Pepstatin (BioDeep_00000004481)
PANOMIX_OTCML-2023 Volatile Flavor Compounds
代谢物信息卡片
Pepstatinum
化学式: C34H63N5O9 (685.4625548)
中文名称: 胃蛋白酶抑制剂
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 17.52%
分子结构信息
SMILES: CC(C)CC(=O)NC(C(=O)NC(C(=O)NC(CC(C)C)C(O)CC(=O)NC(C)C(=O)NC(CC(C)C)C(O)CC(=O)O)C(C)C)C(C)C
InChI: InChI=1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23-,24-,25-,26-,30-,31-/m0/s1
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D010436 - Pepstatins
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor
Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease[1][2].
Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease[1][2].
同义名列表
5 个代谢物同义名
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:7989
- KEGG: C74361
- KEGG: C00773
- KEGGdrug: D03818
- PubChem: 5478883
- PubChem: 5462227
- Metlin: METLIN65531
- ChEMBL: CHEMBL296588
- KNApSAcK: C00018785
- CAS: 39324-30-6
- CAS: 26305-03-3
- PMhub: MS000016963
- PubChem: 4035
- NIKKAJI: J17.063A
- medchemexpress: HY-P0018
- KNApSAcK: 7989
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Minho Won, Sunkyung Choi, Seonghye Cheon, Eun-Mi Kim, Taeg Kyu Kwon, Jaewhan Kim, Yong-Eun Kim, Kyung-Cheol Sohn, Gang Min Hur, Kee K Kim. Octyl syringate is preferentially cytotoxic to cancer cells via lysosomal membrane permeabilization and autophagic flux inhibition.
Cell biology and toxicology.
2021 Sep; ?(?):. doi:
10.1007/s10565-021-09653-6. [PMID: 34523043] - Roberta S Valle, Lívia S Ramos, Vanessa J Reis, Mariangela Ziccardi, Marcos Dornelas-Ribeiro, Cátia L Sodré, Marta H Branquinha, André L S Santos. Trichosporon asahii secretes a 30-kDa aspartic peptidase.
Microbiological research.
2017 Dec; 205(?):66-72. doi:
10.1016/j.micres.2017.08.015. [PMID: 28942846] - Pasquale Cocchiaro, Christopher Fox, Nicholas W Tregidgo, Rachel Howarth, Katrina M Wood, Gerhard R Situmorang, Luigi M Pavone, Neil S Sheerin, Anna Moles. Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury.
Scientific reports.
2016 06; 6(?):27112. doi:
10.1038/srep27112. [PMID: 27271556] - Christopher Fox, Pasquale Cocchiaro, Fiona Oakley, Rachel Howarth, Krystena Callaghan, Jack Leslie, Saimir Luli, Katrina M Wood, Federica Genovese, Neil S Sheerin, Anna Moles. Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease.
Scientific reports.
2016 Feb; 6(?):20101. doi:
10.1038/srep20101. [PMID: 26831567] - Karla Fejfarová, Alan Kádek, Hynek Mrázek, Jiří Hausner, Vyacheslav Tretyachenko, Tomáš Koval', Petr Man, Jindřich Hašek, Jan Dohnálek. Crystallization of nepenthesin I using a low-pH crystallization screen.
Acta crystallographica. Section F, Structural biology communications.
2016 Jan; 72(Pt 1):24-8. doi:
10.1107/s2053230x15022323. [PMID: 26750480] - R Benouaret, E Goujon, P Goupil. Grape marc extract causes early perception events, defence reactions and hypersensitive response in cultured tobacco cells.
Plant physiology and biochemistry : PPB.
2014 Apr; 77(?):84-9. doi:
10.1016/j.plaphy.2014.01.021. [PMID: 24561714] - Cecilia E Hanzel, María F Almeira Gubiani, Sandra V Verstraeten. Endosomes and lysosomes are involved in early steps of Tl(III)-mediated apoptosis in rat pheochromocytoma (PC12) cells.
Archives of toxicology.
2012 Nov; 86(11):1667-80. doi:
10.1007/s00204-012-0878-3. [PMID: 22669516] - Chiara Magni, Fabio Sessa, Gabriella Tedeschi, Armando Negri, Alessio Scarafoni, Alessandro Consonni, Marcello Duranti. Identification in lupin seed of a serine-endopeptidase activity cleaving between twin arginine pairs and causing limited proteolysis of seed storage proteins.
Molecular plant.
2012 Sep; 5(5):1011-9. doi:
10.1093/mp/ssr116. [PMID: 22217442] - Karina Mastropasqua Rebello, Caroline Reis de Siqueira, Erika Louise Ribeiro, Richard Hemmi Valente, Ester Maria Mota, Jonas Perales, Ana Gisele da Costa Neves-Ferreira, Henrique Leonel Lenzi. Proteolytic activity in the adult and larval stages of the human roundworm parasite Angiostrongylus costaricensis.
