Cycloserine (BioDeep_00000407608)
Main id: BioDeep_00000014653
natural product Chemicals and Drugs Antibiotics
代谢物信息卡片
D-Cycloserine
化学式: C3H6N2O2 (102.04292559999999)
中文名称: D-环丝氨酸
谱图信息:
最多检出来源 Ailuropoda melanoleuca(urine) 50%
分子结构信息
SMILES: C1C(C(=O)NO1)N
InChI: InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
描述信息
J - Antiinfectives for systemic use > J04 - Antimycobacterials > J04A - Drugs for treatment of tuberculosis > J04AB - Antibiotics
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent > C280 - Antitubercular Agent
D000890 - Anti-Infective Agents > D023303 - Oxazolidinones
D009676 - Noxae > D000963 - Antimetabolites
D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research[1][2].
D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research[1][2].
同义名列表
2 个代谢物同义名
数据库引用编号
29 个数据库交叉引用编号
- ChEBI: CHEBI:40009
- KEGG: C08057
- KEGGdrug: D00877
- PubChem: 6234
- DrugBank: DB00260
- ChEMBL: CHEMBL771
- LipidMAPS: LMPK14000007
- MeSH: Cycloserine
- CAS: 68-41-7
- MoNA: VF-NPL-QEHF027825
- MoNA: VF-NPL-QEHF027824
- MoNA: VF-NPL-QEHF027823
- MoNA: VF-NPL-QEHF027822
- MoNA: VF-NPL-QEHF027821
- MoNA: VF-NPL-QEHF027820
- MoNA: VF-NPL-QEHF027819
- MoNA: VF-NPL-QEHF027818
- MoNA: VF-NPL-QEHF027817
- MoNA: VF-NPL-QEHF027816
- MoNA: VF-NPL-QEHF027815
- MoNA: VF-NPL-QEHF027814
- MoNA: VF-NPL-QEHF027813
- MoNA: VF-NPL-QEHF027812
- MoNA: VF-NPL-QEHF027811
- PubChem: 10257
- PDB-CCD: 4AX
- 3DMET: B02142
- NIKKAJI: J8.592H
- medchemexpress: HY-B0030
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tingting Zhang, Xia Yu, Shu'an Wen, Yi Xue, Hua Xiao, Ruyan Ren, Fen Wang, Lingling Dong, Shibing Qin, Hairong Huang. Bone Penetration of Cycloserine in Osteoarticular Tuberculosis Patients of China.
Antimicrobial agents and chemotherapy.
2022 05; 66(5):e0222421. doi:
10.1128/aac.02224-21. [PMID: 35400177] - Xiaocui Wu, Guangkun Tan, Wei Sha, Haican Liu, Jinghui Yang, Yinjuan Guo, Xin Shen, Zheyuan Wu, Hongbo Shen, Fangyou Yu. Use of Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Complex Drug Resistance from Early Positive Liquid Cultures.
Microbiology spectrum.
2022 04; 10(2):e0251621. doi:
10.1128/spectrum.02516-21. [PMID: 35311541] - Wing-Kee Lee, Michelle Maaß, Amy Quach, Nataliya Poscic, Holly Prangley, Erin-Claire Pallott, Jiyoon L Kim, Jason S Pierce, Besim Ogretmen, Anthony H Futerman, Frank Thévenod. Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer.
The Journal of biological chemistry.
2022 02; 298(2):101492. doi:
10.1016/j.jbc.2021.101492. [PMID: 34915026] - Xuyen H Le, Chun-Pong Lee, A Harvey Millar. The mitochondrial pyruvate carrier (MPC) complex mediates one of three pyruvate-supplying pathways that sustain Arabidopsis respiratory metabolism.
The Plant cell.
2021 08; 33(8):2776-2793. doi:
10.1093/plcell/koab148. [PMID: 34137858] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Richard Court, Chad M Centner, Maxwell Chirehwa, Lubbe Wiesner, Paolo Denti, Nihal de Vries, Joseph Harding, Tawanda Gumbo, Gary Maartens, Helen McIlleron. Neuropsychiatric toxicity and cycloserine concentrations during treatment for multidrug-resistant tuberculosis.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2021 Apr; 105(?):688-694. doi:
10.1016/j.ijid.2021.03.001. [PMID: 33684562] - Md Ajijur Rahman, Frank Kaiser, Shirin Jamshidi, Marta Freitas Monteiro, Khondaker Miraz Rahman, Peter Mullany, Adam P Roberts. Integron gene cassettes harboring novel variants of D-alanine-D-alanine ligase confer high-level resistance to D-cycloserine.
Scientific reports.
2020 11; 10(1):20709. doi:
10.1038/s41598-020-77377-4. [PMID: 33244063] - Maxwell T Chirehwa, Richard Court, Mariana de Kock, Lubbe Wiesner, Nihal de Vries, Joseph Harding, Tawanda Gumbo, Gary Maartens, Rob Warren, Paolo Denti, Helen McIlleron. Population Pharmacokinetics of Cycloserine and Pharmacokinetic/Pharmacodynamic Target Attainment in Multidrug-Resistant Tuberculosis Patients Dosed with Terizidone.
