Parathion (BioDeep_00000001403)

 

Secondary id: BioDeep_00000229711, BioDeep_00001867643

human metabolite Endogenous Industrial Pollutants


代谢物信息卡片


p-Nitrophenol O-ester with O,O-diethylphosphorothioic acid

化学式: C10H14NO5PS (291.03302840000003)
中文名称: 巴拉松, 对硫磷
谱图信息: 最多检出来源 Homo sapiens(blood) 0.79%

分子结构信息

SMILES: CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-]
InChI: InChI=1S/C10H14NO5PS/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

描述信息

Parathion is a highly toxic cholinesterase inhibitor that is used as an acaricide and as an insecticide.
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
A highly toxic cholinesterase inhibitor that is used as an acaricide and as an insecticide. [HMDB]
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D010575 - Pesticides > D007306 - Insecticides
D004791 - Enzyme Inhibitors
D016573 - Agrochemicals

同义名列表

119 个代谢物同义名

p-Nitrophenol O-ester with O,O-diethylphosphorothioic acid; Ethyl parathion (O,O-diethyl-O-p-nitrophenylthiophosphate); Phosphorothioic acid, O,O-diethyl O-(4-nitrophenyl) ester; Phosphorothioic acid O,O-diethyl-O-(4-nitrophenyl) ester; p-Nitrophenol O-ester with O,O-diethylphosphorothioate; Phosphorothioate, O,O-diethyl O-(4-nitrophenyl) ester; O,O-Diethyl O-(4-nitrophenyl) thiophosphoric acid; O,O-Diethyl O-(p-nitrophenyl) thiophosphoric acid; O,O-Diethyl O-p-nitrophenyl phosphorothioic acid; O,O-Diethyl-O-(p-nitrophenyl)thionophosphate; O,O-diethyl O-4-nitrophenyl phosphorothioate; Diethyl O-p-nitrophenyl phosphorothioic acid; O,O-Diethyl O-p-nitrophenyl phosphorothioate; O,O-Diethyl O-(4-nitrophenyl) thiophosphate; O,O-Diethyl O-(p-nitrophenyl) thiophosphate; Diethyl p-nitrophenyl thiophosphoric acid; Diethyl O-p-nitrophenyl phosphorothioate; Diethyl-p-nitrophenyl monothiophosphate; Diethyl 4-nitrophenyl phosphorothionate; Diethyl para-nitrophenol thiophosphate; Diethyl p-nitrophenyl thionophosphate; Diethyl p-nitrophenyl thiophosphate; Deoxynucleoside 5-triphosphate; Stabilized ethyl parathion; Sixty-three special e.c; American cyanamid 3422; dibutyl butanedioate; Phosphorothioic acid; Drexel parathion 8E; Diethyl parathion; Thionspray no.84; Aqua 9-parathion; Phosphorothioate; diethyl p-nitrop; Diethylparathion; Parathion, ethyl; Lethalaire g-54; Folidol e e 605; Phosphostigmine; Ethyl parathion; Super rodiatox; Thiophos 3422; Oleoparaphene; Oleoparathion; Nitrostygmine; Folidol e605; Folidol oil; Pestox plus; Fosferno 50; Parathion-e; Paramar 50; Phosphenol; Soprathion; Rhodiatrox; Phosphemol; Oleofos 20; Nourithion; Rhodiasol; Rhodiatox; parathion; Orthophos; Corthione; Strathion; Parathene; Lirothion; Penncap e; Genithion; Corothion; Niuif-100; Durathion; Panthion; Paraphos; Thiophos; Parthion; Gearphos; Stathion; Aphamite; Foliclal; Fosfermo; Danthion; Selephos; Fosferno; Kypthion; Paradust; Vapophos; Phoskil; Paramar; Pethion; Folidol; Fostern; Kolphos; Parawet; Alleron; Thiofos; Thiomex; Fosfive; Ecatox; Bladen; OMS 19; Fosfex; Sulfos; Etilon; Ethlon; Vitrex; Tiofos; Bladan; Fosova; Fostox; Alkron; Murfos; Niran; Pacol; Viran; Aralo; DNTP; T-47; PAC; PAT; Parathion