Memorias do Instituto Oswaldo Cruz.
2012 Sep; 107(6):752-9. doi:
10.1590/s0074-02762012000600008. [PMID: 22990964] - Daniela Lufrano, Rosário Faro, Pedro Castanheira, Gustavo Parisi, Paula Veríssimo, Sandra Vairo-Cavalli, Isaura Simões, Carlos Faro. Molecular cloning and characterization of procirsin, an active aspartic protease precursor from Cirsium vulgare (Asteraceae).
Phytochemistry.
2012 Sep; 81(?):7-18. doi:
10.1016/j.phytochem.2012.05.028. [PMID: 22727116] - Carla Malaquias Almeida, Cláudia Pereira, Diana Soares da Costa, Susana Pereira, José Pissarra, Isaura Simões, Carlos Faro. Chlapsin, a chloroplastidial aspartic proteinase from the green algae Chlamydomonas reinhardtii.
Planta.
2012 Jul; 236(1):283-96. doi:
10.1007/s00425-012-1605-2. [PMID: 22349731] - Maura H Parker, Julia von Maltzahn, Nadine Bakkar, Ban Al-Joubori, Jeff Ishibashi, Denis Guttridge, Michael A Rudnicki. MyoD-dependent regulation of NF-κB activity couples cell-cycle withdrawal to myogenic differentiation.
Skeletal muscle.
2012 05; 2(1):6. doi:
10.1186/2044-5040-2-6. [PMID: 22541644] - Nobuo N Noda, Takafumi Kobayashi, Wakana Adachi, Yuko Fujioka, Yoshinori Ohsumi, Fuyuhiko Inagaki. Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy.
The Journal of biological chemistry.
2012 May; 287(20):16256-66. doi:
10.1074/jbc.m112.348250. [PMID: 22437838] - A Eisenberg-Lerner, A Kimchi. PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk.
Cell death and differentiation.
2012 May; 19(5):788-97. doi:
10.1038/cdd.2011.149. [PMID: 22095288] - Azza Al-Tawashi, Sung Yun Jung, Dou Liu, Bing Su, Jun Qin. Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity.
The Journal of biological chemistry.
2012 Apr; 287(18):14644-58. doi:
10.1074/jbc.m111.261875. [PMID: 22375002] - Xuan Yao, Wei Xiong, Tiantian Ye, Yan Wu. Overexpression of the aspartic protease ASPG1 gene confers drought avoidance in Arabidopsis.
Journal of experimental botany.
2012 Apr; 63(7):2579-93. doi:
10.1093/jxb/err433. [PMID: 22268147] - Antonio Galindo, Ana María Calcagno-Pizarelli, Herbert N Arst, Miguel Ángel Peñalva. An ordered pathway for the assembly of fungal ESCRT-containing ambient pH signalling complexes at the plasma membrane.
Journal of cell science.
2012 Apr; 125(Pt 7):1784-95. doi:
10.1242/jcs.098897. [PMID: 22344261] - Li Yuan, Lijun Wang, Zujing Han, Yuanzhong Jiang, Lili Zhao, Hong Liu, Li Yang, Keming Luo. Molecular cloning and characterization of PtrLAR3, a gene encoding leucoanthocyanidin reductase from Populus trichocarpa, and its constitutive expression enhances fungal resistance in transgenic plants.
Journal of experimental botany.
2012 Apr; 63(7):2513-24. doi:
10.1093/jxb/err425. [PMID: 22268151] - Cao Xu, Yonghong Wang, Yanchun Yu, Jingbo Duan, Zhigang Liao, Guosheng Xiong, Xiangbing Meng, Guifu Liu, Qian Qian, Jiayang Li. Degradation of MONOCULM 1 by APC/C(TAD1) regulates rice tillering.
Nature communications.
2012 Mar; 3(?):750. doi:
10.1038/ncomms1743. [PMID: 22434193] - Aphrodite T Choumessi, Mathieu Danel, Stefan Chassaing, Isabelle Truchet, Véronique B Penlap, Anatole Constant Pieme, Tazoacha Asonganyi, Bernard Ducommun, Annie Valette. Characterization of the antiproliferative activity of Xylopia aethiopica.
Cell division.
2012 Mar; 7(1):8. doi:
10.1186/1747-1028-7-8. [PMID: 22409878] - Patricia Gangoiti, Caterina Bernacchioni, Chiara Donati, Francesca Cencetti, Alberto Ouro, Antonio Gómez-Muñoz, Paola Bruni. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.
Biochimie.
2012 Mar; 94(3):597-607. doi:
10.1016/j.biochi.2011.09.009. [PMID: 21945811] - Chul Min Ahn, Håkan Sandler, Tom Saldeen. Decreased lung hyaluronan in a model of ARDS in the rat: effect of an inhibitor of leukocyte elastase.
