Doxacurium (BioDeep_00000006529)

   


代谢物信息卡片


Doxacurium

化学式: C56H78N2O16+2 (1034.5351)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COc1cc(CC2c3c(cc(OC)c(OC)c3OC)CC[N+]2(C)CCCOC(=O)CCC(=O)OCCC[N+]2(C)CCc3cc(OC)c(OC)c(OC)c3C2Cc2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC
InChI: InChI=1S/C56H78N2O16/c1-57(23-19-37-33-45(65-7)53(69-11)55(71-13)49(37)39(57)27-35-29-41(61-3)51(67-9)42(30-35)62-4)21-15-25-73-47(59)17-18-48(60)74-26-16-22-58(2)24-20-38-34-46(66-8)54(70-12)56(72-14)50(38)40(58)28-36-31-43(63-5)52(68-10)44(32-36)64-6/h29-34,39-40H,15-28H2,1-14H3/q+2

描述信息

D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents

同义名列表

1 个代谢物同义名

Doxacurium



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Patrick Lafrance, Vincent Lemaire, France Varin, François Donati, Jacques Bélair, Fahima Nekka. Spatial effects in modeling pharmacokinetics of rapid action drugs. Bulletin of mathematical biology. 2002 May; 64(3):483-500. doi: 10.1006/bulm.2001.0281. [PMID: 12094406]
  • J Laurin, F Donati, F Nekka, F Varin. Peripheral link model as an alternative for pharmacokinetic-pharmacodynamic modeling of drugs having a very short elimination half-life. Journal of pharmacokinetics and pharmacodynamics. 2001 Feb; 28(1):7-25. doi: 10.1023/a:1011513618081. [PMID: 11253615]
  • D M Fisher, K S Reynolds, V D Schmith, J Hsu, M D Sokoll, R L Lennon, J E Caldwell. The influence of renal function on the pharmacokinetics and pharmacodynamics and simulated time course of doxacurium. Anesthesia and analgesia. 1999 Sep; 89(3):786-95. doi: 10.1097/00000539-199909000-00049. [PMID: 10475326]
  • D P Atherton, J M Hunter. Clinical pharmacokinetics of the newer neuromuscular blocking drugs. Clinical pharmacokinetics. 1999 Mar; 36(3):169-89. doi: 10.2165/00003088-199936030-00001. [PMID: 10223167]
  • B Asokumar, D Cheng, F Chung, C Peniston, A Sandler, F Varin. Pharmacokinetics of doxacurium during normothermic and hypothermic cardiopulmonary bypass surgery. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 1998 Jun; 45(6):515-20. doi: 10.1007/bf03012700. [PMID: 9669003]
  • Y Zhu, G Audibert, F Donati, F Varin. Pharmacokinetic-pharmacodynamic modeling of doxacurium: effect of input rate. Journal of pharmacokinetics and biopharmaceutics. 1997 Feb; 25(1):23-37. doi: 10.1023/a:1025715626164. [PMID: 9353692]
  • W T Denman, N G Goudsouzian, C Gelb. Comparison of neuromuscular, cardiovascular, and histamine-releasing properties of doxacurium and pipecuronium. Journal of clinical anesthesia. 1996 Mar; 8(2):113-8. doi: 10.1016/0952-8180(95)00194-8. [PMID: 8695092]
  • M Cameron, F Donati, F Varin. In vitro plasma protein binding of neuromuscular blocking agents in different subpopulations of patients. Anesthesia and analgesia. 1995 Nov; 81(5):1019-25. doi: 10.1097/00000539-199511000-00022. [PMID: 7486041]
  • M J Murray, D B Coursin, P E Scuderi, G Kamath, D S Prough, D M Howard, M A Abou-Donia. Double-blind, randomized, multicenter study of doxacurium vs. pancuronium in intensive care unit patients who require neuromuscular-blocking agents. Critical care medicine. 1995 Mar; 23(3):450-8. doi: 10.1097/00003246-199503000-00007. [PMID: 7874894]
  • C J Hull. Pharmacokinetics and pharmacodynamics of the benzylisoquinolinium muscle relaxants. Acta anaesthesiologica Scandinavica. Supplementum. 1995; 106(?):13-7. doi: 10.1111/j.1399-6576.1995.tb04302.x. [PMID: 8533537]
  • N T Campkin, J R Hood, S A Feldman. Recovery of mivacurium and doxacurium versus vecuronium in the isolated forearm. Anaesthesia. 1994 Jun; 49(6):501-2. doi: 10.1111/j.1365-2044.1994.tb03520.x. [PMID: 7912478]
  • D R Bevan. Newer neuromuscular blocking agents. Pharmacology & toxicology. 1994 Jan; 74(1):3-9. doi: 10.1111/j.1600-0773.1994.tb01065.x. [PMID: 8159634]
  • P B Embree. Long-acting nondepolarizing neuromuscular blocking agents. AANA journal. 1993 Aug; 61(4):382-7. doi: . [PMID: 8397465]
  • L P Gariepy, F Varin, F Donati, Y Salib, D R Bevan. Influence of aging on the pharmacokinetics and pharmacodynamics of doxacurium. Clinical pharmacology and therapeutics. 1993 Mar; 53(3):340-7. doi: 10.1038/clpt.1993.30. [PMID: 8453853]
  • R K Mirakhur. Newer neuromuscular blocking drugs. An overview of their clinical pharmacology and therapeutic use. Drugs. 1992 Aug; 44(2):182-99. doi: 10.2165/00003495-199244020-00003. [PMID: 1382013]
  • D R Cook, J A Freeman, A A Lai, K A Robertson, Y Kang, R L Stiller, S Aggarwal, M M Abou-Donia, R M Welch. Pharmacokinetics and pharmacodynamics of doxacurium in normal patients and in those with hepatic or renal failure. Anesthesia and analgesia. 1991 Feb; 72(2):145-50. doi: 10.1213/00000539-199102000-00002. [PMID: 1824669]
  • D L Dresner, S J Basta, H H Ali, A F Schwartz, P B Embree, W A Wargin, A A Lai, K A Brady, J J Savarese. Pharmacokinetics and pharmacodynamics of doxacurium in young and elderly patients during isoflurane anesthesia. Anesthesia and analgesia. 1990 Nov; 71(5):498-502. doi: 10.1213/00000539-199011000-00008. [PMID: 2145783]
  • R DeAngelis, P Loebs, R Maehr, J Savarese, R Welch. High-performance liquid chromatographic analysis of doxacurium, a new long-acting neuromuscular blocker. Journal of chromatography. 1990 Feb; 525(2):389-400. doi: 10.1016/s0378-4347(00)83415-5. [PMID: 2139440]
  • J N Cashman, J J Luke, R M Jones. Neuromuscular block with doxacurium (BW A938U) in patients with normal or absent renal function. British journal of anaesthesia. 1990 Feb; 64(2):186-92. doi: 10.1093/bja/64.2.186. [PMID: 2138489]
  • D L Reich. Transient systemic arterial hypotension and cutaneous flushing in response to doxacurium chloride. Anesthesiology. 1989 Nov; 71(5):783-5. doi: 10.1097/00000542-198911000-00026. [PMID: 2817475]
  • S J Basta, J J Savarese, H H Ali, P B Embree, A F Schwartz, G D Rudd, W B Wastila. Clinical pharmacology of doxacurium chloride. A new long-acting nondepolarizing muscle relaxant. Anesthesiology. 1988 Oct; 69(4):478-86. doi: 10.1097/00000542-198810000-00006. [PMID: 2972233]