Licochalcone B (BioDeep_00000402905)

 

Secondary id: BioDeep_00000017229

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(E)-3-(3,4-dihydroxy-2-methoxy-phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

化学式: C16H14O5 (286.0841194)
中文名称: 甘草查尔酮B, 甘草查尔酮B
谱图信息: 最多检出来源 Viridiplantae(plant) 3.88%

分子结构信息

SMILES: COC1=C(C=CC(=C1O)O)C=CC(=O)C2=CC=C(C=C2)O
InChI: InChI=1S/C16H14O5/c1-21-16-11(5-9-14(19)15(16)20)4-8-13(18)10-2-6-12(17)7-3-10/h2-9,17,19-20H,1H3/b8-4+

描述信息

Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction[1][2][3][4].
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction[1][2][3][4].

同义名列表

10 个代谢物同义名

(E)-3-(3,4-dihydroxy-2-methoxy-phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one; (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one; 3-(3,4-dihydroxy-2-methoxy-phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one; (E)-3-(3,4-Dihydroxy-2-methoxy-phenyl)-1-(4-hydroxy-phenyl)-propenone; 3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one; (E)-3-(3,4-Dihydroxy-2-methoxy-phenyl)-1-(4-hydroxy-phenyl)propenone; Licochalcone B; AIDS-095932; AIDS095932; 58749-23-8