Upsala journal of medical sciences.
2012 Mar; 117(1):1-9. doi:
10.3109/03009734.2011.622812. [PMID: 22283425] - Detina Zalli, Richard Bayliss, Andrew M Fry. The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis.
Human molecular genetics.
2012 Mar; 21(5):1155-71. doi:
10.1093/hmg/ddr544. [PMID: 22106379] - Eva Szafranski-Schneider, Marc Swidergall, Fabien Cottier, Denis Tielker, Elvira Román, Jesus Pla, Joachim F Ernst. Msb2 shedding protects Candida albicans against antimicrobial peptides.
PLoS pathogens.
2012 Feb; 8(2):e1002501. doi:
10.1371/journal.ppat.1002501. [PMID: 22319443] - Fernanda Stanisçuaski, Célia R Carlini. Plant ureases and related peptides: understanding their entomotoxic properties.
Toxins.
2012 02; 4(2):55-67. doi:
10.3390/toxins4020055. [PMID: 22474566] - Michiko Sekine, Toshiaki Monkawa, Ryuji Morizane, Kunie Matsuoka, Choji Taya, Yoshiko Akita, Kensuke Joh, Hiroshi Itoh, Matsuhiko Hayashi, Yoshiaki Kikkawa, Kenji Kohno, Akemi Suzuki, Hiromichi Yonekawa. Selective depletion of mouse kidney proximal straight tubule cells causes acute kidney injury.
Transgenic research.
2012 Feb; 21(1):51-62. doi:
10.1007/s11248-011-9504-z. [PMID: 21431867] - Markus Huber-Lang, Stephanie Denk, Simone Fulda, Ellen Erler, Miriam Kalbitz, Sebastian Weckbach, E Marion Schneider, Manfred Weiss, Sandip M Kanse, Mario Perl. Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro.
Molecular immunology.
2012 Feb; 50(1-2):60-5. doi:
10.1016/j.molimm.2011.12.005. [PMID: 22244896] - Adriana Arita, Jingping Niu, Qingshan Qu, Najuan Zhao, Ye Ruan, Arthur Nadas, Yana Chervona, Fen Wu, Hong Sun, Richard B Hayes, Max Costa. Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel.
Environmental health perspectives.
2012 Feb; 120(2):198-203. doi:
10.1289/ehp.1104140. [PMID: 22024396] - K M Habegger, B A Penque, W Sealls, L Tackett, L N Bell, E K Blue, P J Gallagher, M Sturek, M A Alloosh, H O Steinberg, R V Considine, J S Elmendorf. Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle.
Diabetologia.
2012 Feb; 55(2):457-67. doi:
10.1007/s00125-011-2334-y. [PMID: 22002007] - Sonia Giacometti, Claudia Adriana Marrano, Maria Cristina Bonza, Laura Luoni, Margherita Limonta, Maria Ida De Michelis. Phosphorylation of serine residues in the N-terminus modulates the activity of ACA8, a plasma membrane Ca2+-ATPase of Arabidopsis thaliana.
Journal of experimental botany.
2012 Feb; 63(3):1215-24. doi:
10.1093/jxb/err346. [PMID: 22090438] - Andria P Medina, Jialing Lin, Paul H Weigel. Hyaluronan synthase mediates dye translocation across liposomal membranes.
BMC biochemistry.
2012 Jan; 13(?):2. doi:
10.1186/1471-2091-13-2. [PMID: 22276637] - Sophie Doublier, Dimas C Belisario, Manuela Polimeni, Laura Annaratone, Chiara Riganti, Elena Allia, Dario Ghigo, Amalia Bosia, Anna Sapino. HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast.
BMC cancer.
2012 Jan; 12(?):4. doi:
10.1186/1471-2407-12-4. [PMID: 22217342] - Taísa Magnani Dinamarco, Fernanda Zanolli Freitas, Ricardo S Almeida, Neil Andrew Brown, Thaila Fernanda dos Reis, Leandra Naira Zambelli Ramalho, Marcela Savoldi, Maria Helena S Goldman, Maria Célia Bertolini, Gustavo Henrique Goldman. Functional characterization of an Aspergillus fumigatus calcium transporter (PmcA) that is essential for fungal infection.
PloS one.
2012; 7(5):e37591. doi:
10.1371/journal.pone.0037591. [PMID: 22649543] - Siham Yasari, Denis Prud'homme, Frédérique Tesson, Marek Jankowski, Jolanta Gutkowska, Emile Levy, Jean-Marc Lavoie. Effects of exercise training on molecular markers of lipogenesis and lipid partitioning in fructose-induced liver fat accumulation.
Journal of nutrition and metabolism.
2012; 2012(?):181687. doi:
10.1155/2012/181687. [PMID: 21860785] - Akiko Muroyama, Aya Fujita, Cheng Lv, Shota Kobayashi, Yoshiyasu Fukuyama, Yasuhide Mitsumoto. Magnolol Protects against MPTP/MPP(+)-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson's Disease.