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

11 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(11)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Valéria Costa Da Silva, Gerlane Coelho Bernardo Guerra, Daline Fernandes De Souza Araújo, Edilane Rodrigues De Araújo, Aurigena Antunes De Araújo, Renato Dantas-Medeiros, Ana Caroline Zanatta, Isadora Luisa Gomes Da Silva, Raimundo Fernandes De Araújo Júnior, Debora Esposito, Marvin Moncada, Silvana Maria Zucolotto. Chemopreventive and immunomodulatory effects of phenolic-rich extract of Commiphora leptophloeos against inflammatory bowel disease: Preclinical evidence. Journal of ethnopharmacology. 2024 Jun; 328(?):118025. doi: 10.1016/j.jep.2024.118025. [PMID: 38458342]
  • Stefania Lama, Ester Pagano, Francesca Borrelli, Maria Maisto, Gian Carlo Tenore, Maria Francesca Nanì, Pilar Chacon-Millan, Ettore Novellino, Paola Stiuso. Polyphenol-Rich Extract from 'Limoncella' Apple Variety Ameliorates Dinitrobenzene Sulfonic Acid-Induced Colitis and Linked Liver Damage. International journal of molecular sciences. 2024 Mar; 25(6):. doi: 10.3390/ijms25063210. [PMID: 38542183]
  • Tommaso Venneri, Giada Giorgini, Nadine Leblanc, Nicolas Flamand, Francesca Borrelli, Cristoforo Silvestri, Vincenzo Di Marzo. Altered endocannabinoidome bioactive lipid levels accompany reduced DNBS-induced colonic inflammation in germ-free mice. Lipids in health and disease. 2023 May; 22(1):63. doi: 10.1186/s12944-023-01823-1. [PMID: 37189092]
  • Saroj K Amar, Keri B Donohue, Kurt A Gust. Cellular and molecular responses to ethyl-parathion in undifferentiated SH-SY5Y cells provide neurotoxicity pathway indicators for organophosphorus impacts. Toxicological sciences : an official journal of the Society of Toxicology. 2023 Feb; 191(2):285-295. doi: 10.1093/toxsci/kfac125. [PMID: 36458919]
  • José R Cruz-Muñoz, Tonatiuh Barrios-García, Eduardo E Valdez-Morales, María F Durán-Vazquez, Karen B Méndez-Rodríguez, Alma Barajas-Espinosa, Fernando Ochoa-Cortes, María C Martínez-Saldaña, Yenny A Gómez-Aguirre, Raquel Guerrero Alba. Ethanolic extract from Lepidium virginicum L. ameliorates DNBS-induced colitis in rats. Journal of ethnopharmacology. 2022 May; 289(?):115056. doi: 10.1016/j.jep.2022.115056. [PMID: 35104576]
  • Kelin Tao, Haixia Tian, Jing Fan, Dongxiao Li, Chaoyang Liu, Mallavarapu Megharaj, Huayong Li, Min Hu, Hanzhong Jia, Wenxiang He. Kinetics and catalytic efficiency of soil fluorescein diacetate hydrolase under the pesticide parathion stress. The Science of the total environment. 2021 Jun; 771(?):144835. doi: 10.1016/j.scitotenv.2020.144835. [PMID: 33548707]
  • Emiliano Manzo, Aniello Schiano Moriello, Francesco Tinto, Roberta Verde, Marco Allarà, Luciano De Petrocellis, Ester Pagano, Angelo A Izzo, Vincenzo Di Marzo, Stefania Petrosino. A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator. Cells. 2021 02; 10(2):. doi: 10.3390/cells10020450. [PMID: 33672574]
  • Ali Salari, Kambiz Roshanaei, Bahram Rasoulian, Javad Khalili Fard. Carvacrol loaded beta cyclodextrin-alginate-chitosan based nanoflowers attenuates renal toxicity induced by malathion and parathion: A comparative toxicity. Pesticide biochemistry and physiology. 2021 Feb; 172(?):104747. doi: 10.1016/j.pestbp.2020.104747. [PMID: 33518056]
  • Carmen Parisio, Elena Lucarini, Laura Micheli, Alessandra Toti, Maria Bellumori, Lorenzo Cecchi, Laura Calosi, Daniele Bani, Lorenzo Di Cesare Mannelli, Nadia Mulinacci, Carla Ghelardini. Extra virgin olive oil and related by-products (Olea europaea L.) as natural sources of phenolic compounds for abdominal pain relief in gastrointestinal disorders in rats. Food & function. 2020 Dec; 11(12):10423-10435. doi: 10.1039/d0fo02293d. [PMID: 33237043]
  • Duo Miao, Song Zhao, Kecheng Zhu, Peng Zhang, Tiecheng Wang, Hanzhong Jia, Hongwen Sun. Activation of persulfate and removal of ethyl-parathion from soil: Effect of microwave irradiation. Chemosphere. 2020 Aug; 253(?):126679. doi: 10.1016/j.chemosphere.2020.126679. [PMID: 32283425]
