12-O-Tetradecanoylphorbol-13-acetate (BioDeep_00000000580)

 

Secondary id: BioDeep_00000399705

PANOMIX_OTCML-2023


代谢物信息卡片


Tetradecanoic acid, 9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa(3,4)benz(1,2-e)azulen-9-yl ester, (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))-

化学式: C36H56O8 (616.3974976000001)
中文名称: (12-)十四酸佛波酯(-13-)乙酸盐, 佛波醇12-十四酸酯13-乙酸酯, 伏波酯, 佛波酯, 佛波醇12-十四酸酯13-乙酸酯
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 3.62%

分子结构信息

SMILES: C1=C(CO)C[C@]2(O)C(C(C)=C[C@@]2([H])[C@@]2(O)[C@@H]([C@@H](OC(CCCCCCCCCCCCC)=O)[C@@]3(OC(C)=O)C(C)(C)[C@@]3([H])[C@@]21[H])C)=O
InChI: InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1

描述信息

12-o-tetradecanoylphorbol-13-acetate appears as white crystals. (NTP, 1992)
Phorbol 13-acetate 12-myristate is a phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types. It has a role as a protein kinase C agonist, an antineoplastic agent, a reactive oxygen species generator, a plant metabolite, a mitogen, a carcinogenic agent and an apoptosis inducer. It is an acetate ester, a tetradecanoate ester, a diester, a tertiary alpha-hydroxy ketone and a phorbol ester.
Phorbol 12-myristate 13-acetate diester is an inducer of neutrophil extracellular traps (NETs).
Phorbol 12-myristate 13-acetate is a natural product found in Iris tectorum, Phormidium tenue, and other organisms with data available.
Tetradecanoylphorbol Acetate is a phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. (NCI04)
A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.
A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D009676 - Noxae > D002273 - Carcinogens > D010703 - Phorbol Esters
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator[1][2]. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells[3][7].
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator[1][2]. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells[3][7].

同义名列表

103 个代谢物同义名

Tetradecanoic acid, 9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa(3,4)benz(1,2-e)azulen-9-yl ester, (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))-; Myristic acid, 9-ester with 1,1a-alpha,1b-beta,4,4a,7a-alpha,7b,8,9,9a-decahydro-4a-beta,7b-alpha,9-beta,9a-alpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-alpha-tetramethyl-5H-cyclopropa(3,4)benz(1,2-e)azulen-5-one, 9a-acetate; Myristic acid, 9-ester with 1,1aalpha,1bbeta,4,4a,7aalpha,7b,8,9,9a-decahydro-4abeta,7balpha,9beta,9aalpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8alpha-tetramethyl-5H-cyclopropa(3,4)benz(1,2-e)azulen-5-one 9a-acetate, (+)-; Tetradecanoic acid, 9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9, 9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa(3,4)benz(1,2-e)azulen-9-yl ester, (1aR-(1aa,1bb,4ab,7aa,7ba, 8a,9b,9aa))-; Tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester; 5H-Cyclopropa(3,4)benz(1,2-e)azulen-5-one, 1,1a-beta,1b-alpha,4,4a,7a-beta,7b,8,9,9a-decahydro-4a-alpha,7b-beta,9-alpha,9a-beta-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-beta-tetramethyl-, 9a-acetate 9-myristate; tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9; 5H-Cyclopropa(3,4)benz(1,2-e)azulen-5-one, 1,1a-beta,1b-alpha,4,4a,7a-beta,7b,8,9,9a-decahydro-4a-alpha,7b-beta,9-alpha,9a-beta-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-beta-tetramethyl-, 9a-acetate 9-m; Tetradecanoic acid, 9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester, [1aR-(1aalpha,1bbeta,; Myristic acid, 9-ester with 1,1aalpha,1bbeta,4,4a,7aalpha,7b,8,9,9a-decahydro-4abeta,7balpha,9beta,9aalpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8alpha-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5; (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a ,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate; (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate; (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate; (1S,2S,6R,10S,11R,13S,14R,15R)-13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0^{2,6}.0^{11,13}]pentadeca-3,8-dien-14-yl tetradecanoate; [(1S,2S,6R,10S,11R,13S,14R,15R)-13-acetyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] tetradecanoate; [acetoxy-dihydroxy-(hydroxymethyl)-tetramethyl-oxo-[?]yl] tetradecanoate; 12-O-tetradecanoyl phorbol-13-acetate;Cocarcinogen A1; Cocarcinogen C3; 1H-Cyclopropa[3,4]benz[1,2-e]azulene, tetradecanoic acid deriv.; Phorbol 12-myristate 13-acetate, >=99\\% (TLC), film or powder; PMA, for use in molecular biology applications, >=99\\% (TLC); Phorbol 12-myristate 13-acetate, synthetic, >=98.0\\% (TLC); Pentahydroxy-tigliadienone-monoacetate(c)monomyristate(b); Phorbol-12-myristate-13-acetate - CAS 16561-29-8; 4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha)]-; Tetradecanoylphorbol Acetate, 4a alpha-Isomer; Tetradecanoylphorbol Acetate, 4a alpha Isomer; PHORBOL 12-MYRISTATE 13-ACETATE DIESTER [MI]; 12-O-Tetradekanoylphorbol-13-acetat [German]; 12-O-TETRADECANOYLPHORBOL-13-ACETATE [HSDB]; 12-o-tetradecanoylphorbol-13-acetate (tpa); Phorbol 12-myristate 13-acetate diester; 13-Acetate, 12-O-Tetradecanoyl Phorbol; 12-Tetradecanoylphorbol 13-monoacetate; Phorbol 13-Acetate, 12-O-Tetradecanoyl; Phorbol 12-myristate 13-acetate (PMA); 12-o-tetradecanoyl-phorbol-13-acetate; 12 O Tetradecanoyl Phorbol 13 Acetate; 12-O-Tetradecanoyl Phorbol 13-Acetate; 4beta-Phorbol-12-myristate-13-acetate; 4beta-Phorbol 12-myristate 13-acetate; 12-O-Tetradecanoylphorbol 13-acetate; Phorbol 12-tetradecanoate 13-acetate; 4-.beta.