Sophoranone (BioDeep_00000006938)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(2S)-7-hydroxy-2-[4-hydroxy-3,5-bis(3-methylbut-2-enyl)phenyl]-8-(3-methylbut-2-enyl)-4-chromanone

化学式: C30H36O4 (460.2613456)
中文名称: 山豆根色满二氢黄酮Ⅰ, 山豆根素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 32.47%

分子结构信息

SMILES: C1(O)C(C/C=C(/C)\C)=C2O[C@]([H])(C3C=C(C/C=C(/C)\C)C(O)=C(C/C=C(/C)\C)C=3)CC(=O)C2=CC=1
InChI: InChI=1S/C30H36O4/c1-18(2)7-10-21-15-23(16-22(29(21)33)11-8-19(3)4)28-17-27(32)25-13-14-26(31)24(30(25)34-28)12-9-20(5)6/h7-9,13-16,28,31,33H,10-12,17H2,1-6H3/t28-/m0/s1

描述信息

A dihydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 7 and 4 and prenyl groups at positions 3 and 5 respectively.

同义名列表

6 个代谢物同义名

Sophoranone; (2S)-7-hydroxy-2-[4-hydroxy-3,5-bis(3-methylbut-2-enyl)phenyl]-8-(3-methylbut-2-enyl)-4-chromanone; (2S)-7-hydroxy-2-[4-hydroxy-3,5-bis(3-methylbut-2-enyl)phenyl]-8-(3-methylbut-2-enyl)chroman-4-one; 23057-55-8; C08719; (-)-Sophoranone



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Guo-Qing Long, Gao-Sheng Hu, Xiao-Xu Gao, Jing-Ming Jia, An-Hua Wang. Sophoranone A and B: two new cytotoxic prenylated metabolites and their analogs from the root bark of Sophora flavescens. Natural product research. 2022 Mar; 36(6):1515-1521. doi: 10.1080/14786419.2021.1894562. [PMID: 33678085]
  • Yannan Li, Jing Ning, Yan Wang, Chao Wang, Chengpeng Sun, Xiaokui Huo, Zhenlong Yu, Lei Feng, Baojing Zhang, Xiangge Tian, Xiaochi Ma. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicology letters. 2018 Sep; 294(?):27-36. doi: 10.1016/j.toxlet.2018.05.008. [PMID: 29753067]
  • Xinzhou Yang, Shihao Deng, Mi Huang, Jialin Wang, Li Chen, Mingrui Xiong, Jie Yang, Sijiang Zheng, Xinhua Ma, Ping Zhao, Yunjiang Feng. Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities. Bioorganic & medicinal chemistry letters. 2017 03; 27(6):1463-1466. doi: 10.1016/j.bmcl.2017.01.078. [PMID: 28236591]
  • Soo Min Jang, Soo Hyeon Bae, Woong-Kee Choi, Jung Bae Park, Doyun Kim, Jee Sun Min, Hunseung Yoo, Minseok Kang, Keun Ho Ryu, Soo Kyung Bae. Pharmacokinetic properties of trifolirhizin, (-)-maackiain, (-)-sophoranone and 2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran after intravenous and oral administration of Sophora tonkinensis extract in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2015; 45(12):1092-104. doi: 10.3109/00498254.2015.1041181. [PMID: 26068519]
  • Hunseung Yoo, Keun Ho Ryu, Soo Kyung Bae, Jinwoong Kim. Simultaneous determination of trifolirhizin, (-)-maackiain, (-)-sophoranone, and 2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran from Sophora tonkinensis in rat plasma by liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study. Journal of separation science. 2014 Nov; 37(22):3235-44. doi: 10.1002/jssc.201400691. [PMID: 25156071]
  • Makoto Inoue, Hiroki Tanabe, Ken-ichi Nakashima, Yukihiro Ishida, Hitoshi Kotani. Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene. Journal of natural products. 2014 Jul; 77(7):1670-7. doi: 10.1021/np5002016. [PMID: 24959987]
  • Xing-Nuo Li, Zhi-Qiang Lu, Guang-Tong Chen, Hai-Xia Yan, Na Sha, Shu-Hong Guan, Min Yang, Hui-Ming Hua, Li-Jun Wu, De-An Guo. NMR spectral assignments of isoprenylated flavanones from Sophora tonkinensis. Magnetic resonance in chemistry : MRC. 2008 Sep; 46(9):898-902. doi: 10.1002/mrc.2274. [PMID: 18615626]
  • Guan Ye, Hai-Yan Zhu, Zhi-Xiong Li, Chun-Hui Ma, Ming-Song Fan, Zhao-Lin Sun, Cheng-Gang Huang. LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts. Biomedical chromatography : BMC. 2007 Jun; 21(6):655-60. doi: 10.1002/bmc.805. [PMID: 17370298]
  • Sachiko Kajimoto, Noriko Takanashi, Tetsuya Kajimoto, Man Xu, Judong Cao, Yutaka Masuda, Toshihiro Aiuchi, Shigeo Nakajo, Yoshiteru Ida, Kazuyasu Nakaya. Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores. International journal of cancer. 2002 Jun; 99(6):879-90. doi: 10.1002/ijc.10414. [PMID: 12115492]