  • Lindsay M Jaacks, Nancy Diao, Antonia M Calafat, Maria Ospina, Maitreyi Mazumdar, Md Omar Sharif Ibne Hasan, Robert Wright, Quazi Quamruzzaman, David C Christiani. Association of prenatal pesticide exposures with adverse pregnancy outcomes and stunting in rural Bangladesh. Environment international. 2019 12; 133(Pt B):105243. doi: 10.1016/j.envint.2019.105243. [PMID: 31675560]
  • Seyedhossein Hekmatimoghaddam, Maryam Iman, Hossein Shahdadi Sardo, Ali Jebali. Gelatin hydrogel containing cerium oxide nanoparticles covered by interleukin-17 aptamar as an anti- inflammatory agent for brain inflammation. Journal of neuroimmunology. 2019 01; 326(?):79-83. doi: 10.1016/j.jneuroim.2018.11.011. [PMID: 30544018]
  • Valéria Costa da Silva, Aurigena Antunes de Araújo, Daline Fernandes de Souza Araújo, Maíra Conceição Jerônimo Souza Lima, Roseane Carvalho Vasconcelos, Raimundo Fernandes de Araújo Júnior, Silvana Maria Zucolotto Langasnner, Matheus de Freitas Fernandes Pedrosa, Caroline Addison Carvalho Xavier de Medeiros, Gerlane Coelho Bernardo Guerra. Intestinal Anti-Inflammatory Activity of the Aqueous Extract from Ipomoea asarifolia in DNBS-Induced Colitis in Rats. International journal of molecular sciences. 2018 Dec; 19(12):. doi: 10.3390/ijms19124016. [PMID: 30545135]
  • Mohamed Khairy, Haytham A Ayoub, Craig E Banks. Non-enzymatic electrochemical platform for parathion pesticide sensing based on nanometer-sized nickel oxide modified screen-printed electrodes. Food chemistry. 2018 Jul; 255(?):104-111. doi: 10.1016/j.foodchem.2018.02.004. [PMID: 29571455]
  • Qian Bo, Lu Chen, Yahui Liu, Chunjie Chang, Xiaoli Ying, Fengliang Li, Luogen Cheng. Analysis of Ran related to pesticide resistance in Drosophila Kc cells. Gene. 2018 Jul; 663(?):131-137. doi: 10.1016/j.gene.2018.04.031. [PMID: 29680247]
  • Haina Sun, Nicolas Buchon, Jeffrey G Scott. Mdr65 decreases toxicity of multiple insecticides in Drosophila melanogaster. Insect biochemistry and molecular biology. 2017 10; 89(?):11-16. doi: 10.1016/j.ibmb.2017.08.002. [PMID: 28803989]
  • Jing Bao, Changjun Hou, Qiuchen Dong, Xiaoyu Ma, Jun Chen, Danqun Huo, Mei Yang, Khaled Hussein Abd El Galil, Wilfred Chen, Yu Lei. ELP-OPH/BSA/TiO2 nanofibers/c-MWCNTs based biosensor for sensitive and selective determination of p-nitrophenyl substituted organophosphate pesticides in aqueous system. Biosensors & bioelectronics. 2016 Nov; 85(?):935-942. doi: 10.1016/j.bios.2016.05.094. [PMID: 27315519]
  • Marika Cordaro, Daniela Impellizzeri, Enrico Gugliandolo, Rosalba Siracusa, Rosalia Crupi, Emanuela Esposito, Salvatore Cuzzocrea. Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease. Molecular pharmacology. 2016 Nov; 90(5):549-561. doi: 10.1124/mol.116.105668. [PMID: 27625036]
  • Noureddine Bribi, Francesca Algieri, Alba Rodriguez-Nogales, Teresa Vezza, Jose Garrido-Mesa, María Pilar Utrilla, María Del Mar Contreras, Fadila Maiza, Antonio Segura-Carretero, Maria Elena Rodriguez-Cabezas, Julio Gálvez. Intestinal anti-inflammatory effects of total alkaloid extract from Fumaria capreolata in the DNBS model of mice colitis and intestinal epithelial CMT93 cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Aug; 23(9):901-13. doi: 10.1016/j.phymed.2016.05.003. [PMID: 27387398]
  • Erin Gallagher, Il Minn, Janice E Chambers, Peter C Searson. In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs). Fluids and barriers of the CNS. 2016 Jul; 13(1):10. doi: 10.1186/s12987-016-0035-0. [PMID: 27396356]
  • Haiyan Shi, Enze Sheng, Lu Feng, Liangliang Zhou, Xiude Hua, Minghua Wang. Simultaneous detection of imidacloprid and parathion by the dual-labeled time-resolved fluoroimmunoassay. Environmental science and pollution research international. 2015 Oct; 22(19):14882-90. doi: 10.1007/s11356-015-4697-y. [PMID: 25994268]
  • Jing Liu, Loren Parsons, Carey Pope. Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum. Neurotoxicology. 2015 Sep; 50(?):20-7. doi: 10.1016/j.neuro.2015.07.006. [PMID: 26215119]
  • Nidhi Goyal, Ajay Rana, Krishna Reddy V Bijjem, Puneet Kumar. Effect of chenodeoxycholic acid and sodium hydrogen sulfide in dinitro benzene sulfonic acid (DNBS)--Induced ulcerative colitis in rats. Pharmacological reports : PR. 2015 Jun; 67(3):616-23. doi: 10.1016/j.pharep.2014.12.018. [PMID: 25933978]
