Avenacin A-1 (BioDeep_00000007058)

 

Secondary id: BioDeep_00000019943

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


oat triterpenoid saponin

化学式: C55H83NO21 (1093.5457)
中文名称:
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: CC12CCC(C(C1CCC3(C2CC4C5(C3(CC(C6(C5CC(C(C6)OC(=O)C7=CC=CC=C7NC)(C)C=O)C)O)C)O4)C)(C)CO)OC8C(C(C(CO8)OC9C(C(C(C(O9)CO)O)O)O)O)OC1C(C(C(C(O1)CO)O)O)O
InChI: InChI=1S/C55H83NO21/c1-49(23-59)17-32-51(3,19-36(49)74-45(69)25-10-8-9-11-26(25)56-7)33(61)18-54(6)53(5)15-12-30-50(2,31(53)16-35-55(32,54)77-35)14-13-34(52(30,4)24-60)75-48-44(76-47-43(68)41(66)38(63)28(21-58)72-47)39(64)29(22-70-48)73-46-42(67)40(65)37(62)27(20-57)71-46/h8-11,23,27-44,46-48,56-58,60-68H,12-22,24H2,1-7H3/t27-,28-,29+,30-,31-,32-,33+,34+,35-,36+,37-,38-,39+,40+,41+,42-,43-,44-,46+,47+,48+,49+,50+,51+,52+,53-,54+,55-/m1/s1

