4-Hydroxychalcone (BioDeep_00000009772)

 

Secondary id: BioDeep_00000395478

human metabolite PANOMIX_OTCML-2023 Endogenous Cytotoxicity


代谢物信息卡片


(2Z)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one

化学式: C15H12O2 (224.0837252)
中文名称: 4-羟基查耳酮, 2-羟基查耳酮
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 82.2%

分子结构信息

SMILES: C1=CC=C(C=C1)C(=O)C=CC2=CC=C(C=C2)O
InChI: InChI=1S/C15H12O2/c16-14-9-6-12(7-10-14)8-11-15(17)13-4-2-1-3-5-13/h1-11,16H/b11-8-

描述信息

4-Hydroxychalcone is found in herbs and spices. 4-Hydroxychalcone is a constituent of Glycyrrhiza glabra (licorice) roots
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].

同义名列表

12 个代谢物同义名

(2Z)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one; (2E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one; 3-(4-hydroxyphenyl)-1-phenyl-2-propen-1-one; (E)-3-(4-Hydroxy-phenyl)-1-phenyl-propenone; 3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one; W-p-Hydroxybenzylideneacetophenone; 4-Hydroxystyryl phenyl ketone; 4-Hydroxychalcone, 8ci; 4-hydroxy chalcone; 4-Hydroxychalcone; 4-Hydroxychalcone; 4-Hydroxychalcone



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lei Ma, Zhengyi Yang, Chenjing Li, Zhiyuan Zhu, Xu Shen, Lihong Hu. Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1). Journal of enzyme inhibition and medicinal chemistry. 2011 Oct; 26(5):643-8. doi: 10.3109/14756366.2010.543420. [PMID: 21222511]
  • Monika Mueller, Verena Beck, Alois Jungbauer. PPARα activation by culinary herbs and spices. Planta medica. 2011 Mar; 77(5):497-504. doi: 10.1055/s-0030-1250435. [PMID: 20957597]
  • Stefan Oswald, Eberhard Scheuch, Ingolf Cascorbi, Werner Siegmund. A LC-MS/MS method to quantify the novel cholesterol lowering drug ezetimibe in human serum, urine and feces in healthy subjects genotyped for SLCO1B1. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Jan; 830(1):143-50. doi: 10.1016/j.jchromb.2005.10.034. [PMID: 16280261]
  • Yun Wang, Franky L Chan, Shiuan Chen, Lai K Leung. The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase. Life sciences. 2005 May; 77(1):39-51. doi: 10.1016/j.lfs.2004.12.014. [PMID: 15848217]