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yuyun Li, Siyan Li, Zeren Shou, Yibin Li, Axin Li, Wenli Liu, Xin Zhang, Chengliang Zhou, Daohua Xu, Lin Li. Integration of network pharmacology with experimental validation to reveal the mechanism of action of Longdan Xiegan Decoction against HSV2 infection and determine its effective components. Journal of ethnopharmacology. 2024 Feb; ?(?):117861. doi: 10.1016/j.jep.2024.117861. [PMID: 38316223]
  • Ju Huang, Yu Zhu, Songtao Li, Huanyu Jiang, Nianzhi Chen, Hang Xiao, Jingwen Liu, Dan Liang, Qiao Zheng, Jianyuan Tang, Xiangrui Meng. Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway. Redox report : communications in free radical research. 2023 Dec; 28(1):2243423. doi: 10.1080/13510002.2023.2243423. [PMID: 37565601]
  • Qianru Zhao, Xu Zhang, Siru Long, Shaobing Wang, Hui Yu, Yongsheng Zhou, Yi Li, Lu Xue, Yan Hu, Shijin Yin. Licochalcone Mediates the Pain Relief by Targeting the Voltage-Gated Sodium Channel. Molecular pharmacology. 2023 Jul; ?(?):. doi: 10.1124/molpharm.122.000658. [PMID: 37419692]
  • Lei Ye, Ming Su, Xinyi Qiao, Shaowei Wang, Ke Zheng, Yang Zhu, Huitao Li, Yiyan Wang, Ren-Shan Ge. Chalcone derivatives from licorice inhibit human and rat gonadal 3β-hydroxysteroid dehydrogenases as therapeutic uses. Journal of ethnopharmacology. 2023 May; ?(?):116690. doi: 10.1016/j.jep.2023.116690. [PMID: 37245711]
  • Maoru Wang, Bin Yu, Jisheng Wang, Yu Wang, Libo Liang. Exploring the role of Xingren on COVID-19 based on network pharmacology and molecular docking. Journal of food biochemistry. 2022 10; 46(10):e14363. doi: 10.1111/jfbc.14363. [PMID: 35933696]
  • Yun-Yun Zhang, Pan-Pan Feng, Hong-Fei Wang, Heng Zhang, Tao Liang, Xiao-Shan Hao, Feng-Ze Wang, Hong-Rong Fei. Licochalcone B induces DNA damage, cell cycle arrest, apoptosis, and enhances TRAIL sensitivity in hepatocellular carcinoma cells. Chemico-biological interactions. 2022 Sep; 365(?):110076. doi: 10.1016/j.cbi.2022.110076. [PMID: 35948134]
  • Qiang Li, Hui Feng, Hongbo Wang, Yinghao Wang, Wenqing Mou, Guang Xu, Ping Zhang, Ruisheng Li, Wei Shi, Zhilei Wang, Zhie Fang, Lutong Ren, Yan Wang, Li Lin, Xiaorong Hou, Wenzhang Dai, Zhiyong Li, Ziying Wei, Tingting Liu, Jiabo Wang, Yuming Guo, Pengyan Li, Xu Zhao, Xiaoyan Zhan, Xiaohe Xiao, Zhaofang Bai. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction. EMBO reports. 2022 02; 23(2):e53499. doi: 10.15252/embr.202153499. [PMID: 34882936]
  • Fangfang Xu, Tao Hou, Aijin Shen, Hongli Jin, Yuansheng Xiao, Wenyi Yu, Xiaonong Li, Jixia Wang, Yanfang Liu, Xinmiao Liang. Mechanism deconvolution of Qing Fei Pai Du decoction for treatment of Coronavirus Disease 2019 (COVID-19) by label-free integrative pharmacology assays. Journal of ethnopharmacology. 2021 Nov; 280(?):114488. doi: 10.1016/j.jep.2021.114488. [PMID: 34358653]
  • Yunjia Hu, Meiqin Liu, Hongbo Qin, Haofeng Lin, Xiaoping An, Zhengli Shi, Lihua Song, Xinglou Yang, Huahao Fan, Yigang Tong. Artemether, Artesunate, Arteannuin B, Echinatin, Licochalcone B and Andrographolide Effectively Inhibit SARS-CoV-2 and Related Viruses In Vitro. Frontiers in cellular and infection microbiology. 2021; 11(?):680127. doi: 10.3389/fcimb.2021.680127. [PMID: 34527599]
  • Yingying Cao, Wenxing Xu, Yiyou Huang, Xing Zeng. Licochalcone B, a chalcone derivative from Glycyrrhiza inflata, as a multifunctional agent for the treatment of Alzheimer's disease. Natural product research. 2020 Mar; 34(5):736-739. doi: 10.1080/14786419.2018.1496429. [PMID: 30345819]
  • Jun Wang, Ai-Mei Liao, Kiran Thakur, Jian-Guo Zhang, Ji-Hong Huang, Zhao-Jun Wei. Licochalcone B Extracted from Glycyrrhiza uralensis Fisch Induces Apoptotic Effects in Human Hepatoma Cell HepG2. Journal of agricultural and food chemistry. 2019 Mar; 67(12):3341-3353. doi: 10.1021/acs.jafc.9b00324. [PMID: 30835110]
  • Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Shuai Ji, Kuan Chen, Wei Song, Xue Qiao, Min Ye. Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice. Bioorganic & medicinal chemistry. 2017 10; 25(20):5522-5530. doi: 10.1016/j.bmc.2017.08.018. [PMID: 28835349]
  • Yi Kuang, Yan Lin, Kai Li, Wei Song, Shuai Ji, Xue Qiao, Qingying Zhang, Min Ye. Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2017 Oct; 34(?):59-66. doi: 10.1016/j.phymed.2017.08.005. [PMID: 28899510]
  • Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Wei Song, Xue Qiao, Gulnar Sabir, Min Ye. Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. Bioorganic & medicinal chemistry. 2017 07; 25(14):3706-3713. doi: 10.1016/j.bmc.2017.05.009. [PMID: 28522265]
  • Hana Oh, Goo Yoon, Jae-Cheon Shin, Seon-Min Park, Seung-Sik Cho, Jin Hyoung Cho, Mee-Hyun Lee, Kangdong Liu, Young Sik Cho, Jung-Il Chae, Jung-Hyun Shim. Licochalcone B induces apoptosis of human oral squamous cell carcinoma through the extrinsic- and intrinsic-signaling pathways. International journal of oncology. 2016 Apr; 48(4):1749-57. doi: 10.3892/ijo.2016.3365. [PMID: 26847145]
  • Hong Zhao, Xuan Yuan, Jiangtao Jiang, Penglong Wang, Xiling Sun, Dong Wang, Qiusheng Zheng. Antimetastatic effects of licochalcone B on human bladder carcinoma T24 by inhibition of matrix metalloproteinases-9 and NF-кB activity. Basic & clinical pharmacology & toxicology. 2014 Dec; 115(6):527-33. doi: 10.1111/bcpt.12273. [PMID: 25099010]
  • Peng Zeng, Yong Zhang, Chen Pan, Qi Jia, Fu-Jiang Guo, Wei-Liang Zhu, Yi-Ming Li, Kai-Xian Chen. [Phenolic constituents from Lysimachia patungensis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Mar; 48(3):377-82. doi: . [PMID: 23724651]