  • Wei Wang, Si-Lu Liu, Yang-Yang Liu, Chuan-Ling Qiao, Shao-Liang Chen, Feng Cui. Over-transcription of genes in a parathion-resistant strain of mosquito Culex pipiens quinquefasciatus. Insect science. 2015 Feb; 22(1):150-6. doi: 10.1111/1744-7917.12106. [PMID: 24431295]
  • Wen S Lan, Ti K Lu, Zhi F Qin, Xiu J Shi, Jin J Wang, Yun F Hu, Bin Chen, Yi H Zhu, Zheng Liu. Genetically modified microorganism Spingomonas paucimobilis UT26 for simultaneously degradation of methyl-parathion and γ-hexachlorocyclohexane. Ecotoxicology (London, England). 2014 Jul; 23(5):840-50. doi: 10.1007/s10646-014-1224-8. [PMID: 24648032]
  • Vijay Morampudi, Ganive Bhinder, Xiujuan Wu, Chuanbin Dai, Ho Pan Sham, Bruce A Vallance, Kevan Jacobson. DNBS/TNBS colitis models: providing insights into inflammatory bowel disease and effects of dietary fat. Journal of visualized experiments : JoVE. 2014 Feb; ?(84):e51297. doi: 10.3791/51297. [PMID: 24637969]
  • Xiangjiang Tang, Bo Liang, Tuyong Yi, Giuseppe Manco, Ilaria Palchetti, Ilariapalchetti, Aihua Liu. Cell surface display of organophosphorus hydrolase for sensitive spectrophotometric detection of p-nitrophenol substituted organophosphates. Enzyme and microbial technology. 2014 Feb; 55(?):107-12. doi: 10.1016/j.enzmictec.2013.10.006. [PMID: 24411452]
  • Isabelle Olivier, Vassilia Theodorou, Philippe Valet, Isabelle Castan-Laurell, Laurent Ferrier, Hélène Eutamène. Modifications of mesenteric adipose tissue during moderate experimental colitis in mice. Life sciences. 2014 Jan; 94(1):1-7. doi: 10.1016/j.lfs.2013.09.028. [PMID: 24215755]
  • Th Zilker. [Acute intoxication in adults - what you should know]. Deutsche medizinische Wochenschrift (1946). 2014 Jan; 139(1-2):31-46; quiz 43. doi: 10.1055/s-0033-1359902. [PMID: 24390849]
  • Issam Ben Salem, Sana Fekih, Haitham Sghaier, Mehrez Bousselmi, Mouldi Saidi, Ahmed Landoulsi, Sami Fattouch. Effect of ionising radiation on polyphenolic content and antioxidant potential of parathion-treated sage (Salvia officinalis) leaves. Food chemistry. 2013 Nov; 141(2):1398-405. doi: 10.1016/j.foodchem.2013.04.008. [PMID: 23790930]
  • R Nishino, T Fukuyama, Y Tajima, L Miyashita, Y Watanabe, H Ueda, T Kosaka. Prior oral exposure to environmental immunosuppressive chemicals methoxychlor, parathion, or piperonyl butoxide aggravates allergic airway inflammation in NC/Nga mice. Toxicology. 2013 Jul; 309(?):1-8. doi: 10.1016/j.tox.2013.03.018. [PMID: 23583882]
  • Riccardo Funari, Bartolomeo Della Ventura, Luigi Schiavo, Rosario Esposito, Carlo Altucci, Raffaele Velotta. Detection of parathion pesticide by quartz crystal microbalance functionalized with UV-activated antibodies. Analytical chemistry. 2013 Jul; 85(13):6392-7. doi: 10.1021/ac400852c. [PMID: 23721081]
  • Falicia L Edwards, Clement G Yedjou, Paul B Tchounwou. Involvement of oxidative stress in methyl parathion and parathion-induced toxicity and genotoxicity to human liver carcinoma (HepG₂) cells. Environmental toxicology. 2013 Jun; 28(6):342-8. doi: 10.1002/tox.20725. [PMID: 21544925]
  • D Strøbæk, D T Brown, D P Jenkins, Y-J Chen, N Coleman, Y Ando, P Chiu, S Jørgensen, J Demnitz, H Wulff, P Christophersen. NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. British journal of pharmacology. 2013 Jan; 168(2):432-44. doi: 10.1111/j.1476-5381.2012.02143.x. [PMID: 22891655]
  • Helena Shifrin, Mirela Nadler-Milbauer, Shai Shoham, Marta Weinstock. Rivastigmine alleviates experimentally induced colitis in mice and rats by acting at central and peripheral sites to modulate immune responses. PloS one. 2013; 8(2):e57668. doi: 10.1371/journal.pone.0057668. [PMID: 23469045]
  • T Fukuyama, T Kosaka, L Miyashita, R Nishino, K Wada, K Hayashi, H Ueda, T Harada. Role of regulatory T cells in the induction of atopic dermatitis by immunosuppressive chemicals. Toxicology letters. 2012 Sep; 213(3):392-401. doi: 10.1016/j.toxlet.2012.07.018. [PMID: 22842586]
