Vinblastine (BioDeep_00000402850)

Main id: BioDeep_00000003673

 

natural product PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate

化学式: C46H58N4O9 (810.4203578)
中文名称: 长春质碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
InChI: InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01C - Plant alkaloids and other natural products > L01CA - Vinca alkaloids and analogues
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
D000970 - Antineoplastic Agents > D014748 - Vinca Alkaloids
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C932 - Vinca Alkaloid Compound
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
C1907 - Drug, Natural Product

同义名列表

3 个代谢物同义名

methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate; Vincaleukoblastine; Vinblastine



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Masoomeh Nabaei, Rayhaneh Amooaghaie, Mansour Ghorbanpour, Alimohammad Ahadi. Crosstalk between melatonin and nitric oxide restrains Cadmium-induced oxidative stress and enhances vinblastine biosynthesis in Catharanthus roseus (L) G Don. Plant cell reports. 2024 May; 43(6):139. doi: 10.1007/s00299-024-03229-4. [PMID: 38735908]
  • Pooja Singh, Seema Yadav, Saumya Shah, Karuna Shanker, Velusamy Sundaresan, Ashutosh K Shukla. Characterization of a CrPME indicates its possible role in determining vindoline accumulation in Catharanthus roseus leaves. Physiologia plantarum. 2024 Mar; 176(2):e14276. doi: 10.1111/ppl.14276. [PMID: 38566244]
  • Jun Guo, Di Gao, Jiazhang Lian, Yang Qu. De novo biosynthesis of antiarrhythmic alkaloid ajmaline. Nature communications. 2024 Jan; 15(1):457. doi: 10.1038/s41467-024-44797-z. [PMID: 38212296]
  • Jawad Ahmed, Yasar Sajjad, Aasia Latif, Mohammad Saeed Lodhi, Muhammad Huzafa, Chen Situ, Raza Ahmad, Muhammad Maroof Shah, Amjad Hassan. Genome-wide identification and characterization of wall-associated kinases, molecular docking and polysaccharide elicitation of monoterpenoid indole alkaloids in micro-propagated Catharanthus roseus. Journal of plant research. 2024 Jan; 137(1):125-142. doi: 10.1007/s10265-023-01504-1. [PMID: 37962734]
  • Zhongping Xu, Guanying Wang, Qiongqiong Wang, Xiaoting Li, Guangyu Zhang, Ali Qurban, Can Zhang, Yi Zhou, Huan Si, Lisong Hu, Fuqiu Wang, Ying Wang, Zhitao Tian, Wei Chen, Shuangxia Jin, Fang Ding. A near-complete genome assembly of Catharanthus roseus and insights into its vinblastine biosynthesis and high susceptibility to the Huanglongbing pathogen. Plant communications. 2023 Nov; 4(6):100661. doi: 10.1016/j.xplc.2023.100661. [PMID: 37464741]
  • Maneesha Mall, Karuna Shanker, Dinesh A Nagegowda, Abdul Samad, Alok Kalra, Alok Pandey, Velusamy Sundaresan, Ashutosh K Shukla. Temperature-induced lipocalin-mediated membrane integrity: Possible implications for vindoline accumulation in Catharanthus roseus leaves. Physiologia plantarum. 2023 Sep; 175(5):e13994. doi: 10.1111/ppl.13994. [PMID: 37882277]