-Phorbol 12-myristate 13-OAc; 12-O-Tetradecanoylphorbol-13-acetate; beta-Phorbol 12-myristate 13-acetate; PHORBOL-12-TETRADECANOYL-13-ACETATE; 12-o-Tetradekanoylphorbol-13-acetat; 12-Tetradecanoylphorbol-13-acetate; tetradecanoyl-beta-phorbol acetate; 12-Tetradecanoylphorbol 13-acetate; 12-O-Tetradecanoyl phorbol acetate; Phorbol monoacetate monomyristate; 13-O-Acetylphorbol 12-myristate; 13-Tetradecanoylphorbol acetate; Phorbol-12-myristate 13-acetate; Phorbol 12-myristate 13-acetate; phorbol-12-myristate-13-acetate; Phorbol 13 Acetate 12 Myristate; phorbol 13-acetate 12-myristate; 12-Myristoyl-13-acetylphorbol; Acetate, Tetradecanoylphorbol; 12 Myristoyl 13 acetylphorbol; phorbol12-myristate13-acetate; Tetradecanoylphorbol acetate; -one 9a-acetate, (+)- (8CI); PHEDXBVPIONUQT-RGYGYFBISA-N; Myristate Acetate, Phorbol; Phorbol acetate, myristate; Acetate, Phorbol Myristate; Phorbol myristate acetate; Phorbol-myristate acetate; TPA (phorbol derivative); PMA (tumor promoter); Pma (phorbol ester); Tpa (phorbol ester); Spectrum4_000889; Spectrum5_001855; BCBcMAP01_000182; Spectrum2_001911; UNII-NI40JAQ945; Cocarcinogen C3; Cocarcinogen A1; Phorbol ester; DivK1c_006897; KBio1_001841; KBio2_000364; KBio2_002932; KBio3_000708; KBio3_000707; KBio2_005500; Bio2_000352; Bio1_000300; Bio1_001278; Bio1_000789; IDI1_002107; Bio2_000832; NI40JAQ945; -yl ester; Factor A1; C36H56O8; yristate; PMA; TPA



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huan Wang, Yuejia Lan, Cuiping Chen, Lu Yang, Jiayi Sun, Yong Zeng, Jiasi Wu. LPS and ATP-induced Death of PMA-differentiated THP-1 Macrophages and its Validation. Journal of visualized experiments : JoVE. 2024 May; ?(207):. doi: 10.3791/66831. [PMID: 38767387]
  • Ettore Vanni, Karina Lindner, Anne-Claude Gavin, Christophe Montessuit. Differential intracellular management of fatty acids impacts on metabolic stress-stimulated glucose uptake in cardiomyocytes. Scientific reports. 2023 09; 13(1):14805. doi: 10.1038/s41598-023-42072-7. [PMID: 37684349]
  • Weigao Zhang, Jiapeng Jie, Qian Xu, Rong Wei, Xin Liao, Danyang Zhang, Yayun Zhang, Jianfa Zhang, Guanyong Su, Yuxin Chen, Dan Weng. Characterizing the obesogenic and fatty liver-inducing effects of Acetyl tributyl citrate (ATBC) plasticizer using both in vivo and in vitro models. Journal of hazardous materials. 2023 03; 445(?):130548. doi: 10.1016/j.jhazmat.2022.130548. [PMID: 37055963]
  • Altaf Al-Romaiyan, Willias Masocha, Sunday Oyedemi, Sulaiman K Marafie, Guo-Cai Huang, Peter M Jones, Shanta J Persaud. Commiphora myrrha stimulates insulin secretion from β-cells through activation of atypical protein kinase C and mitogen-activated protein kinase. Journal of ethnopharmacology. 2023 Feb; 302(Pt B):115937. doi: 10.1016/j.jep.2022.115937. [PMID: 36410575]
  • Mohamed Sofiane Merakeb, Noureddine Bribi, Riad Ferhat, Meriem Aziez, Betitera Yanat. Alkaloids Extract from Linum usitatissimum Attenuates 12-O-Tetradecanoylphorbol-13-Acetate (TPA)-induced Inflammation and Oxidative Stress in Mouse Skin. Anti-inflammatory & anti-allergy agents in medicinal chemistry. 2022 Dec; ?(?):. doi: 10.2174/1871523022666221212121621. [PMID: 36515033]
  • Pakize Neslihan Taşlı. Usage of celery root exosome as an immune suppressant; Lipidomic characterization of apium graveolens originated exosomes and its suppressive effect on PMA/ionomycin mediated CD4+ T lymphocyte activation. Journal of food biochemistry. 2022 12; 46(12):e14393. doi: 10.1111/jfbc.14393. [PMID: 36181394]
  • Ming-Shan Chen, Kung-Ssu Yang, Wen-Chun Lin, Chien-Liang Fang, Hsin-Fu Chen, Shew-Meei Sheu. Lipofundin mediates major inhibition of intravenous propofol on phorbol myristate acetate and Escherichia coli-induced neutrophil extracellular traps. Molecular biology reports. 2022 Jul; 49(7):6517-6529. doi: 10.1007/s11033-022-07482-2. [PMID: 35637315]
  • Li Xiao, Mai Mochizuki, Yumei Fan, Taka Nakahara, Feng Liao. Enzyme-digested Colla Corii Asini (E'jiao) suppresses lipopolysaccharide-induced inflammatory changes in THP-1 macrophages and OP9 adipocytes. Human cell. 2022 May; 35(3):885-895. doi: 10.1007/s13577-022-00694-5. [PMID: 35359251]
  • Gilda Varricchi, Luca Modestino, Remo Poto, Leonardo Cristinziano, Luca Gentile, Loredana Postiglione, Giuseppe Spadaro, Maria Rosaria Galdiero. Neutrophil extracellular traps and neutrophil-derived mediators as possible biomarkers in bronchial asthma. Clinical and experimental medicine. 2022 May; 22(2):285-300. doi: 10.1007/s10238-021-00750-8. [PMID: 34342773]