Antimicrobial agents and chemotherapy.
2020 10; 64(11):. doi:
10.1128/aac.01381-20. [PMID: 32816738] - Ruben van der Galiën, Natasha Van't Boveneind-Vrubleuskaya, Charles Peloquin, Alena Skrahina, Daan J Touw, Jan-Willem C Alffenaar. Pharmacokinetic Modeling, Simulation, and Development of a Limited Sampling Strategy of Cycloserine in Patients with Multidrug-/Extensively Drug-Resistant Tuberculosis.
Clinical pharmacokinetics.
2020 07; 59(7):899-910. doi:
10.1007/s40262-020-00860-8. [PMID: 31981103] - Stefanie Malan-Müller, Vladimir B C de Souza, Willie M U Daniels, Soraya Seedat, Mark D Robinson, Sîan M J Hemmings. Shedding Light on the Transcriptomic Dark Matter in Biological Psychiatry: Role of Long Noncoding RNAs in D-cycloserine-Induced Fear Extinction in Posttraumatic Stress Disorder.
Omics : a journal of integrative biology.
2020 06; 24(6):352-369. doi:
10.1089/omi.2020.0031. [PMID: 32453623] - Matthew W Johnson, Natalie R Bruner, Patrick S Johnson, Kenneth Silverman, Meredith S Berry. Randomized controlled trial of d-cycloserine in cocaine dependence: Effects on contingency management and cue-induced cocaine craving in a naturalistic setting.
Experimental and clinical psychopharmacology.
2020 Apr; 28(2):157-168. doi:
10.1037/pha0000306. [PMID: 31368770] - Halina Baran, Carina Kronsteiner, Berthold Kepplinger. Kynurenine Aminotransferases I, II and III Are Present in Saliva.
Neuro-Signals.
2020 03; 28(1):1-13. doi:
10.33594/000000217. [PMID: 32153151] - Hui Liu, Zhi-Zhi Liu. Aggressive-like behavior and increased glycine transporters in a zebrafish model of CHARGE syndrome.
Behavioural brain research.
2020 01; 378(?):112293. doi:
10.1016/j.bbr.2019.112293. [PMID: 31610215] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Lulu Yao, Zongliang Wang, Di Deng, Rongzhen Yan, Jun Ju, Qiang Zhou. The impact of D-cycloserine and sarcosine on in vivo frontal neural activity in a schizophrenia-like model.
BMC psychiatry.
2019 10; 19(1):314. doi:
10.1186/s12888-019-2306-1. [PMID: 31653237] - Mwila Mulubwa, Pierre Mugabo. Steady-state population pharmacokinetics of terizidone and its metabolite cycloserine in patients with drug-resistant tuberculosis.
British journal of clinical pharmacology.
2019 09; 85(9):1946-1956. doi:
10.1111/bcp.13975. [PMID: 31046167] - Sireesha Dodda, Ajitha Makula, Raj Narayana Kandhagatla. Development and validation of bioanalytical method for quantification of cycloserine in human plasma by liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study.
Biomedical chromatography : BMC.
2019 Aug; 33(8):e4548. doi:
10.1002/bmc.4548. [PMID: 30945752] - Mwila Mulubwa, Pierre Mugabo. Sensitive Ultra-performance Liquid Chromatography Tandem Mass Spectrometry Method for Determination of Cycloserine in Plasma for a Pharmacokinetics Study.
Journal of chromatographic science.
2019 Jul; 57(6):560-564. doi:
10.1093/chromsci/bmz028. [PMID: 30927010] - Rajeev Ranjan, Ashish Srivastava, Reena Bharti, Trisha Roy, Sonia Verma, Lipika Ray, Amit Misra. Preclinical Development of Inhalable d-Cycloserine and Ethionamide To Overcome Pharmacokinetic Interaction and Enhance Efficacy against Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy.
2019 06; 63(6):. doi:
10.1128/aac.00099-19. [PMID: 30962335] - M Alizadeh Asfestani, E Braganza, J Schwidetzky, J Santiago, S Soekadar, J Born, G B Feld. Overnight memory consolidation facilitates rather than interferes with new learning of similar materials-a study probing NMDA receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2018 10; 43(11):2292-2298. doi:
10.1038/s41386-018-0139-0. [PMID: 30046156] - H Zhu, S-C Guo, Z-Q Liu, B Wang, L Fu, N-H Chu, Y Lu. Therapeutic drug monitoring of cycloserine and linezolid during anti-tuberculosis treatment in Beijing, China.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
2018 08; 22(8):931-936. doi:
10.5588/ijtld.17.0648. [PMID: 29991404] - Agibothu Kupparam Hemanth Kumar, Alok Kumar, Thiruvengadam Kannan, Rakesh Bhatia, Dipti Agarwal, Santosh Kumar, Rajeshwar Dayal, Sheo Pratap Singh, Geetha Ramachandran. Pharmacokinetics of Second-Line Antituberculosis Drugs in Children with Multidrug-Resistant Tuberculosis in India.
