dihydro-3-hydroxy-4,4-dimethyl- 2(3H)-Furanone (BioDeep_00000004540)

 

Secondary id: BioDeep_00000399996, BioDeep_00001883211

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


2,4-Dihydroxy-3,3-dimethylbutyric acid gamma-lactone

化学式: C6H10O3 (130.062991)
中文名称: D-(-)-泛酰内酯, DL-泛酰内酯
谱图信息: 最多检出来源 Viridiplantae(plant) 0.1%

分子结构信息

SMILES: CC1(C)COC(=O)C1O
InChI: InChI=1S/C6H10O3/c1-6(2)3-9-5(8)4(6)7/h4,7H,3H2,1-2H3

描述信息

Flavouring compound [Flavornet]
DL-Pantolactone can be hydrolyzed to Pantoic acid by the lactonohydrolase of Fusarium oxysporum. DL-Pantolactone also can be used in the preparation of 3,5-dinitrobenzoyl-DL-pantolactone[1][2].
DL-Pantolactone can be hydrolyzed to Pantoic acid by the lactonohydrolase of Fusarium oxysporum. DL-Pantolactone also can be used in the preparation of 3,5-dinitrobenzoyl-DL-pantolactone[1][2].
Pantolactone is an endogenous metabolite.

同义名列表

13 个代谢物同义名

2,4-Dihydroxy-3,3-dimethylbutyric acid gamma-lactone; (3R)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone; Pantolactone, 2-(14)C-labeled CPD, (+,-)-isomer; dihydro-3-hydroxy-4,4-dimethyl- 2(3H)-Furanone; (3R)-3-hydroxy-4,4-dimethyloxolan-2-one; Pantolactone, (S)-isomer; Pantolactone, (R)-isomer; (R)-Pantoyl lactone; D-(-)-Pantolactone; (R)-Pantolactone; DL-Pantolactone; Pantoyl lactone; Pantolactone



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

300 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(296)

INOH(0)

PlantCyc(3)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hua Fang, Jianlin He, Tan Ran, Hui Chen, Wenhui Jin, Bowen Tang, Zhuan Hong, Meijuan Fang. Synthesis, biological activities, and docking studies of d-pantolactone derivatives as novel FAS inhibitors. Bioorganic & medicinal chemistry. 2019 10; 27(20):115069. doi: 10.1016/j.bmc.2019.115069. [PMID: 31492533]
  • Kai Lv, Li Zhang, Wensheng Lu, Minghua Liu. Control of supramolecular chirality of nanofibers and its effect on protein adhesion. ACS applied materials & interfaces. 2014; 6(21):18878-84. doi: 10.1021/am504702p. [PMID: 25302778]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Reza Khorassani, Ursula Hettwer, Astrid Ratzinger, Bernd Steingrobe, Petr Karlovsky, Norbert Claassen. Citramalic acid and salicylic acid in sugar beet root exudates solubilize soil phosphorus. BMC plant biology. 2011 Aug; 11(?):121. doi: 10.1186/1471-2229-11-121. [PMID: 21871058]
  • Christy E Manyi-Loh, Roland N Ndip, Anna M Clarke. Volatile compounds in honey: a review on their involvement in aroma, botanical origin determination and potential biomedical activities. International journal of molecular sciences. 2011; 12(12):9514-32. doi: 10.3390/ijms12129514. [PMID: 22272147]
  • Ying Xiong, Ke-Zhong Deng, Wen-Yuan Gao, Yuan-Qiang Guo. [Studies on chemical constituents of Ranunculus ternatus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Apr; 33(8):909-11. doi: ". [PMID: 18619350]
  • Ihsan Ergün, M Cenk Akbostanci, Başol Canbakan, Bilge Koçer, Arzu Ensari, Gökhan Nergizoglu, Kenan Keven. Minimal change nephrotic syndrome with stiff-person syndrome: is there a link?. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2005 Jul; 46(1):e11-4. doi: 10.1053/j.ajkd.2005.03.009. [PMID: 15983949]
  • Bala Rathinasabapathi, Suresh Babu Raman. Exogenous supply of pantoyl lactone to excised leaves increases their pantothenate levels. Annals of botany. 2005 May; 95(6):1033-7. doi: 10.1093/aob/mci114. [PMID: 15767268]