描述信息

同义名列表

3 个代谢物同义名

Avenacin A-1; oat triterpenoid saponin; Avenacin A-1



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

33 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yan Li, Aymeric Leveau, Qiang Zhao, Qi Feng, Hengyun Lu, Jiashun Miao, Zheyong Xue, Azahara C Martin, Eva Wegel, Jing Wang, Anastasia Orme, Maria-Dolores Rey, Miroslava Karafiátová, Jan Vrána, Burkhard Steuernagel, Ryan Joynson, Charlotte Owen, James Reed, Thomas Louveau, Michael J Stephenson, Lei Zhang, Xuehui Huang, Tao Huang, Danling Fan, Congcong Zhou, Qilin Tian, Wenjun Li, Yiqi Lu, Jiaying Chen, Yan Zhao, Ying Lu, Chuanrang Zhu, Zhenhua Liu, Guy Polturak, Rebecca Casson, Lionel Hill, Graham Moore, Rachel Melton, Neil Hall, Brande B H Wulff, Jaroslav Doležel, Tim Langdon, Bin Han, Anne Osbourn. Subtelomeric assembly of a multi-gene pathway for antimicrobial defense compounds in cereals. Nature communications. 2021 05; 12(1):2563. doi: 10.1038/s41467-021-22920-8. [PMID: 33963185]
  • Ariane C Kemen, Suvi Honkanen, Rachel E Melton, Kim C Findlay, Sam T Mugford, Keiko Hayashi, Kosmas Haralampidis, Susan J Rosser, Anne Osbourn. Investigation of triterpene synthesis and regulation in oats reveals a role for β-amyrin in determining root epidermal cell patterning. Proceedings of the National Academy of Sciences of the United States of America. 2014 Jun; 111(23):8679-84. doi: 10.1073/pnas.1401553111. [PMID: 24912185]
  • Sam T Mugford, Thomas Louveau, Rachel Melton, Xiaoquan Qi, Saleha Bakht, Lionel Hill, Tetsu Tsurushima, Suvi Honkanen, Susan J Rosser, George P Lomonossoff, Anne Osbourn. Modularity of plant metabolic gene clusters: a trio of linked genes that are collectively required for acylation of triterpenes in oat. The Plant cell. 2013 Mar; 25(3):1078-92. doi: 10.1105/tpc.113.110551. [PMID: 23532069]
  • Amorn Owatworakit, Belinda Townsend, Thomas Louveau, Helen Jenner, Martin Rejzek, Richard K Hughes, Gerhard Saalbach, Xiaoquan Qi, Saleha Bakht, Abhijeet Deb Roy, Sam T Mugford, Rebecca J M Goss, Robert A Field, Anne Osbourn. Glycosyltransferases from oat (Avena) implicated in the acylation of avenacins. The Journal of biological chemistry. 2013 Feb; 288(6):3696-704. doi: 10.1074/jbc.m112.426155. [PMID: 23258535]
  • Mieko Kunii, Yutaka Kitahama, Ery Odette Fukushima, Hikaru Seki, Toshiya Muranaka, Yuzo Yoshida, Yuri Aoyama. β-Amyrin oxidation by oat CYP51H10 expressed heterologously in yeast cells: the first example of CYP51-dependent metabolism other than the 14-demethylation of sterol precursors. Biological & pharmaceutical bulletin. 2012; 35(5):801-4. doi: 10.1248/bpb.35.801. [PMID: 22687421]
  • Eva Wegel, Rachil Koumproglou, Peter Shaw, Anne Osbourn. Cell type-specific chromatin decondensation of a metabolic gene cluster in oats. The Plant cell. 2009 Dec; 21(12):3926-36. doi: 10.1105/tpc.109.072124. [PMID: 20040536]
  • Pawel Bednarek, Anne Osbourn. Plant-microbe interactions: chemical diversity in plant defense. Science (New York, N.Y.). 2009 May; 324(5928):746-8. doi: 10.1126/science.1171661. [PMID: 19423814]
  • Panagiota Mylona, Amorn Owatworakit, Kalliopi Papadopoulou, Helen Jenner, Bo Qin, Kim Findlay, Lionel Hill, Xiaoquan Qi, Saleha Bakht, Rachel Melton, Anne Osbourn. Sad3 and sad4 are required for saponin biosynthesis and root development in oat. The Plant cell. 2008 Jan; 20(1):201-12. doi: 10.1105/tpc.107.056531. [PMID: 18203919]
  • Catherine M Collins, Patrick G Murray, Stuart Denman, John P Morrissey, Lucy Byrnes, Tuula T Teeri, Maria G Tuohy. Molecular cloning and expression analysis of two distinct beta-glucosidase genes, bg1 and aven1, with very different biological roles from the thermophilic, saprophytic fungus Talaromyces emersonii. Mycological research. 2007 Jul; 111(Pt 7):840-9. doi: 10.1016/j.mycres.2007.05.007. [PMID: 17664063]
  • Xiaoquan Qi, Saleha Bakht, Bo Qin, Mike Leggett, Andrew Hemmings, Fred Mellon, John Eagles, Daniele Werck-Reichhart, Hubert Schaller, Agnes Lesot, Rachel Melton, Anne Osbourn. A different function for a member of an ancient and highly conserved cytochrome P450 family: from essential sterols to plant defense. Proceedings of the National Academy of Sciences of the United States of America. 2006 Dec; 103(49):18848-53. doi: 10.1073/pnas.0607849103. [PMID: 17124172]
  • M R Trojanowska, A E Osbourn, M J Daniels, D R Threlfall. Biosynthesis of avenacins and phytosterols in roots of Avena sativa cv. Image. Phytochemistry. 2000 May; 54(2):153-64. doi: 10.1016/s0031-9422(00)00062-5. [PMID: 10872206]
  • J P Carter, J Spink, P F Cannon, M J Daniels, A E Osbourn. Isolation, characterization, and avenacin sensitivity of a diverse collection of cereal-root-colonizing fungi. Applied and environmental microbiology. 1999 Aug; 65(8):3364-72. doi: 10.1128/aem.65.8.3364-3372.1999. [PMID: 10427021]
  • C N Armah, A R Mackie, C Roy, K Price, A E Osbourn, P Bowyer, S Ladha. The membrane-permeabilizing effect of avenacin A-1 involves the reorganization of bilayer cholesterol. Biophysical journal. 1999 Jan; 76(1 Pt 1):281-90. doi: 10.1016/s0006-3495(99)77196-1. [PMID: 9876141]
  • P Bowyer, B R Clarke, P Lunness, M J Daniels, A E Osbourn. Host range of a plant pathogenic fungus determined by a saponin detoxifying enzyme. Science (New York, N.Y.). 1995 Jan; 267(5196):371-4. doi: 10.1126/science.7824933. [PMID: 7824933]