Parkinson's disease.
2012; 2012(?):985157. doi:
10.1155/2012/985157. [PMID: 22655218] - Giuseppe Procino, Lisa Mastrofrancesco, Grazia Tamma, Domenica Rita Lasorsa, Marianna Ranieri, Gilda Stringini, Francesco Emma, Maria Svelto, Giovanna Valenti. Calcium-sensing receptor and aquaporin 2 interplay in hypercalciuria-associated renal concentrating defect in humans. An in vivo and in vitro study.
PloS one.
2012; 7(3):e33145. doi:
10.1371/journal.pone.0033145. [PMID: 22403735] - Xiaoning Chen, Kara J Margolis, Michael D Gershon, Gary J Schwartz, Ji Y Sze. Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake.
PloS one.
2012; 7(3):e32511. doi:
10.1371/journal.pone.0032511. [PMID: 22412882] - Gabriella Cotugno, Patrizia Annunziata, Maria Vittoria Barone, Marianthi Karali, Sandro Banfi, Alberto Auricchio. Impact of age at administration, lysosomal storage, and transgene regulatory elements on AAV2/8-mediated rat liver transduction.
PloS one.
2012; 7(3):e33286. doi:
10.1371/journal.pone.0033286. [PMID: 22428010] - Jueun Oh, Tao Yu, Soo Jeong Choi, Yanyan Yang, Heung Soo Baek, Soon Ae An, Lee Kyoung Kwon, Jinsol Kim, Ho Sik Rho, Song Seok Shin, Wahn Soo Choi, Sungyoul Hong, Jae Youl Cho. Syk/Src pathway-targeted inhibition of skin inflammatory responses by carnosic acid.
Mediators of inflammation.
2012; 2012(?):781375. doi:
10.1155/2012/781375. [PMID: 22577255] - Jodie M Fleming, Erika Ginsburg, Anita S Goldhar, Joshua Plant, Barbara K Vonderhaar. Progesterone receptor activates Msx2 expression by downregulating TNAP/Akp2 and activating the Bmp pathway in EpH4 mouse mammary epithelial cells.
PloS one.
2012; 7(3):e34058. doi:
10.1371/journal.pone.0034058. [PMID: 22457812] - Maria Luisa Sirico, Bruna Guida, Alfredo Procino, Andrea Pota, Maurizio Sodo, Giuseppe Grandaliano, Simona Simone, Giovanni Pertosa, Eleonora Riccio, Bruno Memoli. Human mature adipocytes express albumin and this expression is not regulated by inflammation.
Mediators of inflammation.
2012; 2012(?):236796. doi:
10.1155/2012/236796. [PMID: 22675238] - Lin Wang, Yu Jia, Ren-Jie Tang, Zheng Xu, Yong-Bing Cao, Xin-Ming Jia, Yuan-Ying Jiang. Proteomic analysis of Rta2p-dependent raft-association of detergent-resistant membranes in Candida albicans.
PloS one.
2012; 7(5):e37768. doi:
10.1371/journal.pone.0037768. [PMID: 22662216] - M Raschid Hoda, Gerit Theil, Nasreldin Mohammed, Kersten Fischer, Paolo Fornara. The adipocyte-derived hormone leptin has proliferative actions on androgen-resistant prostate cancer cells linking obesity to advanced stages of prostate cancer.
Journal of oncology.
2012; 2012(?):280386. doi:
10.1155/2012/280386. [PMID: 22690216] - Jacob Jeppesen, Andreas B Jordy, Kim A Sjøberg, Joachim Füllekrug, Andreas Stahl, Lars Nybo, Bente Kiens. Enhanced fatty acid oxidation and FATP4 protein expression after endurance exercise training in human skeletal muscle.
PloS one.
2012; 7(1):e29391. doi:
10.1371/journal.pone.0029391. [PMID: 22235293] - Sayani Banerjee, Pratip Chakraborty, Piyali Saha, Soma Aditya Bandyopadhyay, Sutapa Banerjee, Syed N Kabir. Ovotoxic effects of galactose involve attenuation of follicle-stimulating hormone bioactivity and up-regulation of granulosa cell p53 expression.
PloS one.
2012; 7(2):e30709. doi:
10.1371/journal.pone.0030709. [PMID: 22319579] - Julien Giron-Michel, Sandy Azzi, Krystel Khawam, Erwan Mortier, Anne Caignard, Aurore Devocelle, Silvano Ferrini, Michela Croce, Hélène François, Lola Lecru, Bernard Charpentier, Salem Chouaib, Bruno Azzarone, Pierre Eid. Interleukin-15 plays a central role in human kidney physiology and cancer through the γc signaling pathway.
PloS one.
