertension. Current opinion in cardiology. 2006 Jul; 21(4):295-304. doi: 10.1097/01.hco.0000231398.64362.94. [PMID: 16755197]
  • Hakuo Takahashi, Yutaka Komiyama. [Endogenous digitalis-like factor]. Nihon rinsho. Japanese journal of clinical medicine. 2006 Jul; 64 Suppl 5(?):177-81. doi: NULL. [PMID: 16895183]
  • David J Kennedy, Sandeep Vetteth, Sankaridrug M Periyasamy, Mohamed Kanj, Larisa Fedorova, Samer Khouri, M Bashar Kahaleh, Zijian Xie, Deepak Malhotra, Nikolai I Kolodkin, Edward G Lakatta, Olga V Fedorova, Alexei Y Bagrov, Joseph I Shapiro. Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy. Hypertension (Dallas, Tex. : 1979). 2006 Mar; 47(3):488-95. doi: 10.1161/01.hyp.0000202594.82271.92. [PMID: 16446397]
  • I I Krivoĭ, T M Drabkina, A N Vasil'ev, V V Kravtsova, F Mandel. [Analysis of the interaction between nicotinic acetylcholine receptor and Na+,K(+)-ATPase in the rat skeletal muscle and the Torpedo electric organ membrane preparation]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2006 Feb; 92(2):191-203. doi: NULL. [PMID: 16739652]
  • Wilhelm Schoner, Georgios Scheiner-Bobis. Endogenous cardiac glycosides: hormones using the sodium pump as signal transducer. Seminars in nephrology. 2005 Sep; 25(5):343-51. doi: 10.1016/j.semnephrol.2005.03.010. [PMID: 16139690]
  • Hop V Vu, Monica R Ianosi-Irimie, Candice A Pridjian, Joy M Whitbred, Janelle M Durst, Alexei Y Bagrov, Olga V Fedorova, Gabriella Pridjian, Jules B Puschett. Involvement of marinobufagenin in a rat model of human preeclampsia. American journal of nephrology. 2005 Sep; 25(5):520-8. doi: 10.1159/000088461. [PMID: 16179779]
  • Y Y Bagrov, N B Manusova, I A Egorova, E V Frolova, O V Fedorova, A Y Bagrov. Marinobufagenin, an endogenous inhibitor of alpha-1 Na/K-ATPase, is a novel factor in pathogenesis of diabetes mellitus. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 2005 Sep; 404(?):333-7. doi: 10.1007/s10630-005-0128-4. [PMID: 16405108]
  • Olga V Fedorova, Natalia I Agalakova, Mark I Talan, Edward G Lakatta, Alexei Y Bagrov. Brain ouabain stimulates peripheral marinobufagenin via angiotensin II signalling in NaCl-loaded Dahl-S rats. Journal of hypertension. 2005 Aug; 23(8):1515-23. doi: 10.1097/01.hjh.0000174969.79836.8b. [PMID: 16003178]
  • Sankaridrug M Periyasamy, Jiang Liu, Feras Tanta, Besher Kabak, Brent Wakefield, Deepak Malhotra, David J Kennedy, Alaa Nadoor, Olga V Fedorova, William Gunning, Zijian Xie, Alexei Y Bagrov, Joseph I Shapiro. Salt loading induces redistribution of the plasmalemmal Na/K-ATPase in proximal tubule cells. Kidney international. 2005 May; 67(5):1868-77. doi: 10.1111/j.1523-1755.2005.00285.x. [PMID: 15840034]
  • Olga V Fedorova, Nikolai I Kolodkin, Natalia I Agalakova, Alexandra R Namikas, Anton Bzhelyansky, Jean St-Louis, Edward G Lakatta, Alexei Y Bagrov. Antibody to marinobufagenin lowers blood pressure in pregnant rats on a high NaCl intake. Journal of hypertension. 2005 Apr; 23(4):835-42. doi: 10.1097/01.hjh.0000163153.27954.33. [PMID: 15775789]
  • Yutaka Komiyama, Xian Hui Dong, Noriko Nishimura, Hiroya Masaki, Masamichi Yoshika, Midori Masuda, Hakuo Takahashi. A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure. Clinical biochemistry. 2005 Jan; 38(1):36-45. doi: 10.1016/j.clinbiochem.2004.08.005. [PMID: 15607315]
  • Mark F McCarty. Marinobufagenin may mediate the adverse impact of salty diets on renal calcium retention by impairing the efficiency of renal tubular sodium-calcium exchange. Medical hypotheses. 2005; 64(5):1027-9. doi: 10.1016/j.mehy.2003.10.033. [PMID: 15780505]
  • Atsuo Goto, Kaoru Yamada. [Involvement of ouabain (digitalis-like factor) in the pathogenesis of hypertension and hypertensive target-organ damage]. Nihon rinsho. Japanese journal of clinical medicine. 2004 Mar; 62 Suppl 3(?):169-73. doi: NULL. [PMID: 15171364]
  • Olga V Fedorova, Mark I Talan, Natalia I Agalakova, Edward G Lakatta, Alexei Y Bagrov. Coordinated shifts in Na/K-ATPase isoforms and their endogenous ligands during cardiac hypertrophy and failure in NaCl-sensitive hypertension. Journal of hypertension. 2004 Feb; 22(2):389-97. doi: 10.1097/00004872-200402000-00025. [PMID: 15076199]
  • Snigdha Priyadarshi, Brandon Valentine, Chi Han, Olga V Fedorova, Alexei Y Bagrov, Jiang Liu, Sankaridrug M Periyasamy, David Kennedy, Deepak Malhotra, Zijian Xie, Joseph I Shapiro. Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat. Kidney international. 2003 May; 63(5):1785-90. doi: 10.1046/j.1523-1755.2003.00914.x. [PMID: 12675854]
  • Olga V Fedorova, Mark I Talan, Natalia I Agalakova, Marie-Therese Droy-Lefaix, Edward G Lakatta, Alexei Y Bagrov. Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension. Hypertension (Dallas, Tex. : 1979). 2003 Mar; 41(3):505-11. doi: 10.1161/01.hyp.0000053446.43894.9f. [PMID: 12623951]
  • Jiang Liu, Sankaridrug M Periyasamy, William Gunning, Olga V Fedorova, Alexei Y Bagrov, Deepak Malhotra, Zijian Xie, Joseph I Shapiro. Effects of cardiac glycosides on sodium pump expression and function in LLC-PK1 and MDCK cells. Kidney international. 2002 Dec; 62(6):2118-25. doi: 10.1046/j.1523-1755.2002.00672.x. [PMID: 12427136]
  • Alexander I Fridman, Sergei A Matveev, Natalia I Agalakova, Olga V Fedorova, Edward G Lakatta, Alexei Y Bagrov. Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity. Journal of hypertension. 2002 Jun; 20(6):1189-94. doi: 10.1097/00004872-200206000-00032. [PMID: 12023690]
  • Olga V Fedorova, Mark I Talan, Natalia I Agalakova, Edward G Lakatta, Alexei Y Bagrov. Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension. Circulation. 2002 Mar; 105(9):1122-7. doi: 10.1161/hc0902.104710. [PMID: 11877366]