N-depropylpropafenone (BioDeep_00000054187)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


1-[2-(3-amino-2-hydroxypropoxy)phenyl]-3-phenylpropan-1-one

化学式: C18H21NO3 (299.1521356)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: C1=CC=C(C=C1)CCC(=O)C2=CC=CC=C2OCC(CN)O
InChI: InChI=1S/C18H21NO3/c19-12-15(20)13-22-18-9-5-4-8-16(18)17(21)11-10-14-6-2-1-3-7-14/h1-9,15,20H,10-13,19H2

描述信息

N-depropylpropafenone is a metabolite of propafenone. Propafenone is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias. (Wikipedia)

同义名列表

5 个代谢物同义名

1-[2-(3-amino-2-hydroxypropoxy)phenyl]-3-phenylpropan-1-one; 1-(2-(3-Amino-2-hydroxypropoxy)phenyl)-3-phenyl-1-propanone; N-Despropylpropafenone; N-Desmethylpropafenone; N-depropylpropafenone



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Harilal Patel, Ashok Ghoghari, Chandrakant Bhatt, Shaival Shah, Anilkumar Jha, Nirmal Desai, Nuggehally R Srinivas. A sensitive quantitative assay for the determination of propafenone and two metabolites, 5-hydroxypropafenone and N-depropylpropafenone, in human K2EDTA plasma using LC-MS/MS with ESI operated in positive mode. Biomedical chromatography : BMC. 2017 Oct; 31(10):. doi: 10.1002/bmc.3967. [PMID: 28261841]
  • Minoo Afshar, Wolfgang Thormann. Validated capillary electrophoresis assay for the simultaneous enantioselective determination of propafenone and its major metabolites in biological samples. Electrophoresis. 2006 Apr; 27(8):1517-25. doi: 10.1002/elps.200500663. [PMID: 16532516]
  • K Fonck, C Haenebalcke, A Hemeryck, F Belpaire, L Jordaens, P Calle, W Buylaert. ECG changes and plasma concentrations of propafenone and its metabolites in a case of severe poisoning. Journal of toxicology. Clinical toxicology. 1998; 36(3):247-51. doi: 10.3109/15563659809028948. [PMID: 9656983]
  • C Woodland, Z Verjee, E Giesbrecht, G Koren, S Ito. The digoxin-propafenone interaction: characterization of a mechanism using renal tubular cell monolayers. The Journal of pharmacology and experimental therapeutics. 1997 Oct; 283(1):39-45. doi: NULL. [PMID: 9336306]
  • W L Zhang, Y N Tang. [Simultaneous determination of propafenone and its active metabolite in serum by high performance liquid chromatography]. Yao xue xue bao = Acta pharmaceutica Sinica. 1992; 27(7):552-5. doi: NULL. [PMID: 1442090]
  • M S Leloux, R A Maes. Identification and determination of propafenone and its principal metabolites in human urine using capillary gas chromatography/mass spectrometry. Biological mass spectrometry. 1991 Jun; 20(6):382-8. doi: 10.1002/bms.1200200609. [PMID: 1888783]
  • S Vozeh, W Haefeli, H R Ha, J Vlcek, F Follath. Nonlinear kinetics of propafenone metabolites in healthy man. European journal of clinical pharmacology. 1990; 38(5):509-13. doi: 10.1007/bf02336693. [PMID: 2379537]
  • R G Zoble, E B Kirsten, J Brewington. Pharmacokinetic and pharmacodynamic evaluation of propafenone in patients with ventricular arrhythmia. Propafenone Research Group. Clinical pharmacology and therapeutics. 1989 May; 45(5):535-41. doi: 10.1038/clpt.1989.69. [PMID: 2721109]
  • G Malfatto, A Zaza, M Forster, B Sodowick, P Danilo, M R Rosen. Electrophysiologic, inotropic and antiarrhythmic effects of propafenone, 5-hydroxypropafenone and N-depropylpropafenone. The Journal of pharmacology and experimental therapeutics. 1988 Aug; 246(2):419-26. doi: NULL. [PMID: 3404440]
  • K A Thompson, D H Iansmith, L A Siddoway, R L Woosley, D M Roden. Potent electrophysiologic effects of the major metabolites of propafenone in canine Purkinje fibers. The Journal of pharmacology and experimental therapeutics. 1988 Mar; 244(3):950-5. doi: NULL. [PMID: 3252042]
  • R E Kates, Y G Yee, R A Winkle. Metabolite cumulation during chronic propafenone dosing in arrhythmia. Clinical pharmacology and therapeutics. 1985 Jun; 37(6):610-4. doi: 10.1038/clpt.1985.97. [PMID: 4006362]