  • Mhd Yousuf Yassouf, Xu Zhang, Zisheng Huang, Da Zhai, Reiko Sekiya, Tsuyoshi Kawabata, Tao-Sheng Li. Biphasic effect of mechanical stress on lymphocyte activation. Journal of cellular physiology. 2022 02; 237(2):1521-1531. doi: 10.1002/jcp.30623. [PMID: 34724217]
  • Daria V Grigorieva, Irina V Gorudko, Natalia A Grudinina, Oleg M Panasenko, Igor V Semak, Alexey V Sokolov, Alexander V Timoshenko. Lactoferrin modified by hypohalous acids: Partial loss in activation of human neutrophils. International journal of biological macromolecules. 2022 Jan; 195(?):30-40. doi: 10.1016/j.ijbiomac.2021.11.165. [PMID: 34863835]
  • Eduardo Perez, Jose R Fernandez, Corey Fitzgerald, Karl Rouzard, Masanori Tamura, Christopher Savile. In Vitro and Clinical Evaluation of Cannabigerol (CBG) Produced via Yeast Biosynthesis: A Cannabinoid with a Broad Range of Anti-Inflammatory and Skin Health-Boosting Properties. Molecules (Basel, Switzerland). 2022 Jan; 27(2):. doi: 10.3390/molecules27020491. [PMID: 35056807]
  • Jingwen Chen, Eun Na, Sun Young Lim. Effect of Fractions from Lycopus lucidus Turcz. Leaves on Genomic DNA Oxidation and Matrix Metalloproteinase Activity. Combinatorial chemistry & high throughput screening. 2022; 25(10):1778-1784. doi: 10.2174/1386207324666210909162626. [PMID: 34503410]
  • Fangxiang Mu, Yuqing Wang, Hong Wu, Qingxia You, Daimin Zhang. The myocardial infarction-associated transcript 2 inhibits lipid accumulation and promotes cholesterol efflux in oxidized low-density lipoprotein-induced THP-1-derived macrophages via inhibiting mitogen-activated protein kinase signaling and activating the nuclear factor erythroid-related factor 2 signaling pathway. Bioengineered. 2022 01; 13(1):407-417. doi: 10.1080/21655979.2021.2005932. [PMID: 34783297]
  • Csilla Sebők, Stephanie Walmsley, Patrik Tráj, Máté Mackei, Júlia Vörösházi, Janka Petrilla, László Kovács, Ágnes Kemény, Zsuzsanna Neogrády, Gábor Mátis. Immunomodulatory effects of chicken cathelicidin-2 on a primary hepatic cell co-culture model. PloS one. 2022; 17(10):e0275847. doi: 10.1371/journal.pone.0275847. [PMID: 36215285]
  • Imran Khan, Debasish Kumar Dey, Jai-Heon Lee, Sun Chul Kang. Bamboo leave extract ameliorated 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ear inflammation by reducing MAP kinase levels and NF-κB activation in mice model. Natural product research. 2021 Dec; 35(23):5299-5303. doi: 10.1080/14786419.2020.1753053. [PMID: 32290690]
  • Katarzyna Bocheńska, Marta Moskot, Magdalena Gabig-Cimińska. Use of Cytokine Mix-, Imiquimod-, and Serum-Induced Monoculture and Lipopolysaccharide- and Interferon Gamma-Treated Co-Culture to Establish In Vitro Psoriasis-like Inflammation Models. Cells. 2021 11; 10(11):. doi: 10.3390/cells10112985. [PMID: 34831208]
  • Kiran L Sharma, Shuo Jia, Tasnim H Beacon, Ifeoluwa Adewumi, Camila López, Pingzhao Hu, Wayne Xu, James R Davie. Mitogen-induced transcriptional programming in human fibroblasts. Gene. 2021 Oct; 800(?):145842. doi: 10.1016/j.gene.2021.145842. [PMID: 34274479]
  • Theresa Wolfram, Leonie M Weidenbach, Johanna Adolf, Maria Schwarz, Patrick Schädel, André Gollowitzer, Oliver Werz, Andreas Koeberle, Anna P Kipp, Solveigh C Koeberle. The Trace Element Selenium Is Important for Redox Signaling in Phorbol Ester-Differentiated THP-1 Macrophages. International journal of molecular sciences. 2021 Oct; 22(20):. doi: 10.3390/ijms222011060. [PMID: 34681720]
  • Norman Urrego, Paula Sepúlveda, Marcela Aragón, Freddy A Ramos, Geison M Costa, Luis F Ospina, Leonardo Castellanos. Flavonoids and saponins from Passiflora edulis f. edulis leaves (purple passion fruit) and its potential anti-inflammatory activity. The Journal of pharmacy and pharmacology. 2021 Oct; 73(11):1530-1538. doi: 10.1093/jpp/rgab117. [PMID: 34436599]
  • Na-Ra Han, Seong-Gyu Ko, Phil-Dong Moon, Hi-Joon Park. Chloroquine attenuates thymic stromal lymphopoietin production via suppressing caspase-1 signaling in mast cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Sep; 141(?):111835. doi: 10.1016/j.biopha.2021.111835. [PMID: 34146852]
  • Tong Zhu, Xiaoming Zou, Chunfa Yang, Liangliang Li, Bing Wang, Rong Li, Hongxuan Li, Zhangxuan Xu, Di Huang, Qingyun Wu. Neutrophil extracellular traps promote gastric cancer metastasis by inducing epithelial‑mesenchymal transition. International journal of molecular medicine. 2021 Jul; 48(1):. doi: 10.3892/ijmm.2021.4960. [PMID: 34013374]
  • Sorely Adelina Sosa-Luis, William de Jesús Ríos-Ríos, Ángeles Esmeralda Gómez-Bustamante, María de Los Ángeles Romero-Tlalolini, Sergio Roberto Aguilar-Ruiz, Rafael Baltierez-Hoyos, Honorio Torres-Aguilar. Structural differences of neutrophil extracellular traps induced by biochemical and microbiologic stimuli under healthy and autoimmune milieus. Immunologic research. 2021 06; 69(3):264-274. doi: 10.1007/s12026-021-09199-z. [PMID: 33966252]
