beta-propiolactone (BioDeep_00000012740)
Secondary id: BioDeep_00001867711
human metabolite blood metabolite
代谢物信息卡片
3-Hydroxypropionic acid beta-lactone
化学式: C3H4O2 (72.0211284)
中文名称: 丙内酯
谱图信息:
最多检出来源 Mus musculus(blood) 95.24%
分子结构信息
SMILES: C1COC1=O
InChI: InChI=1S/C3H4O2/c4-3-1-2-5-3/h1-2H2
描述信息
D000890 - Anti-Infective Agents
D004202 - Disinfectants
同义名列表
45 个代谢物同义名
3-Hydroxypropionic acid beta-lactone; 3-Hydroxypropionic acid b-lactone; 3-Hydroxypropionic acid β-lactone; 3-Hydroxypropionate beta-lactone; 3-Hydroxypropionate β-lactone; Hydracrylic acid beta-lactone; beta-Lactone hydracrylic acid; 3-Hydroxypropionate b-lactone; beta-Propanoic acid lactone; b-Lactone hydracrylic acid; Hydracrylic acid b-lactone; Β-lactone hydracrylic acid; Hydracrylic acid β-lactone; beta-Lactone hydracrylate; Hydracrylate beta-lactone; Β-propanoic acid lactone; b-Propanoic acid lactone; beta-Propanoate lactone; Hydracrylate b-lactone; Β-lactone hydracrylate; Hydracrylate β-lactone; b-Lactone hydracrylate; Β-propanoate lactone; b-Propanoate lactone; beta-Propionolactone; beta-propiolactone; beta Propiolactone; b-Propionolactone; Β-propionolactone; 1,3-Propiolactone; beta-Propiolakton; β propiolactone; b-Propiolactone; β-Propiolactone; Propiolactonum; Β-propiolakton; b-Propiolakton; Propiolactona; 3-Propanolide; Propiolactone; oxetan-2-one; Propanolide; 2-Oxetanone; Betaprone; Betapron
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:49073
- KEGG: C19297
- KEGGdrug: D05630
- PubChem: 2365
- HMDB: HMDB0249149
- Metlin: METLIN44656
- DrugBank: DB09348
- ChEMBL: CHEMBL1200627
- Wikipedia: Propiolactone
- MeSH: Propiolactone
- chemspider: 2275
- CAS: 25037-58-5
- CAS: 57-57-8
- PMhub: MS000027069
- PubChem: 124489969
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Virus research.
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1990 Jan; 36(1):175. doi:
10.1093/clinchem/36.1.175a. [PMID: 2404641] - W Stephan. Inactivation of hepatitis viruses and HIV in plasma and plasma derivatives by treatment with beta-propiolactone/UV irradiation.
Current studies in hematology and blood transfusion.
1989; ?(56):122-7. doi:
10.1159/000416562. [PMID: 2642784] - H Dichtelmüller, W Stephan. [Monitoring of sterilization procedures for plasma derivatives using bacteriophages].
Immunitat und Infektion.
1988 Feb; 16(1):18-20. doi:
NULL. [PMID: 3283031] - M C Anderson, H Baer, D J Frazier, G V Quinnan. The role of specific IgE and beta-propiolactone in reactions resulting from booster doses of human diploid cell rabies vaccine.
The Journal of allergy and clinical immunology.
1987 Dec; 80(6):861-8. doi:
10.1016/s0091-6749(87)80278-6. [PMID: 3693763] - M J Ball. Effect of two disinfectant treatments on laboratory analyses.
Journal of the Royal Society of Medicine.
1987 Aug; 80(8):482-4. doi:
10.1177/014107688708000808. [PMID: 2821254] - M C Swanson, E Rosanoff, M Gurwith, M Deitch, P Schnurrenberger, C E Reed. IgE and IgG antibodies to beta-propiolactone and human serum albumin associated with urticarial reactions to rabies vaccine.
The Journal of infectious diseases.
1987 May; 155(5):909-13. doi:
10.1093/infdis/155.5.909. [PMID: 3559291] - H Dichtelmüller, W Stephan, A M Prince, L Gürtler, F Deinhardt. Inactivation of HIV in plasma derivatives by beta-propiolactone and UV irradiation.
Infection.
1987; 15(5):367-9. doi:
10.1007/bf01647745. [PMID: 3121517] - D Heinrich, U Sugg, H H Brackmann, W Stephan, R Lissner. Virus safety of beta-propiolactone treated plasma preparations. Clinical experiences.
Developments in biological standardization.
1987; 67(?):311-7. doi:
NULL. [PMID: 3649316] - M J Ball, V Spriggs, P M Sutton, H Chapel. Effect of beta-propiolactone--an inhibitor of HTLV III/LAV activity--on immunological analyses.
Journal of immunological methods.