2012; 7(2):e31624. doi:
10.1371/journal.pone.0031624. [PMID: 22363690] - Gina M Whitaker, Francis C Lynn, Christopher H S McIntosh, Eric A Accili. Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization.
PloS one.
2012; 7(3):e32675. doi:
10.1371/journal.pone.0032675. [PMID: 22412906] - Sung A Jung, Miseon Choi, Sohee Kim, Rina Yu, Taesun Park. Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation.
PPAR research.
2012; 2012(?):541204. doi:
10.1155/2012/541204. [PMID: 22675336] - Michael R Breen, Marta Camps, Francisco Carvalho-Simoes, Antonio Zorzano, Paul F Pilch. Cholesterol depletion in adipocytes causes caveolae collapse concomitant with proteosomal degradation of cavin-2 in a switch-like fashion.
PloS one.
2012; 7(4):e34516. doi:
10.1371/journal.pone.0034516. [PMID: 22493697] - Yi-Fang Li, Rong-Rong He, Bun Tsoi, Xiao-Di Li, Wei-Xi Li, Keiichi Abe, Hiroshi Kurihara. Anti-stress effects of carnosine on restraint-evoked immunocompromise in mice through spleen lymphocyte number maintenance.
PloS one.
2012; 7(4):e33190. doi:
10.1371/journal.pone.0033190. [PMID: 22511917] - Thérèse Keravis, Fanny Monneaux, Issaka Yougbaré, Lucien Gazi, Jean-Jacques Bourguignon, Sylviane Muller, Claire Lugnier. Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor.
PloS one.
2012; 7(1):e28899. doi:
10.1371/journal.pone.0028899. [PMID: 22247763] - Ali Mobasheri, Elisa Trujillo, Mari-Francis Arteaga, Pablo Martín-Vasallo. Na(+), K(+)-ATPase subunit composition in a human chondrocyte cell line; evidence for the presence of α1, α3, β1, β2 and β3 isoforms.
International journal of molecular sciences.
2012; 13(4):5019-34. doi:
10.3390/ijms13045019. [PMID: 22606027] - René Anour, Olena Andrukhova, Eva Ritter, Ute Zeitz, Reinhold G Erben. Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo.
PloS one.
2012; 7(2):e31376. doi:
10.1371/journal.pone.0031376. [PMID: 22319626] - Eugene Tkachenko, Dan Tse, Olga Sideleva, Sophie J Deharvengt, Marcus R Luciano, Yan Xu, Caitlin L McGarry, John Chidlow, Paul F Pilch, William C Sessa, Derek K Toomre, Radu V Stan. Caveolae, fenestrae and transendothelial channels retain PV1 on the surface of endothelial cells.
PloS one.
2012; 7(3):e32655. doi:
10.1371/journal.pone.0032655. [PMID: 22403691] - Judy A Brusslan, Ana M Rus Alvarez-Canterbury, Nishanth Ulhas Nair, Judd C Rice, Michael J Hitchler, Matteo Pellegrini. Genome-wide evaluation of histone methylation changes associated with leaf senescence in Arabidopsis.
PloS one.
2012; 7(3):e33151. doi:
10.1371/journal.pone.0033151. [PMID: 22427974] - Mehdi Shakibaei, David Allaway, Simone Nebrich, Ali Mobasheri. Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):509383. doi:
10.1155/2012/509383. [PMID: 22474508] - Rosaria Santangelo, Cesare Mancuso, Simona Marchetti, Enrico Di Stasio, Giovambattista Pani, Giovanni Fadda. Bilirubin: An Endogenous Molecule with Antiviral Activity in vitro.
Frontiers in pharmacology.
2012; 3(?):36. doi:
10.3389/fphar.2012.00036. [PMID: 22408623] - Alexander V Chibalin, Judith A Heiny, Boubacar Benziane, Alexander V Prokofiev, Alexander V Vasiliev, Violetta V Kravtsova, Igor I Krivoi. Chronic nicotine modifies skeletal muscle Na,K-ATPase activity through its interaction with the nicotinic acetylcholine receptor and phospholemman.
PloS one.
2012; 7(3):e33719. doi:
10.1371/journal.pone.0033719. [PMID: 22442718] - Alak Manna, Piu Saha, Avijit Sarkar, Debanjan Mukhopadhyay, Ajay K Bauri, Deepak Kumar, Padma Das, Subrata Chattopadhyay, Mitali Chatterjee. Malabaricone-A induces a redox imbalance that mediates apoptosis in U937 cell line.
PloS one.
2012; 7(5):e36938. doi:
10.1371/journal.pone.0036938. [PMID: 22590637] - Xiao juan Wang, Dai lin Wei, Zhi gang Song, Hong chao Jiao, Hai Lin. Effects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickens.
PloS one.
