Fludrocortisone (BioDeep_00000001976)
Secondary id: BioDeep_00000637526
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(1R,2S,10S,11S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one
化学式: C21H29FO5 (380.1998916)
中文名称: 氟可的松-d5
谱图信息:
最多检出来源 Homo sapiens(urine) 33.33%
分子结构信息
SMILES: CC12CCC(=O)C=C1CCC1C3CCC(O)(C(=O)CO)C3(C)CC(O)C12F
InChI: InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1
描述信息
Fludrocortisone is only found in individuals that have used or taken this drug. It is a synthetic mineralocorticoid with anti-inflammatory activity. [PubChem]Fludrocortisone binds the mineralocorticoid receptor (aldosterone receptor). This binding (or activation of the mineralocorticoid receptor by fludrocortisone) in turn causes an increase in ion and water transport and thus raises extracellular fluid volume and blood pressure and lowers potassium levels.
H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AA - Mineralocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents
同义名列表
28 个代谢物同义名
(1R,2S,10S,11S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one; 9alpha-fluoro-11beta,17alpha,21-trihydroxy-pregn-4-ene-3,20-dione; 9 alpha Fluoro 17 hydroxycorticosterone; 9 alpha-Fluoro-17-hydroxycorticosterone; Merck brand OF fludrocortisone; 9 alpha Fluorohydrocortisone; 9 alpha Fludrohydrocortisone; 9 alpha-Fluorohydrocortisone; 9 Fluoro 17 hydroxycortisone; 9-Fluoro-17-hydroxycortisone; 9 Fluorohydrocortisone; 9-Fluorohydrocortisone; 9ALPHA-FLUOROCORTISOL; 9a-FLUOROCORTISOL; 9Α-fluorocortisol; 9-Fluorocortisol; Fludrocortisonum; 9 Fluorocortisol; fludrocortisone; Fludrocortisona; SCHEMBL13026141; Merck, astonin; Astonin merck; Astonin-H; Astonin H; Astonin; FCOL; Fludrocortisone
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:50885
- KEGG: C07004
- KEGGdrug: D07967
- PubChem: 31378
- HMDB: HMDB0014825
- Metlin: METLIN2715
- DrugBank: DB00687
- ChEMBL: CHEMBL1201388
- Wikipedia: Fludrocortisone
- MeSH: Fludrocortisone
- chemspider: 29111
- CAS: 127-31-1
- PMhub: MS000001580
- PubChem: 9217
- LipidMAPS: LMST02030103
- PDB-CCD: ZK5
- NIKKAJI: J10.052H
- RefMet: Fludrocortisone
- KNApSAcK: 50885
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Osama A Gheith, Mohammed Dahab, Ayman Maher Nagib, Mohamed Adel, Nabil Elserwy, Islam Sobhy, Mohamed AbdelMonem, Hasaneen Abo Atya, Torki Al-Otaibi. Fludrocortisone Among Adult Renal Transplant Recipients With Persistent Hyperkalemia: Single-Center Experience.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2022 03; 20(Suppl 1):69-73. doi:
10.6002/ect.mesot2021.o27. [PMID: 35384810] - Busra Gurpinar Tosun, Yasemin Kendir Demirkol, Tuba Seven Menevse, Sare Betul Kaygusuz, Mehmet Nuri Ozbek, Selda Ayca Altincik, Jamala Mammadova, Atilla Cayir, Esra Doger, Elvan Bayramoglu, Ozlem Nalbantoglu, Gul Yesiltepe Mutlu, AghaRza Aghayev, Serap Turan, Abdullah Bereket, Tulay Guran. Catch-up Growth and Discontinuation of Fludrocortisone Treatment in Aldosterone Synthase Deficiency.
The Journal of clinical endocrinology and metabolism.
2022 01; 107(1):e106-e117. doi:
10.1210/clinem/dgab619. [PMID: 34415991] - Rouvick M Gama, David Makanjuola, Mona Wahba, Virginia Quan, Mysore Phanish. Fludrocortisone Is an Effective Treatment for Hyperkalaemic Metabolic Acidosis in Kidney Transplant Recipients on Tacrolimus: A Case Series.
Nephron.
2022; 146(2):190-196. doi:
10.1159/000519670. [PMID: 34784594] - Daan H H M Viering, Anneke P Bech, Jeroen H F de Baaij, Eric J Steenbergen, A H Jan Danser, Jack F M Wetzels, René J M Bindels, Jaap Deinum. Functional tests to guide management in an adult with loss of function of type-1 angiotensin II receptor.
Pediatric nephrology (Berlin, Germany).
2021 09; 36(9):2731-2737. doi:
10.1007/s00467-021-05018-7. [PMID: 33768328] - Muneera A Alabdulqader, Ahmad Azzam, Alanoud A Alshami. Incidence of hyperkalemic RTA in pediatric post-renal transplant patients and the role of fludrocortisone.
Pediatric transplantation.
2021 Sep; 25(6):e14029. doi:
10.1111/petr.14029. [PMID: 34021680] - Tuğba Çetin, İhsan Turan. Co-existence of Congenital Adrenal Hyperplasia and Familial Hypokalemic Periodic Paralysis due to CYP21A2 and SCN4A Pathogenic Variants.
Journal of clinical research in pediatric endocrinology.
