1-Eicosanol (BioDeep_00000601564)

Main id: BioDeep_00000017680

 

PANOMIX_OTCML-2023


代谢物信息卡片


Arachinyl alcohol

化学式: C20H42O (298.3235482)
中文名称: 1-二十醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCCCCO
InChI: InChI=1S/C20H42O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21/h21H,2-20H2,1H3

描述信息

同义名列表

3 个代谢物同义名

Arachinyl alcohol; 1-Eicosanol; Icosan-1-ol



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

40 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Brad R Baker, Callum M Ives, Ashley Bray, Martin Caffrey, Stephen A Cochrane. Undecaprenol kinase: Function, mechanism and substrate specificity of a potential antibiotic target. European journal of medicinal chemistry. 2021 Jan; 210(?):113062. doi: 10.1016/j.ejmech.2020.113062. [PMID: 33310291]
  • M Zanardi, E Quirico, C Benvenuti, A Pezzana. Use of a lipid-lowering food supplement in patients on hormone therapy following breast cancer. Minerva ginecologica. 2012 Oct; 64(5):431-5. doi: ". [PMID: 23018482]
  • Gregorio Martínez-Sánchez, Livan Delgado-Roche, Arquímides Díaz-Batista, Gema Pérez-Davison, Lamberto Re. Effects of ozone therapy on haemostatic and oxidative stress index in coronary artery disease. European journal of pharmacology. 2012 Sep; 691(1-3):156-62. doi: 10.1016/j.ejphar.2012.07.010. [PMID: 22796450]
  • Valentina Trimarco, Claudia Sara Cimmino, Mario Santoro, Gianpiero Pagnano, Maria Virginia Manzi, Anna Piglia, Caterina Anna Giudice, Nicola De Luca, Raffaele Izzo. Nutraceuticals for blood pressure control in patients with high-normal or grade 1 hypertension. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension. 2012 Sep; 19(3):117-22. doi: 10.1007/bf03262460. [PMID: 22994579]
  • Flora Affuso, Valentina Mercurio, Antonio Ruvolo, Concetta Pirozzi, Filomena Micillo, Guido Carlomagno, Fabrizia Grieco, Serafino Fazio. A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome. World journal of cardiology. 2012 Mar; 4(3):77-83. doi: 10.4330/wjc.v4.i3.77. [PMID: 22451856]
  • H Gupta, D Pawar, A Riva, E Bombardelli, P Morazzoni. A randomized, double-blind, placebo-controlled trial to evaluate efficacy and tolerability of an optimized botanical combination in the management of patients with primary hypercholesterolemia and mixed dyslipidemia. Phytotherapy research : PTR. 2012 Feb; 26(2):265-72. doi: 10.1002/ptr.3542. [PMID: 21674629]
  • Anderson Marques de Oliveira, Lucia M Conserva, Jamylle N De Souza Ferro, Fabíola de Almeida Brito, Rosângela P Lyra Lemos, Emiliano Barreto. Antinociceptive and anti-inflammatory effects of octacosanol from the leaves of Sabicea grisea var. grisea in mice. International journal of molecular sciences. 2012; 13(2):1598-1611. doi: 10.3390/ijms13021598. [PMID: 22408410]
  • L S Afinisha Deepam, C Arumughan. Effect of saponification on composition of unsaponifiable matter in rice bran oil. Journal of oleo science. 2012; 61(5):241-7. doi: 10.5650/jos.61.241. [PMID: 22531051]
  • Janine Hellenbrand, Eva-Maria Biester, Jens Gruber, Mats Hamberg, Margrit Frentzen. Fatty acyl-CoA reductases of birds. BMC biochemistry. 2011 Dec; 12(?):64. doi: 10.1186/1471-2091-12-64. [PMID: 22151413]
  • Giuseppe Marazzi, Luca Cacciotti, Francesco Pelliccia, Luigi Iaia, Maurizio Volterrani, Giuseppe Caminiti, Barbara Sposato, Rosalba Massaro, Fabrizia Grieco, Giuseppe Rosano. Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients. Advances in therapy. 2011 Dec; 28(12):1105-13. doi: 10.1007/s12325-011-0082-5. [PMID: 22113535]