  • Katalin Nagy, Éva Darkó, Gabriella Szalai, Tibor Janda, Zsuzsa Jókai, Márta Ladányi, Mohamed Ramadan Rady, Mihály Dernovics. UPLC-ESI-QTOF-MS assisted targeted metabolomics to study the enrichment of vinca alkaloids and related metabolites in Catharanthus roseus plants grown under controlled LED environment. Journal of pharmaceutical and biomedical analysis. 2023 Jul; 235(?):115611. doi: 10.1016/j.jpba.2023.115611. [PMID: 37542828]
  • Hossam S El-Beltagi, Salwa M El-Sayed, Ahmed N Abdelhamid, Karim M Hassan, Walaa A Elshalakany, Mona Ibrahim Nossier, Nadiyah M Alabdallah, Nadi Awad Al-Harbi, Salem Mesfir Al-Qahtani, Doaa Bahaa Eldin Darwish, Zahid Khorshid Abbas, Hemmat A Ibrahim. Potentiating Biosynthesis of Alkaloids and Polyphenolic Substances in Catharanthus roseus Plant Using ĸ-Carrageenan. Molecules (Basel, Switzerland). 2023 Apr; 28(8):. doi: 10.3390/molecules28083642. [PMID: 37110876]
  • Yuanjian Yang, Liuyu Ding, Ying Zhou, Zizheng Guo, Rongmin Yu, Jianhua Zhu. Establishment of recombinant Catharanthus roseus stem cells stably overexpressing ORCA4 for terpenoid indole alkaloids biosynthesis. Plant physiology and biochemistry : PPB. 2023 Feb; 196(?):783-792. doi: 10.1016/j.plaphy.2023.02.039. [PMID: 36848864]
  • Valentina Laghezza Masci, Davide Stefanoni, Angelo D'Alessandro, Marta Zambelli, Lorenzo Modesti, Daniele Pollini, Elisa Ovidi, Antonio Tiezzi. Induction of Drug-Resistance and Production of a Culture Medium Able to Induce Drug-Resistance in Vinblastine Untreated Murine Myeloma Cells. Molecules (Basel, Switzerland). 2023 Feb; 28(5):. doi: 10.3390/molecules28052051. [PMID: 36903299]
  • Dagny Grzech, Benke Hong, Lorenzo Caputi, Prashant D Sonawane, Sarah E O'Connor. Engineering the Biosynthesis of Late-Stage Vinblastine Precursors Precondylocarpine Acetate, Catharanthine, Tabersonine in Nicotiana benthamiana. ACS synthetic biology. 2023 01; 12(1):27-34. doi: 10.1021/acssynbio.2c00434. [PMID: 36516122]
  • Fanfan Li, Stephen Bordeleau, Kyung Hee Kim, Jonathan Turcotte, Benjamin Davis, Lan Liu, Stéphane Bayen, Vincenzo De Luca, Mehran Dastmalchi. A lesion-mimic mutant of Catharanthus roseus accumulates the opioid agonist, akuammicine. Phytochemistry. 2022 Nov; 203(?):113422. doi: 10.1016/j.phytochem.2022.113422. [PMID: 36055422]
  • M Ahmadzadeh, A H Keshtkar, K Moslemkhany, M Ahmadzadeh. Effect of the plant probiotic bacteria on terpenoid indole alkaloid biosynthesis pathway gene expression profiling, vinblastine and vincristine content in the root of Catharanthus roseus. Molecular biology reports. 2022 Nov; 49(11):10357-10365. doi: 10.1007/s11033-022-07841-z. [PMID: 36097118]
  • Armando Moreno-Velasco, Pedro de Jesús Flores-Tafoya, Mabel Fragoso-Serrano, Suzana Guimarães Leitão, Rogelio Pereda-Miranda. Resin Glycosides from Operculina hamiltonii and Their Synergism with Vinblastine in Cancer Cells. Journal of natural products. 2022 10; 85(10):2385-2394. doi: 10.1021/acs.jnatprod.2c00594. [PMID: 36162138]
  • Narges Soltani, Farhad Nazarian Firouzabadi, Alireza Shafeinia, Masoud Shirali, Ayeh Sadat Sadr. De Novo transcriptome assembly and differential expression analysis of catharanthus roseus in response to salicylic acid. Scientific reports. 2022 10; 12(1):17803. doi: 10.1038/s41598-022-20314-4. [PMID: 36280677]