2021 08; 13(3):362-366. doi:
10.4274/jcrpe.galenos.2020.2020.0219. [PMID: 33389921] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Priyanka Khandelwal, Mahesh V, Vijay Prakash Mathur, Sumantra Raut, Thenral S Geetha, Sandhya Nair, Pankaj Hari, Aditi Sinha, Arvind Bagga. Phenotypic variability in distal acidification defects associated with WDR72 mutations.
Pediatric nephrology (Berlin, Germany).
2021 04; 36(4):881-887. doi:
10.1007/s00467-020-04747-5. [PMID: 33033857] - M Abdalla, J A Dave, I L Ross. Addison's disease associated with hypokalemia: a case report.
Journal of medical case reports.
2021 Mar; 15(1):131. doi:
10.1186/s13256-021-02724-6. [PMID: 33761983] - İbrahim Mert Erbaş, Selda Ayça Altincik, Gönül Çatli, Tolga Ünüvar, Bayram Özhan, Ayhan Abaci, Ahmet Anik. Does fludrocortisone treatment cause hypomagnesemia in children with primary adrenal insufficiency?.
Turkish journal of medical sciences.
2021 02; 51(1):231-237. doi:
10.3906/sag-2008-167. [PMID: 33155789] - Döndü Üsküdar Cansu, Güven Barış Cansu, Sultan Güvenir, Cengiz Korkmaz. Hyperkalemia in type 4 renal tubular acidosis associated with systemic lupus erythematosus.
Rheumatology international.
2020 Nov; 40(11):1895-1901. doi:
10.1007/s00296-020-04546-z. [PMID: 32166438] - Clemens Kamrath, Michaela F Hartmann, Jörn Pons-Kühnemann, Stefan A Wudy. Urinary GC-MS steroid metabotyping in treated children with congenital adrenal hyperplasia.
Metabolism: clinical and experimental.
2020 11; 112(?):154354. doi:
10.1016/j.metabol.2020.154354. [PMID: 32916150] - Zeng Guo, Marko Poglitsch, Brett C McWhinney, Jacobus P J Ungerer, Ashraf H Ahmed, Richard D Gordon, Martin Wolley, Michael Stowasser. Measurement of Equilibrium Angiotensin II in the Diagnosis of Primary Aldosteronism.
Clinical chemistry.
2020 03; 66(3):483-492. doi:
10.1093/clinchem/hvaa001. [PMID: 32068832] - Yuki Kyono, Kandai Nozu, Taku Nakagawa, Yuichi Takami, Hideki Fujita, Tomoaki Ioroi, Masaaki Kugo, Kazumoto Iijima, Naohiro Kamiyoshi. Combination of furosemide and fludrocortisone as a loading test for diagnosis of distal renal tubular acidosis in a pediatric case.
CEN case reports.
2020 02; 9(1):81-86. doi:
10.1007/s13730-019-00432-1. [PMID: 31705302] - Maud Cazenave, Vincent Audard, Jean-Philippe Bertocchio, Anoosha Habibi, Stéphanie Baron, Caroline Prot-Bertoye, Jugurtha Berkenou, Gérard Maruani, Thomas Stehlé, Nicolas Cornière, Hamza Ayari, Gérard Friedlander, Frédéric Galacteros, Pascal Houillier, Pablo Bartolucci, Marie Courbebaisse. Tubular Acidification Defect in Adults with Sickle Cell Disease.
Clinical journal of the American Society of Nephrology : CJASN.
2020 01; 15(1):16-24. doi:
10.2215/cjn.07830719. [PMID: 31822527] - Nupur N Uppal, Rimda Wanchoo, Richard Barnett, Avani Sinha, Kenar D Jhaveri. Hyponatremia in a Patient With Cancer.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2020 01; 75(1):A15-A18. doi:
10.1053/j.ajkd.2019.09.005. [PMID: 31864502] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Y S Aleksandrovich, K V Pshenisnov, A S Ustinova, V V Kopylov, I V Aleksandrovich, V I Gordeev. [Sodium balance impairment in a child with severe traumatic brain injury].
Problemy endokrinologii.
2019 05; 65(1):39-45. doi:
10.14341/probl9668. [PMID: 31091049] - Adriana de Sousa Lages, Beatriz Vale, Patrícia Oliveira, Rita Cardoso, Isabel Dinis, Francisco Carrilho, Alice Mirante. Congenital hyperreninemic hypoaldosteronism due to aldosterone synthase deficiency type I in a Portuguese patient - Case report and review of literature.
Archives of endocrinology and metabolism.
2019 Feb; 63(1):84-88. doi:
10.20945/2359-3997000000107. [PMID: 30864636] - Cenk Gökalp, Faruk Yildiz, Simge Tuzun, Gorkem Karadag, Ilhan Kurultak, Sedat Ustundag. Adrenal Insufficiency Secondary to Peritoneal Dialysis-Related Peritonitis: A Case Report.
Blood purification.
