HISPIDIN (BioDeep_00000644367)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


HISPIDIN

化学式: C13H10O5 (246.0528)
中文名称: 牛奶树碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1C=CC2=CC(=CC(=O)O2)O)O)O
InChI: InChI=1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+

描述信息

Fungal metabolite first found in basidiomycete Inonotus hispidus (formerly Polyporus hispidus).
Hispidin, a PKC inhibitor and a phenolic compound from Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties[1].

同义名列表

1 个代谢物同义名

HISPIDIN



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

103 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Talia Serseg, Khedidja Benarous, Mohamed Yousfi. Hispidin and Lepidine E: Two Natural Compounds and Folic Acid as Potential Inhibitors of 2019-novel Coronavirus Main Protease (2019- nCoVMpro), Molecular Docking and SAR Study. Current computer-aided drug design. 2021; 17(3):469-479. doi: 10.2174/1573409916666200422075440. [PMID: 32321407]
  • Sonam Tamrakar, Katsuya Fukami, Gopal Prasad Parajuli, Kuniyoshi Shimizu. Antiallergic Activity of the Wild Mushrooms of Nepal and the Pure Compound Hispidin. Journal of medicinal food. 2019 Feb; 22(2):225-227. doi: 10.1089/jmf.2018.4267. [PMID: 30596532]
  • Jeanne D Mihail, Landon Bilyeu, Sara R Lalk. Bioluminescence expression during the transition from mycelium to mushroom in three North American Armillaria and Desarmillaria species. Fungal biology. 2018 11; 122(11):1064-1068. doi: 10.1016/j.funbio.2018.08.007. [PMID: 30342622]
  • Tat'yana G Gornostai, Gennadii G Borovskii, Nina I Kashchenko, Daniil N Olennikov. Phenolic Compounds of Inonotus rheades (Agaricomycetes) Mycelium: RP-UPLC-DAD-ESI/MS Profile and Effect of Light Wavelength on Styrylpyrone Content. International journal of medicinal mushrooms. 2018; 20(7):637-645. doi: 10.1615/intjmedmushrooms.2018026595. [PMID: 30055555]
  • Jong Seok Lee, Jun Myoung Park, Sarah Lee, Hye Jin Lee, Hee-Sun Yang, Joohong Yeo, Ki Rim Lee, Byung Hyun Choi, Eock Kee Hong. Hispidin rescues palmitate‑induced insulin resistance in C2C12 myotubes. Molecular medicine reports. 2017 Oct; 16(4):4229-4234. doi: 10.3892/mmr.2017.7042. [PMID: 28731188]
  • Carsten Gründemann, Mandy Arnhold, Stefanie Meier, Christian Bäcker, Manuel Garcia-Käufer, Franziska Grunewald, Carmen Steinborn, Amy Marisa Klemd, Radim Wille, Roman Huber, Ulrike Lindequist. Effects of Inonotus hispidus Extracts and Compounds on Human Immunocompetent Cells. Planta medica. 2016 Oct; 82(15):1359-1367. doi: 10.1055/s-0042-111693. [PMID: 27428885]
  • Ning Li, Lijie Zhao, Tzi Bun Ng, Jack Ho Wong, Yan Yan, Zhong Shi, Fang Liu. Separation and purification of the antioxidant compound hispidin from mushrooms by molecularly imprinted polymer. Applied microbiology and biotechnology. 2015 Sep; 99(18):7569-77. doi: 10.1007/s00253-015-6499-z. [PMID: 25786737]
  • Byung Soon Hwang, In-Kyoung Lee, Hwa Jung Choi, Bong-Sik Yun. Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii. Bioorganic & medicinal chemistry letters. 2015 Aug; 25(16):3256-60. doi: 10.1016/j.bmcl.2015.05.081. [PMID: 26077494]