2012; 7(5):e36663. doi:
10.1371/journal.pone.0036663. [PMID: 22623960] - Rukmini Govekar, Poonam Kawle, Renjan Thomas, Suresh Advani, Sheena Pv, Surekha Zingde. Eryptotic phenotype in chronic myeloid leukemia: contribution of neutrophilic cathepsin g.
Anemia.
2012; 2012(?):659303. doi:
10.1155/2012/659303. [PMID: 22506108] - Setsuko Fukushima, Michiteru Yoshida, Hiroshi Takatsuji. Role of Linkers between Zinc Fingers in Spacing Recognition by Plant TFIIIA-Type Zinc-Finger Proteins.
Journal of amino acids.
2012; 2012(?):848037. doi:
10.1155/2012/848037. [PMID: 22312478] - Youjia Zeng, Xiao Yang, Juan Wang, Jinjin Fan, Qingyu Kong, Xueqing Yu. Aristolochic acid I induced autophagy extenuates cell apoptosis via ERK 1/2 pathway in renal tubular epithelial cells.
PloS one.
2012; 7(1):e30312. doi:
10.1371/journal.pone.0030312. [PMID: 22276178] - Verena K Hehle, Matthew J Paul, Pascal M Drake, Julian K C Ma, Craig J van Dolleweerd. Antibody degradation in tobacco plants: a predominantly apoplastic process.
BMC biotechnology.
2011 Dec; 11(?):128. doi:
10.1186/1472-6750-11-128. [PMID: 22208820] - Yuki Wakayama, Koichi Miura, Hisataka Sabe, Naoki Mochizuki. EphrinA1-EphA2 signal induces compaction and polarization of Madin-Darby canine kidney cells by inactivating Ezrin through negative regulation of RhoA.
The Journal of biological chemistry.
2011 Dec; 286(51):44243-44253. doi:
10.1074/jbc.m111.267047. [PMID: 21979959] - Shalini John, Sundarapandian Thangapandian, Mahreen Arooj, Jong Chan Hong, Kwang Dong Kim, Keun Woo Lee. Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors.
BMC bioinformatics.
2011 Dec; 12 Suppl 14(?):S4. doi:
10.1186/1471-2105-12-s14-s4. [PMID: 22372967] - Kumiko Yokogawa, Isao Matsui-Yuasa, Akiko Tamura, Masaki Terada, Akiko Kojima-Yuasa. Inhibitory effects of Ecklonia cava extract on high glucose-induced hepatic stellate cell activation.
Marine drugs.
2011 Dec; 9(12):2793-2808. doi:
10.3390/md9122793. [PMID: 22363250] - Jianling Xie, Godwin A Ponuwei, Claire E Moore, Gary B Willars, Andrew R Tee, Terence P Herbert. cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.
Cellular signalling.
2011 Dec; 23(12):1927-35. doi:
10.1016/j.cellsig.2011.06.025. [PMID: 21763421] - Tânia R Cabrito, Miguel C Teixeira, Ashutosh Singh, Rajendra Prasad, Isabel Sá-Correia. The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance.
The Biochemical journal.
2011 Dec; 440(2):195-202. doi:
10.1042/bj20110876. [PMID: 21831043] - Cynthia Wei-Sheng Lee, Jia-Ying Yan, Yao-Chang Chiang, Tsai-Wei Hung, Hung-Li Wang, Lih-Chu Chiou, Ing-Kang Ho. Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.
Neurochemical research.
2011 Nov; 36(11):2008-21. doi:
10.1007/s11064-011-0525-z. [PMID: 21671107] - Martin C Herzig, Carine Kolly, Elke Persohn, Diethilde Theil, Tatjana Schweizer, Thomas Hafner, Christine Stemmelen, Thomas J Troxler, Peter Schmid, Simone Danner, Christian R Schnell, Matthias Mueller, Bernd Kinzel, Armelle Grevot, Federico Bolognani, Martina Stirn, Rainer R Kuhn, Klemens Kaupmann, P Herman van der Putten, Giorgio Rovelli, Derya R Shimshek. LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.
Human molecular genetics.
2011 Nov; 20(21):4209-23. doi:
10.1093/hmg/ddr348. [PMID: 21828077] - Urszula Szawłowska, Edyta Zdunek-Zastocka, Wiesław Bielawski. Biochemical characterisation of prolyl aminopeptidase from shoots of triticale seedlings and its activity changes in response to suboptimal growth conditions.
Plant physiology and biochemistry : PPB.
2011 Nov; 49(11):1342-9. doi:
10.1016/j.plaphy.2011.05.008. [PMID: 21689943] - Chandeshwari Chilampalli, Ruth Guillermo, Xiaoying Zhang, Radhey S Kaushik, Alan Young, David Zeman, Michael B Hildreth, Hesham Fahmy, Chandradhar Dwivedi. Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action.
BMC cancer.