  • James M Backes, Cheryl A Gibson, Janelle F Ruisinger, Patrick M Moriarty. Modified-policosanol does not reduce plasma lipoproteins in hyperlipidemic patients when used alone or in combination with statin therapy. Lipids. 2011 Oct; 46(10):923-9. doi: 10.1007/s11745-011-3591-8. [PMID: 21739240]
  • Dong Min Jung, Mi Jin Lee, Suk Hoo Yoon, Mun Yhung Jung. A gas chromatography-tandem quadrupole mass spectrometric analysis of policosanols in commercial vegetable oils. Journal of food science. 2011 Aug; 76(6):C891-9. doi: 10.1111/j.1750-3841.2011.02232.x. [PMID: 22417487]
  • Jingbo Huang, Jiri Frohlich, Andrew P Ignaszewski. The impact of dietary changes and dietary supplements on lipid profile. The Canadian journal of cardiology. 2011 Jul; 27(4):488-505. doi: 10.1016/j.cjca.2010.12.077. [PMID: 21801978]
  • Qun Li, Alan B R Thomson, Michael T Clandinin. Cholesterol ester and free fatty acids are modulated by policosanol in CaCo-2 intestinal cells. Journal of the American College of Nutrition. 2011 Jun; 30(3):201-9. doi: 10.1080/07315724.2011.10719961. [PMID: 21896878]
  • O Guardamagna, F Abello, V Baracco, B Stasiowska, F Martino. The treatment of hypercholesterolemic children: efficacy and safety of a combination of red yeast rice extract and policosanols. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2011 Jun; 21(6):424-9. doi: 10.1016/j.numecd.2009.10.015. [PMID: 20153154]
  • Barbara Swanson, Joyce K Keithley, Beverly E Sha, Louis Fogg, Judith Nerad, Richard M Novak, Oluwatoyin Adeyemi, Gregory T Spear. Policosanol for managing human immunodeficiency virus-related dyslipidemia in a medically underserved population: a randomized, controlled clinical trial. Alternative therapies in health and medicine. 2011 Mar; 17(2):30-5. doi: . [PMID: 21717822]
  • Joanna Klepacka, Elżbieta Gujska, Joanna Michalak. Phenolic compounds as cultivar- and variety-distinguishing factors in some plant products. Plant foods for human nutrition (Dordrecht, Netherlands). 2011 Mar; 66(1):64-9. doi: 10.1007/s11130-010-0205-1. [PMID: 21243436]
  • Luciana María Cocchiararo-Bastias, Sergio Javier Mijailovsky, Gustavo Mario Calderon-Fernández, Alicia Nieves Lorenzo Figueiras, M Patricia Juárez. epicuticle lipids mediate mate recognition in Triatoma infestans. Journal of chemical ecology. 2011 Mar; 37(3):246-52. doi: 10.1007/s10886-011-9927-2. [PMID: 21373991]
  • Wong Yau Hsiung, Habsah Abdul Kadir. Leea indica Ethyl Acetate Fraction Induces Growth-Inhibitory Effect in Various Cancer Cell Lines and Apoptosis in Ca Ski Human Cervical Epidermoid Carcinoma Cells. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):293060. doi: 10.1155/2011/293060. [PMID: 21423690]
  • Alice Dillard, Nirupa R Matthan, Alice H Lichtenstein. Use of hamster as a model to study diet-induced atherosclerosis. Nutrition & metabolism. 2010 Dec; 7(?):89. doi: 10.1186/1743-7075-7-89. [PMID: 21143982]
  • F Affuso, A Ruvolo, F Micillo, L Saccà, S Fazio. Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2010 Nov; 20(9):656-61. doi: 10.1016/j.numecd.2009.05.017. [PMID: 19699071]
  • Augusta Caligiani, Francesca Bonzanini, Gerardo Palla, Martina Cirlini, Renato Bruni. Characterization of a potential nutraceutical ingredient: pomegranate (Punica granatum L.) seed oil unsaponifiable fraction. Plant foods for human nutrition (Dordrecht, Netherlands). 2010 Sep; 65(3):277-83. doi: 10.1007/s11130-010-0173-5. [PMID: 20607413]
  • Anthony Fardet. New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?. Nutrition research reviews. 2010 Jun; 23(1):65-134. doi: 10.1017/s0954422410000041. [PMID: 20565994]