  • A Mujib, Samar Fatima, Moien Qadir Malik. Cryo-derived plants through embryogenesis showed same levels of vinblastine and vincristine (anticancer) in Catharanthus roseus and had normal genome size. Scientific reports. 2022 10; 12(1):16635. doi: 10.1038/s41598-022-20993-z. [PMID: 36198853]
  • Shagufta Iqbal, Caitlin Flux, Deborah A Briggs, Evelyne Deplazes, Jiansi Long, Ruth Skrzypek, Alice Rothnie, Ian D Kerr, Richard Callaghan. Vinca alkaloid binding to P-glycoprotein occurs in a processive manner. Biochimica et biophysica acta. Biomembranes. 2022 10; 1864(10):184005. doi: 10.1016/j.bbamem.2022.184005. [PMID: 35863425]
  • A Mujib, Samar Fatima, Moien Qadir Malik. Gamma ray-induced tissue responses and improved secondary metabolites accumulation in Catharanthus roseus. Applied microbiology and biotechnology. 2022 Sep; 106(18):6109-6123. doi: 10.1007/s00253-022-12122-7. [PMID: 35962802]
  • Jie Zhang, Lea G Hansen, Olga Gudich, Konrad Viehrig, Lærke M M Lassen, Lars Schrübbers, Khem B Adhikari, Paulina Rubaszka, Elena Carrasquer-Alvarez, Ling Chen, Vasil D'Ambrosio, Beata Lehka, Ahmad K Haidar, Saranya Nallapareddy, Konstantina Giannakou, Marcos Laloux, Dushica Arsovska, Marcus A K Jørgensen, Leanne Jade G Chan, Mette Kristensen, Hanne B Christensen, Suresh Sudarsan, Emily A Stander, Edward Baidoo, Christopher J Petzold, Tune Wulff, Sarah E O'Connor, Vincent Courdavault, Michael K Jensen, Jay D Keasling. A microbial supply chain for production of the anti-cancer drug vinblastine. Nature. 2022 09; 609(7926):341-347. doi: 10.1038/s41586-022-05157-3. [PMID: 36045295]
  • Wojciech Trybus, Ewa Trybus, Teodora Król. Emodin Sensitizes Cervical Cancer Cells to Vinblastine by Inducing Apoptosis and Mitotic Death. International journal of molecular sciences. 2022 Jul; 23(15):. doi: 10.3390/ijms23158510. [PMID: 35955645]
  • Jasmine Ga May Eng, Mohammadamin Shahsavarani, Daniel Patrick Smith, Josef Hájíček, Vincenzo De Luca, Yang Qu. A Catharanthus roseus Fe(II)/α-ketoglutarate-dependent dioxygenase catalyzes a redox-neutral reaction responsible for vindolinine biosynthesis. Nature communications. 2022 06; 13(1):3335. doi: 10.1038/s41467-022-31100-1. [PMID: 35680936]
  • L T van der Heijden, A Gebretensae, B Thijssen, L van Andel, A L Nijstad, Y Wang, H Rosing, A D R Huitema, J H Beijnen. A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2022 Jun; 215(?):114772. doi: 10.1016/j.jpba.2022.114772. [PMID: 35462284]
  • K Zhao, H Q Wang, L Li, T Song, S P Li, M H Qiu. [Efficacy and safety of Camrelizumab and AVD in the first-line treatment of classic Hodgkin's lymphoma]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 2022 05; 43(5):431-434. doi: 10.3760/cma.j.issn.0253-2727.2022.05.015. [PMID: 35680603]
  • Maneesha Mall, Karuna Shanker, Abdul Samad, Alok Kalra, Velusamy Sundaresan, Ashutosh K Shukla. Stress responsiveness of vindoline accumulation in Catharanthus roseus leaves is mediated through co-expression of allene oxide cyclase with pathway genes. Protoplasma. 2022 May; 259(3):755-773. doi: 10.1007/s00709-021-01701-6. [PMID: 34459997]