1986 Dec; 95(1):113-6. doi:
10.1016/0022-1759(86)90324-8. [PMID: 3640791] - R H Smith, B Ziola. Cyclophosphamide and dimethyl dioctadecyl ammonium bromide immunopotentiate the delayed-type hypersensitivity response to inactivated enveloped viruses.
Immunology.
1986 Jun; 58(2):245-50. doi:
NULL. [PMID: 2423444] - I S Levenbook, B A Merritt, E A Fitzgerald, B L Elisberg. Sensitization induced in guinea pigs with beta-propiolactone-treated serum albumin: experimental evidence for the cause of allergic reactions in humans receiving human diploid cell rabies vaccines.
International archives of allergy and applied immunology.
1986; 80(1):110-1. doi:
10.1159/000234035. [PMID: 3957443] - M Höckel, R Kaufmann. Placental transfer of class G immunoglobulins treated with beta-propiolactone (beta-PL) for intravenous application--a case report.
Journal of perinatal medicine.
1986; 14(3):205-8. doi:
NULL. [PMID: 3783391] - L E Podoplekina, N A Shutova, Fyodorov YuV. Influence of several chemical reagents on lymphocytic choriomeningitis and Tacaribe viruses.
Virologie.
1986 Jan; 37(1):43-8. doi:
". [PMID: 3962180] - A M Prince, W Stephan, H Dichtelmüller, B Brotman, T Huima. Inactivation of the Hutchinson strain of non-A, non-B hepatitis virus by combined use of beta-propiolactone and ultraviolet irradiation.
Journal of medical virology.
1985 Jun; 16(2):119-25. doi:
10.1002/jmv.1890160204. [PMID: 3925077] - M J Ball, D Griffiths. Effect on chemical analyses of beta-propiolactone treatment of whole blood and plasma.
Lancet (London, England).
1985 May; 1(8438):1160-1. doi:
10.1016/s0140-6736(85)92465-1. [PMID: 2860363] - R L Levings, M L Kaeberle, D E Reed. The effect of some common inactivation procedures on the antigens of bovine herpesvirus 1.
Veterinary microbiology.
1984 Aug; 9(4):313-28. doi:
10.1016/0378-1135(84)90001-4. [PMID: 6093334] - W Stephan. Contributions to the optimal use of human blood. IX. Elimination of hepatitis B transmission by (potentially) infectious plasma derivatives.
Vox sanguinis.
1984; 46(6):421. doi:
NULL. [PMID: 6431692] - A M Prince, W Stephan, B Brotman. Inactivation of non-A, non-B virus infectivity by a beta propiolactone/ultraviolet irradiation treatment and Aerosil adsorption procedure used for preparation of a stabilized human serum.
Vox sanguinis.
1984; 46(2):80-5. doi:
10.1111/j.1423-0410.1984.tb00056.x. [PMID: 6322448] - H Yoshizawa, Y Itoh, S Iwakiri, K Kitajima, Y Noguchi, K Tachibana, T Nakamura, Y Miyakawa, M Mayumi. Beta-propiolactone for the inactivation of non-A/non-B type 1 hepatitis virus capable of inducing cytoplasmic tubular ultrastructures in chimpanzees.
Vox sanguinis.
1984; 46(2):86-91. doi:
10.1111/j.1423-0410.1984.tb00057.x. [PMID: 6422638] - A M Prince, W Stephan, R Kotitschke, B Brotman. Inactivation of hepatitis B and non-A, non-B viruses by combined use of Tween 80, beta-propiolactone, and ultraviolet irradiation.
Thrombosis and haemostasis.
1983 Aug; 50(2):534-6. doi:
10.1055/s-0038-1665248. [PMID: 6415846] - G G Frösner, W Stephan, H Dichtelmüller. Inactivation of hepatitis A virus added to pooled human plasma by beta-propiolactone treatment and ultraviolet irradiation.
European journal of clinical microbiology.
1983 Aug; 2(4):355-7. doi:
10.1007/bf02019469. [PMID: 6313360] - R Kotitschke, W Stephan, A M Prince, B Brotman. Evaluation of thrombogenicity of beta-propiolactone/ultraviolet (beta-PL/UV) treated PPSB in chimpanzees.
Thrombosis research.
1983 May; 30(3):235-44. doi:
10.1016/0049-3848(83)90077-4. [PMID: 6868023] - A M Prince, W Stephan, B Brotman. beta-propiolactone/ultraviolet irradiation: a review of its effectiveness for inactivation of viruses in blood derivatives.
Reviews of infectious diseases.
1983 Jan; 5(1):92-107. doi:
10.1093/clinids/5.1.92. [PMID: 6828813] - D Heinrich, R Kotitschke, H Berthold. Clinical evaluation of the hepatitis safety of a beta-propiolactone/ultraviolet treated factor IX concentrate (PPSB).
Thrombosis research.