2019; 48(3):272-275. doi:
10.1159/000501391. [PMID: 31291617] - Krister Bamberg, Lena William-Olsson, Ulrika Johansson, Rasmus Jansson-Löfmark, Judith Hartleib-Geschwindner. The selective mineralocorticoid receptor modulator AZD9977 reveals differences in mineralocorticoid effects of aldosterone and fludrocortisone.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2019 Jan; 20(1):1470320319827449. doi:
10.1177/1470320319827449. [PMID: 30813831] - Zeng Guo, Marko Poglitsch, Brett C McWhinney, Jacobus P J Ungerer, Ashraf H Ahmed, Richard D Gordon, Martin Wolley, Michael Stowasser. Aldosterone LC-MS/MS Assay-Specific Threshold Values in Screening and Confirmatory Testing for Primary Aldosteronism.
The Journal of clinical endocrinology and metabolism.
2018 11; 103(11):3965-3973. doi:
10.1210/jc.2018-01041. [PMID: 30137438] - Michael Stowasser, Ashraf H Ahmed, Diane Cowley, Martin Wolley, Zeng Guo, Brett C McWhinney, Jacobus P Ungerer, Richard D Gordon. Comparison of Seated With Recumbent Saline Suppression Testing for the Diagnosis of Primary Aldosteronism.
The Journal of clinical endocrinology and metabolism.
2018 11; 103(11):4113-4124. doi:
10.1210/jc.2018-01394. [PMID: 30239841] - Usha K Misra, Jayantee Kalita, Mritunjai Kumar. Safety and Efficacy of Fludrocortisone in the Treatment of Cerebral Salt Wasting in Patients With Tuberculous Meningitis: A Randomized Clinical Trial.
JAMA neurology.
2018 11; 75(11):1383-1391. doi:
10.1001/jamaneurol.2018.2178. [PMID: 30105362] - Joanna Kanarek-Kucner, Adrian Stefański, Rufus Barraclough, Tomasz Gorycki, Jacek Wolf, Krzysztof Narkiewicz, Michał Hoffmann. Insufficiency of the zona glomerulosa of the adrenal cortex and progressive kidney insufficiency following unilateral adrenalectomy - case report and discussion.
Blood pressure.
2018 10; 27(5):304-312. doi:
10.1080/08037051.2018.1470460. [PMID: 29742971] - Yukiko Yasuoka, Yuichiro Izumi, Takanori Nagai, Takashi Fukuyama, Yushi Nakayama, Hideki Inoue, Kahori Horikawa, Miho Kimura, Masayoshi Nanami, Kengo Yanagita, Tomomi Oshima, Taiga Yamazaki, Takayuki Uematsu, Rui Yamamura, Noritada Kobayashi, Yoshitaka Shimada, Yasushi Nagaba, Takeshi Nakanishi, Tetsuro Yamashita, Masashi Mukoyama, Yuichi Sato, Katsumasa Kawahara, Hiroshi Nonoguchi. Fludrocortisone stimulates erythropoietin production in the intercalated cells of the collecting ducts.
Biochemical and biophysical research communications.
2018 09; 503(4):3121-3127. doi:
10.1016/j.bbrc.2018.08.102. [PMID: 30146260] - Jonathan M Nizar, Blythe D Shepard, Vianna T Vo, Vivek Bhalla. Renal tubule insulin receptor modestly promotes elevated blood pressure and markedly stimulates glucose reabsorption.
JCI insight.
2018 08; 3(16):. doi:
10.1172/jci.insight.95107. [PMID: 30135311] - Maria Manuel Costa, César Esteves, José Luís Castedo, Josué Pereira, Davide Carvalho. A challenging coexistence of central diabetes insipidus and cerebral salt wasting syndrome: a case report.
Journal of medical case reports.
2018 Jul; 12(1):212. doi:
10.1186/s13256-018-1678-z. [PMID: 30012213] - Pierre-Florent Petit, Philippe Hantson, Michel Jadoul, Valentine Gillion. The Case Severe hypokalemia complicated by a syncope.
Kidney international.
2018 07; 94(1):225-226. doi:
10.1016/j.kint.2017.12.009. [PMID: 29933854] - Fredrik Erlandsson, Muna Albayaty, Ligia Chialda, Hans Ericsson, Carl Amilon, Karin Nelander, Rasmus Jansson-Löfmark, Linda Wernevik, Magnus Kjaer, Krister Bamberg, Judith Hartleib-Geschwindner. Clinical safety, tolerability, pharmacokinetics and effects on urinary electrolyte excretion of AZD9977, a novel, selective mineralocorticoid receptor modulator.
British journal of clinical pharmacology.
2018 07; 84(7):1486-1493. doi:
10.1111/bcp.13562. [PMID: 29468715] - Juuso Tainio. Calcineurin inhibitor-associated electrolyte disturbances after pediatric renal transplantation: Could fludrocortisone therapy have a role?.
Pediatric transplantation.
2018 03; 22(2):. doi:
10.1111/petr.13097. [PMID: 29222873] - S R Ali, I Shaheen, D Young, I Ramage, H Maxwell, D A Hughes, D Athavale, M G Shaikh. Fludrocortisone-a treatment for tubulopathy post-paediatric renal transplantation: A national paediatric nephrology unit experience.
Pediatric transplantation.
2018 03; 22(2):. doi:
10.1111/petr.13134. [PMID: 29345400] - Ying Song, Shumin Yang, Wenwen He, Jinbo Hu, Qingfeng Cheng, Yue Wang, Ting Luo, Linqiang Ma, Qianna Zhen, Suhua Zhang, Mei Mei, Zhihong Wang, Hua Qing, Dennis Bruemmer, Bin Peng, Qifu Li. Confirmatory Tests for the Diagnosis of Primary Aldosteronism: A Prospective Diagnostic Accuracy Study.