Antimicrobial agents and chemotherapy.
2018 05; 62(5):. doi:
10.1128/aac.02410-17. [PMID: 29463539] - A K Hemanth Kumar, Arun Kumar Polisetty, V Sudha, A Vijayakumar, Geetha Ramachandran. A selective and sensitive high performance liquid chromatography assay for the determination of cycloserine in human plasma.
The Indian journal of tuberculosis.
2018 Apr; 65(2):118-123. doi:
10.1016/j.ijtb.2017.08.034. [PMID: 29579424] - Y-M Fan, S-P Ding, Z-J Bao, L-M Wu, L-B Zhen, Q Xia, M Zhu. Prognostic factors for treatment success in patients with multidrug-resistant tuberculosis in China.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
2018 03; 22(3):300-305. doi:
10.5588/ijtld.17.0183. [PMID: 29471908] - Xia Yu, Xiling Zeng, Wenhui Shi, Yanjie Hu, Wenjuan Nie, Naihui Chu, Hairong Huang. Validation of Cycloserine Efficacy in Treatment of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis in Beijing, China.
Antimicrobial agents and chemotherapy.
2018 03; 62(3):. doi:
10.1128/aac.01824-17. [PMID: 29311073] - R Court, L Wiesner, A Stewart, N de Vries, J Harding, G Maartens, T Gumbo, H McIlleron. Steady state pharmacokinetics of cycloserine in patients on terizidone for multidrug-resistant tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
2018 01; 22(1):30-33. doi:
10.5588/ijtld.17.0475. [PMID: 29297422] - Peter Karel, Francesca Calabrese, Marco Riva, Paola Brivio, Bas Van der Veen, Liesbeth Reneman, Michel Verheij, Judith Homberg. d-Cycloserine enhanced extinction of cocaine-induced conditioned place preference is attenuated in serotonin transporter knockout rats.
Addiction biology.
2018 01; 23(1):120-129. doi:
10.1111/adb.12483. [PMID: 27957784] - Jiazhen Chen, Shuo Zhang, Peng Cui, Wanliang Shi, Wenhong Zhang, Ying Zhang. Identification of novel mutations associated with cycloserine resistance in Mycobacterium tuberculosis.
The Journal of antimicrobial chemotherapy.
2017 Dec; 72(12):3272-3276. doi:
10.1093/jac/dkx316. [PMID: 28961957] - Zhengsheng Mao, Xin Wang, Bingxin Li, Jing Jin, Ming Xu, Youping Liu, Xin Di. A simplified LC-MS/MS method for rapid determination of cycloserine in small-volume human plasma using protein precipitation coupled with dilution techniques to overcome matrix effects and its application to a pharmacokinetic study.
Analytical and bioanalytical chemistry.
2017 Apr; 409(11):3025-3032. doi:
10.1007/s00216-017-0249-2. [PMID: 28224247] - M R Kapolowicz, L T Thompson. Acute high-intensity noise induces rapid Arc protein expression but fails to rapidly change GAD expression in amygdala and hippocampus of rats: Effects of treatment with D-cycloserine.
Hearing research.
2016 12; 342(?):69-79. doi:
10.1016/j.heares.2016.09.010. [PMID: 27702572] - Seth T Housman, Mary Anne Banevicius, Lucinda M Lamb, David P Nicolau. Isolation and quantitation of Clostridium difficile in aqueous and fecal matter using two types of selective media.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2016 Jun; 49(3):445-7. doi:
10.1016/j.jmii.2015.05.012. [PMID: 26198865] - Ernesto Roque Bongarzone, Maria Luisa Escolar, Steven James Gray, Tal Kafri, Charles Herman Vite, Mark Steven Sands. Insights into the Pathogenesis and Treatment of Krabbe Disease.
Pediatric endocrinology reviews : PER.
2016 Jun; 13 Suppl 1(?):689-96. doi:
. [PMID: 27491217] - Gouranga Santra, Rudrajit Paul, Avik Karak, Somnath Mukhopadhay. Gitelman-like Syndrome with Kanamycin Toxicity.
The Journal of the Association of Physicians of India.
2016 05; 64(5):90-92. doi:
. [PMID: 27735167] - Sang-In Park, Jaeseong Oh, Kyungho Jang, Jangsoo Yoon, Seol Ju Moon, Jong Sun Park, Jae Ho Lee, Junghan Song, In-Jin Jang, Kyung-Sang Yu, Jae-Yong Chung. Pharmacokinetics of Second-Line Antituberculosis Drugs after Multiple Administrations in Healthy Volunteers.
Antimicrobial agents and chemotherapy.
