Lochnericine (BioDeep_00000008796)

 

Secondary id: BioDeep_00001871074

natural product


代谢物信息卡片


Methyl (1R,12S,20R)-12-ethyl-14-oxa-8,17-diazahexacyclo[10.7.1.01,9.02,7.013,15.017,20]icosa-2,4,6,9-tetraene-10-carboxylate

化学式: C21H24N2O3 (352.1787)
中文名称: 洛柯因
谱图信息: 最多检出来源 Homo sapiens(blood) 14.29%

分子结构信息

SMILES: CCC12CC(=C3C4(C1N(CC4)CC5C2O5)C6=CC=CC=C6N3)C(=O)OC
InChI: InChI=1S/C21H24N2O3/c1-3-20-10-12(18(24)25-2)16-21(13-6-4-5-7-14(13)22-16)8-9-23(19(20)21)11-15-17(20)26-15/h4-7,15,17,19,22H,3,8-11H2,1-2H3/t15-,17-,19-,20+,21-/m0/s1

描述信息

An Aspidosperma alkaloid with molecular formula C21H24N2O3 found in the roots of Madagascar periwinkle (Catharanthus roseus, formerly known as Vinca rosea).

同义名列表

2 个代谢物同义名

Lochnericine; Methyl (1R,12S,20R)-12-ethyl-14-oxa-8,17-diazahexacyclo[10.7.1.01,9.02,7.013,15.017,20]icosa-2,4,6,9-tetraene-10-carboxylate



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

44 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Inês Carqueijeiro, Stephanie Brown, Khoa Chung, Thu-Thuy Dang, Manish Walia, Sébastien Besseau, Thomas Dugé de Bernonville, Audrey Oudin, Arnaud Lanoue, Kevin Billet, Thibaut Munsch, Konstantinos Koudounas, Céline Melin, Charlotte Godon, Bienvenue Razafimandimby, Johan-Owen de Craene, Gaëlle Glévarec, Jillian Marc, Nathalie Giglioli-Guivarc'h, Marc Clastre, Benoit St-Pierre, Nicolas Papon, Rodrigo B Andrade, Sarah E O'Connor, Vincent Courdavault. Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived Alkaloid Biosynthesis in Catharanthus roseus. Plant physiology. 2018 08; 177(4):1473-1486. doi: 10.1104/pp.18.00549. [PMID: 29934299]
  • Zerihun Demessie, Kathlyn N Woolfson, Fang Yu, Yang Qu, Vincenzo De Luca. The ATP binding cassette transporter, VmTPT2/VmABCG1, is involved in export of the monoterpenoid indole alkaloid, vincamine in Vinca minor leaves. Phytochemistry. 2017 Aug; 140(?):118-124. doi: 10.1016/j.phytochem.2017.04.019. [PMID: 28478314]
  • Qing Wang, Jiawei He, Jin Yan, Di Wu, Hui Li. Spectroscopy and docking simulations of the interaction between lochnericine and bovine serum albumin. Luminescence : the journal of biological and chemical luminescence. 2015 Mar; 30(2):240-6. doi: 10.1002/bio.2724. [PMID: 24942935]
  • Francisco Fernández-Pérez, Lorena Almagro, Maria A Pedreño, Laura V Gómez Ros. Synergistic and cytotoxic action of indole alkaloids produced from elicited cell cultures of Catharanthus roseus. Pharmaceutical biology. 2013 Mar; 51(3):304-10. doi: 10.3109/13880209.2012.722646. [PMID: 23137274]
  • Ya-Ping Liu, Yan Li, Xiang-Hai Cai, Xing-Yao Li, Ling-Mei Kong, Gui-Guang Cheng, Xiao-Dong Luo. Melodinines M-U, cytotoxic alkaloids from Melodinus suaveolens. Journal of natural products. 2012 Feb; 75(2):220-4. doi: 10.1021/np2009169. [PMID: 22260257]