Hypertension (Dallas, Tex. : 1979).
2018 01; 71(1):118-124. doi:
10.1161/hypertensionaha.117.10197. [PMID: 29158354] - Ramanan Rajagopal, Ganesh Swaminathan, Shalini Nair, Mathew Joseph. Hyponatremia in Traumatic Brain Injury: A Practical Management Protocol.
World neurosurgery.
2017 Dec; 108(?):529-533. doi:
10.1016/j.wneu.2017.09.013. [PMID: 28899834] - Rola Abboud, Mohammad Akil, Catherine Charcosset, Hélène Greige-Gerges. Interaction of glucocorticoids and progesterone derivatives with human serum albumin.
Chemistry and physics of lipids.
2017 10; 207(Pt B):271-278. doi:
10.1016/j.chemphyslip.2017.04.007. [PMID: 28435101] - Anneke P Bech, Jack F M Wetzels, Tom Nijenhuis. Use of the Furosemide Fludrocortisone Test to Clinically Assess Distal Tubular Acidification.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2017 10; 70(4):589-591. doi:
10.1053/j.ajkd.2017.05.009. [PMID: 28634085] - Nasser A Dhayat, Michael W Gradwell, Ganesh Pathare, Manuel Anderegg, Lisa Schneider, David Luethi, Cedric Mattmann, Orson W Moe, Bruno Vogt, Daniel G Fuster. Furosemide/Fludrocortisone Test and Clinical Parameters to Diagnose Incomplete Distal Renal Tubular Acidosis in Kidney Stone Formers.
Clinical journal of the American Society of Nephrology : CJASN.
2017 Sep; 12(9):1507-1517. doi:
10.2215/cjn.01320217. [PMID: 28775126] - Jose-Alberto Palma, Lucy Norcliffe-Kaufmann, Miguel A Perez, Christy L Spalink, Horacio Kaufmann. Sudden Unexpected Death During Sleep in Familial Dysautonomia: A Case-Control Study.
Sleep.
2017 08; 40(8):. doi:
10.1093/sleep/zsx083. [PMID: 28521050] - S J H Dobbin, J R Petrie, M E J Lean, G A McKay. Fludrocortisone therapy for persistent hyperkalaemia.
Diabetic medicine : a journal of the British Diabetic Association.
2017 07; 34(7):1005-1008. doi:
10.1111/dme.13359. [PMID: 28375568] - Noureddine Hamitouche, Emmanuelle Comets, Mégane Ribot, Jean-Claude Alvarez, Eric Bellissant, Bruno Laviolle. Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers.
The AAPS journal.
2017 05; 19(3):727-735. doi:
10.1208/s12248-016-0041-9. [PMID: 28083797] - Clemens Kamrath, Lisa Wettstaedt, Claudia Boettcher, Michaela F Hartmann, Stefan A Wudy. The urinary steroidome of treated children with classic 21-hydroxylase deficiency.
The Journal of steroid biochemistry and molecular biology.
2017 01; 165(Pt B):396-406. doi:
10.1016/j.jsbmb.2016.08.006. [PMID: 27544322] - Andrea Polito, Noureddine Hamitouche, Mégane Ribot, Angelo Polito, Bruno Laviolle, Eric Bellissant, Djillali Annane, Jean-Claude Alvarez. Pharmacokinetics of oral fludrocortisone in septic shock.
British journal of clinical pharmacology.
2016 12; 82(6):1509-1516. doi:
10.1111/bcp.13065. [PMID: 27416887] - Linda Shavit, Lucia Chen, Fayha Ahmed, Pietro Manuel Ferraro, Shabbir Moochhala, Steven B Walsh, Robert Unwin. Selective screening for distal renal tubular acidosis in recurrent kidney stone formers: initial experience and comparison of the simultaneous furosemide and fludrocortisone test with the short ammonium chloride test.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2016 11; 31(11):1870-1876. doi:
10.1093/ndt/gfv423. [PMID: 26961999] - Yanbin Zhao, Kun Zhang, Karl Fent. Corticosteroid Fludrocortisone Acetate Targets Multiple End Points in Zebrafish (Danio rerio) at Low Concentrations.
Environmental science & technology.
2016 09; 50(18):10245-54. doi:
10.1021/acs.est.6b03436. [PMID: 27618422] - Min Jeong Han, Soon Chul Kim, Chan Uhng Joo, Sun Jun Kim. Cerebral salt-wasting syndrome in a child with Wernicke encephalopathy treated with fludrocortisone therapy: A case report.
Medicine.
2016 Sep; 95(36):e4393. doi:
10.1097/md.0000000000004393. [PMID: 27603336] - A Uçar, Y Aydemir, A Doğan, E Tunçez. Relative hypoaldosteronism in a patient with Wolcott-Rallison syndrome.
Diabetic medicine : a journal of the British Diabetic Association.
2016 Mar; 33(3):e13-6. doi:
10.1111/dme.12968. [PMID: 26433138] - Brian L Block, Samuel Bernard, Richard M Schwartzstein. Hypo-Hypo: A Complex Metabolic Disorder.