  • Vyoma Mistry, Siddhi Darji, Pragya Tiwari, Abhishek Sharma. Engineering Catharanthus roseus monoterpenoid indole alkaloid pathway in yeast. Applied microbiology and biotechnology. 2022 Apr; 106(7):2337-2347. doi: 10.1007/s00253-022-11883-5. [PMID: 35333954]
  • Wenzhu Tang, Xiaoqi Liu, Yuning He, Fan Yang. Enhancement of Vindoline and Catharanthine Accumulation, Antioxidant Enzymes Activities, and Gene Expression Levels in Catharanthus roseus Leaves by Chitooligosaccharides Elicitation. Marine drugs. 2022 Mar; 20(3):. doi: 10.3390/md20030188. [PMID: 35323487]
  • Mohammadamin Shahsavarani, Maisha Farzana, Vincenzo De Luca, Yang Qu. Generating an EMS Mutant Population and Rapid Mutant Screening by Thin-Layer Chromatography Enables the Studies of Monoterpenoid Indole Alkaloids Biosynthesis in Catharanthus Roseus. Methods in molecular biology (Clifton, N.J.). 2022; 2505(?):181-190. doi: 10.1007/978-1-0716-2349-7_13. [PMID: 35732945]
  • Tuan-Anh Minh Nguyen, Matthew McConnachie, Trinh-Don Nguyen, Thu-Thuy T Dang. Discovery and Characterization of Oxidative Enzymes Involved in Monoterpenoid Indole Alkaloid Biosynthesis. Methods in molecular biology (Clifton, N.J.). 2022; 2505(?):141-164. doi: 10.1007/978-1-0716-2349-7_11. [PMID: 35732943]
  • Matthew J Murray, Rafael Moleron, Jennifer Adamski, Martin English, G A Amos Burke, Justin Cross, Thankamma Ajithkumar, Sara Stoneham, James C Nicholson. Vinblastine monotherapy induction prior to radiotherapy for patients with intracranial germinoma during the COVID-19 pandemic. Pediatric blood & cancer. 2022 01; 69(1):e29359. doi: 10.1002/pbc.29359. [PMID: 34520101]
  • Szabolcs Mayer, Nóra Nagy, Péter Keglevich, Áron Szigetvári, Miklós Dékány, Csaba Szántay Junior, László Hazai. Synthesis of Novel Vindoline-Chrysin Hybrids. Chemistry & biodiversity. 2022 Jan; 19(1):e202100725. doi: 10.1002/cbdv.202100725. [PMID: 34874114]
  • Zhichun Li, Liliang Ren. Study on Effects of Cyclophosphamide Combined with Vinorelbine in Advanced Small Cell Lung Cancer and Anteroposterior Changes in MRI. Contrast media & molecular imaging. 2022; 2022(?):3104879. doi: 10.1155/2022/3104879. [PMID: 36043147]
  • Dikki Pedenla Bomzan, H B Shilpashree, Dinesh A Nagegowda. Agrobacterium-Mediated in Planta Transformation in Periwinkle. Methods in molecular biology (Clifton, N.J.). 2022; 2505(?):301-315. doi: 10.1007/978-1-0716-2349-7_22. [PMID: 35732954]
  • E R El-Sayed. Discovery of the anticancer drug vinblastine from the endophytic Alternaria alternata and yield improvement by gamma irradiation mutagenesis. Journal of applied microbiology. 2021 Dec; 131(6):2886-2898. doi: 10.1111/jam.15169. [PMID: 34062037]
  • Hiroyuki Fujii, Taisuke Tsuji, Mio Sugitani, Yosuke Matsumoto, Tatsuya Yuba, Shunya Tanaka, Yoshifumi Suga, Aosa Matsuyama, Shiho Goda, Ayaka Omura, Shinsuke Shiotsu, Chieko Takumi, Seiko Ono, Noriya Hiraoka. Prolonged persistence of SARS-CoV-2 infection during A+AVD therapy for classical Hodgkin's lymphoma: A case report. Current problems in cancer. 2021 12; 45(6):100739. doi: 10.1016/j.currproblcancer.2021.100739. [PMID: 33810911]