  • Amy Campbell. Natural ways to lower your cholesterol. Diabetes self-management. 2010 May; 27(3):40, 42, 44-6. doi: ". [PMID: 20575327]
  • Mohi Iqbal Mohammed Abdul, Xuemin Jiang, Kenneth M Williams, Richard O Day, Basil D Roufogalis, Winston S Liauw, Hongmei Xu, Anita Matthias, Reginald P Lehmann, Andrew J McLachlan. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. British journal of clinical pharmacology. 2010 May; 69(5):508-15. doi: 10.1111/j.1365-2125.2010.03620.x. [PMID: 20573086]
  • Shawn A Ritchie, Pearson W K Ahiahonu, Dushmanthi Jayasinghe, Doug Heath, Jun Liu, Yingshen Lu, Wei Jin, Amir Kavianpour, Yasuyo Yamazaki, Amin M Khan, Mohammad Hossain, Khine Khine Su-Myat, Paul L Wood, Kevin Krenitsky, Ichiro Takemasa, Masakazu Miyake, Mitsugu Sekimoto, Morito Monden, Hisahiro Matsubara, Fumio Nomura, Dayan B Goodenowe. Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC medicine. 2010 Feb; 8(?):13. doi: 10.1186/1741-7015-8-13. [PMID: 20156336]
  • Nurhan T Dunford, Jeff Edwards. Nutritional bioactive components of wheat straw as affected by genotype and environment. Bioresource technology. 2010 Jan; 101(1):422-5. doi: 10.1016/j.biortech.2009.08.009. [PMID: 19716291]
  • Mary P McGowan, Suzanne Proulx. Nutritional supplements and serum lipids: does anything work?. Current atherosclerosis reports. 2009 Nov; 11(6):470-6. doi: 10.1007/s11883-009-0070-2. [PMID: 19852889]
  • Shu Pan, Ai-Jun Hou. New long-chain hydroxyalkyl ferulates from the root bark of Lycium chinense Mill. Journal of Asian natural products research. 2009 Jul; 11(7):681-5. doi: 10.1080/10286020903002139. [PMID: 20183307]
  • Amira N Kassis, Stan Kubow, Peter J H Jones. Sugar cane policosanols do not reduce LDL oxidation in hypercholesterolemic individuals. Lipids. 2009 May; 44(5):391-6. doi: 10.1007/s11745-009-3295-5. [PMID: 19337769]
  • Niko Radulović, Polina Blagojević, Radosav Palić. Fatty acid derived compounds--the dominant volatile class of the essential oil poor Sonchus arvensis subsp. uliginosus (Bieb.) Nyman. Natural product communications. 2009 Mar; 4(3):405-10. doi: ". [PMID: 19413122]
  • Matthias Briel, Ignacio Ferreira-Gonzalez, John J You, Paul J Karanicolas, Elie A Akl, Ping Wu, Boris Blechacz, Dirk Bassler, Xinge Wei, Asheer Sharman, Irene Whitt, Suzana Alves da Silva, Zahira Khalid, Alain J Nordmann, Qi Zhou, Stephen D Walter, Noah Vale, Neera Bhatnagar, Christopher O'Regan, Edward J Mills, Heiner C Bucher, Victor M Montori, Gordon H Guyatt. Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis. BMJ (Clinical research ed.). 2009 Feb; 338(?):b92. doi: 10.1136/bmj.b92. [PMID: 19221140]
  • Luis J López-Giraldo, Mickaël Laguerre, Jérome Lecomte, Maria-Cruz Figueroa-Espinoza, Bruno Baréa, Jochen Weiss, Eric A Decker, Pierre Villeneuve. Kinetic and stoichiometry of the reaction of chlorogenic acid and its alkyl esters against the DPPH radical. Journal of agricultural and food chemistry. 2009 Feb; 57(3):863-70. doi: 10.1021/jf803148z. [PMID: 19143487]
  • Takafumi Okabe, Takayoshi Toda, Masashi Inafuku, Koji Wada, Hironori Iwasaki, Hirosuke Oku. Antiatherosclerotic function of Kokuto, Okinawan noncentrifugal cane sugar. Journal of agricultural and food chemistry. 2009 Jan; 57(1):69-75. doi: 10.1021/jf802796m. [PMID: 19072226]
  • Karen J Murphy, David A Saint, Peter R C Howe. Lack of effect of sugar cane and sunflower seed policosanols on plasma cholesterol in rabbits. Journal of the American College of Nutrition. 2008 Aug; 27(4):476-84. doi: 10.1080/07315724.2008.10719728. [PMID: 18978167]
