Docosanol (BioDeep_00000406887)

 

Secondary id: BioDeep_00000017472, BioDeep_00000594470, BioDeep_00000860021

natural product PANOMIX_OTCML-2023 Chemicals and Drugs Antibiotics


代谢物信息卡片


1-Docosanol

化学式: C22H46O (326.3548466)
中文名称: 正二十二醇
谱图信息: 最多检出来源 Viridiplantae(plant) 0.19%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCCCCCCO
InChI: InChI=1S/C22H46O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23/h23H,2-22H2,1H3

描述信息

D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BB - Antivirals
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C254 - Anti-Infective Agent > C281 - Antiviral Agent
1-Docosanol is a saturated fatty alcohol with reported inhibitory activity against lipid-enveloped viruses, including herpes simplex virus.
1-Docosanol is a saturated fatty alcohol with reported inhibitory activity against lipid-enveloped viruses, including herpes simplex virus.

同义名列表

3 个代谢物同义名

1-Docosanol; Docosanol; Behenyl alcohol



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

26 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Marion Callau, Nina Jenkins, Koudedii Sow-Kebe, Clement Levivier, Anne-Laure Fameau. The Effect of Vegetable Oil Composition on the Structural Properties of Oleogels Based on Behenyl Alcohol/Behenic Acid Oleogelator System. Journal of cosmetic science. 2021 Jul; 72(4):399-417. doi: ". [PMID: 35262481]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Victoria Psomiadou, Christos Iavazzo, Athanasios Douligeris, Alexandros Fotiou, Anastasia Prodromidou, Nikolaos Blontzos, Evgenia Karavioti, George Vorgias. An Alternative Treatment for Vaginal Cuff Wart: a Case Report. Acta medica (Hradec Kralove). 2020; 63(1):49-51. doi: 10.14712/18059694.2020.15. [PMID: 32422116]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Wei Shao, Arghya Paul, Bin Zhao, Crystal Lee, Laetitia Rodes, Satya Prakash. Carbon nanotube lipid drug approach for targeted delivery of a chemotherapy drug in a human breast cancer xenograft animal model. Biomaterials. 2013 Dec; 34(38):10109-19. doi: 10.1016/j.biomaterials.2013.09.007. [PMID: 24060420]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Caroline A C Kadu, Alexandra Parich, Silvio Schueler, Heino Konrad, Geoffrey M Muluvi, Oscar Eyog-Matig, Alice Muchugi, Vivienne L Williams, Lolona Ramamonjisoa, Consolatha Kapinga, Bernard Foahom, Cuthbert Katsvanga, David Hafashimana, Crisantos Obama, Barbara Vinceti, Rainer Schumacher, Thomas Geburek. Bioactive constituents in Prunus africana: geographical variation throughout Africa and associations with environmental and genetic parameters. Phytochemistry. 2012 Nov; 83(?):70-8. doi: 10.1016/j.phytochem.2012.06.001. [PMID: 22795601]
  • Ting Tang, Laifu Zuo, Zhi Na, Youkai Xu. [Chemical constituents from stems of Dysoxylum laxiracemosum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 May; 37(9):1237-40. doi: 10.4268/cjcmm20120914. [PMID: 22803367]
  • Timothy J Wilt, Roderick Macdonald, Areef Ishani, Indy Rutks, Gerold Stark. WITHDRAWN: Cernilton for benign prostatic hyperplasia. The Cochrane database of systematic reviews. 2011 May; ?(5):CD001042. doi: 10.1002/14651858.cd001042.pub2. [PMID: 21563128]
  • Luciana María Cocchiararo-Bastias, Sergio Javier Mijailovsky, Gustavo Mario Calderon-Fernández, Alicia Nieves Lorenzo Figueiras, M Patricia Juárez. epicuticle lipids mediate mate recognition in Triatoma infestans. Journal of chemical ecology. 2011 Mar; 37(3):246-52. doi: 10.1007/s10886-011-9927-2. [PMID: 21373991]