  • Stéphane Culine, Valentin Harter, Gwenaelle Gravis, Aude Fléchon, Christine Chevreau, Hakim Mahammedi, Brigitte Laguerre, Aline Guillot, Florence Joly, Sophie Abadie-Lacourtoisie, Lionnel Geoffrois, Frédéric Di Fiore, Guilhem Roubaud, Philippe Barthélémy, Eric Voog, Sheik Emambux, Camille Serrate, Carolina Saldana, Thierry Nguyen-Tan-Hon, Yohann Loriot, Jean-Christophe Eymard, Olivier Huillard, Frédéric Rolland, Nadine Houédé, Jean-Philippe Spano, Mounira El Demery, Sabine Vieillot, Tifenn L'Haridon, Werner Hilgers, Yves Allory, Christian Pfister. Chemotherapy for Muscle-invasive Bladder Cancer: Impact of Cisplatin Delivery on Renal Function and Local Control Rate in the Randomized Phase III VESPER (GETUG-AFU V05) Trial. Clinical genitourinary cancer. 2021 12; 19(6):554-562. doi: 10.1016/j.clgc.2021.08.005. [PMID: 34602349]
  • Natalja Kulagina, Grégory Guirimand, Céline Melin, Pamela Lemos-Cruz, Ines Carqueijeiro, Johan-Owen De Craene, Audrey Oudin, Vladimir Heredia, Konstantinos Koudounas, Marianne Unlubayir, Arnaud Lanoue, Nadine Imbault, Benoit St-Pierre, Nicolas Papon, Marc Clastre, Nathalie Giglioli-Guivarc'h, Jillian Marc, Sébastien Besseau, Vincent Courdavault. Enhanced bioproduction of anticancer precursor vindoline by yeast cell factories. Microbial biotechnology. 2021 11; 14(6):2693-2699. doi: 10.1111/1751-7915.13898. [PMID: 34302444]
  • Shamsher Ali, Eric Hénon, Ritchy Leroy, Georges Massiot. Addition of Vindoline to p-Benzoquinone: Regiochemistry, Stereochemistry and Symmetry Considerations. Molecules (Basel, Switzerland). 2021 Oct; 26(21):. doi: 10.3390/molecules26216395. [PMID: 34770804]
  • Oktay Perk, Tanıl Kendirli, Handan Dinçaslan, Ebru Azapağası, Gokcen Meral. Overlap Stevens Johnson Syndrome/Toxic Epidermal Necrolysis developed due to the use of toxic-dose vinblastine in case of Langerhans Cell Histiocytosis(Letterer-Siwe). Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 2021 Oct; 60(5):103173. doi: 10.1016/j.transci.2021.103173. [PMID: 34215518]
  • Tengfei Liu, Ying Huang, Lihong Jiang, Chang Dong, Yuanwei Gou, Jiazhang Lian. Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae. Communications biology. 2021 09; 4(1):1089. doi: 10.1038/s42003-021-02617-w. [PMID: 34531512]
  • Pamela Lemos Cruz, Natalja Kulagina, Grégory Guirimand, Johan-Owen De Craene, Sébastien Besseau, Arnaud Lanoue, Audrey Oudin, Nathalie Giglioli-Guivarc'h, Nicolas Papon, Marc Clastre, Vincent Courdavault. Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories. Molecules (Basel, Switzerland). 2021 Jun; 26(12):. doi: 10.3390/molecules26123596. [PMID: 34208368]
  • Minghui Kang, Rao Fu, Pingyu Zhang, Shangling Lou, Xuchen Yang, Yang Chen, Tao Ma, Yang Zhang, Zhenxiang Xi, Jianquan Liu. A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis. Nature communications. 2021 06; 12(1):3531. doi: 10.1038/s41467-021-23872-9. [PMID: 34112794]
  • David D'Andrea, Surena Matin, Peter C Black, Firas G Petros, Homayoun Zargar, Colin P Dinney, Michael S Cookson, Wassim Kassouf, Marc A Dall'Era, John S McGrath, Jonathan L Wright, Andrew C Thorpe, Todd M Morgan, Jeffrey M Holzbeierlein, Trinity J Bivalacqua, Srikala S Sridhar, Scott North, Daniel A Barocas, Yair Lotan, Andrew J Stephenson, Bas W van Rhijn, Philippe E Spiess, Siamak Daneshmand, Shahrokh F Shariat. Comparative effectiveness of neoadjuvant chemotherapy in bladder and upper urinary tract urothelial carcinoma. BJU international. 2021 05; 127(5):528-537. doi: 10.1111/bju.15253. [PMID: 32981193]