  • G Thippeswamy, M L Sheela, Bharathi P Salimath. Octacosanol isolated from Tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-B and its DNA binding activity. European journal of pharmacology. 2008 Jul; 588(2-3):141-50. doi: 10.1016/j.ejphar.2008.04.027. [PMID: 18513715]
  • Jayesh J Kattla, Rosemarie M Carew, Mediha Heljic, Catherine Godson, Derek P Brazil. Protein kinase B/Akt activity is involved in renal TGF-beta1-driven epithelial-mesenchymal transition in vitro and in vivo. American journal of physiology. Renal physiology. 2008 Jul; 295(1):F215-25. doi: 10.1152/ajprenal.00548.2007. [PMID: 18495798]
  • Govindarajapuram Varadarajan Srinivasan, Choorikkat Ranjith, Kochukaratu Krishnan Vijayan. Identification of chemical compounds from the leaves of Leea indica. Acta pharmaceutica (Zagreb, Croatia). 2008 Jun; 58(2):207-14. doi: 10.2478/v10007-008-0002-7. [PMID: 18515230]
  • Stefan P J Dullens, Ronald P Mensink, Marjolijn C E Bragt, Arie K Kies, Jogchum Plat. Effects of emulsified policosanols with different chain lengths on cholesterol metabolism in heterozygous LDL receptor-deficient mice. Journal of lipid research. 2008 Apr; 49(4):790-6. doi: 10.1194/jlr.m700497-jlr200. [PMID: 18162663]
  • F Francini-Pesenti, F Brocadello, D Beltramolli, M Nardi, L Caregaro. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: a double blind, controlled study. Complementary therapies in medicine. 2008 Apr; 16(2):61-5. doi: 10.1016/j.ctim.2007.08.003. [PMID: 18514906]
  • Yoshiji Ohta, Koji Ohashi, Tatsuya Matsura, Kenji Tokunaga, Akira Kitagawa, Kazuo Yamada. Octacosanol attenuates disrupted hepatic reactive oxygen species metabolism associated with acute liver injury progression in rats intoxicated with carbon tetrachloride. Journal of clinical biochemistry and nutrition. 2008 Mar; 42(2):118-25. doi: 10.3164/jcbn.2008017. [PMID: 18385828]
  • F Francini-Pesenti, D Beltramolli, S Dall'acqua, F Brocadello. Effect of sugar cane policosanol on lipid profile in primary hypercholesterolemia. Phytotherapy research : PTR. 2008 Mar; 22(3):318-22. doi: 10.1002/ptr.2315. [PMID: 18167048]
  • Yohani Pérez, Rosa Más, Rosa María González, Sonia Jiménez, Vivian Molina. Effects of D-003, a mixture of very long chain saturated fatty acids, and policosanol on in vivo lipid peroxidation in rats. Arzneimittel-Forschung. 2008; 58(3):126-30. doi: 10.1055/s-0031-1296481. [PMID: 18488809]
  • Zeljko Reiner, Eugenia Tedeschi-Reiner. Rice policosanol does not have any effects on blood coagulation factors in hypercholesterolemic patients. Collegium antropologicum. 2007 Dec; 31(4):1061-4. doi: NULL. [PMID: 18217459]
  • Amira N Kassis, Christopher P F Marinangeli, Deepak Jain, Naoyuki Ebine, Peter J H Jones. Lack of effect of sugar cane policosanol on plasma cholesterol in Golden Syrian hamsters. Atherosclerosis. 2007 Sep; 194(1):153-8. doi: 10.1016/j.atherosclerosis.2006.10.008. [PMID: 17123537]
  • Katie M Queenan, Maria L Stewart, Kristen N Smith, William Thomas, R Gary Fulcher, Joanne L Slavin. Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial. Nutrition journal. 2007 Mar; 6(?):6. doi: 10.1186/1475-2891-6-6. [PMID: 17386092]
  • Jeffrey Knox, Barak Gaster. Dietary supplements for the prevention and treatment of coronary artery disease. Journal of alternative and complementary medicine (New York, N.Y.). 2007 Jan; 13(1):83-95. doi: 10.1089/acm.2006.6206. [PMID: 17309382]