  • Jean-Louis Mariage, Anja Gallinat, Philippe Hantson. Organ donation following fatal organophosphate poisoning. Transplant international : official journal of the European Society for Organ Transplantation. 2012 Jun; 25(6):e71-2. doi: 10.1111/j.1432-2277.2012.01466.x. [PMID: 22443143]
  • Alejandro A Canales-Aguirre, Ulises A Gomez-Pinedo, Sonia Luquin, Mario A Ramírez-Herrera, María L Mendoza-Magaña, Alfredo Feria-Velasco. Curcumin protects against the oxidative damage induced by the pesticide parathion in the hippocampus of the rat brain. Nutritional neuroscience. 2012 Mar; 15(2):62-9. doi: 10.1179/1476830511y.0000000034. [PMID: 22333997]
  • Ellen G Duysen, John R Cashman, Lawrence M Schopfer, Florian Nachon, Patrick Masson, Oksana Lockridge. Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran. Chemico-biological interactions. 2012 Feb; 195(3):189-98. doi: 10.1016/j.cbi.2011.12.006. [PMID: 22209767]
  • T Subramani, K S Chandrashekharaiah, N Ramachandra Swamy, K R Siddalinga Murthy. Purification and characterization of carboxylesterase from the seeds of Jatropha curcas. The protein journal. 2012 Feb; 31(2):120-8. doi: 10.1007/s10930-011-9380-7. [PMID: 22173274]
  • Reza Ahmadkhaniha, Nasrin Samadi, Mona Salimi, Parisa Sarkhail, Noushin Rastkari. Simultaneous determination of parathion, malathion, diazinon, and pirimiphos methyl in dried medicinal plants using solid-phase microextraction fibre coated with single-walled carbon nanotubes. TheScientificWorldJournal. 2012; 2012(?):627607. doi: 10.1100/2012/627607. [PMID: 22645439]
  • T Fukuyama, Y Tajima, K Hayashi, H Ueda, T Kosaka. Prior or coinstantaneous oral exposure to environmental immunosuppressive agents aggravates mite allergen-induced atopic dermatitis-like immunoreaction in NC/Nga mice. Toxicology. 2011 Nov; 289(2-3):132-40. doi: 10.1016/j.tox.2011.08.003. [PMID: 21864637]
  • Ellen G Duysen, Oksana Lockridge. Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons. Toxicology and applied pharmacology. 2011 Sep; 255(2):214-20. doi: 10.1016/j.taap.2011.06.021. [PMID: 21767560]
  • Robert J Foxenberg, Corie A Ellison, James B Knaak, Changxing Ma, James R Olson. Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion. Toxicology. 2011 Jul; 285(1-2):57-66. doi: 10.1016/j.tox.2011.04.002. [PMID: 21514354]
  • Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb; 280(3):77-87. doi: 10.1016/j.tox.2010.11.008. [PMID: 21115097]
  • Sheila M Innis, Chuanbin Dai, Xiujuan Wu, Alison M J Buchan, Kevan Jacobson. Perinatal lipid nutrition alters early intestinal development and programs the response to experimental colitis in young adult rats. American journal of physiology. Gastrointestinal and liver physiology. 2010 Dec; 299(6):G1376-85. doi: 10.1152/ajpgi.00258.2010. [PMID: 20864654]
  • T Leon Lassiter, Ian T Ryde, Edward D Levin, Frederic J Seidler, Theodore A Slotkin. Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits. Brain research bulletin. 2010 Jan; 81(1):85-91. doi: 10.1016/j.brainresbull.2009.07.002. [PMID: 19615431]
  • Theodore A Slotkin, Nicola Wrench, Ian T Ryde, T Leon Lassiter, Edward D Levin, Frederic J Seidler. Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood. Neurotoxicology and teratology. 2009 Nov; 31(6):390-9. doi: 10.1016/j.ntt.2009.07.003. [PMID: 19616088]
  • Florian Eyer, Franz Worek, Peter Eyer, Norbert Felgenhauer, Mike Haberkorn, Thomas Zilker, Horst Thiermann. Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness. Clinical toxicology (Philadelphia, Pa.). 2009 Sep; 47(8):798-806. doi: 10.1080/15563650903206828. [PMID: 19778163]
  • Horst Thiermann, Franz Worek, Peter Eyer, Florian Eyer, Norbert Felgenhauer, Thomas Zilker. Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships. Clinical toxicology (Philadelphia, Pa.). 2009 Sep; 47(8):807-13. doi: 10.1080/15563650903206836. [PMID: 19778190]
  • Joshua Ka-Shun Ko, Cecilia Wai-Shan Chik. The protective action of radix Astragalus membranaceus against hapten-induced colitis through modulation of cytokines. Cytokine. 2009 Aug; 47(2):85-90. doi: 10.1016/j.cyto.2009.05.014. [PMID: 19539495]
  • Theodore A Slotkin, Edward D Levin, Frederic J Seidler. Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood. Neurotoxicology and teratology. 2009 Jan; 31(1):11-7. doi: 10.1016/j.ntt.2008.08.004. [PMID: 18773955]