  • Buket Kara, Kubilay K Kart, Yavuz Koksal. A Prolonged Activated Partial Thromboplastin Time in a Child With Hodgkin Lymphoma. Journal of pediatric hematology/oncology. 2021 04; 43(3):e401-e403. doi: 10.1097/mph.0000000000001732. [PMID: 32000198]
  • Ying Liu, Li-Ying Sun, Zhi-Jun Zhu, Lin Wei, Wei Qu, Lin Wang, Lei-Lei Yuan, Zhi-Gui Zeng. Post-transplant lymphoproliferative disorder after paediatric liver transplantation. International journal of clinical practice. 2021 Apr; 75(4):e13843. doi: 10.1111/ijcp.13843. [PMID: 33222369]
  • Kenji Zennami, Makoto Sumitomo, Kiyoshi Takahara, Takuhisa Nukaya, Masashi Takenaka, Kosuke Fukaya, Manabu Ichino, Naohiko Fukami, Hitomi Sasaki, Mamoru Kusaka, Ryoichi Shiroki. Two cycles of neoadjuvant chemotherapy improves survival in patients with high-risk upper tract urothelial carcinoma. BJU international. 2021 03; 127(3):332-339. doi: 10.1111/bju.15230. [PMID: 32896105]
  • Guilherme Machado Xavier, André Luiz Sena Guimarães, Carlos Alberto de Carvalho Fraga, Talita Antunes Guimarães, Marcela Gonçalves de Souza, Kimberly Marie Jones, Lucyana Conceição Farias. Pathways Related to the Anti-Cancer Effects of Metabolites Derived from Cerrado Biome Native Plants: An Update and Bioinformatics Analysis on Oral Squamous Cell Carcinoma. Protein and peptide letters. 2021; 28(7):735-749. doi: 10.2174/0929866527999201209221012. [PMID: 33302827]
  • Matthew R Trendowski, Heather E Wheeler, Omar El-Charif, Darren R Feldman, Robert J Hamilton, David J Vaughn, Chunkit Fung, Christian Kollmannsberger, Lawrence H Einhorn, Lois B Travis, M Eileen Dolan. Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 12; 26(24):6550-6558. doi: 10.1158/1078-0432.ccr-20-2682. [PMID: 32998964]
  • Mediline Goboza, Mervin Meyer, Yapo G Aboua, Oluwafemi O Oguntibeju. In Vitro Antidiabetic and Antioxidant Effects of Different Extracts of Catharanthus roseus and Its Indole Alkaloid, Vindoline. Molecules (Basel, Switzerland). 2020 Nov; 25(23):. doi: 10.3390/molecules25235546. [PMID: 33256043]
  • Wen-Fang Yi, Xiao Ding, Yuan-Zhi Chen, Tiwalade A Adelakun, Yu Zhang, Xiao-Jiang Hao. Tabernaesines A-I, Cytotoxic Aspidosperma-Aspidosperma-Type Bisindole Alkaloids from Tabernaemontana pachysiphon. Journal of natural products. 2020 11; 83(11):3215-3222. doi: 10.1021/acs.jnatprod.9b00768. [PMID: 33112136]
  • Oleg O Glebov. Understanding SARS-CoV-2 endocytosis for COVID-19 drug repurposing. The FEBS journal. 2020 09; 287(17):3664-3671. doi: 10.1111/febs.15369. [PMID: 32428379]
  • Brendan O'Kelly, Padraig McGettrick, Daniel Angelov, Michael Fay, Tara McGinty, Aoife G Cotter, Gerard Sheehan, John S Lambert. Outcome of a patient with refractory Hodgkin lymphoma on pembrolizumab, infected with SARS-CoV-2. British journal of haematology. 2020 Jul; 190(1):e1-e3. doi: 10.1111/bjh.16798. [PMID: 32379903]