  • Luigi X Cubeddu, Roberto J Cubeddu, Todd Heimowitz, Beatriz Restrepo, Gervasio A Lamas, Gloria B Weinberg. Comparative lipid-lowering effects of policosanol and atorvastatin: a randomized, parallel, double-blind, placebo-controlled trial. American heart journal. 2006 Nov; 152(5):982.e1-5. doi: 10.1016/j.ahj.2006.08.009. [PMID: 17070175]
  • Leslie K Nies, Alicia A Cymbala, Sheila L Kasten, Donald G Lamprecht, Kari L Olson. Complementary and alternative therapies for the management of dyslipidemia. The Annals of pharmacotherapy. 2006 Nov; 40(11):1984-92. doi: 10.1345/aph.1h040. [PMID: 17047144]
  • Heiner K Berthold, Susanne Unverdorben, Ralf Degenhardt, Michael Bulitta, Ioanna Gouni-Berthold. Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia: a randomized controlled trial. JAMA. 2006 May; 295(19):2262-9. doi: 10.1001/jama.295.19.2262. [PMID: 16705107]
  • A Greyling, C De Witt, W Oosthuizen, J C Jerling. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. The British journal of nutrition. 2006 May; 95(5):968-75. doi: 10.1079/bjn20061715. [PMID: 16611388]
  • Eugenia Tedeschi-Reiner, Zeljko Reiner, Zeljko Romić, Davor Ivanković. [A randomized, double-blind, placebo-controlled study of the antilipemic efficacy and tolerability of food supplement policosanol in patients with moderate hypercholesterolemia]. Lijecnicki vjesnik. 2005 Nov; 127(11-12):273-9. doi: . [PMID: 16583932]
  • Miriam Noa, Rosa Mas. Protective effect of policosanol on atherosclerotic plaque on aortas in monkeys. Archives of medical research. 2005 Sep; 36(5):441-7. doi: 10.1016/j.arcmed.2005.03.039. [PMID: 16099319]
  • Chi Ho Ng, Ka Yiu Leung, Yu Huang, Zhen Yu Chen. Policosanol has no antioxidant activity in human low-density lipoprotein but increases excretion of bile acids in hamsters. Journal of agricultural and food chemistry. 2005 Aug; 53(16):6289-93. doi: 10.1021/jf051269a. [PMID: 16076108]
  • Sibel Irmak, Nurhan Turgut Dunford. Policosanol contents and compositions of wheat varieties. Journal of agricultural and food chemistry. 2005 Jul; 53(14):5583-6. doi: 10.1021/jf050508r. [PMID: 15998118]
  • Ana Paula M Bernardi, Alexandre B F Ferraz, Daniela V Albring, Sérgio A L Bordignon, Jan Schripsema, Raquel Bridi, Carlos Severo Dutra-Filho, Amélia T Henriques, Gilsane Lino von Poser. Benzophenones from Hypericum carinatum. Journal of natural products. 2005 May; 68(5):784-6. doi: 10.1021/np040149e. [PMID: 15921431]
  • Yanwen Wang, Naoyuki Ebine, Xiaoming Jia, Peter J H Jones, Clint Fairow, Ralf Jaeger. Very long chain fatty acids (policosanols) and phytosterols affect plasma lipid levels and cholesterol biosynthesis in hamsters. Metabolism: clinical and experimental. 2005 Apr; 54(4):508-14. doi: 10.1016/j.metabol.2004.11.004. [PMID: 15798959]
  • Roberto Menéndez, David Marrero, Rosa Más, Ivon Fernández, Luis González, Rosa Maria González. In vitro and in vivo study of octacosanol metabolism. Archives of medical research. 2005 Mar; 36(2):113-9. doi: 10.1016/j.arcmed.2004.12.006. [PMID: 15847942]
  • Judy T Chen, Robert Wesley, Robert D Shamburek, Frank Pucino, Gyorgy Csako. Meta-analysis of natural therapies for hyperlipidemia: plant sterols and stanols versus policosanol. Pharmacotherapy. 2005 Feb; 25(2):171-83. doi: 10.1592/phco.25.2.171.56942. [PMID: 15767233]
  • Ivo Setnikar, Paolo Senin, Lucio C Rovati. Antiatherosclerotic efficacy of policosanol, red yeast rice extract and astaxanthin in the rabbit. Arzneimittel-Forschung. 2005; 55(6):312-7. doi: 10.1055/s-0031-1296865. [PMID: 16032970]