1982 Oct; 28(1):75-83. doi:
10.1016/0049-3848(82)90035-4. [PMID: 7157232] - R V Pollock, L E Carmichael. Dog response to inactivated canine parvovirus and feline panleukopenia virus vaccines.
The Cornell veterinarian.
1982 Jan; 72(1):16-35. doi:
. [PMID: 6279359] - W Stephan, H Berthold, A M Prince. Effect of combined treatment of serum containing hepatitis B virus with beta-propiolactone and ultraviolet irradiation.
Vox sanguinis.
1981 Sep; 41(3):134-8. doi:
10.1111/j.1423-0410.1981.tb01026.x. [PMID: 7331286] - W Stephan, R Kotitschke, A M Prince, B Brotman. Long-term tolerance and recovery of beta-propiolactone/ultraviolet (beta PL/UV) treated PPSB in chimpanzees.
Thrombosis and haemostasis.
1981 Aug; 46(2):511-4. doi:
10.1055/s-0038-1653399. [PMID: 7302890] - D C Graves, L V Jones. Early syncytium formation by bovine leukemia virus.
Journal of virology.
1981 Jun; 38(3):1055-63. doi:
10.1128/jvi.38.3.1055-1063.1981. [PMID: 6264150] - R Jennings, T Smith, C W Potter. Use of the enzyme-linked immunosorbent assay (ELISA) for the estimation of serum antibodies in an influenza virus vaccine study.
Medical microbiology and immunology.
1981; 169(4):247-58. doi:
10.1007/bf02125524. [PMID: 6268957] - A M Prince, W Stephan, B Brotman, M C van den Ende. Evaluation of the effect of betapropiolactone/ultraviolet irradiation (BPL/UV) treatment of source plasma on hepatitis transmission by factor IX complex in chimpanzees.
Thrombosis and haemostasis.
1980 Dec; 44(3):138-42. doi:
. [PMID: 7466740] - H H Sonneborn, W Stephan. [Tolerance of beta-propiolactone-treated and UV-irradiated rat serum].
Infusionstherapie und klinische Ernahrung.
1980 Jun; 7(3):145-7. doi:
NULL. [PMID: 7191834] - Y Tomita, T Kuwata. Suppressive effects of interferon on syncytium formation by RD-114 virus in human transformed cells.
The Journal of general virology.
1979 Apr; 43(1):111-7. doi:
10.1099/0022-1317-43-1-111. [PMID: 225412] - Z O Kubinski, H Kubinski. Alterations in Bacillus subtilis transforming DNA induced by beta-propiolactone and 1,3-propane sultone, two mutagenic and carcinogenic alkylating agents.
Journal of bacteriology.
1978 Dec; 136(3):854-66. doi:
10.1128/jb.136.3.854-866.1978. [PMID: 102637] - O Tomori, A Fabiyi. Orungo virus, an orbivirus from Africa: effects of physical and chemical agents.
African journal of medicine and medical sciences.
1977 Mar; 6(1):33-8. doi:
". [PMID: 24332] - T J Wiktor, P C Doherty, H Koprowski. In vitro evidence of cell-mediated immunity after exposure of mice to both live and inactivated rabies virus.
Proceedings of the National Academy of Sciences of the United States of America.
1977 Jan; 74(1):334-8. doi:
10.1073/pnas.74.1.334. [PMID: 299948] - S Barandun, F Skvaril, A Morell. [Prophylaxis and therapy with gamma globulin. General characterization and clinical use of gamma globulin preparations].
Schweizerische medizinische Wochenschrift.
1976 Apr; 106(16):533-42. doi:
NULL. [PMID: 62393] - T A Koski, G G Christianson, F L Cole. Inactivation of mycoplasmas by use of phenol, formalin and beta-propiolactone.
Journal of biological standardization.
1976 Apr; 4(2):151-4. doi:
10.1016/0092-1157(76)90026-3. [PMID: 819443] - B C Del Villano, B P Croker, P J McConahey, F J Dixon. Immunopathogenicity and oncogenicity of murine leukemia viruses. II. Infection of mice and rats with Scripps leukemia virus.
The American journal of pathology.
1976 Feb; 82(2):299-314. doi:
NULL. [PMID: 175661] - D Pruggmayer, W Stephan. Gas chromatographic trace analysis of beta-propiolactone in sterilized serum proteins.
Vox sanguinis.
1976; 31?-73(3):191-8. doi:
10.1159/000467314. [PMID: 969391] - H M Sottnek, W A Cassel, W G Campbell. The pathogenesis of Vaccinia virus toxicity. I. The role of virus-platelet interaction.
Laboratory investigation; a journal of technical methods and pathology.
1975 Nov; 33(5):514-21. doi:
NULL. [PMID: 1195668] - G P Demakov, M A Shilov, V N Ogorodnikova. [Sterilization of the serum of convalescents with betapropiolactone].
Veterinariia.
1975 Aug; ?(8):109-10. doi:
NULL. [PMID: 1216618]