Annals of the American Thoracic Society.
2016 Jan; 13(1):127-33. doi:
10.1513/annalsats.201507-449cc. [PMID: 26730868] - Hideo Okonogi, Mikio Harada, Hironobu Sato, Kazuhiko Tokoro, Issei Nakayama, Nobuo Tsuboi, Yoichi Miyazaki, Tetsuya Kawamura, Makoto Ogura, Takashi Yokoo. Fluctuation in Serum Sodium Levels Related to Ipragliflozin Administration in a Patient with Diabetic Nephropathy and Sequela of Traumatic Brain Injury.
Internal medicine (Tokyo, Japan).
2016; 55(14):1887-91. doi:
10.2169/internalmedicine.55.5482. [PMID: 27432098] - Filipa Correia, Alexandre Fernandes, Teresa C Mota, Milagros Garcia, Cíntia Castro-Correia, Manuel Fontoura, Augusto Ribeiro. Hyponatremia in a Teenager: A Rare Diagnosis.
Pediatric emergency care.
2015 Dec; 31(12):860-3. doi:
10.1097/pec.0000000000000633. [PMID: 26626895] - Christos K Koutinas, Nektarios C Soubasis, Sylvia C Djajadiningrat-Laanen, Elissavet Kolia, Konstantina Theodorou. Urinary Aldosterone/Creatinine Ratio After Fludrocortisone Suppression Consistent with PHA in a Cat.
Journal of the American Animal Hospital Association.
2015 Sep; 51(5):338-41. doi:
10.5326/jaaha-ms-6201. [PMID: 26355586] - Ashraf H Ahmed, Richard D Gordon, Gregory Ward, Martin Wolley, Cynthia Kogovsek, Michael Stowasser. Should aldosterone suppression tests be conducted during a particular phase of the menstrual cycle, and, if so, which phase? Results of a preliminary study.
Clinical endocrinology.
2015 Sep; 83(3):303-7. doi:
10.1111/cen.12705. [PMID: 25523596] - Jagadeesh Banda, Ramalingam Lakshmanan, Shiva Prasad Vvs, Srinibas Patro Gudla, Rosaiah Prudhivi. A highly sensitive method for the quantification of fludrocortisone in human plasma using ultra-high-performance liquid chromatography tandem mass spectrometry and its pharmacokinetic application.
Biomedical chromatography : BMC.
2015 Aug; 29(8):1213-9. doi:
10.1002/bmc.3410. [PMID: 25611194] - Joshua E Raizman, Eleftherios P Diamandis, Daniel Holmes, Michael Stowasser, Richard Auchus, Etienne Cavalier. A renin-ssance in primary aldosteronism testing: obstacles and opportunities for screening, diagnosis, and management.
Clinical chemistry.
2015 Aug; 61(8):1022-7. doi:
10.1373/clinchem.2015.242990. [PMID: 26106077] - Julie Richer, Hussein Daoud, Pavel Geier, Olga Jarinova, Nancy Carson, Jana Feberova, Nadya Ben Fadel, Nadya Ben Fadfel, Jennifer Unrau, Eric Bareke, Karine Khatchadourian, Dennis E Bulman, Jacek Majewski, Kym M Boycott, David A Dyment. Resolution of refractory hypotension and anuria in a premature newborn with loss-of-function of ACE.
American journal of medical genetics. Part A.
2015 Jul; 167(7):1654-8. doi:
10.1002/ajmg.a.37067. [PMID: 25899979] - Beatriz Maia Vale, Sofia Morais, Joana Mesquita, Gabriela Mimoso. Reset osmostat: a rare cause of hyponatraemia.
BMJ case reports.
2015 Jun; 2015(?):. doi:
10.1136/bcr-2013-009111. [PMID: 26123451] - Stephen J Winters, Todd Vitaz, Michael R Nowacki, Durrett C Craddock, Craig Silverman. Addison's Disease and Pituitary Enlargement.
The American journal of the medical sciences.
2015 Jun; 349(6):526-9. doi:
10.1097/maj.0000000000000305. [PMID: 25004119] - Tim Both, Ewout J Hoorn, Robert Zietse, Jan A M van Laar, Virgil A S H Dalm, Zana Brkic, Marjan A Versnel, P Martin van Hagen, Paul L A van Daele. Prevalence of distal renal tubular acidosis in primary Sjögren's syndrome.
Rheumatology (Oxford, England).
2015 May; 54(5):933-9. doi:
10.1093/rheumatology/keu401. [PMID: 25354755] - Mayu Matsuda, Ellen N Behrend, Robert Kemppainen, Kent Refsal, Aime Johnson, Hollie Lee. Serum aldosterone and cortisol concentrations before and after suppression with fludrocortisone in cats: a pilot study.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.
2015 May; 27(3):361-8. doi:
10.1177/1040638715583530. [PMID: 25901003] - Haroon Younas, Omer Sabir, Ilyas Baig, Nauman Tarif. Cerebral salt wasting: a report of three cases.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2015 Jan; 25(1):73-5. doi:
01.2015/jcpsp.7375. [PMID: 25604375] - Marcus Quinkler, Wolgang Oelkers, Hanna Remde, Bruno Allolio. Mineralocorticoid substitution and monitoring in primary adrenal insufficiency.