  • T Leon Lassiter, Ian T Ryde, Emiko A Mackillop, Kathleen K Brown, Edward D Levin, Frederic J Seidler, Theodore A Slotkin. Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood. Environmental health perspectives. 2008 Nov; 116(11):1456-62. doi: 10.1289/ehp.11673. [PMID: 19057696]
  • D Jun, L Musilova, K Kuca, J Kassa, J Bajgar. Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro. Chemico-biological interactions. 2008 Sep; 175(1-3):421-4. doi: 10.1016/j.cbi.2008.05.004. [PMID: 18617161]
  • Emanuela Esposito, Emanuela Mazzon, Luisa Riccardi, Rocco Caminiti, Rosaria Meli, Salvatore Cuzzocrea. Matrix metalloproteinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis. Journal of pineal research. 2008 Sep; 45(2):166-73. doi: 10.1111/j.1600-079x.2008.00572.x. [PMID: 18429971]
  • M B Sabbe, D Desruelles, W Lissens. Is beta-glucuronidase a clinical useful biomarker for an acute organophosphorus poisoning?. Human & experimental toxicology. 2008 May; 27(5):431-3. doi: 10.1177/0960327108094614. [PMID: 18715890]
  • Daniel K Nomura, Kazutoshi Fujioka, Roger S Issa, Anna M Ward, Benjamin F Cravatt, John E Casida. Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification. Toxicology and applied pharmacology. 2008 Apr; 228(1):42-8. doi: 10.1016/j.taap.2007.11.021. [PMID: 18164358]
  • J Boucher, F Cengelli, D Trumbic, I W Marison. Sorption of hydrophobic organic compounds (HOC) in rapeseed oil bodies. Chemosphere. 2008 Feb; 70(8):1452-8. doi: 10.1016/j.chemosphere.2007.08.065. [PMID: 17942138]
  • Li-Chun Xu, Lu Liu, Xiang-Mei Ren, Mei-Rong Zhang, Ning Cong, Ai-Qin Xu, Ji-Hong Shao. Evaluation of androgen receptor transcriptional activities of some pesticides in vitro. Toxicology. 2008 Jan; 243(1-2):59-65. doi: 10.1016/j.tox.2007.09.028. [PMID: 17980950]
  • Jean-Eric Ghia, Patricia Blennerhassett, Stephen M Collins. Vagus nerve integrity and experimental colitis. American journal of physiology. Gastrointestinal and liver physiology. 2007 Sep; 293(3):G560-7. doi: 10.1152/ajpgi.00098.2007. [PMID: 17585014]
  • J Boucher, L Steiner, I W Marison. Bio-sorption of atrazine in the press-cake from oilseeds. Water research. 2007 Aug; 41(15):3209-16. doi: 10.1016/j.watres.2007.05.038. [PMID: 17575996]
  • Seong H Kim, Jeong Hoon Kim, Bang-Kwon Kang. Decomposition reaction of organophosphorus nerve agents on solid surfaces with atmospheric radio frequency plasma generated gaseous species. Langmuir : the ACS journal of surfaces and colloids. 2007 Jul; 23(15):8074-8. doi: 10.1021/la700692t. [PMID: 17579467]
  • M Ramanathan, A L Simonian. Array biosensor based on enzyme kinetics monitoring by fluorescence spectroscopy: application for neurotoxins detection. Biosensors & bioelectronics. 2007 Jun; 22(12):3001-7. doi: 10.1016/j.bios.2006.12.029. [PMID: 17270415]
  • Richard P Moody, Mohammed Akram, Eva Dickson, Ih Chu. In vitro dermal absorption of methyl salicylate, ethyl parathion, and malathion: first responder safety. Journal of toxicology and environmental health. Part A. 2007 Jun; 70(12):985-99. doi: 10.1080/15287390600870874. [PMID: 17497409]
  • Minze Leistra, Frederik van den Berg. Volatilization of parathion and chlorothalonil from a potato crop simulated by the PEARL model. Environmental science & technology. 2007 Apr; 41(7):2243-8. doi: 10.1021/es0627242. [PMID: 17438770]
  • Jing Liu, Ramesh C Gupta, John T Goad, Subramanya Karanth, Carey Pope. Modulation of parathion toxicity by glucose feeding: Is nitric oxide involved?. Toxicology and applied pharmacology. 2007 Mar; 219(2-3):106-13. doi: 10.1016/j.taap.2006.11.005. [PMID: 17178140]
  • H R Contreras, V Paredes, B Urquieta, L Del Valle, E Bustos-Obregón. Testosterone production and spermatogenic damage induced by organophosphorate pesticides. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al. 2006 Dec; 30(3):423-9. doi: 10.32604/biocell.2006.30.423. [PMID: 17375462]
  • E Gallardo, M Barroso, C Margalho, A Cruz, D N Vieira, M López-Rivadulla. Determination of parathion in biological fluids by means of direct solid-phase microextraction. Analytical and bioanalytical chemistry. 2006 Nov; 386(6):1717-26. doi: 10.1007/s00216-006-0735-4. [PMID: 16953314]
