Pheneturide (BioDeep_00000009360)

 

Secondary id: BioDeep_00000858762

human metabolite blood metabolite


代谢物信息卡片


1-[(C-hydroxycarbonimidoyl)imino]-2-phenylbutan-1-ol

化学式: C11H14N2O2 (206.1055)
中文名称: 苯丁酰脲
谱图信息: 最多检出来源 Homo sapiens(blood) 64.29%

分子结构信息

SMILES: CCC(C(=O)NC(=N)O)c1ccccc1
InChI: InChI=1S/C11H14N2O2/c1-2-9(10(14)13-11(12)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H3,12,13,14,15)

描述信息

C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics
Same as: D01190

同义名列表

10 个代谢物同义名

1-[(C-hydroxycarbonimidoyl)imino]-2-phenylbutan-1-ol; Ethylphenacemide, (+-)-isomer; (2-Phenylbutyryl)urea; Ethylphenylacetylurea; Phenylethylacetylurea; Ethyl phenacemide; Ethylphenacemide; Pheneturide; Benuride; Pheneturide



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Hugo M Neels, Ann C Sierens, Kristine Naelaerts, Simon L Scharpé, George M Hatfield, Willy E Lambert. Therapeutic drug monitoring of old and newer anti-epileptic drugs. Clinical chemistry and laboratory medicine. 2004; 42(11):1228-55. doi: 10.1515/cclm.2004.245. [PMID: 15576287]
  • B A Diwan, R W Nims, J M Ward, H Hu, R A Lubet, J M Rice. Tumor promoting activities of ethylphenylacetylurea and diethylacetylurea, the ring hydrolysis products of barbiturate tumor promoters phenobarbital and barbital, in rat liver and kidney initiated by N-nitrosodiethylamine. Carcinogenesis. 1989 Jan; 10(1):189-94. doi: 10.1093/carcin/10.1.189. [PMID: 2910522]
  • J Vachta, K Valter, P Gold-Aubert. Metabolism of pheneturide in the rat and in man. European journal of drug metabolism and pharmacokinetics. 1986 Jul; 11(3):195-204. doi: 10.1007/bf03189847. [PMID: 3816875]
  • J A Christofides, D E Fry. Measurement of anticonvulsants in serum by reversed-phase ion-pair liquid chromatography. Clinical chemistry. 1980 Mar; 26(3):499-501. doi: . [PMID: 7363472]
  • R L Galeazzi, M Egli, N Wad. Pharmacokinetics of phenylethylacetylurea (pheneturide), an old antiepileptic drug. Journal of pharmacokinetics and biopharmaceutics. 1979 Oct; 7(5):453-62. doi: 10.1007/bf01062387. [PMID: 529017]
  • A N Latham, G D Sweeney. Binding of anticonvulsant drugs to cytochrome P-450: correlation with evidence of induction of hepatic microsomal enzymes. Canadian journal of physiology and pharmacology. 1976 Dec; 54(6):844-9. doi: 10.1139/y76-118. [PMID: 1021219]