2015 Aug; 59(8):4429-35. doi:
10.1128/aac.00354-15. [PMID: 25987620] - Seung Heon Lee, Kyung-Ah Seo, Young Min Lee, Hyun-Kyung Lee, Je Hyeong Kim, Chol Shin, Jong-Ryul Ghim, Jae-Gook Shin, Dong Hyun Kim. Low Serum Concentrations of Moxifloxacin, Prothionamide, and Cycloserine on Sputum Conversion in Multi-Drug Resistant TB.
Yonsei medical journal.
2015 Jul; 56(4):961-7. doi:
10.3349/ymj.2015.56.4.961. [PMID: 26069117] - Huili Zhou, Guolan Wu, Xingjiang Hu, Meixiang Zhu, You Zhai, Jian Liu, Jianzhong Shentu, Lihua Wu. Pharmacokinetic Properties and Tolerability of Cycloserine Following Oral Administration in Healthy Chinese Volunteers: A Randomized, Open-Label, Single- and Multiple-Dose 3-Way Crossover Study.
Clinical therapeutics.
2015 Jun; 37(6):1292-300. doi:
10.1016/j.clinthera.2015.03.015. [PMID: 25869627] - Natasha Fillmore, Wendy Keung, Sandra E Kelly, Spencer D Proctor, Gary D Lopaschuk, John R Ussher. Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat.
Experimental physiology.
2015 Jun; 100(6):730-41. doi:
10.1113/ep085052. [PMID: 25786668] - Jacqueline A Hawkins-Salsbury, Lauren Shea, Xuntian Jiang, Daniel A Hunter, A Miguel Guzman, Adarsh S Reddy, Elizabeth Y Qin, Yedda Li, Steven J Gray, Daniel S Ory, Mark S Sands. Mechanism-based combination treatment dramatically increases therapeutic efficacy in murine globoid cell leukodystrophy.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015 Apr; 35(16):6495-505. doi:
10.1523/jneurosci.4199-14.2015. [PMID: 25904800] - Donatus Wewura Adongo, Kennedy Kwami Edem Kukuia, Priscilla Kolibea Mante, Elvis Ofori Ameyaw, Eric Woode. Antidepressant-Like Effect of the Leaves of Pseudospondias microcarpa in Mice: Evidence for the Involvement of the Serotoninergic System, NMDA Receptor Complex, and Nitric Oxide Pathway.
BioMed research international.
2015; 2015(?):397943. doi:
10.1155/2015/397943. [PMID: 26539489] - W-Y Hung, M-C Yu, Y-C Chiang, J-H Chang, C-Y Chiang, C-C Chang, H-C Chuang, K-J Bai. Serum concentrations of cycloserine and outcome of multidrug-resistant tuberculosis in Northern Taiwan.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
2014 May; 18(5):601-6. doi:
10.5588/ijtld.13.0268. [PMID: 24903799] - JoAnn Difede, Judith Cukor, Katarzyna Wyka, Megan Olden, Hunter Hoffman, Francis S Lee, Margaret Altemus. D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2014 Apr; 39(5):1052-8. doi:
10.1038/npp.2013.317. [PMID: 24217129] - Stellah G Mpagama, Norah Ndusilo, Suzanne Stroup, Happiness Kumburu, Charles A Peloquin, Jean Gratz, Eric R Houpt, Gibson S Kibiki, Scott K Heysell. Plasma drug activity in patients on treatment for multidrug-resistant tuberculosis.
Antimicrobial agents and chemotherapy.
2014; 58(2):782-8. doi:
10.1128/aac.01549-13. [PMID: 24247125] - Dmitry V Yaroshenko, Alexander V Grigoriev, Alla A Sidorova. Development and validation of a LC-MS/MS method for D-cycloserine determination in human plasma for bioequivalence study.
Analytical and bioanalytical chemistry.
2014 Jan; 406(3):923-7. doi:
10.1007/s00216-013-7521-x. [PMID: 24337137] - Kerry C Carson, Lusiana V Boseiwaqa, Sara K Thean, Niki F Foster, Thomas V Riley. Isolation of Clostridium difficile from faecal specimens--a comparison of chromID C. difficile agar and cycloserine-cefoxitin-fructose agar.
Journal of medical microbiology.
2013 Sep; 62(Pt 9):1423-1427. doi:
10.1099/jmm.0.056515-0. [PMID: 23579394] - Kerin L Tyrrell, Diane M Citron, Eliza S Leoncio, C Vreni Merriam, Ellie J C Goldstein. Evaluation of cycloserine-cefoxitin fructose agar (CCFA), CCFA with horse blood and taurocholate, and cycloserine-cefoxitin mannitol broth with taurocholate and lysozyme for recovery of Clostridium difficile isolates from fecal samples.
Journal of clinical microbiology.
2013 Sep; 51(9):3094-6. doi:
10.1128/jcm.00879-13. [PMID: 23804392] - Gary Baisa, Nicholas J Stabo, Rodney A Welch. Characterization of Escherichia coli D-cycloserine transport and resistant mutants.