  • Julliana F Sant'Anna, Vanessa S Baldez, Natalie A Razuck-Garrão, Thiago Lemos, Bruno L Diaz, Marcelo Einicker-Lamas. Lysophosphatidic acid (LPA) as a modulator of plasma membrane Ca2+-ATPase from basolateral membranes of kidney proximal tubules. Journal of physiology and biochemistry. 2021 May; 77(2):321-329. doi: 10.1007/s13105-021-00800-5. [PMID: 33704695]
  • Yuka Nagata, Hirokazu Ando, Yohei Sasaki, Ryo Suzuki. Ephedra Herb, Mao, Inhibits Antigen-Induced Mast Cell Degranulation by Induction of the Affinity Receptor for IgE Internalization. Pharmaceutical research. 2021 Apr; 38(4):569-581. doi: 10.1007/s11095-021-03020-0. [PMID: 33754256]
  • Alessia D'Aloia, Laura Molteni, Francesca Gullo, Elena Bresciani, Valentina Artusa, Laura Rizzi, Michela Ceriani, Ramona Meanti, Marzia Lecchi, Silvia Coco, Barbara Costa, Antonio Torsello. Palmitoylethanolamide Modulation of Microglia Activation: Characterization of Mechanisms of Action and Implication for Its Neuroprotective Effects. International journal of molecular sciences. 2021 Mar; 22(6):. doi: 10.3390/ijms22063054. [PMID: 33802689]
  • Li Xiao, Nobuhiko Miwa. Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents. Cells. 2021 03; 10(3):. doi: 10.3390/cells10030626. [PMID: 33799840]
  • Guillaume Cardin, Cyril Poupet, Muriel Bonnet, Philippe Veisseire, Isabelle Ripoche, Pierre Chalard, Anne Chauder, Etienne Saunier, Julien Priam, Stéphanie Bornes, Laurent Rios. A Mechanistic Study of the Antiaging Effect of Raw-Milk Cheese Extracts. Nutrients. 2021 Mar; 13(3):. doi: 10.3390/nu13030897. [PMID: 33802038]
  • Erle Dang, George Man, Dale Lee, Debbie A Crumrine, Theodora M Mauro, Peter M Elias, Mao-Qiang Man. Mutations in 3β-hydroxysteroid-δ8, δ7-isomerase paradoxically benefit epidermal permeability barrier homeostasis in mice. Experimental dermatology. 2021 03; 30(3):384-389. doi: 10.1111/exd.14236. [PMID: 33205489]
  • Jennifer M Zerbato, Georges Khoury, Wei Zhao, Matthew J Gartner, Rachel D Pascoe, Ajantha Rhodes, Ashanti Dantanarayana, Megan Gooey, Jenny Anderson, Peter Bacchetti, Steven G Deeks, James McMahon, Michael Roche, Thomas A Rasmussen, Damian Fj Purcell, Sharon R Lewin. Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency. EBioMedicine. 2021 Mar; 65(?):103241. doi: 10.1016/j.ebiom.2021.103241. [PMID: 33647768]
  • Aram Niaz, Jocelyn Karunia, Mawj Mandwie, Kevin A Keay, Giuseppe Musumeci, Ghaith Al-Badri, Alessandro Castorina. Robust Dopaminergic Differentiation and Enhanced LPS-Induced Neuroinflammatory Response in Serum-Deprived Human SH-SY5Y Cells: Implication for Parkinson's Disease. Journal of molecular neuroscience : MN. 2021 Mar; 71(3):565-582. doi: 10.1007/s12031-020-01678-6. [PMID: 32789724]
  • Carlos Machahua, Ivette Buendia-Roldan, Ranferi Ocaña-Guzman, María Molina-Molina, Annie Pardo, Leslie Chavez-Galan, Moises Selman. CD4+T cells in ageing-associated interstitial lung abnormalities show evidence of pro-inflammatory phenotypic and functional profile. Thorax. 2021 02; 76(2):152-160. doi: 10.1136/thoraxjnl-2020-215520. [PMID: 33298584]
  • Hamza Saidi, Babar Murtaza, Amira Sayed Khan, Elhadj Ahmed Koceir, Aziz Hichami, Naim Akhtar Khan. DHA induces Jurkat T-cell arrest in G2/M phase of cell cycle and modulates the plasma membrane expression of TRPC3/6 channels. Biochimie. 2021 Feb; 181(?):169-175. doi: 10.1016/j.biochi.2020.12.005. [PMID: 33333171]
  • Nami Ito, Momoko Yamada, Koichi Morishita, Satoshi Nojima, Kei Motooka, Natsumi Sakata, Tatsuya Asuka, Ryoji Otsu, Shinji Takamatsu, Yoshihiro Kamada, Soichiro Mori, Hirofumi Akita, Hidetoshi Eguchi, Eiichi Morii, Eiji Miyoshi. Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism. Glycoconjugate journal. 2021 02; 38(1):45-54. doi: 10.1007/s10719-020-09970-8. [PMID: 33523362]
  • Bao-Jun Zhu, Ze-Quan Qian, Hui-Run Yang, Ru-Xia Li. Tripterine: A Potential Anti-Allergic Compound. Current pharmaceutical biotechnology. 2021; 22(1):159-167. doi: 10.2174/1389201021666200327163322. [PMID: 32216736]
  • Emmanuel Flores-Espinoza, Aldo Meizoso-Huesca, Sócrates Villegas-Comonfort, Guadalupe Reyes-Cruz, J Adolfo García-Sáinz. Effect of docosahexaenoic acid, phorbol myristate acetate, and insulin on the interaction of the FFA4 (short isoform) receptor with Rab proteins. European journal of pharmacology. 2020 Dec; 889(?):173595. doi: 10.1016/j.ejphar.2020.173595. [PMID: 32986985]
  • Sukkum Ngullie Chang, Debasish Kumar Dey, Seong Taek Oh, Won Ho Kong, Kiu Hyung Cho, Ebtesam M Al-Olayan, Buyng Su Hwang, Sun Chul Kang, Jae Gyu Park. Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1α-NF-κB Crosstalk In Vitro and In Vivo. International journal of molecular sciences. 2020 Dec; 21(23):. doi: 10.3390/ijms21239261. [PMID: 33291656]