  • Jean Eric Ghia, Patricia Blennerhassett, Harry Kumar-Ondiveeran, Elena F Verdu, Stephen M Collins. The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology. 2006 Oct; 131(4):1122-30. doi: 10.1053/j.gastro.2006.08.016. [PMID: 17030182]
  • Jie Zhu, Yuguan Ze, Chi Zhang, Yuhui Zang, Haiqin Lu, Ping Chu, Manji Sun, Junchuan Qin. High-level expression of recombinant human paraoxonase 1 Q in silkworm larvae (Bombyx mori). Applied microbiology and biotechnology. 2006 Aug; 72(1):103-108. doi: 10.1007/s00253-005-0246-9. [PMID: 16331452]
  • Ulrich Hoffmann, Thomas Papendorf. Organophosphate poisonings with parathion and dimethoate. Intensive care medicine. 2006 Mar; 32(3):464-8. doi: 10.1007/s00134-005-0051-z. [PMID: 16479380]
  • Masao Fukushima, Toshiyuki Katagi. Photodegradation of fenitrothion and parathion in tomato epicuticular waxes. Journal of agricultural and food chemistry. 2006 Jan; 54(2):474-9. doi: 10.1021/jf052113d. [PMID: 16417307]
  • R Kacham, S Karanth, P Baireddy, J Liu, C Pope. Interactive toxicity of chlorpyrifos and parathion in neonatal rats: role of esterases in exposure sequence-dependent toxicity. Toxicology and applied pharmacology. 2006 Jan; 210(1-2):142-9. doi: 10.1016/j.taap.2005.09.014. [PMID: 16260018]
  • Kun Zeng, Tangbin Yang, Pin Zhong, Lina Qu, Shiyi Zhou, Jia He, Zhisheng Jiang. Development and identification of monoclonal antibodies against parathion. Hybridoma (2005). 2005 Dec; 24(6):298-304. doi: 10.1089/hyb.2005.24.298. [PMID: 16332196]
  • Marina Guizzetti, Shantha Pathak, Gennaro Giordano, Lucio G Costa. Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology. 2005 Nov; 215(3):182-90. doi: 10.1016/j.tox.2005.07.004. [PMID: 16102884]
  • Joshua-Ka-Shun Ko, Flora-Ying-Lee Lam, Andrew-Pok-Lap Cheung. Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis. World journal of gastroenterology. 2005 Oct; 11(37):5787-94. doi: 10.3748/wjg.v11.i37.5787. [PMID: 16270386]
  • Ender Içen, Ferah Armutçu, Kemal Büyükgüzel, Ahmet Gürel. Biochemical stress indicators of greater wax moth exposure to organophosphorus insecticides. Journal of economic entomology. 2005 Apr; 98(2):358-66. doi: . [PMID: 15889724]
  • Naoki Kunugita, Tsunehiro Oyama, Toshihiro Kawamoto. [p-Nitrophenol]. Nihon rinsho. Japanese journal of clinical medicine. 2004 Dec; 62 Suppl 12(?):495-7. doi: NULL. [PMID: 15658373]
  • Dílson Silva, Célia M Cortez, Jayme Cunha-Bastos, Sônia R W Louro. Methyl parathion interaction with human and bovine serum albumin. Toxicology letters. 2004 Feb; 147(1):53-61. doi: 10.1016/j.toxlet.2003.10.014. [PMID: 14700528]
  • Hong Fang, Weida Tong, William S Branham, Carrie L Moland, Stacy L Dial, Huixiao Hong, Qian Xie, Roger Perkins, William Owens, Daniel M Sheehan. Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. Chemical research in toxicology. 2003 Oct; 16(10):1338-58. doi: 10.1021/tx030011g. [PMID: 14565775]
  • Burton W Lee, Leslie London, Joseph Paulauskis, Jonny Myers, David C Christiani. Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers. Journal of occupational and environmental medicine. 2003 Feb; 45(2):118-22. doi: 10.1097/01.jom.0000052953.59271.e1. [PMID: 12625227]
  • Florian Eyer, Veronika Meischner, Daniela Kiderlen, Horst Thiermann, Franz Worek, Michael Haberkorn, Norbert Felgenhauer, Thomas Zilker, Peter Eyer. Human parathion poisoning. A toxicokinetic analysis. Toxicological reviews. 2003; 22(3):143-63. doi: 10.2165/00139709-200322030-00003. [PMID: 15181664]
  • John S Vogel, Garrett A Keating, Bruce A Buchholz. Protein binding of isofluorophate in vivo after coexposure to multiple chemicals. Environmental health perspectives. 2002 Dec; 110 Suppl 6(?):1031-6. doi: 10.1289/ehp.02110s61031. [PMID: 12634135]
  • Jeffrey R Scott, Alison E Fox-Robichaud. Hepatic leukocyte recruitment in a model of acute colitis. American journal of physiology. Gastrointestinal and liver physiology. 2002 Sep; 283(3):G561-6. doi: 10.1152/ajpgi.00462.2001. [PMID: 12181168]