Journal of bacteriology.
2013 Apr; 195(7):1389-99. doi:
10.1128/jb.01598-12. [PMID: 23316042] - Srinivasa Rao Polagani, Nageswara Rao Pilli, Rambabu Maddela, Ramakrishna Gajula, Venkateswarlu Gandu. A rapid and sensitive liquid chromatography-tandem mass spectrometric assay for cycloserine in 50μL of human plasma: Its pharmacokinetic application.
Journal of pharmaceutical and biomedical analysis.
2013 Mar; 76(?):21-7. doi:
10.1016/j.jpba.2012.11.036. [PMID: 23291439] - Lauren Debrouse, Benita Hurd, Carly Kiselycznyk, Aaron Plitt, Alyssa Todaro, Masayoshi Mishina, Seth G N Grant, Marguerite Camp, Ozge Gunduz-Cinar, Andrew Holmes. Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.
Alcoholism, clinical and experimental research.
2013 Feb; 37(2):223-33. doi:
10.1111/j.1530-0277.2012.01922.x. [PMID: 22934986] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Wen-Xiao Tian, Shi Yu, Muhammad Ibrahim, Abdul Wareth Almonaofy, Liu He, Qiu Hui, Zhu Bo, Bin Li, Guan-Lin Xie. Copper as an antimicrobial agent against opportunistic pathogenic and multidrug resistant Enterobacter bacteria.
Journal of microbiology (Seoul, Korea).
2012 Aug; 50(4):586-93. doi:
10.1007/s12275-012-2067-8. [PMID: 22923106] - Jan Stříbrný, Miloš Sokol, Barbora Merová, Peter Ondra. GC/MS determination of ibotenic acid and muscimol in the urine of patients intoxicated with Amanita pantherina.
International journal of legal medicine.
2012 Jul; 126(4):519-24. doi:
10.1007/s00414-011-0599-9. [PMID: 21751026] - Anil K Jain, Ish K Dhammi, Prashant Modi, Jaswant Kumar, Ravi Sreenivasan, Namita Singh Saini. Tuberculosis spine: Therapeutically refractory disease.
Indian journal of orthopaedics.
2012 Mar; 46(2):171-8. doi:
10.4103/0019-5413.93685. [PMID: 22448055] - Kyong-Oh Shin, Myong-Yong Park, Cho-Hee Seo, Yong-Ill Lee, Hyun Sik Kim, Hwan-Soo Yoo, Jin Tae Hong, Jae-Kyung Jung, Yong-Moon Lee. Terpene alcohols inhibit de novo sphingolipid biosynthesis.
Planta medica.
2012 Mar; 78(5):434-9. doi:
10.1055/s-0031-1298155. [PMID: 22274813] - Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jan; 40(1):130-8. doi:
10.1124/dmd.111.040758. [PMID: 21965623] - David T Thwaites, Catriona M H Anderson. The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport.
British journal of pharmacology.
2011 Dec; 164(7):1802-16. doi:
10.1111/j.1476-5381.2011.01438.x. [PMID: 21501141] - G Ryzinska-Paier, R Sommer, J M Haider, S Knetsch, C Frick, A K T Kirschner, A H Farnleitner. Acid phosphatase test proves superior to standard phenotypic identification procedure for Clostridium perfringens strains isolated from water.
Journal of microbiological methods.
2011 Nov; 87(2):189-94. doi:
10.1016/j.mimet.2011.08.006. [PMID: 21872622] - Dinesh S Patel, Naveen Sharma, Mukesh C Patel, Bhavin N Patel, Pranav S Shrivastav, Mallika Sanyal. Development and validation of a selective and sensitive LC-MS/MS method for determination of cycloserine in human plasma: application to bioequivalence study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Aug; 879(23):2265-73. doi:
10.1016/j.jchromb.2011.06.011. [PMID: 21727043] - Dorothee Heemskerk, Jeremy Day, Tran Thi Hong Chau, Nguyen Huy Dung, Nguyen Thi Bich Yen, Nguyen Duc Bang, Laura Merson, Piero Olliaro, Thomas Pouplin, Maxine Caws, Marcel Wolbers, Jeremy Farrar. Intensified treatment with high dose rifampicin and levofloxacin compared to standard treatment for adult patients with tuberculous meningitis (TBM-IT): protocol for a randomized controlled trial.
Trials.
2011 Feb; 12(?):25. doi:
10.1186/1745-6215-12-25. [PMID: 21288325] - John H Krystal, Ismene L Petrakis, Diana Limoncelli, Susan Krasnicki Nappi, Louis Trevisan, Brian Pittman, Deepak C D'Souza, Raymond F Suckow. Characterization of the interactive effects of glycine and D-cycloserine in men: further evidence for enhanced NMDA receptor function associated with human alcohol dependence.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2011 Feb; 36(3):701-10. doi:
10.1038/npp.2010.203. [PMID: 21124304] - Abdullah A Alangari, Fahad Al-Zamil, Abdulrahman Al-Mazrou, Saleh Al-Muhsen, Stéphanie Boisson-Dupuis, Sitalbanat Awadallah, Abdelmageed Kambal, Jean-Laurent Casanova. Treatment of disseminated mycobacterial infection with high-dose IFN-γ in a patient with IL-12Rβ1 deficiency.