  • Zhili Jin, Yini Wang, Na Wei, Zhao Wang. Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis-a dangerous disease. Annals of hematology. 2020 Jul; 99(7):1575-1581. doi: 10.1007/s00277-020-04093-4. [PMID: 32500223]
  • Nerea Arratibel, Eduardo Sobejano, Jose Carlos Moran, Luis G Diaz, Almudena Blázquez, Mónica Baile, Álvaro Veiga, Maria Dolores Caballero, Ramón García-Sanz. A Case of Paraneoplastic Cerebellar Degeneration that Preceded the Diagnosis of Classical Hodgkin's Lymphoma by 16 Months. The American journal of case reports. 2020 Jun; 21(?):e922342. doi: 10.12659/ajcr.922342. [PMID: 32574156]
  • Anamika Das, Sutanu Sarkar, Somnath Bhattacharyya, Saikat Gantait. Biotechnological advancements in Catharanthus roseus (L.) G. Don. Applied microbiology and biotechnology. 2020 Jun; 104(11):4811-4835. doi: 10.1007/s00253-020-10592-1. [PMID: 32303816]
  • Ramalingam Parthasarathy, Rajasree Shanmuganathan, Arivalagan Pugazhendhi. Vinblastine production by the endophytic fungus Curvularia verruculosa from the leaves of Catharanthus roseus and its in vitro cytotoxicity against HeLa cell line. Analytical biochemistry. 2020 03; 593(?):113530. doi: 10.1016/j.ab.2019.113530. [PMID: 31794703]
  • Premanand Krishnan, Fong-Kai Lee, Veronica Alicia Yap, Yun-Yee Low, Toh-Seok Kam, Kien-Thai Yong, Kang-Nee Ting, Kuan-Hon Lim. Schwarzinicines A-G, 1,4-Diarylbutanoid-Phenethylamine Conjugates from the Leaves of Ficus schwarzii. Journal of natural products. 2020 01; 83(1):152-158. doi: 10.1021/acs.jnatprod.9b01160. [PMID: 31935094]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Diamond L McGehee, Mohammad Alimohammadi, Mariya V Khodakovskaya. Carbon-based nanomaterials as stimulators of production of pharmaceutically active alkaloids in cell culture of Catharanthus roseus. Nanotechnology. 2019 Jul; 30(27):275102. doi: 10.1088/1361-6528/ab1286. [PMID: 30901766]
  • Yongliang Liu, Barunava Patra, Sitakanta Pattanaik, Ying Wang, Ling Yuan. GATA and Phytochrome Interacting Factor Transcription Factors Regulate Light-Induced Vindoline Biosynthesis in Catharanthus roseus. Plant physiology. 2019 07; 180(3):1336-1350. doi: 10.1104/pp.19.00489. [PMID: 31123092]
  • Yuki Yokota, Kazutaka Mitsuke, Hiroko Minami, Akihiko Morita, Hiromichi Takahashi, Satoshi Kamei. [Acute sensory neuropathy associated with Hodgkin's lymphoma: a case study]. Rinsho shinkeigaku = Clinical neurology. 2019 Jun; 59(6):349-355. doi: 10.5692/clinicalneurol.cn-001271. [PMID: 31142709]
  • Yongyan Zhu, Ruixuan Liu, Haoji Huang, Quanhong Zhu. Vinblastine-Loaded Nanoparticles with Enhanced Tumor-Targeting Efficiency and Decreasing Toxicity: Developed by One-Step Molecular Imprinting Process. Molecular pharmaceutics. 2019 06; 16(6):2675-2689. doi: 10.1021/acs.molpharmaceut.9b00243. [PMID: 31050894]
  • Sebastián J Castro, Carina N Casero, José M Padrón, Viviana E Nicotra. Selective Antiproliferative Withanolides from Species in the Genera Eriolarynx and Deprea. Journal of natural products. 2019 05; 82(5):1338-1344. doi: 10.1021/acs.jnatprod.9b00117. [PMID: 31070367]