2011 Oct; 11(?):456. doi:
10.1186/1471-2407-11-456. [PMID: 22014088] - Juan Elías Olivares, Claudia Díaz-Camino, Georgina Estrada-Navarrete, Xochitl Alvarado-Affantranger, Margarita Rodríguez-Kessler, Fernando Z Zamudio, Timoteo Olamendi-Portugal, Yamile Márquez, Luis Eduardo Servín, Federico Sánchez. Nodulin 41, a novel late nodulin of common bean with peptidase activity.
BMC plant biology.
2011 Oct; 11(?):134. doi:
10.1186/1471-2229-11-134. [PMID: 21985276] - Elena Lissina, Brian Young, Malene L Urbanus, Xue Li Guan, Jonathan Lowenson, Shawn Hoon, Anastasia Baryshnikova, Isabelle Riezman, Magali Michaut, Howard Riezman, Leah E Cowen, Markus R Wenk, Steven G Clarke, Guri Giaever, Corey Nislow. A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis.
PLoS genetics.
2011 Oct; 7(10):e1002332. doi:
10.1371/journal.pgen.1002332. [PMID: 22028670] - Sergey N Lomin, Keiko Yonekura-Sakakibara, Georgy A Romanov, Hitoshi Sakakibara. Ligand-binding properties and subcellular localization of maize cytokinin receptors.
Journal of experimental botany.
2011 Oct; 62(14):5149-59. doi:
10.1093/jxb/err220. [PMID: 21778179] - Supansa Pata, Pavel Otáhal, Tomáš Brdička, Witida Laopajon, Kodchakorn Mahasongkram, Watchara Kasinrerk. Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses.
BMC research notes.
2011 Aug; 4(?):293. doi:
10.1186/1756-0500-4-293. [PMID: 21838920] - Kunju Sathishkumar, Rebekah Elkins, Vijayakumar Chinnathambi, Haijun Gao, Gary D V Hankins, Chandra Yallampalli. Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport.
Reproductive biology and endocrinology : RB&E.
2011 Aug; 9(?):110. doi:
10.1186/1477-7827-9-110. [PMID: 21812961] - José Francisco Höfling, Rita Cássia Mardegan, Paula Cristina Anibal, Vivian Fernandes Furletti, Mary Ann Foglio. Evaluation of antifungal activity of medicinal plant extracts against oral Candida albicans and proteinases.
Mycopathologia.
2011 Aug; 172(2):117-24. doi:
10.1007/s11046-011-9404-z. [PMID: 21409409] - Kashyap B Choksi, Jonathan E Nuss, James H DeFord, John Papaconstantinou. Mitochondrial electron transport chain functions in long-lived Ames dwarf mice.
Aging.
2011 Aug; 3(8):754-67. doi:
10.18632/aging.100357. [PMID: 21934186] - Michael A Djordjevic, Marie Oakes, Chui E Wong, Mohan Singh, Prem Bhalla, Lucia Kusumawati, Nijat Imin. Border sequences of Medicago truncatula CLE36 are specifically cleaved by endoproteases common to the extracellular fluids of Medicago and soybean.
Journal of experimental botany.
2011 Aug; 62(13):4649-59. doi:
10.1093/jxb/err185. [PMID: 21633083] - Julie A Law, Ajay A Vashisht, James A Wohlschlegel, Steven E Jacobsen. SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV.
PLoS genetics.
2011 Jul; 7(7):e1002195. doi:
10.1371/journal.pgen.1002195. [PMID: 21811420] - Sergio González-Pérez, Jorge Gutiérrez, Francisco García-García, Daniel Osuna, Joaquín Dopazo, Óscar Lorenzo, José L Revuelta, Juan B Arellano. Early transcriptional defense responses in Arabidopsis cell suspension culture under high-light conditions.
Plant physiology.
2011 Jul; 156(3):1439-56. doi:
10.1104/pp.111.177766. [PMID: 21531897] - Alexis Régent, Hanadi Dib, Kim H Ly, Christian Agard, Mathieu C Tamby, Nicolas Tamas, Babette Weksler, Christian Federici, Cédric Broussard, Loïc Guillevin, Luc Mouthon. Identification of target antigens of anti-endothelial cell and anti-vascular smooth muscle cell antibodies in patients with giant cell arteritis: a proteomic approach.
Arthritis research & therapy.
2011 Jun; 13(3):R107. doi:
10.1186/ar3388. [PMID: 21711540] - Mandy So, Mandeep P Gaidhu, Babak Maghdoori, Rolando B Ceddia. Analysis of time-dependent adaptations in whole-body energy balance in obesity induced by high-fat diet in rats.
Lipids in health and disease.
2011 Jun; 10(?):99. doi:
10.1186/1476-511x-10-99. [PMID: 21679418] - Buchra Younes, Clara Cilindre, Sandra Villaume, Maryline Parmentier, Philippe Jeandet, Yann Vasserot. Evidence for an extracellular acid proteolytic activity secreted by living cells of Saccharomyces cerevisiae PlR1: impact on grape proteins.