  • Bárbara E Souza, Marcelo H F Ottoni, Priscila G M de Alvarenga, Agnes Batista Meireles, João V W Silveira, Valéria Gomes Almeida, Michaelle G Dos Santos, Libardo Andrés González-Torres, Cristiane F Fuzer Grael, Gustavo Eustáquio Alvim Brito-Melo, Bethânia A Avelar-Freitas. Effect of essential oil from Ageratum fastigiatum on beta-integrin (CD18) expression on human lymphocytes stimulated with phorbol myristate acetate in vitro. Natural product research. 2020 Dec; 34(23):3409-3413. doi: 10.1080/14786419.2019.1569653. [PMID: 30758988]
  • Li Zheng, Andrew J Trease, Kenichi Katsurada, Gaelle Spagnol, Hanjun Li, Wen Shi, Bin Duan, Kaushik P Patel, Paul L Sorgen. Inhibition of Pyk2 and Src activity improves Cx43 gap junction intercellular communication. Journal of molecular and cellular cardiology. 2020 12; 149(?):27-40. doi: 10.1016/j.yjmcc.2020.09.004. [PMID: 32956670]
  • Shreepa J Chauhan, Anita Thyagarajan, Yanfang Chen, Jeffrey B Travers, Ravi P Sahu. Platelet-Activating Factor-Receptor Signaling Mediates Targeted Therapies-Induced Microvesicle Particles Release in Lung Cancer Cells. International journal of molecular sciences. 2020 Nov; 21(22):. doi: 10.3390/ijms21228517. [PMID: 33198218]
  • Ayako Taima, Atsushi Fukui, Ayano Yamaya, Megumi Yokota, Rie Fukuhara, Yoshihito Yokoyama. A semen-based stimulation method to analyze cytokine production by uterine CD56bright natural killer cells in women with recurrent pregnancy loss. Journal of reproductive immunology. 2020 11; 142(?):103206. doi: 10.1016/j.jri.2020.103206. [PMID: 32957051]
  • Chung-Yuan Lee, Ying-Erh Chou, Min-Chien Hsin, Chiao-Wen Lin, Po-Hui Wang, Shun-Fa Yang, Yi-Hsuan Hsiao. Dioscorea nipponica Makino suppresses TPA-induced migration and invasion through inhibition of matrix metalloproteinase-9 in human cervical cancer cells. Environmental toxicology. 2020 Nov; 35(11):1194-1201. doi: 10.1002/tox.22984. [PMID: 32519806]
  • Chun Hua Piao, Thi Tho Bui, Yan Jing Fan, Thi Van Nguyen, Dong-Uk Shin, Chang Ho Song, So-Young Lee, Hee Soon Shin, Hyoung Tae Kim, Ok Hee Chai. In vivo and in vitro anti‑allergic and anti‑inflammatory effects of Dryopteris crassirhizoma through the modulation of the NF‑ĸB signaling pathway in an ovalbumin‑induced allergic asthma mouse model. Molecular medicine reports. 2020 Nov; 22(5):3597-3606. doi: 10.3892/mmr.2020.11460. [PMID: 33000211]
  • Monterrosas-Brisson Nayeli, Herrera-Ruiz Maribel, Jiménez-Ferrer Enrique, Bahena-Pérez Rafael, Avilés-Flores Margarita, Fuentes-Mata Macrina, Martínez-Duncker Ivan, González-Cortazar Manasés. Anti-inflammatory activity of coumarins isolated from Tagetes lucida Cav. Natural product research. 2020 Nov; 34(22):3244-3248. doi: 10.1080/14786419.2018.1553172. [PMID: 30618303]
  • Gustavo de-Los-Santos-Cocotle, Juan Carlos Martínez-Morales, M Teresa Romero-Ávila, Guadalupe Reyes-Cruz, J Adolfo García-Sáinz. Effects of agonists and phorbol esters on α1A-adrenergic receptor-Rab protein interactions. European journal of pharmacology. 2020 Oct; 885(?):173423. doi: 10.1016/j.ejphar.2020.173423. [PMID: 32750368]
  • Ting Yang, Jiamao Chen, Lingqiang Gao, Yuanyu Huang, Guochao Liao, Yi Cao. Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study. Toxicology letters. 2020 Oct; 332(?):65-73. doi: 10.1016/j.toxlet.2020.07.007. [PMID: 32649966]
  • Xing Hu, Liang Wang, Lili Zhang, Tao Zhang. β-Elemene inhibits 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced skin tumorigenesis through suppression of NF-κB-associated signaling events in the mouse skin model. Journal of biochemical and molecular toxicology. 2020 Oct; 34(10):e22550. doi: 10.1002/jbt.22550. [PMID: 32662567]
  • Chen-Liang Chao, Hui-Chi Huang, Hsiou-Yu Ding, Jenn-Haung Lai, Hang-Ching Lin, Wen-Liang Chang. A new macrocyclic diterpenoid from Anisomeles indica. Natural product research. 2020 Oct; 34(19):2737-2745. doi: 10.1080/14786419.2019.1586692. [PMID: 30908093]
  • Katarzyna Anna Radaszkiewicz, Deborah Beckerová, Lucie Woloszczuková, Tomasz Witold Radaszkiewicz, Petra Lesáková, Olga Vondálová Blanářová, Lukáš Kubala, Petr Humpolíček, Jiří Pachernik. 12-O-Tetradecanoylphorbol-13-acetate increases cardiomyogenesis through PKC/ERK signaling. Scientific reports. 2020 09; 10(1):15922. doi: 10.1038/s41598-020-73074-4. [PMID: 32985604]
  • Belén Palomares, Martín Garrido-Rodriguez, Claudia Gonzalo-Consuegra, María Gómez-Cañas, Suwipa Saen-Oon, Robert Soliva, Juan A Collado, Javier Fernández-Ruiz, Gaetano Morello, Marco A Calzado, Giovanni Appendino, Eduardo Muñoz. Δ9 -Tetrahydrocannabinolic acid alleviates collagen-induced arthritis: Role of PPARγ and CB1 receptors. British journal of pharmacology. 2020 09; 177(17):4034-4054. doi: 10.1111/bph.15155. [PMID: 32510591]
  • Giorgio Mattiuz, Sabrina Nicolò, Alberto Antonelli, Tommaso Giani, Ilaria Baccani, Antonio Cannatelli, Ann Maria Clemente, Giuseppe Castronovo, Michele Tanturli, Federico Cozzolino, Gian Maria Rossolini, Maria Gabriella Torcia. mcr-1 Gene Expression Modulates the Inflammatory Response of Human Macrophages to Escherichia coli. Infection and immunity. 2020 07; 88(8):. doi: 10.1128/iai.00018-20. [PMID: 32513853]