  • Pham Thi Be Tu, Shinkichi Tawata. Anti-obesity effects of hispidin and Alpinia zerumbet bioactives in 3T3-L1 adipocytes. Molecules (Basel, Switzerland). 2014 Oct; 19(10):16656-71. doi: 10.3390/molecules191016656. [PMID: 25322285]
  • Jun-Jie Han, Li Bao, Lu-Wei He, Xiao-Qing Zhang, Xiao-Li Yang, Shao-Jie Li, Yi-Jian Yao, Hong-wei Liu. Phaeolschidins A-E, five hispidin derivatives with antioxidant activity from the fruiting body of Phaeolus schweinitzii collected in the Tibetan Plateau. Journal of natural products. 2013 Aug; 76(8):1448-53. doi: 10.1021/np400234u. [PMID: 23869482]
  • Prabodh Risal, Pyoung Han Hwang, Bong Sik Yun, Ho-Keun Yi, Baik Hwan Cho, Kyu Yun Jang, Yeon Jun Jeong. Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice. Journal of natural products. 2012 Oct; 75(10):1683-9. doi: 10.1021/np300099a. [PMID: 23025331]
  • Eduard Sarró, Conxita Jacobs-Cachá, Emilio Itarte, Anna Meseguer. A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells. Toxicology and applied pharmacology. 2012 Jan; 258(2):275-87. doi: 10.1016/j.taap.2011.11.007. [PMID: 22155090]
  • Jung Hyun Lee, Jong Seok Lee, Young Rae Kim, Woo Chul Jung, Keun Eok Lee, Shin Young Lee, Eock Kee Hong. Hispidin isolated from Phellinus linteus protects against hydrogen peroxide-induced oxidative stress in pancreatic MIN6N β-cells. Journal of medicinal food. 2011 Nov; 14(11):1431-8. doi: 10.1089/jmf.2010.1493. [PMID: 22003875]
  • Yeon Sil Lee, Il-Jun Kang, Moo Ho Won, Jae-Yong Lee, Jin Kyu Kim, Soon Sung Lim. Inhibition of protein tyrosine phosphatase 1beta by hispidin derivatives isolated from the fruiting body of Phellinus linteus. Natural product communications. 2010 Dec; 5(12):1927-30. doi: ". [PMID: 21299122]
  • Mohamed Yousfi, Amar Djeridane, Isabelle Bombarda, Bernard Duhem, Emile M Gaydou. Isolation and characterization of a new hispolone derivative from antioxidant extracts of Pistacia atlantica. Phytotherapy research : PTR. 2009 Sep; 23(9):1237-42. doi: 10.1002/ptr.2543. [PMID: 19274680]
  • Craig Slattery, Michael P Ryan, Tara McMorrow. Protein kinase C beta overexpression induces fibrotic effects in human proximal tubular epithelial cells. The international journal of biochemistry & cell biology. 2008; 40(10):2218-29. doi: 10.1016/j.biocel.2008.03.005. [PMID: 18440851]
  • Hsiu-An Wei, Tzi-Wei Lian, Yi-Chen Tu, Jing-Ting Hong, Mei-Chun Kou, Ming-Jiuan Wu. Inhibition of low-density lipoprotein oxidation and oxidative burst in polymorphonuclear neutrophils by caffeic acid and hispidin derivatives isolated from sword brake fern (Pteris ensiformis Burm.). Journal of agricultural and food chemistry. 2007 Dec; 55(26):10579-84. doi: 10.1021/jf071173b. [PMID: 18038974]
  • In-Hye Park, So-Young Jeon, Hee-Ju Lee, Sang-In Kim, Kyung-Sik Song. A beta-secretase (BACE1) inhibitor hispidin from the mycelial cultures of Phellinus linteus. Planta medica. 2004 Feb; 70(2):143-6. doi: 10.1055/s-2004-815491. [PMID: 14994192]
  • N A Awadh Ali, R A A Mothana, A Lesnau, H Pilgrim, U Lindequist. Antiviral activity of Inonotus hispidus. Fitoterapia. 2003 Jul; 74(5):483-5. doi: 10.1016/s0367-326x(03)00119-9. [PMID: 12837367]