Journal of agricultural and food chemistry.
2011 Jun; 59(11):6239-46. doi:
10.1021/jf200348n. [PMID: 21528928] - Gillian L Fell, Amanda M Munson, Merriah A Croston, Anne G Rosenwald. Identification of yeast genes involved in k homeostasis: loss of membrane traffic genes affects k uptake.
G3 (Bethesda, Md.).
2011 Jun; 1(1):43-56. doi:
10.1534/g3.111.000166. [PMID: 22384317] - Marina S Defferrari, Diogo R Demartini, Thiago B Marcelino, Paulo M Pinto, Celia R Carlini. Insecticidal effect of Canavalia ensiformis major urease on nymphs of the milkweed bug Oncopeltus fasciatus and characterization of digestive peptidases.
Insect biochemistry and molecular biology.
2011 Jun; 41(6):388-99. doi:
10.1016/j.ibmb.2011.02.008. [PMID: 21377528] - Anthony Gandin, Sylvain Gutjahr, Pierre Dizengremel, Line Lapointe. Source-sink imbalance increases with growth temperature in the spring geophyte Erythronium americanum.
Journal of experimental botany.
2011 Jun; 62(10):3467-79. doi:
10.1093/jxb/err020. [PMID: 21335435] - Nuria Sánchez-Pons, Sami Irar, Nora García-Muniz, Carlos M Vicient. Transcriptomic and proteomic profiling of maize embryos exposed to camptothecin.
BMC plant biology.
2011 May; 11(1):91. doi:
10.1186/1471-2229-11-91. [PMID: 21595924] - Yeonhwa Jeong, Hoon Cheong, Okhee Choi, Jung Kyu Kim, Yongsung Kang, Jinwoo Kim, Seungdon Lee, Serry Koh, Jae Sun Moon, Ingyu Hwang. An HrpB-dependent but type III-independent extracellular aspartic protease is a virulence factor of Ralstonia solanacearum.
Molecular plant pathology.
2011 May; 12(4):373-80. doi:
10.1111/j.1364-3703.2010.00679.x. [PMID: 21453432] - Chiung-Swey Joanne Chang, Julin N Maloof, Shu-Hsing Wu. COP1-mediated degradation of BBX22/LZF1 optimizes seedling development in Arabidopsis.
Plant physiology.
2011 May; 156(1):228-39. doi:
10.1104/pp.111.175042. [PMID: 21427283] - Dongliang Song, Wang Xi, Junhui Shen, Ting Bi, Laigeng Li. Characterization of the plasma membrane proteins and receptor-like kinases associated with secondary vascular differentiation in poplar.
Plant molecular biology.
2011 May; 76(1-2):97-115. doi:
10.1007/s11103-011-9771-3. [PMID: 21431780] - Juan M Murillo-Maldonado, Gustavo Sánchez-Chávez, Luis M Salgado, Rocío Salceda, Juan R Riesgo-Escovar. Drosophila insulin pathway mutants affect visual physiology and brain function besides growth, lipid, and carbohydrate metabolism.
Diabetes.
2011 May; 60(5):1632-6. doi:
10.2337/db10-1288. [PMID: 21464442] - Young-A Lee, Yukiori Goto. Neurodevelopmental disruption of cortico-striatal function caused by degeneration of habenula neurons.
PloS one.
2011 Apr; 6(4):e19450. doi:
10.1371/journal.pone.0019450. [PMID: 21559387] - Nady Braidy, Gilles J Guillemin, Hussein Mansour, Tailoi Chan-Ling, Anne Poljak, Ross Grant. Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats.
PloS one.
2011 Apr; 6(4):e19194. doi:
10.1371/journal.pone.0019194. [PMID: 21541336] - Henricus A M Mutsaers, Lambertus P van den Heuvel, Lauke H J Ringens, Anita C A Dankers, Frans G M Russel, Jack F M Wetzels, Joost G Hoenderop, Rosalinde Masereeuw. Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations.
PloS one.
2011 Apr; 6(4):e18438. doi:
10.1371/journal.pone.0018438. [PMID: 21483698] - L Q Meng, J W Tang, Y Wang, J R Zhao, M Y Shang, M Zhang, S Y Liu, L Qu, S Q Cai, X M Li. Astragaloside IV synergizes with ferulic acid to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy.
British journal of pharmacology.
2011 Apr; 162(8):1805-18. doi:
10.1111/j.1476-5381.2011.01206.x. [PMID: 21232035] - Rui Zeng, Min Han, Yun Luo, Caixia Li, Guangchang Pei, Wenhui Liao, Shoujun Bai, Shuwang Ge, Xiaocheng Liu, Gang Xu. Role of Sema4C in TGF-β1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Apr; 26(4):1149-56. doi:
10.1093/ndt/gfq619. [PMID: 20959347]