  • Consuelo Mori, Ángel G Valdivieso, Mariángeles Clauzure, María M Massip-Copiz, María Á Aguilar, Eduardo G A Cafferata, Tomás A Santa Coloma. Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene. Archives of biochemistry and biophysics. 2020 07; 687(?):108375. doi: 10.1016/j.abb.2020.108375. [PMID: 32339486]
  • Takayoshi Gocho, Hisatake Mori, Md Monirul Islam, Yuki Maruchi, Nobuyoshi Takenaka, Atsutoshi Tomino, Masanobu Tsuda, Hideki Kano, Naoshi Takeyama. Removal of Circulating Neutrophil Extracellular Trap Components With an Immobilized Polymyxin B Filter: A Preliminary Study. Shock (Augusta, Ga.). 2020 07; 54(1):44-49. doi: 10.1097/shk.0000000000001476. [PMID: 31764624]
  • Andrea Gerbino, Roberta De Zio, Daniela Russo, Luigi Milella, Serena Milano, Giuseppe Procino, Michael Pusch, Maria Svelto, Monica Carmosino. Role of PKC in the Regulation of the Human Kidney Chloride Channel ClC-Ka. Scientific reports. 2020 06; 10(1):10268. doi: 10.1038/s41598-020-67219-8. [PMID: 32581267]
  • Ramona Fecker, Valentina Buda, Ersilia Alexa, Stefana Avram, Ioana Zinuca Pavel, Delia Muntean, Ileana Cocan, Claudia Watz, Daliana Minda, Cristina Adriana Dehelean, Codruta Soica, Corina Danciu. Phytochemical and Biological Screening of Oenothera Biennis L. Hydroalcoholic Extract. Biomolecules. 2020 05; 10(6):. doi: 10.3390/biom10060818. [PMID: 32466573]
  • Ananda Beatriz Munhoz Cretella, Bruna da Silva Soley, Priscila Lúcia Pawloski, Rebecca Marquini Ruziska, Dilamara Riva Scharf, Jociani Ascari, Daniela Almeida Cabrini, Michel Fleith Otuki. Expanding the anti-inflammatory potential of Moringa oleifera: topical effect of seed oil on skin inflammation and hyperproliferation. Journal of ethnopharmacology. 2020 May; 254(?):112708. doi: 10.1016/j.jep.2020.112708. [PMID: 32142866]
  • Fernanda Grillo Rocha, Margareth de Mello Brandenburg, Priscila Lúcia Pawloski, Bruna da Silva Soley, Simone Castagna Angelim Costa, Cristiane Claudia Meinerz, Irinéia Paulina Baretta, Michel Fleith Otuki, Daniela Almeida Cabrini. Preclinical study of the topical anti-inflammatory activity of Cyperus rotundus L. extract (Cyperaceae) in models of skin inflammation. Journal of ethnopharmacology. 2020 May; 254(?):112709. doi: 10.1016/j.jep.2020.112709. [PMID: 32109543]
  • Joobyoung Yoon, Youngkyung Cho, Ki Yeon Kim, Min Ji Yoon, Hyo Seon Lee, Sangjun Davie Jeon, Yongcheol Cho, Chungho Kim, Moon Gyo Kim. A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CβII. The Journal of biological chemistry. 2020 05; 295(20):7168-7177. doi: 10.1074/jbc.ra119.011206. [PMID: 32241917]
  • Min-Jeong Heo, Soo Young Choi, Chanmi Lee, Yeong Min Choi, In-Sook An, Seunghee Bae, Sungkwan An, Jin Hyuk Jung. Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis. International journal of molecular sciences. 2020 May; 21(9):. doi: 10.3390/ijms21093241. [PMID: 32375285]
  • Yan-Ning Rui, Yawen Chen, Yichen Guo, Caroline E Bock, John P Hagan, Dong H Kim, Zhen Xu. Podosome formation impairs endothelial barrier function by sequestering zonula occludens proteins. Journal of cellular physiology. 2020 05; 235(5):4655-4666. doi: 10.1002/jcp.29343. [PMID: 31637713]
  • Cintia Delai da Silva Horinouchi, Bruna da Silva Soley, Daniel Augusto Gasparin Bueno Mendes, Bárbara Guerreira Alpande Ferreira, Christiane Meyre-Silva, Ingrid Vicente Farias, Clarissa de Medeiros Amorim Krueger, Tania Mari Bellé Bresolin, Jamil Assreuy, Katia Christina Zuffellato-Ribas, Daniela Almeida Cabrini, Michel Fleith Otuki. Corticoid-like anti-inflammatory effect of Vochysia bifalcata Warm.: Preclinical evidence of efficacy and safety. Journal of ethnopharmacology. 2020 Apr; 252(?):112472. doi: 10.1016/j.jep.2019.112472. [PMID: 31836516]
  • Hiroshi Matsuoka, Riki Tokunaga, Miyu Katayama, Yuichiro Hosoda, Kaoruko Miya, Kento Sumi, Ami Ohishi, Jun Kamishikiryo, Akiho Shima, Akihiro Michihara. Retinoic acid receptor-related orphan receptor α reduces lipid droplets by upregulating neutral cholesterol ester hydrolase 1 in macrophages. BMC molecular and cell biology. 2020 Apr; 21(1):32. doi: 10.1186/s12860-020-00276-z. [PMID: 32321446]
  • Jia-Ying Wu, Ying-Jie Chen, Lu Bai, Yu-Xi Liu, Xiu-Qiong Fu, Pei-Li Zhu, Jun-Kui Li, Ji-Yao Chou, Cheng-Le Yin, Ya-Ping Wang, Jing-Xuan Bai, Ying Wu, Zheng-Zhi Wu, Zhi-Ling Yu. Chrysoeriol ameliorates TPA-induced acute skin inflammation in mice and inhibits NF-κB and STAT3 pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Mar; 68(?):153173. doi: 10.1016/j.phymed.2020.153173. [PMID: 31999977]
  • Sun Young Park, Zhengwei Cui, Beomjin Kim, Geuntae Park, Young-Whan Choi. Treatment with Gold Nanoparticles Using Cudrania tricuspidata Root Extract Induced Downregulation of MMP-2/-9 and PLD1 and Inhibited the Invasiveness of Human U87 Glioblastoma Cells. International journal of molecular sciences. 2020 Feb; 21(4):. doi: 10.3390/ijms21041282. [PMID: 32074974]