Clinical & developmental immunology.
2011; 2011(?):691956. doi:
10.1155/2011/691956. [PMID: 21234109] - Mariko Saito, Goutam Chakraborty, Medha Hegde, Jason Ohsie, Sun-Mee Paik, Csaba Vadasz, Mitsuo Saito. Involvement of ceramide in ethanol-induced apoptotic neurodegeneration in the neonatal mouse brain.
Journal of neurochemistry.
2010 Oct; 115(1):168-77. doi:
10.1111/j.1471-4159.2010.06913.x. [PMID: 20663015] - Lakshmiprasad Potluri, Aneta Karczmarek, Jolanda Verheul, Andre Piette, Jean-Marc Wilkin, Nadine Werth, Manuel Banzhaf, Waldemar Vollmer, Kevin D Young, Martine Nguyen-Distèche, Tanneke den Blaauwen. Septal and lateral wall localization of PBP5, the major D,D-carboxypeptidase of Escherichia coli, requires substrate recognition and membrane attachment.
Molecular microbiology.
2010 Jul; 77(2):300-23. doi:
10.1111/j.1365-2958.2010.07205.x. [PMID: 20545860] - Lay-Gaik Ooi, Min-Tze Liong. Cholesterol-lowering effects of probiotics and prebiotics: a review of in vivo and in vitro findings.
International journal of molecular sciences.
2010 Jun; 11(6):2499-522. doi:
10.3390/ijms11062499. [PMID: 20640165] - S Svraka, E Kuijper, E Duizer, D Bakker, M Koopmans. Clostridium difficile is not associated with outbreaks of viral gastroenteritis in the elderly in the Netherlands.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2010 Jun; 29(6):677-82. doi:
10.1007/s10096-010-0913-3. [PMID: 20339889] - C Rousseau, I Poilane, F Diakite, L Feghoul, P Cruaud, A Collignon. [Comparison of three Clostridium difficile culture media: interest of enhancing spore germination media?].
Pathologie-biologie.
2010 Feb; 58(1):58-61. doi:
10.1016/j.patbio.2009.07.001. [PMID: 19892495] - Elizabeth J Santa Ana, Bruce J Rounsaville, Tami L Frankforter, Charla Nich, Theresa Babuscio, James Poling, Kishorchandra Gonsai, Kevin P Hill, Kathleen M Carroll. D-Cycloserine attenuates reactivity to smoking cues in nicotine dependent smokers: a pilot investigation.
Drug and alcohol dependence.
2009 Oct; 104(3):220-7. doi:
10.1016/j.drugalcdep.2009.04.023. [PMID: 19592176] - H W Lee, D W Kim, J H Park, S-D Kim, M-S Lim, P B Phapale, E-H Kim, S K Park, Y-R Yoon. Pharmacokinetics of prothionamide in patients with multidrug-resistant tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
2009 Sep; 13(9):1161-6. doi:
NULL. [PMID: 19723408] - Syed Imteyaz Alam, Sunita Bansod, Ravi Bhushan Kumar, Nabonita Sengupta, Lokendra Singh. Differential proteomic analysis of Clostridium perfringens ATCC13124; identification of dominant, surface and structure associated proteins.
BMC microbiology.
2009 Aug; 9(?):162. doi:
10.1186/1471-2180-9-162. [PMID: 19664283] - Aude Antignac, Alexander Tomasz. Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene.
Antimicrobial agents and chemotherapy.
2009 Feb; 53(2):435-41. doi:
10.1128/aac.01099-08. [PMID: 19015345] - Joost T van Dongen, Anja Fröhlich, Santiago J Ramírez-Aguilar, Nicolas Schauer, Alisdair R Fernie, Alexander Erban, Joachim Kopka, Jeremy Clark, Anke Langer, Peter Geigenberger. Transcript and metabolite profiling of the adaptive response to mild decreases in oxygen concentration in the roots of arabidopsis plants.
Annals of botany.
2009 Jan; 103(2):269-80. doi:
10.1093/aob/mcn126. [PMID: 18660497] - Seong S Shim, Michael D Hammonds, Baik S Kee. Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site.
European archives of psychiatry and clinical neuroscience.
2008 Feb; 258(1):16-27. doi:
10.1007/s00406-007-0757-8. [PMID: 17901997] - Louis Trevisan, Ismene L Petrakis, Brian Pittman, Ralitza Gueorguieva, D Cyril D'Souza, Edward Perry, Diana Limoncelli, John H Krystal. Absence of significant interactive effects of high-dose D-cycloserine and ethanol in healthy human subjects: preliminary insights into ethanol actions at the glycine B site of NMDA glutamate receptors.
