altenusin (BioDeep_00000407504)

   

natural product


代谢物信息卡片


altenusin

化学式: C15H14O6 (290.0790344)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(natural_products) 9.09%

分子结构信息

SMILES: CC1=CC(=C(C=C1C2=C(C(=CC(=C2)OC)O)C(=O)O)O)O
InChI: InChI=1S/C15H14O6/c1-7-3-11(16)12(17)6-9(7)10-4-8(21-2)5-13(18)14(10)15(19)20/h3-6,16-18H,1-2H3,(H,19,20)

描述信息

A carboxybiphenyl that is [biphenyl]-2-carboxylic acid which is substituted by a hydroxy group at positions 3, 4 and 5, methoxy group at position 5 and a methyl group at position 2. It is a a metabolite isolated from Alternaria and several other fungal species.

同义名列表

1 个代谢物同义名

altenusin



相关代谢途径

Reactome(0)

BioCyc(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Margaret N Holme, Subinoy Rana, Hanna M G Barriga, Ulrike Kauscher, Nicholas J Brooks, Molly M Stevens. A Robust Liposomal Platform for Direct Colorimetric Detection of Sphingomyelinase Enzyme and Inhibitors. ACS nano. 2018 08; 12(8):8197-8207. doi: 10.1021/acsnano.8b03308. [PMID: 30080036]
  • Zhihui Zheng, Zanmei Zhao, Shuqiang Li, Xinhua Lu, Mengxi Jiang, Jie Lin, Yunqi An, Yang Xie, Meishu Xu, Wenbin Shen, Grace L Guo, Yixian Huang, Song Li, Xuexia Zhang, Wen Xie. Altenusin, a Nonsteroidal Microbial Metabolite, Attenuates Nonalcoholic Fatty Liver Disease by Activating the Farnesoid X Receptor. Molecular pharmacology. 2017 10; 92(4):425-436. doi: 10.1124/mol.117.108829. [PMID: 28739572]
  • Jatuporn Phaopongthai, Suthep Wiyakrutta, Duangdeun Meksuriyen, Nongluksna Sriubolmas, Khanit Suwanborirux. Azole-synergistic anti-candidal activity of altenusin, a biphenyl metabolite of the endophytic fungus Alternaria alternata isolated from Terminalia chebula Retz. Journal of microbiology (Seoul, Korea). 2013 Dec; 51(6):821-8. doi: 10.1007/s12275-013-3189-3. [PMID: 24385360]
  • Julia Kjer, Victor Wray, RuAngelie Edrada-Ebel, Rainer Ebel, Alexander Pretsch, Wenhan Lin, Peter Proksch. Xanalteric acids I and II and related phenolic compounds from an endophytic Alternaria sp. isolated from the mangrove plant Sonneratia alba. Journal of natural products. 2009 Nov; 72(11):2053-7. doi: 10.1021/np900417g. [PMID: 19835393]
  • Betania Barros Cota, Luiz Henrique Rosa, Rachel Basques Caligiorne, Ana Lúcia Teles Rabello, Tânia Maria Almeida Alves, Carlos Augusto Rosa, Carlos Leomar Zani. Altenusin, a biphenyl isolated from the endophytic fungus Alternaria sp., inhibits trypanothione reductase from Trypanosoma cruzi. FEMS microbiology letters. 2008 Aug; 285(2):177-82. doi: 10.1111/j.1574-6968.2008.01221.x. [PMID: 18557945]
  • Amal H Aly, RuAngelie Edrada-Ebel, Ine Dewi Indriani, Victor Wray, Werner E G Müller, Frank Totzke, Ute Zirrgiebel, Christoph Schächtele, Michael H G Kubbutat, W H Lin, Peter Proksch, Rainer Ebel. Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. Journal of natural products. 2008 Jun; 71(6):972-80. doi: 10.1021/np070447m. [PMID: 18494522]