  • Zainul Amiruddin Zakaria, Rushduddin Al Jufri Roosli, Najihah Hanisah Marmaya, Maizatul Hasyima Omar, Rusliza Basir, Muhammad Nazrul Somchit. Methanol Extract of Dicranopteris linearis Leaves Attenuate Pain via the Modulation of Opioid/NO-Mediated Pathway. Biomolecules. 2020 02; 10(2):. doi: 10.3390/biom10020280. [PMID: 32059475]
  • Kyu-Shik Lee, Gi Suk Nam, Junyoung Baek, Soyoung Kim, Kyung-Soo Nam. Inhibition of TPA‑induced metastatic potential by morin hydrate in MCF‑7 human breast cancer cells via the Akt/GSK‑3β/c‑Fos signaling pathway. International journal of oncology. 2020 Feb; 56(2):630-640. doi: 10.3892/ijo.2020.4954. [PMID: 31939617]
  • Acharya Balkrishna, Pradeep Nain, Anshul Chauhan, Niti Sharma, Abhishek Gupta, Ravikant Ranjan, Anurag Varshney. Super Critical Fluid Extracted Fatty Acids from Withania somnifera Seeds Repair Psoriasis-Like Skin Lesions and Attenuate Pro-Inflammatory Cytokines (TNF-α and IL-6) Release. Biomolecules. 2020 01; 10(2):. doi: 10.3390/biom10020185. [PMID: 31991752]
  • Linda E Cox, Kai Walstein, Lena Völlger, Friederike Reuner, Alexandra Bick, Annika Dötsch, Andrea Engler, Jürgen Peters, Maren von Köckritz-Blickwede, Simon T Schäfer. Neutrophil extracellular trap formation and nuclease activity in septic patients. BMC anesthesiology. 2020 01; 20(1):15. doi: 10.1186/s12871-019-0911-7. [PMID: 31931719]
  • Hamed Tavakkoli, Morteza Akhond, Gholam Abbas Ghorbankhani, Ghodratollah Absalan. Electrochemical sensing of hydrogen peroxide using a glassy carbon electrode modified with multiwalled carbon nanotubes and zein nanoparticle composites: application to HepG2 cancer cell detection. Mikrochimica acta. 2020 01; 187(2):105. doi: 10.1007/s00604-019-4064-7. [PMID: 31916024]
  • Tarfa Albrahim, Moonerah M Alnasser, Mashael R Al-Anazi, Muneera D ALKahtani, Saad Alkahtani, Ahmed A Al-Qahtani. In Vitro Studies on the Immunomodulatory Effects of Pulicaria crispa Extract on Human THP-1 Monocytes. Oxidative medicine and cellular longevity. 2020; 2020(?):7574606. doi: 10.1155/2020/7574606. [PMID: 33628359]
  • Astrid Fabri, Khalil Kandara, Rémy Coudereau, Morgane Gossez, Paul Abraham, Céline Monard, Martin Cour, Thomas Rimmelé, Laurent Argaud, Guillaume Monneret, Fabienne Venet. Characterization of Circulating IL-10-Producing Cells in Septic Shock Patients: A Proof of Concept Study. Frontiers in immunology. 2020; 11(?):615009. doi: 10.3389/fimmu.2020.615009. [PMID: 33613540]
  • Mohan Shankar G, Vijai V Alex, Amrutha Nisthul A, Smitha V Bava, Sankar Sundaram, Archana P Retnakumari, Sadasivan Chittalakkottu, Ruby John Anto. Pre-clinical evidences for the efficacy of tryptanthrin as a potent suppressor of skin cancer. Cell proliferation. 2020 Jan; 53(1):e12710. doi: 10.1111/cpr.12710. [PMID: 31663659]
  • Yun-Peng Wang, Yu Guo, Ping-Shan Wen, Zhen-Zhen Zhao, Jian Xie, Kai Yang, Qing Yang, Jia-Feng Wang, Xiao-Ming Deng. Three Ingredients of Safflower Alleviate Acute Lung Injury and Inhibit NET Release Induced by Lipopolysaccharide. Mediators of inflammation. 2020; 2020(?):2720369. doi: 10.1155/2020/2720369. [PMID: 32189992]
  • Aye Aye, Young-Jae Song, Yong-Deok Jeon, Jong-Sik Jin. Xanthone suppresses allergic contact dermatitis in vitro and in vivo. International immunopharmacology. 2020 Jan; 78(?):106061. doi: 10.1016/j.intimp.2019.106061. [PMID: 31821937]
  • Céline Barthelemy, Bruno André. Ubiquitylation and endocytosis of the human LAT1/SLC7A5 amino acid transporter. Scientific reports. 2019 11; 9(1):16760. doi: 10.1038/s41598-019-53065-w. [PMID: 31728037]
  • Marlene Christina Nielsen, Morten Nørgaard Andersen, Nikolaj Rittig, Sidsel Rødgaard-Hansen, Henning Grønbaek, Søren Kragh Moestrup, Holger Jon Møller, Anders Etzerodt. The macrophage-related biomarkers sCD163 and sCD206 are released by different shedding mechanisms. Journal of leukocyte biology. 2019 11; 106(5):1129-1138. doi: 10.1002/jlb.3a1218-500r. [PMID: 31242338]
  • Heng Chi, Kristian Gillebo Sørmo, Jing Diao, Roy Ambli Dalmo. T-box transcription factor eomesodermin/Tbr2 in Atlantic cod (Gadus morhua L.): Molecular characterization, promoter structure and function analysis. Fish & shellfish immunology. 2019 Oct; 93(?):28-38. doi: 10.1016/j.fsi.2019.07.021. [PMID: 31302288]
  • Gaowa Bai, Takashi Matsuba, Haruhisa Kikuchi, Haorile Chagan-Yasutan, Hirotoshi Motoda, Ryo Ozuru, Osamu Yamada, Yoshiteru Oshima, Toshio Hattori. Inhibition of inflammatory-molecule synthesis in THP-1 cells stimulated with phorbol 12-myristate 13-acetate by brefelamide derivatives. International immunopharmacology. 2019 Oct; 75(?):105831. doi: 10.1016/j.intimp.2019.105831. [PMID: 31437790]