Alcoholism, clinical and experimental research.
2008 Jan; 32(1):36-42. doi:
10.1111/j.1530-0277.2007.00543.x. [PMID: 18028532] - Teresa Musumeci, Cinzia Anna Ventura, Ignazio Giannone, Rosario Pignatello, Giovanni Puglisi. Development of a liposome formulation for D-cycloserine local delivery.
Journal of liposome research.
2008; 18(3):211-24. doi:
10.1080/08982100802354624. [PMID: 18726817] - Xue-Xian Zhang, Ken Scott, Rebecca Meffin, Paul B Rainey. Genetic characterization of psp encoding the DING protein in Pseudomonas fluorescens SBW25.
BMC microbiology.
2007 Dec; 7(?):114. doi:
10.1186/1471-2180-7-114. [PMID: 18088430] - Jae Youl Cho. Effect of L-cycloserine on cellular responses mediated by macrophages and T cells.
Biological & pharmaceutical bulletin.
2007 Nov; 30(11):2105-12. doi:
10.1248/bpb.30.2105. [PMID: 17978484] - Andrew T Anfora, Rodney A Welch. DsdX is the second D-serine transporter in uropathogenic Escherichia coli clinical isolate CFT073.
Journal of bacteriology.
2006 Sep; 188(18):6622-8. doi:
10.1128/jb.00634-06. [PMID: 16952954] - Tatsuya Nogami, Nobuyasu Sekiya, Tadamichi Mitsuma, Tetsuo Yamaguchi. [A case of pulmonary Mycobacterium fortuitum infection successfully treated with Kampo treatments].
Kekkaku : [Tuberculosis].
2006 Aug; 81(8):525-9. doi:
". [PMID: 16972656] - Nicolas Garmy, Nadira Taïeb, Nouara Yahi, Jacques Fantini. Apical uptake and transepithelial transport of sphingosine monomers through intact human intestinal epithelial cells: physicochemical and molecular modeling studies.
Archives of biochemistry and biophysics.
2005 Aug; 440(1):91-100. doi:
10.1016/j.abb.2005.06.001. [PMID: 16009329] - Byung Yong Kang, Moon Seok Song, Yun A Kim, So Hee Park, Myung Jun Chung, Soo Dong Kim, Dae Heoun Baek, Kyungjae Kim, Nam Joo Ha. Genomic fingerprinting of antituberculosis agents-resistant Lactobacillus ruminus SPM0211 using the Microbial Uniprimer kit.
Archives of pharmacal research.
2005 Jul; 28(7):854-8. doi:
10.1007/bf02977353. [PMID: 16114501] - Donald C Goff, Lawrence Herz, Thomas Posever, Vivian Shih, Guochuan Tsai, David C Henderson, Oliver Freudenreich, A Eden Evins, Iftah Yovel, Hui Zhang, David Schoenfeld. A six-month, placebo-controlled trial of D-cycloserine co-administered with conventional antipsychotics in schizophrenia patients.
Psychopharmacology.
2005 Apr; 179(1):144-50. doi:
10.1007/s00213-004-2032-2. [PMID: 15502972] - Tilla S Worgall, Rebecca A Juliano, Toru Seo, Richard J Deckelbaum. Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein.
Arteriosclerosis, thrombosis, and vascular biology.
2004 May; 24(5):943-8. doi:
10.1161/01.atv.0000125703.20434.4d. [PMID: 15132973] - D E David E Nix, R D Rodney D Adam, Barbara Auclair, T S Todd S Krueger, P G Paul G Godo, C A Charles A Peloquin. Pharmacokinetics and relative bioavailability of clofazimine in relation to food, orange juice and antacid.
Tuberculosis (Edinburgh, Scotland).
2004; 84(6):365-73. doi:
10.1016/j.tube.2004.04.001. [PMID: 15525560] - Nami Katayama, Hiroyoshi Takano, Motoji Sugiyama, Susumu Takio, Atsushi Sakai, Kan Tanaka, Haruko Kuroiwa, Kanji Ono. Effects of antibiotics that inhibit the bacterial peptidoglycan synthesis pathway on moss chloroplast division.
Plant & cell physiology.
2003 Jul; 44(7):776-81. doi:
10.1093/pcp/pcg096. [PMID: 12881507] - Kyoichi Oshida, Takashi Shimizu, Mitsunori Takase, Yoshitaka Tamura, Toshiaki Shimizu, Yuichiro Yamashiro. Effects of dietary sphingomyelin on central nervous system myelination in developing rats.
Pediatric research.
2003 Apr; 53(4):589-93. doi:
10.1203/01.pdr.0000054654.73826.ac. [PMID: 12612207] - Sybille G E Meyer, Herbert de Groot. [14C]serine from phosphatidylserine labels ceramide and sphingomyelin in L929 cells: evidence for a new metabolic relationship between glycerophospholipids and sphingolipids.