  • Richard A Fenske, Chensheng Lu, Dana Barr, Larry Needham. Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State. Environmental health perspectives. 2002 May; 110(5):549-53. doi: 10.1289/ehp.02110549. [PMID: 12003762]
  • Yüksel Gokel, Betül Gulalp, Ayca Acikalin. Parotitis due to organophosphate intoxication. Journal of toxicology. Clinical toxicology. 2002; 40(5):563-5. doi: 10.1081/clt-120014648. [PMID: 12215051]
  • Juan V Sancho, Oscar J Pozo, Francisco J López, Félix Hernández. Different quantitation approaches for xenobiotics in human urine samples by liquid chromatography/electrospray tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2002; 16(7):639-45. doi: 10.1002/rcm.617. [PMID: 11921240]
  • S Karanth, K Olivier, J Liu, C Pope. In vivo interaction between chlorpyrifos and parathion in adult rats: sequence of administration can markedly influence toxic outcome. Toxicology and applied pharmacology. 2001 Dec; 177(3):247-55. doi: 10.1006/taap.2001.9312. [PMID: 11749124]
  • K Olivier, J Liu, S Karanth, H Zhang, D S Roane, C N Pope. Glucose feeding exacerbates parathion-induced neurotoxicity. Journal of toxicology and environmental health. Part A. 2001 Jun; 63(4):253-71. doi: 10.1080/15287390151143659. [PMID: 11437059]
  • S Ribeiro, J P Sousa, A J Nogueira, A M Soares. Effect of endosulfan and parathion on energy reserves and physiological parameters of the terrestrial isopod Porcellio dilatatus. Ecotoxicology and environmental safety. 2001 Jun; 49(2):131-8. doi: 10.1006/eesa.2001.2045. [PMID: 11386726]
  • G Cabello, M Valenzuela, A Vilaxa, V Durán, I Rudolph, N Hrepic, G Calaf. A rat mammary tumor model induced by the organophosphorous pesticides parathion and malathion, possibly through acetylcholinesterase inhibition. Environmental health perspectives. 2001 May; 109(5):471-9. doi: 10.1289/ehp.01109471. [PMID: 11401758]
  • C Grasshoff, H Thiermann, T Gillessen, T Zilker, L Szinicz. Internal standard high-performance liquid chromatography method for the determination of obidoxime in urine of organophosphate-poisoned patients. Journal of chromatography. B, Biomedical sciences and applications. 2001 Apr; 753(2):203-8. doi: 10.1016/s0378-4347(00)00543-0. [PMID: 11334332]
  • R A Videira, M C Antunes-Madeira, V I Lopes, V M Madeira. Changes induced by malathion, methylparathion and parathion on membrane lipid physicochemical properties correlate with their toxicity. Biochimica et biophysica acta. 2001 Apr; 1511(2):360-8. doi: 10.1016/s0005-2736(01)00295-4. [PMID: 11286979]
  • A Gelal, M Gumustekin, S Kalkan, H Guven, O Eminoglu. Effects of subchronic parathion exposure on cyclosporine pharmacokinetics in rats. Journal of toxicology and environmental health. Part A. 2001 Feb; 62(4):289-94. doi: 10.1080/009841001459441. [PMID: 11245398]
  • S Karanth, C Pope. Carboxylesterase and A-esterase activities during maturation and aging: relationship to the toxicity of chlorpyrifos and parathion in rats. Toxicological sciences : an official journal of the Society of Toxicology. 2000 Dec; 58(2):282-9. doi: 10.1093/toxsci/58.2.282. [PMID: 11099640]
  • E Hurh, E J Lee, Y G Kim, S Y Kim, S H Kim, Y C Kim, M G Lee. Effects of physostigmine on the pharmacokinetics of intravenous parathion in rats. Biopharmaceutics & drug disposition. 2000 Nov; 21(8):331-8. doi: 10.1002/bdd.243. [PMID: 11514953]
  • C Padungtod, D A Savitz, J W Overstreet, D C Christiani, L M Ryan, X Xu. Occupational pesticide exposure and semen quality among Chinese workers. Journal of occupational and environmental medicine. 2000 Oct; 42(10):982-92. doi: 10.1097/00043764-200010000-00004. [PMID: 11039162]
  • E Hurh, E Lee, A Lee, Y Kim, S Kim, S Kim, M Lee. Effects of enzyme inducers or inhibitors on the pharmacokinetics of intravenous parathion in rats. Biopharmaceutics & drug disposition. 2000 Jul; 21(5):193-204. doi: 10.1002/1099-081x(200007)21:5<193::aid-bdd229>3.0.co;2-6. [PMID: 11180198]
  • A M Attia. Possible involvement of beta-adrenergic receptors in the enhancement of nocturnal pineal N-acetyltransferase activity due to parathion administration. Toxicology. 2000 Jan; 142(2):79-86. doi: 10.1016/s0300-483x(99)00106-7. [PMID: 10685507]