Best practice & research. Clinical endocrinology & metabolism.
2015 Jan; 29(1):17-24. doi:
10.1016/j.beem.2014.08.008. [PMID: 25617169] - Yuki Kawashima, Takeshi Usui, Masanobu Fujimoto, Naoki Miyahara, Rei Nishimura, Keiichi Hanaki, Susumu Kanzaki. A rare CYP 21 mutation (p.E431K) induced deactivation of CYP 21A2 and resulted in congenital adrenal hyperplasia.
Endocrine journal.
2015; 62(1):101-6. doi:
10.1507/endocrj.ej14-0437. [PMID: 25319875] - Walter Bonfig, Hans Peter Schwarz. Blood pressure, fludrocortisone dose and plasma renin activity in children with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency followed from birth to 4 years of age.
Clinical endocrinology.
2014 Dec; 81(6):871-5. doi:
10.1111/cen.12498. [PMID: 24818525] - Hanène Ayari, Liliana Legedz, Catherine Cerutti, Pierre Lantelme, Patrick Feugier, Marie-Paule Gustin, Olivier Lohez, Ali Nehme, Jacques Yuan Li, Jouda Gharbi-Chihi, Giampiero Bricca. Mutual amplification of corticosteroids and angiotensin systems in human vascular smooth muscle cells and carotid atheroma.
Journal of molecular medicine (Berlin, Germany).
2014 Nov; 92(11):1201-8. doi:
10.1007/s00109-014-1193-7. [PMID: 25088215] - Svetlana Pavleska-Kuzmanovska, Zivko Popov, Ognen Ivanovski, Vesna Ristovska, Jelka Masin-Spasovska, Irena Rambabova-Busljetic, Ninoslav Ivanovski. Cyclosporine nephrotoxicity and early posttransplant hyperkalemia in living-donor renal recipients: report of 4 cases.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2014 Oct; 12(5):479-83. doi:
10.6002/ect.2013.0159. [PMID: 24417207] - Justine Bacchetta, Odile Basmaison, Anne-Laure Leclerc, Aurélia Bertholet-Thomas, Pierre Cochat, Bruno Ranchin. Fludrocortisone as a new tool for managing tubulopathy after pediatric renal transplantation: a series of cases.
Pediatric nephrology (Berlin, Germany).
2014 Oct; 29(10):2061-4. doi:
10.1007/s00467-014-2842-3. [PMID: 24908322] - M E Baumstark, J Nussberger, F S Boretti, M W Baumstark, B Riond, C E Reusch, N S Sieber-Ruckstuhl. Use of plasma renin activity to monitor mineralocorticoid treatment in dogs with primary hypoadrenocorticism: desoxycorticosterone versus fludrocortisone.
Journal of veterinary internal medicine.
2014 Sep; 28(5):1471-8. doi:
10.1111/jvim.12426. [PMID: 25274440] - Ashraf H Ahmed, Diane Cowley, Martin Wolley, Richard D Gordon, Shengxin Xu, Paul J Taylor, Michael Stowasser. Seated saline suppression testing for the diagnosis of primary aldosteronism: a preliminary study.
The Journal of clinical endocrinology and metabolism.
2014 Aug; 99(8):2745-53. doi:
10.1210/jc.2014-1153. [PMID: 24762111] - Wanzhu Tu, George J Eckert, Tamara S Hannon, Hai Liu, Linda M Pratt, Mary Anne Wagner, Linda A Dimeglio, Jeesun Jung, J Howard Pratt. Racial differences in sensitivity of blood pressure to aldosterone.
Hypertension (Dallas, Tex. : 1979).
2014 Jun; 63(6):1212-8. doi:
10.1161/hypertensionaha.113.02989. [PMID: 24711519] - Yves Reznik. [Treatment of adrenal deficiency: To what issues? By which therapeutic means?].
Presse medicale (Paris, France : 1983).
2014 Apr; 43(4 Pt 1):438-43. doi:
10.1016/j.lpm.2014.02.003. [PMID: 24636680] - Rajni Sharma, Anju Seth. Congenital adrenal hyperplasia: issues in diagnosis and treatment in children.
Indian journal of pediatrics.
2014 Feb; 81(2):178-85. doi:
10.1007/s12098-013-1280-8. [PMID: 24254335] - Hanène Ayari, Liliana Legedz, Pierre Lantelme, Patrick Feugier, Jacques Randon, Catherine Cerutti, Olivier Lohez, Jean-Yves Scoazec, Jacques Yuan Li, Jouda Gharbi-Chihi, Giampiero Bricca. Auto-amplification of cortisol actions in human carotid atheroma is linked to arterial remodeling and stroke.
Fundamental & clinical pharmacology.
2014 Feb; 28(1):53-64. doi:
10.1111/j.1472-8206.2012.01064.x. [PMID: 23025717] - V Sivakumar, P Sriramnaveen, C Krishna, Y Manjusha, Y Sandeep Reddy, N Sridhar, S Subramanian. Role of fludrocortisone in the management of tacrolimus-induced hyperkalemia in a renal transplant recipient.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2014 Jan; 25(1):149-51. doi:
10.4103/1319-2442.124539. [PMID: 24434399] - S C Djajadiningrat-Laanen, Galac, M H Boevé, S A E B Boroffka, E C Naan, J IJzer, H S Kooistra. Evaluation of the oral fludrocortisone suppression test for diagnosing primary hyperaldosteronism in cats.