Archives of biochemistry and biophysics.
2003 Feb; 410(1):107-11. doi:
10.1016/s0003-9861(02)00666-5. [PMID: 12559982] - Anat Erdreich-Epstein, Linda B Tran, Nina N Bowman, Hongtao Wang, Myles C Cabot, Donald L Durden, Jitka Vlckova, C Patrick Reynolds, Monique F Stins, Susan Groshen, Melissa Millard. Ceramide signaling in fenretinide-induced endothelial cell apoptosis.
The Journal of biological chemistry.
2002 Dec; 277(51):49531-7. doi:
10.1074/jbc.m209962200. [PMID: 12388538] - Brian W Noland, Janet M Newman, Jörg Hendle, John Badger, Jon A Christopher, Jason Tresser, Michelle D Buchanan, Tobi A Wright, Marc E Rutter, Wendy E Sanderson, Hans Joachim Müller-Dieckmann, Ketan S Gajiwala, Sean G Buchanan. Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme.
Structure (London, England : 1993).
2002 Nov; 10(11):1569-80. doi:
10.1016/s0969-2126(02)00879-1. [PMID: 12429098] - A Eden Evins, Ed Amico, Thomas A Posever, Rob Toker, Donald C Goff. D-Cycloserine added to risperidone in patients with primary negative symptoms of schizophrenia.
Schizophrenia research.
2002 Jul; 56(1-2):19-23. doi:
10.1016/s0920-9964(01)00220-1. [PMID: 12084415] - Thorsteinn Thorsteinsson, Már Másson, Tomi Jarvinen, Tapio Nevalainen, Thorsteinn Loftsson. Cycloserine fatty acid derivatives as prodrugs: synthesis, degradation and in vitro skin permeability.
Chemical & pharmaceutical bulletin.
2002 Apr; 50(4):554-7. doi:
10.1248/cpb.50.554. [PMID: 11964011] - Dongyu Sun, Seth Cohen, Nagraj Mani, Chris Murphy, David M Rothstein. A pathway-specific cell based screening system to detect bacterial cell wall inhibitors.
The Journal of antibiotics.
2002 Mar; 55(3):279-87. doi:
10.7164/antibiotics.55.279. [PMID: 12014443] - Charles A Peloquin. Therapeutic drug monitoring in the treatment of tuberculosis.
Drugs.
2002; 62(15):2169-83. doi:
10.2165/00003495-200262150-00001. [PMID: 12381217] - C A Peloquin, M Zhu, R D Adam, M D Singleton, D E Nix. Pharmacokinetics of para-aminosalicylic acid granules under four dosing conditions.
The Annals of pharmacotherapy.
2001 Nov; 35(11):1332-8. doi:
10.1345/aph.1a088. [PMID: 11724078] - V David, M Ionescu, V Dumitrescu. Determination of cycloserine in human plasma by high-performance liquid chromatography with fluorescence detection, using derivatization with p-benzoquinone.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Sep; 761(1):27-33. doi:
10.1016/s0378-4347(01)00293-6. [PMID: 11585129] - M Zhu, D E Nix, R D Adam, J M Childs, C A Peloquin. Pharmacokinetics of cycloserine under fasting conditions and with high-fat meal, orange juice, and antacids.
Pharmacotherapy.
2001 Aug; 21(8):891-7. doi:
10.1592/phco.21.11.891.34524. [PMID: 11718495] - S E Berning. The role of fluoroquinolones in tuberculosis today.
Drugs.
2001; 61(1):9-18. doi:
10.2165/00003495-200161010-00002. [PMID: 11217874] - H Z Malina, C Richter, M Mehl, O M Hess. Pathological apoptosis by xanthurenic acid, a tryptophan metabolite: activation of cell caspases but not cytoskeleton breakdown.
BMC physiology.
2001; 1(?):7. doi:
10.1186/1472-6793-1-7. [PMID: 11459518] - Y G Kim, Y J Lee, E D Lee, S D Lee, J W Kwon, W B Kim, C K Shim, M G Lee. Bioequivalence assessment of closerin capsule to dura seromycin capsule of cycloserine after a single oral dose administration to healthy male volunteers.
International journal of clinical pharmacology and therapeutics.
2000 Oct; 38(10):461-6. doi:
10.5414/cpp38461. [PMID: 11073286] - Y Dong, X Zhao, B N Kreiswirth, K Drlica. Mutant prevention concentration as a measure of antibiotic potency: studies with clinical isolates of Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy.
2000 Sep; 44(9):2581-4. doi:
10.1128/aac.44.9.2581-2584.2000. [PMID: 10952625] - G De Sarro, S Gratteri, F Naccari, M P Pasculli, A De Sarro. Influence of D-cycloserine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice.
Epilepsy research.
2000 Jul; 40(2-3):109-21. doi:
10.1016/s0920-1211(00)00113-3. [PMID: 10863138]