  • Robert J Shmookler Reis, Lulu Xu, Hoonyong Lee, Minho Chae, John J Thaden, Puneet Bharill, Cagdas Tazearslan, Eric Siegel, Ramani Alla, Piotr Zimniak, Srinivas Ayyadevara. Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. Aging. 2011 Feb; 3(2):125-47. doi: 10.18632/aging.100275. [PMID: 21386131]
  • Anna A Dobritsa, Zhentian Lei, Shuh-Ichi Nishikawa, Ewa Urbanczyk-Wochniak, David V Huhman, Daphne Preuss, Lloyd W Sumner. LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis. Plant physiology. 2010 Jul; 153(3):937-55. doi: 10.1104/pp.110.157446. [PMID: 20442277]
  • Sumit Paliwal, Makoto Ogura, Samir Mitragotri. Rapid sampling of molecules via skin for diagnostic and forensic applications. Pharmaceutical research. 2010 Jul; 27(7):1255-63. doi: 10.1007/s11095-010-0081-2. [PMID: 20238151]
  • David J Simbo. An ethnobotanical survey of medicinal plants in Babungo, Northwest Region, Cameroon. Journal of ethnobiology and ethnomedicine. 2010 Feb; 6(?):8. doi: 10.1186/1746-4269-6-8. [PMID: 20156356]
  • Nurhan T Dunford, Jeff Edwards. Nutritional bioactive components of wheat straw as affected by genotype and environment. Bioresource technology. 2010 Jan; 101(1):422-5. doi: 10.1016/j.biortech.2009.08.009. [PMID: 19716291]
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  • Raj C Dedhia, Kevin T McVary. Phytotherapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia. The Journal of urology. 2008 Jun; 179(6):2119-25. doi: 10.1016/j.juro.2008.01.094. [PMID: 18423748]
  • Li Yongzhi, Shi Benkang, Zhang Jianping, Ran Lingxia, Bian Wei, Zhu Yaofeng, Zhang Keqin, Vincent Laudon. Expression of transforming growth factor beta1 gene, basic fibroblast growth factor gene and hydroxyproline in diabetes-induced bladder dysfunction in a rat model. Neurourology and urodynamics. 2008; 27(3):254-9. doi: 10.1002/nau.20489. [PMID: 17763394]
  • Alembert Tiabou Tchinda, Shamsun Nahar Khan, Victorine Fuendjiep, François Ngandeu, Annie Ngono Ngane, Muhammad Iqbal Choudhary. Alpha-glucosidase inhibitors from Millettia conraui. Chemical & pharmaceutical bulletin. 2007 Sep; 55(9):1402-3. doi: 10.1248/cpb.55.1402. [PMID: 17827772]
  • Ya-li Zong, Yu-ping Lin, Qiong-e Ding, Hui He, Gao-xiong Rao. [Studies on the chemical constituents of the aerial parts of Seseli mairei]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2007 Jan; 30(1):42-4. doi: . [PMID: 17539301]
  • Isabel Molina, Gustavo Bonaventure, John Ohlrogge, Mike Pollard. The lipid polyester composition of Arabidopsis thaliana and Brassica napus seeds. Phytochemistry. 2006 Dec; 67(23):2597-610. doi: 10.1016/j.phytochem.2006.09.011. [PMID: 17055542]
  • Robert Krysiak, Bogusław Okopień, Witold Szkróbka, Zbigniew Stanisław Herman. [Modern pharmacotherapy of benign prostatic hyperplasia]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 2005 Nov; 19(113):710-5. doi: ". [PMID: 16498818]
  • R M Levin, C Whitbeck, P Horan, F Bellamy. Low-dose tadenan protects the rabbit bladder from bilateral ischemia/ reperfusion-induced contractile dysfunction. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2005 Jan; 12(1-2):17-24. doi: 10.1016/j.phymed.2003.10.002. [PMID: 15693703]
  • ". [Tadenan (Pygeum africanum extract) in the treatment of patients with benign prostatic hyperplasia]. Urologiia (Moscow, Russia : 1999). 2004 Sep; ?(5):70-2. doi: ". [PMID: 15560171]
  • Hesham Rushdey El-Seedi, Therese Ringbom, Kurt Torssell, Lars Bohlin. Constituents of Hypericum laricifolium and their cyclooxygenase (COX) enzyme activities. Chemical & pharmaceutical bulletin. 2003 Dec; 51(12):1439-40. doi: 10.1248/cpb.51.1439. [PMID: 14646327]