Journal of veterinary internal medicine.
2013 Nov; 27(6):1493-9. doi:
10.1111/jvim.12216. [PMID: 24627898] - Julia Sicken, Reto Neiger. Addisonian crisis and severe acidosis in a cat: a case of feline hypoadrenocorticism.
Journal of feline medicine and surgery.
2013 Oct; 15(10):941-4. doi:
10.1177/1098612x13480983. [PMID: 23482253] - Mégane Ribot, Andrea Polito, Stanislas Grassin-Delyle, Djillali Annane, Jean-Claude Alvarez. Human plasma quantification of fludrocortisone using liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometry after low-dosage administration.
Clinica chimica acta; international journal of clinical chemistry.
2013 May; 420(?):109-13. doi:
10.1016/j.cca.2012.11.026. [PMID: 23228845] - Athina Markou, Theodora Pappa, Gregory Kaltsas, Aggeliki Gouli, Kostas Mitsakis, Panayiotis Tsounas, Anastasia Prevoli, Vaios Tsiavos, Labrini Papanastasiou, George Zografos, George P Chrousos, George P Piaditis. Evidence of primary aldosteronism in a predominantly female cohort of normotensive individuals: a very high odds ratio for progression into arterial hypertension.
The Journal of clinical endocrinology and metabolism.
2013 Apr; 98(4):1409-16. doi:
10.1210/jc.2012-3353. [PMID: 23471976] - Juan C Guzman, Luciana V Armaganijan, Carlos A Morillo. Treatment of neurally mediated reflex syncope.
Cardiology clinics.
2013 Feb; 31(1):123-9. doi:
10.1016/j.ccl.2012.10.007. [PMID: 23217693] - Anna Lembke, Rowena Gomez, Lakshika Tenakoon, Jennifer Keller, Gregory Cohen, Gordon H Williams, Fredric B Kraemer, Alan F Schatzberg. The mineralocorticoid receptor agonist, fludrocortisone, differentially inhibits pituitary-adrenal activity in humans with psychotic major depression.
Psychoneuroendocrinology.
2013 Jan; 38(1):115-21. doi:
10.1016/j.psyneuen.2012.05.006. [PMID: 22727477] - Ichiro Nakagawa, Yasuo Hironaka, Fumihiko Nishimura, Yasuhiro Takeshima, Ryosuke Matsuda, Shuichi Yamada, Yasushi Motoyama, Young-Su Park, Hiroyuki Nakase. Early inhibition of natriuresis suppresses symptomatic cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
Cerebrovascular diseases (Basel, Switzerland).
2013; 35(2):131-7. doi:
10.1159/000346586. [PMID: 23406891] - Larissa G Gomes, Guiomar Madureira, Berenice B Mendonca, Tania A S S Bachega. Mineralocorticoid replacement during infancy for salt wasting congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Clinics (Sao Paulo, Brazil).
2013; 68(2):147-52. doi:
10.6061/clinics/2013(02)oa05. [PMID: 23525308] - L Norcliffe-Kaufmann, F B Axelrod, H Kaufmann. Developmental abnormalities, blood pressure variability and renal disease in Riley Day syndrome.
Journal of human hypertension.
2013 Jan; 27(1):51-5. doi:
10.1038/jhh.2011.107. [PMID: 22129610] - Casper L Jessen, Jane H Christensen, Niels H Birkebaek, Soren Rittig. Homozygosity for a mutation in the CYP11B2 gene in an infant with congenital corticosterone methyl oxidase deficiency type II.
Acta paediatrica (Oslo, Norway : 1992).
2012 Nov; 101(11):e519-25. doi:
10.1111/j.1651-2227.2012.02823.x. [PMID: 22931312] - Kahori Hori, Takanori Nagai, Yuichiro Izumi, Miho Kimura, Yukiko Hasuike, Yushi Nakayama, Masayoshi Nanami, Masanori Tokuyama, Yoshinaga Otaki, Takahiro Kuragano, Yukimasa Kohda, Masuo Obinata, Katsumasa Kawahara, Akito Tanoue, Kimio Tomita, Takeshi Nakanishi, Hiroshi Nonoguchi. Vasopressin V1a receptor is required for nucleocytoplasmic transport of mineralocorticoid receptor.
American journal of physiology. Renal physiology.
2012 Oct; 303(7):F1080-8. doi:
10.1152/ajprenal.00052.2012. [PMID: 22811487] - Kurt Kimpinski, Juan J Figueroa, Wolfgang Singer, David M Sletten, Valeria Iodice, Paola Sandroni, Philip R Fischer, Tonette L Opfer-Gehrking, Jade A Gehrking, Phillip A Low. A prospective, 1-year follow-up study of postural tachycardia syndrome.
Mayo Clinic proceedings.
2012 Aug; 87(8):746-52. doi:
10.1016/j.mayocp.2012.02.020. [PMID: 22795533] - Bruno Laviolle, Djillali Annane, Claire Fougerou, Eric Bellissant. Gluco- and mineralocorticoid biological effects of a 7-day treatment with low doses of hydrocortisone and fludrocortisone in septic shock.