  • R Gámez, R Máz, M L Arruzazabala, S Mendoza, G Castaño. Effects of concurrent therapy with policosanol and omega-3 fatty acids on lipid profile and platelet aggregation in rabbits. Drugs in R&D. 2005; 6(1):11-9. doi: 10.2165/00126839-200506010-00002. [PMID: 15806713]
  • G Castaño, L Fernández, R Mas, J Illnait, R Gámez, S Mendoza, M Mesa, J Fernández. Effects of addition of policosanol to omega-3 fatty acid therapy on the lipid profile of patients with type II hypercholesterolaemia. Drugs in R&D. 2005; 6(4):207-19. doi: 10.2165/00126839-200506040-00003. [PMID: 16050054]
  • Mark F McCarty. An ezetimibe-policosanol combination has the potential to be an OTC agent that could dramatically lower LDL cholesterol without side effects. Medical hypotheses. 2005; 64(3):636-45. doi: 10.1016/j.mehy.2003.12.051. [PMID: 15617880]
  • Zeljko Reiner, Eugenia Tedeschi-Reiner, Zeljko Romić. Effects of rice policosanol on serum lipoproteins, homocysteine, fibrinogen and C-reactive protein in hypercholesterolaemic patients. Clinical drug investigation. 2005; 25(11):701-7. doi: 10.2165/00044011-200525110-00003. [PMID: 17532716]
  • Yuguang Lin, Mike Rudrum, Reggy P J van der Wielen, Elke A Trautwein, Gerald McNeill, Aafje Sierksma, Gert W Meijer. Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations. Metabolism: clinical and experimental. 2004 Oct; 53(10):1309-14. doi: 10.1016/j.metabol.2004.05.006. [PMID: 15375787]
  • Gladys Castaño, Rosa Más, Rafael Gámez, Lilia Fernández, José Illnait. Effects of policosanol and ticlopidine in patients with intermittent claudication: a double-blinded pilot comparative study. Angiology. 2004 Jul; 55(4):361-71. doi: 10.1177/000331970405500403. [PMID: 15258682]
  • M Noa, R Más, S Mendoza, R Gámez, N Mendoza, J González. Policosanol prevents bone loss in ovariectomized rats. Drugs under experimental and clinical research. 2004; 30(3):117-23. doi: ". [PMID: 15366788]
  • Krista A Varady, Yanwen Wang, Peter J H Jones. Role of policosanols in the prevention and treatment of cardiovascular disease. Nutrition reviews. 2003 Nov; 61(11):376-83. doi: 10.1301/nr.2003.nov.376-383. [PMID: 14677572]
  • Harold Bays, Evan A Stein. Pharmacotherapy for dyslipidaemia--current therapies and future agents. Expert opinion on pharmacotherapy. 2003 Nov; 4(11):1901-38. doi: 10.1517/14656566.4.11.1901. [PMID: 14596646]
  • M F McCarty. IGF-I activity may be a key determinant of stroke risk--a cautionary lesson for vegans. Medical hypotheses. 2003 Sep; 61(3):323-34. doi: 10.1016/s0306-9877(02)00241-4. [PMID: 12944100]
  • Y W Wang, P J H Jones, I Pischel, C Fairow. Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters. Lipids. 2003 Feb; 38(2):165-70. doi: 10.1007/s11745-003-1047-3. [PMID: 12733749]
  • Gladys Castaño, Lilia Fernández, Rosa Mas, José Illnait, Meylin Mesa, J C Fernández. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clinical drug investigation. 2003; 23(10):639-50. doi: 10.2165/00044011-200323100-00003. [PMID: 17535079]
  • Michael H Davidson, Chris T Geohas. Efficacy of over-the-counter nutritional supplements. Current atherosclerosis reports. 2003 Jan; 5(1):15-21. doi: 10.1007/s11883-003-0063-5. [PMID: 12562537]
  • Gladys Castaño, Rosa Mas, Lilia Fernández, José Illnait, Meylin Mesa, Estrella Alvarez, Magnolia Lezcay. Comparison of the efficacy and tolerability of policosanol with atorvastatin in elderly patients with type II hypercholesterolaemia. Drugs & aging. 2003; 20(2):153-63. doi: 10.2165/00002512-200320020-00006. [PMID: 12534315]
