alprenolol (BioDeep_00000408909)

   


代谢物信息卡片


alprenolol

化学式: C15H23NO2 (249.1728698)
中文名称: 阿普洛尔
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CCc(c1)c(ccc1)OCC(O)CNC(C)C
InChI: InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3

描述信息

C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AA - Beta blocking agents, non-selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents

同义名列表

1 个代谢物同义名

alprenolol



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Mohammed M Nooh, Salvatore Mancarella, Suleiman W Bahouth. Novel Paradigms Governing β1-Adrenergic Receptor Trafficking in Primary Adult Rat Cardiac Myocytes. Molecular pharmacology. 2018 08; 94(2):862-875. doi: 10.1124/mol.118.112045. [PMID: 29848777]
  • Virgínia M F Gonçalves, Patrícia Rodrigues, Cláudia Ribeiro, Maria E Tiritan. Quantification of alprenolol and propranolol in human plasma using a two-dimensional liquid chromatography (2D-LC). Journal of pharmaceutical and biomedical analysis. 2017 Jul; 141(?):1-8. doi: 10.1016/j.jpba.2017.03.064. [PMID: 28412606]
  • Jonathan A Rose, Nicholas Wanner, Hoi I Cheong, Kimberly Queisser, Patrick Barrett, Margaret Park, Corrine Hite, Sathyamangla V Naga Prasad, Serpil Erzurum, Kewal Asosingh. Flow Cytometric Quantification of Peripheral Blood Cell β-Adrenergic Receptor Density and Urinary Endothelial Cell-Derived Microparticles in Pulmonary Arterial Hypertension. PloS one. 2016; 11(6):e0156940. doi: 10.1371/journal.pone.0156940. [PMID: 27270458]
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  • Romana Uřinovská, Hana Brozmanová, Pavel Sištík, Petr Silhán, Ivana Kacířová, Karel Lemr, Milan Grundmann. Liquid chromatography-tandem mass spectrometry method for determination of five antidepressants and four atypical antipsychotics and their main metabolites in human serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Oct; 907(?):101-7. doi: 10.1016/j.jchromb.2012.09.009. [PMID: 23026228]
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  • Imju Jeong, Bok Hee Choi, Shin Hee Yoon, Sang June Hahn. Carvedilol blocks the cloned cardiac Kv1.5 channels in a β-adrenergic receptor-independent manner. Biochemical pharmacology. 2012 Feb; 83(4):497-505. doi: 10.1016/j.bcp.2011.11.019. [PMID: 22146582]
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  • Naoya Kishikawa, Mizuho Ohkuma, Mitsuhiro Wada, Kaname Ohyama, Rie Ikeda, Kenichiro Nakashima, Naotaka Kuroda. Labeling of alprenolol with fluorescent aryl iodide as a reagent based on Mizoroki-Heck coupling reaction. Journal of chromatography. A. 2011 May; 1218(20):3002-6. doi: 10.1016/j.chroma.2011.03.030. [PMID: 21489541]
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  • M A Alam, M A Awal, N Subhan, M Mostofa. In-vitro relationship between protein-binding and free drug concentrations of a water-soluble selective beta-adrenoreceptor antagonist (atenolol) and its interaction with arsenic. Journal of health, population, and nutrition. 2009 Feb; 27(1):20-30. doi: 10.3329/jhpn.v27i1.3315. [PMID: 19248645]
  • Xiaogang Hu, Jialiang Pan, Yuling Hu, Gongke Li. Preparation and evaluation of propranolol molecularly imprinted solid-phase microextraction fiber for trace analysis of beta-blockers in urine and plasma samples. Journal of chromatography. A. 2009 Jan; 1216(2):190-7. doi: 10.1016/j.chroma.2008.11.064. [PMID: 19084232]
  • Etienne de Montmollin, Jerome Aboab, Arnaud Mansart, Djillali Annane. Bench-to-bedside review: Beta-adrenergic modulation in sepsis. Critical care (London, England). 2009; 13(5):230. doi: 10.1186/cc8026. [PMID: 19863760]
  • Hongliang Jiang, Xiangyu Jiang, Qin C Ji. Enantioselective determination of alprenolol in human plasma by liquid chromatography with tandem mass spectrometry using cellobiohydrolase chiral stationary phases. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Sep; 872(1-2):121-7. doi: 10.1016/j.jchromb.2008.07.022. [PMID: 18691951]
  • Giovanni D'Orazio, Salvatore Fanali. Enantiomeric separation by using nano-liquid chromatography with on-column focusing. Journal of separation science. 2008 Aug; 31(14):2567-71. doi: 10.1002/jssc.200800114. [PMID: 18623279]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
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  • László Gagyi, Arpád Gyéresi, Ferenc Kilár. Role of chemical structure in stereoselective recognition of beta-blockers and H1-antihistamines by human serum transferrin in capillary zone electrophoresis. Electrophoresis. 2006 Apr; 27(8):1510-6. doi: 10.1002/elps.200500787. [PMID: 16609932]
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  • Maria A Martinez-Gomez, Rosa M Villanueva-Camañas, Salvador Sagrado, Maria J Medina-Hernández. Multivariate optimization approach for chiral resolution of drugs using human serum albumin in affinity electrokinetic chromatography-partial filling technique. Electrophoresis. 2005 Nov; 26(21):4116-26. doi: 10.1002/elps.200500304. [PMID: 16252317]
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  • Hans H Maurer, Oliver Tenberken, Carsten Kratzsch, Armin A Weber, Frank T Peters. Screening for library-assisted identification and fully validated quantification of 22 beta-blockers in blood plasma by liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization. Journal of chromatography. A. 2004 Nov; 1058(1-2):169-81. doi: . [PMID: 15595665]
  • Pekka Suomalainen, Christoffer Johans, Tim Söderlund, Paavo K J Kinnunen. Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry. 2004 Mar; 47(7):1783-8. doi: 10.1021/jm0309001. [PMID: 15027870]
  • Savitha Devanathan, Zhiping Yao, Zdzislaw Salamon, Brian Kobilka, Gordon Tollin. Plasmon-waveguide resonance studies of ligand binding to the human beta 2-adrenergic receptor. Biochemistry. 2004 Mar; 43(11):3280-8. doi: 10.1021/bi035825a. [PMID: 15023079]
  • Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry. 2004 Feb; 47(5):1242-50. doi: 10.1021/jm030408h. [PMID: 14971904]
  • Haruyo Sanbe, Jun Haginaka. Restricted access media-molecularly imprinted polymer for propranolol and its application to direct injection analysis of beta-blockers in biological fluids. The Analyst. 2003 Jun; 128(6):593-7. doi: 10.1039/b301257n. [PMID: 12866873]
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  • Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry. 2002 Jun; 45(13):2867-76. doi: 10.1021/jm0200409. [PMID: 12061889]
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