  • Jian He, Tao-Lin Xie, Xiao Li, Yang Yu, Zhi-Peng Zhan, Shao-Ping Weng, Chang-Jun Guo, Jian-Guo He. Molecular cloning of Y-Box binding protein-1 from mandarin fish and its roles in stress-response and antiviral immunity. Fish & shellfish immunology. 2019 Oct; 93(?):406-415. doi: 10.1016/j.fsi.2019.07.069. [PMID: 31369857]
  • Markus Dietrich, Muhammad Salman Malik, Marianne Skeie, Vibeke Bertelsen, Espen Stang. Protein kinase C regulates ErbB3 turnover. Experimental cell research. 2019 09; 382(2):111473. doi: 10.1016/j.yexcr.2019.06.018. [PMID: 31233741]
  • Mohd Rohaizad Md Roduan, Roslida Abd Hamid, Norhafizah Mohtarrudin. Modulation of cancer signalling pathway(s) in two -stage mouse skin tumorigenesis by annonacin. BMC complementary and alternative medicine. 2019 Sep; 19(1):238. doi: 10.1186/s12906-019-2650-1. [PMID: 31481122]
  • Julie Mondet, Caroline Lo Presti, Catherine Garrel, Kristina Skaare, Clara Mariette, Sylvain Carras, Sophie Park, Martin Carré, Claude-Eric Bulabois, Lysiane Molina, Rémy Gressin, Anne Thiebaut, Stéphane Courby, Nuria Socoro-Yuste, Patrice Faure, Anne Mc Leer-Florin, Jean-Yves Cahn, Pascal Mossuz. Adult patients with de novo acute myeloid leukemia show a functional deregulation of redox balance at diagnosis which is correlated with molecular subtypes and overall survival. Haematologica. 2019 09; 104(9):e393-e397. doi: 10.3324/haematol.2018.206821. [PMID: 30819920]
  • Mmamosheledi E Mothibe, Christina P Kahler-Venter, Elzbieta Osuch. Evaluation of the in vitro effects of commercial herbal preparations significant in African traditional medicine on platelets. BMC complementary and alternative medicine. 2019 Aug; 19(1):224. doi: 10.1186/s12906-019-2644-z. [PMID: 31438931]
  • Ye Feng, Yang Xie, Meishu Xu, Linhao Li, Kyle W Selcer, Patrick J Oberly, Samuel M Poloyac, Hongbing Wang, Chengjiang Li, Fengqin Dong, Chaohui Yu, Wen Xie. Hepatic steroid sulfatase critically determines estrogenic activities of conjugated equine estrogens in human cells in vitro and in mice. The Journal of biological chemistry. 2019 08; 294(32):12112-12121. doi: 10.1074/jbc.ra119.009181. [PMID: 31217279]
  • Morgan E Sutherland-Deveen, Tingzhong Wang, Shawn M Lamothe, Jared N Tschirhart, Jun Guo, Wentao Li, Tonghua Yang, Yuan Du, Shetuan Zhang. Differential Regulation of Human Ether-à-Go-Go-Related Gene (hERG) Current and Expression by Activation of Protein Kinase C. Molecular pharmacology. 2019 07; 96(1):1-12. doi: 10.1124/mol.118.115188. [PMID: 31015282]
  • Magdala Zulema Figueroa-Suárez, Judith González Christen, Alexandre Toshirrico Cardoso-Taketa, María Del Carmen Gutiérrez Villafuerte, Verónica Rodríguez-López. Anti-inflammatory and antihistaminic activity of triterpenoids isolated from Bursera cuneata (Schldl.) Engl. Journal of ethnopharmacology. 2019 Jun; 238(?):111786. doi: 10.1016/j.jep.2019.03.013. [PMID: 30872171]
  • Sonia Maryam, Muhammad Rashid Khan, Sayed Afzal Shah, Zartash Zahra, Riffat Batool, Jawaid Ahmed Zai. Evaluation of anti-inflammatory potential of the leaves of Wendlandia heynei (Schult.) Santapau & Merchant in Sprague Dawley rat. Journal of ethnopharmacology. 2019 Jun; 238(?):111849. doi: 10.1016/j.jep.2019.111849. [PMID: 30953822]
  • Chao Wang, Renyi Wu, Davit Sargsyan, Meinizi Zheng, Shanyi Li, Ran Yin, Shan Su, Ilya Raskin, Ah-Ng Kong. CpG methyl-seq and RNA-seq epigenomic and transcriptomic studies on the preventive effects of Moringa isothiocyanate in mouse epidermal JB6 cells induced by the tumor promoter TPA. The Journal of nutritional biochemistry. 2019 06; 68(?):69-78. doi: 10.1016/j.jnutbio.2019.03.011. [PMID: 31030169]
  • Dongdong Tang, Shipei Wu, Kai Luo, Hanwen Yuan, Weihua Gao, Dashi Zhu, Wenbing Zhang, Qiaoqing Xu. Sequence characterization and expression pattern analysis of six kinds of IL-17 family genes in the Asian swamp eel (Monopterus albus). Fish & shellfish immunology. 2019 Jun; 89(?):257-270. doi: 10.1016/j.fsi.2019.03.050. [PMID: 30922887]
  • Florian Guenther, Deborah Maus, Sarah Hedtrich, Matthias F Melzig. Serine Protease Mauritanicain from Euphorbia mauritanica and Phorbol-12-myristate-13-acetate Modulate the IL-8 Release in Fibroblasts and HaCaT Keratinocytes. Planta medica. 2019 May; 85(7):578-582. doi: 10.1055/a-0735-9911. [PMID: 30248704]
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  • Elsa Neubert, Susanne N Senger-Sander, Veit S Manzke, Julia Busse, Elena Polo, Sophie E F Scheidmann, Michael P Schön, Sebastian Kruss, Luise Erpenbeck. Serum and Serum Albumin Inhibit in vitro Formation of Neutrophil Extracellular Traps (NETs). Frontiers in immunology. 2019; 10(?):12. doi: 10.3389/fimmu.2019.00012. [PMID: 30733715]
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  • Chung-Yuan Lee, Shun-Fa Yang, Po-Hui Wang, Chun-Wen Su, Hua-Fen Hsu, Hsiu-Ting Tsai, Yi-Hsuan Hsiao. Antimetastatic effects of Terminalia catappa leaf extracts on cervical cancer through the inhibition of matrix metalloprotein-9 and MAPK pathway. Environmental toxicology. 2019 Jan; 34(1):60-66. doi: 10.1002/tox.22657. [PMID: 30259628]