  • Miriam Noa, Sarahí Mendoza, Rosa Más, Nilda Mendoza. Effect of policosanol on carbon tetrachloride-induced acute liver damage in Sprague-Dawley rats. Drugs in R&D. 2003; 4(1):29-35. doi: 10.2165/00126839-200304010-00003. [PMID: 12568632]
  • M F McCarty. Policosanol safely down-regulates HMG-CoA reductase - potential as a component of the Esselstyn regimen. Medical hypotheses. 2002 Sep; 59(3):268-79. doi: 10.1016/s0306-9877(02)00226-8. [PMID: 12208152]
  • Mark Janikula. Policosanol: a new treatment for cardiovascular disease?. Alternative medicine review : a journal of clinical therapeutic. 2002 Jun; 7(3):203-17. doi: . [PMID: 12126462]
  • Ioanna Gouni-Berthold, Heiner K Berthold. Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent. American heart journal. 2002 Feb; 143(2):356-65. doi: 10.1067/mhj.2002.119997. [PMID: 11835043]
  • R Menéndez, R Más, A M Amor, N Ledón, J Pérez, R M González, I Rodeiro, M Zayas, S Jiménez. Inhibition of rat lipoprotein lipid peroxidation by the oral administration of D003, a mixture of very long-chain saturated fatty acids. Canadian journal of physiology and pharmacology. 2002 Jan; 80(1):13-21. doi: 10.1139/y01-088. [PMID: 11911221]
  • G Castaño, R Menéndez, R Más, A Amor, J L Fernández, R L González, M Lezcay, E Alvarez. Effects of policosanol and lovastatin on lipid profile and lipid peroxidation in patients with dyslipidemia associated with type 2 diabetes mellitus. International journal of clinical pharmacology research. 2002; 22(3-4):89-99. doi: NULL. [PMID: 12837046]
  • Gladys Castaño, Rosa Más, Julio C Fernández, Lilia Fernández, José Illnait, Ernesto López. Effects of policosanol on older patients with hypertension and type II hypercholesterolaemia. Drugs in R&D. 2002; 3(3):159-72. doi: 10.2165/00126839-200203030-00004. [PMID: 12099160]
  • D Marrero Delange, L González Bravo. Trace determination of 1-octacosanol in rat plasma by solid-phase extraction with Tenax GC and capillary gas chromatography. Journal of chromatography. B, Biomedical sciences and applications. 2001 Oct; 762(1):43-9. doi: 10.1016/s0378-4347(01)00331-0. [PMID: 11589457]
  • G Castaño, R Más, J C Fernández, J Illnait, L Fernández, E Alvarez. Effects of policosanol in older patients with type II hypercholesterolemia and high coronary risk. The journals of gerontology. Series A, Biological sciences and medical sciences. 2001 Mar; 56(3):M186-92. doi: 10.1093/gerona/56.3.m186. [PMID: 11253161]
  • R Menéndez, A M Amor, I Rodeiro, R M González, P C González, J L Alfonso, R Más. Policosanol modulates HMG-CoA reductase activity in cultured fibroblasts. Archives of medical research. 2001 Jan; 32(1):8-12. doi: 10.1016/s0188-4409(00)00265-4. [PMID: 11282173]
  • A Mirkin, R Mas, M Martinto, R Boccanera, A Robertis, R Poudes, A Fuster, E Lastreto, M Yañez, G Irico, B McCook, A Farré. Efficacy and tolerability of policosanol in hypercholesterolemic postmenopausal women. International journal of clinical pharmacology research. 2001; 21(1):31-41. doi: NULL. [PMID: 11708573]
  • G Castaño, R Mas, L Fernández, J Illnait, R Gámez, E Alvarez. Effects of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: a 6-month double-blind study. International journal of clinical pharmacology research. 2001; 21(1):43-57. doi: ". [PMID: 11708574]
  • N Loreau, C Lepreux, R Ardaillou. Calcitonin-sensitive adenylate cyclase in rat renal tubular membranes. The Biochemical journal. 1975 Sep; 150(3):305-14. doi: 10.1042/bj1500305. [PMID: 2153]