  • M Piovano, M C Chamy, J A Garbarino, B Tita, A Vitalone, A Di Fabio, M Nicoletti. Cytotoxic activity of the root extract from Myoschilos oblongum. Fitoterapia. 2003 Jul; 74(5):497-500. doi: 10.1016/s0367-326x(03)00111-4. [PMID: 12837371]
  • Yosh Yoshimura, Osamu Yamaguchi, Francois Bellamy, Christos E Constantinou. Effect of Pygeum africanum tadenan on micturition and prostate growth of the rat secondary to coadministered treatment and post-treatment with dihydrotestosterone. Urology. 2003 Feb; 61(2):474-8. doi: 10.1016/s0090-4295(02)02155-6. [PMID: 12597984]
  • Françoise A Valentini, Robert M Levin, Gilbert R Besson, Pierre P Nelson. Study of detrusor dysfunction due to outlet obstruction: link between analysis of uroflows of men with benign prostatic hyperplasia and animal studies. Advances in experimental medicine and biology. 2003; 539(Pt A):297-309. doi: 10.1007/978-1-4419-8889-8_22. [PMID: 15088913]
  • John F Marcelletti. Synergistic inhibition of herpesvirus replication by docosanol and antiviral nucleoside analogs. Antiviral research. 2002 Nov; 56(2):153-66. doi: 10.1016/s0166-3542(02)00105-5. [PMID: 12367721]
  • Jean Pierre Raynaud, Henri Cousse, Pierre Marie Martin. Inhibition of type 1 and type 2 5alpha-reductase activity by free fatty acids, active ingredients of Permixon. The Journal of steroid biochemistry and molecular biology. 2002 Oct; 82(2-3):233-9. doi: 10.1016/s0960-0760(02)00187-5. [PMID: 12477490]
  • Guadalupe Iglesias, Jason J Hlywka, James E Berg, M H Khalil, Laura E Pope, Dov Tamarkin. The toxicity of behenyl alcohol. II. Reproduction studies in rats and rabbits. Regulatory toxicology and pharmacology : RTP. 2002 Aug; 36(1):80-5. doi: 10.1006/rtph.2002.1566. [PMID: 12383720]
  • Guadalupe Iglesias, Jason J Hlywka, James E Berg, M H Khalil, Laura E Pope, Dov Tamarkin. The toxicity of behenyl alcohol. I. Genotoxicity and subchronic toxicity in rats and dogs. Regulatory toxicology and pharmacology : RTP. 2002 Aug; 36(1):69-79. doi: 10.1006/rtph.2002.1565. [PMID: 12383719]
  • Robert M Levin, Martha A Hass, Francois Bellamy, Pat Horan, Katherine Whitbeck, Pak Ham Chow, L S Kung, John Gosling. Effect of oral Tadenan treatment on rabbit bladder structure and function after partial outlet obstruction. The Journal of urology. 2002 May; 167(5):2253-9. doi: ". [PMID: 11956488]
  • M J Scolaro, L B Gunnill, L E Pope, M H Khalil, D H Katz, J E Berg. The antiviral drug docosanol as a treatment for Kaposi's sarcoma lesions in HIV type 1-infected patients: a pilot clinical study. AIDS research and human retroviruses. 2001 Jan; 17(1):35-43. doi: 10.1089/088922201750056762. [PMID: 11177381]
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  • L E Pope, J F Marcelletti, L R Katz, J Y Lin, D H Katz, M L Parish, P G Spear. The anti-herpes simplex virus activity of n-docosanol includes inhibition of the viral entry process. Antiviral research. 1998 Dec; 40(1-2):85-94. doi: 10.1016/s0166-3542(98)00048-5. [PMID: 9864049]
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  • D H Katz, J F Marcelletti, L E Pope, M H Khalil, L R Katz, R McFadden. n-docosanol: broad spectrum anti-viral activity against lipid-enveloped viruses. Annals of the New York Academy of Sciences. 1994 Jun; 724(?):472-88. doi: 10.1111/j.1749-6632.1994.tb38949.x. [PMID: 8030975]
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  • D H Katz, J F Marcelletti, M H Khalil, L E Pope, L R Katz. Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex. Proceedings of the National Academy of Sciences of the United States of America. 1991 Dec; 88(23):10825-9. doi: 10.1073/pnas.88.23.10825. [PMID: 1660151]
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