Intensive care medicine.
2012 Aug; 38(8):1306-14. doi:
10.1007/s00134-012-2585-1. [PMID: 22584796] - K Sarafoglou, C P Lorentz, N Otten, W S Oetting, S K G Grebe. Molecular testing in congenital adrenal hyperplasia due to 21α-hydroxylase deficiency in the era of newborn screening.
Clinical genetics.
2012 Jul; 82(1):64-70. doi:
10.1111/j.1399-0004.2011.01694.x. [PMID: 21534945] - Min Jeong Choi, Yoon Su Oh, Se Jin Park, Ji Hong Kim, Jae Il Shin. Cerebral salt wasting treated with fludrocortisone in a 17-year-old boy.
Yonsei medical journal.
2012 Jul; 53(4):859-62. doi:
10.3349/ymj.2012.53.4.859. [PMID: 22665358] - Jeffrey L Hastings, Felix Krainski, Peter G Snell, Eric L Pacini, Manish Jain, Paul S Bhella, Shigeki Shibata, Qi Fu, M Dean Palmer, Benjamin D Levine. Effect of rowing ergometry and oral volume loading on cardiovascular structure and function during bed rest.
Journal of applied physiology (Bethesda, Md. : 1985).
2012 May; 112(10):1735-43. doi:
10.1152/japplphysiol.00019.2012. [PMID: 22345434] - Alberto Bettinelli, Laura Longoni, Fabiana Tammaro, Pietro B Faré, Luca Garzoni, Mario G Bianchetti. Renal salt-wasting syndrome in children with intracranial disorders.
Pediatric nephrology (Berlin, Germany).
2012 May; 27(5):733-9. doi:
10.1007/s00467-011-2093-5. [PMID: 22237777] - Machiko Koshimichi, Keisuke Sugimoto, Hidehiko Yanagida, Shinsuke Fujita, Tomoki Miyazawa, Naoki Sakata, Mitsuru Okada, Tsukasa Takemura. Newly-identified symptoms of left renal vein entrapment syndrome mimicking orthostatic disturbance.
World journal of pediatrics : WJP.
2012 May; 8(2):116-22. doi:
10.1007/s12519-012-0349-1. [PMID: 22573421] - Hui-wen Xiao, Hua-mei Ma, Zhe Su, Min-lian Du, Yan-hong Li, Hong-shan Chen, Qiu-li Chen. [Determination of serum steroids in monitoring therapy of congenital adrenal hyperplasia].
Zhonghua er ke za zhi = Chinese journal of pediatrics.
2012 Apr; 50(4):301-7. doi:
. [PMID: 22801236] - Syed Ahmed Zaki, Vijay Lad, Preeti Shanbag. Cerebral salt wasting following tuberculous meningoencephalitis in an infant.
Annals of Indian Academy of Neurology.
2012 Apr; 15(2):148-50. doi:
10.4103/0972-2327.95004. [PMID: 22566734] - Michele Delfino, Jlenia Elia, Norina Imbrogno, Nicola Argese, Rossella Mazzilli, Vincenzo Toscano, Fernando Mazzilli. Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia: prevalence and sonographic, hormonal, and seminal characteristics.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.
2012 Mar; 31(3):383-8. doi:
10.7863/jum.2012.31.3.383. [PMID: 22368128] - Luis E Okamoto, Satish R Raj, Amanda Peltier, Alfredo Gamboa, Cyndya Shibao, André Diedrich, Bonnie K Black, David Robertson, Italo Biaggioni. Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes.
Clinical science (London, England : 1979).
2012 Feb; 122(4):183-92. doi:
10.1042/cs20110200. [PMID: 21906029] - Su Yin Lau, Tuck Yean Yong. Rhabdomyolysis in acute primary adrenal insufficiency complicated by severe hyponatraemia.
Internal medicine (Tokyo, Japan).
2012; 51(17):2371-4. doi:
10.2169/internalmedicine.51.7879. [PMID: 22975551] - Daniel Lienhard, Meret Lauterburg, Geneviève Escher, Felix J Frey, Brigitte M Frey. High salt intake down-regulates colonic mineralocorticoid receptors, epithelial sodium channels and 11β-hydroxysteroid dehydrogenase type 2.
PloS one.
2012; 7(5):e37898. doi:
10.1371/journal.pone.0037898. [PMID: 22693583] - Sarah Vogt, Elena Winkler, Derik Hermsen, Matthias Schott, Sven Schinner, Werner A Scherbaum, Holger S Willenberg. Endothelin-1 and adrenomedullin plasma levels after exposure to fludrocortisone, dexamethasone, and spironolactone.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2012; 34(8):582-7. doi:
10.3109/10641963.2012.681729. [PMID: 22559244] - Robert Krysiak, Bogusław Okopień. [Drug-induced exacerbation of hypoaldosteronism in autoimmune polyglandular syndrome type 2].
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2012; 65(4):239-42. doi:
NULL. [PMID: 23654145] - Marie-Christine Vantyghem, Anne-Sophie Balavoine, Jean-Louis Wémeau, Claire Douillard. Hyponatremia and antidiuresis syndrome.
Annales d'endocrinologie.
2011 Dec; 72(6):500-12. doi:
10.1016/j.ando.2011.10.001. [PMID: 22119069]