  • Mediline Goboza, Yapo G Aboua, Novel Chegou, Oluwafemi O Oguntibeju. Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Apr; 112(?):108638. doi: 10.1016/j.biopha.2019.108638. [PMID: 30784928]
  • Yang Qu, Olga Safonova, Vincenzo De Luca. Completion of the canonical pathway for assembly of anticancer drugs vincristine/vinblastine in Catharanthus roseus. The Plant journal : for cell and molecular biology. 2019 01; 97(2):257-266. doi: 10.1111/tpj.14111. [PMID: 30256480]
  • Aruna Sharma, Rudy J Castellani, Mark A Smith, Dafin Fior Muresanu, Prasanta Kumar Dey, Hari Shanker Sharma. 5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology. International review of neurobiology. 2019; 146(?):1-44. doi: 10.1016/bs.irn.2019.06.005. [PMID: 31349924]
  • Alessandro Gamboni, Claudia Casanova, Vincenzo Salerno, Claudio Dazzi. [Activity and efficacy of vinflunine in third line in patients with advanced urothelial carcinoma of the renal pelvis, progressing to immunotherapy.]. Recenti progressi in medicina. 2018 Nov; 109(11):547-550. doi: 10.1701/3031.30292. [PMID: 30565574]
  • Mark L Schultz, Kelsey L Krus, Susmita Kaushik, Derek Dang, Ravi Chopra, Ling Qi, Vikram G Shakkottai, Ana Maria Cuervo, Andrew P Lieberman. Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD. Nature communications. 2018 09; 9(1):3671. doi: 10.1038/s41467-018-06115-2. [PMID: 30202070]
  • Abhishek Sharma, Priyanka Verma, Archana Mathur, Ajay Kumar Mathur. Overexpression of tryptophan decarboxylase and strictosidine synthase enhanced terpenoid indole alkaloid pathway activity and antineoplastic vinblastine biosynthesis in Catharanthus roseus. Protoplasma. 2018 Sep; 255(5):1281-1294. doi: 10.1007/s00709-018-1233-1. [PMID: 29508069]
  • Lakshmi Mohan, Darpan Raghav, Shabeeba M Ashraf, Jomon Sebastian, Krishnan Rathinasamy. Indirubin, a bis-indole alkaloid binds to tubulin and exhibits antimitotic activity against HeLa cells in synergism with vinblastine. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Sep; 105(?):506-517. doi: 10.1016/j.biopha.2018.05.127. [PMID: 29883946]
  • Huyen T Tran, Eva-Maria Pferschy-Wenzig, Nadine Kretschmer, Olaf Kunert, Loi Huynh, Rudolf Bauer. Antiproliferative Carvotacetones from Sphaeranthus africanus. Journal of natural products. 2018 08; 81(8):1829-1834. doi: 10.1021/acs.jnatprod.8b00309. [PMID: 30074787]
  • Chenghui Huang, Hui Wu, Haihua Zhu, Lan Liu, Ruifang Tian, Cong Xu, Xiaofei Li, Lihui Wang, Ke Cao, Peiguo Cao. [NAPD regimen for patients with recurrent refractory diffuse large B-cell lymphoma]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2018 Jul; 43(7):754-759. doi: 10.11817/j.issn.1672-7347.2018.07.009. [PMID: 30124211]
  • Lorenzo Caputi, Jakob Franke, Scott C Farrow, Khoa Chung, Richard M E Payne, Trinh-Don Nguyen, Thu-Thuy T Dang, Inês Soares Teto Carqueijeiro, Konstantinos Koudounas, Thomas Dugé de Bernonville, Belinda Ameyaw, D Marc Jones, Ivo Jose Curcino Vieira, Vincent Courdavault, Sarah E O'Connor. Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle. Science (New York, N.Y.). 2018 06; 360(6394):1235-1239. doi: 10.1126/science.aat4100. [PMID: 29724909]
  • Wen-Qiong Wang, Shan-Shan Liu, Wei-Bin Song, Jun Li, Li-Jiang Xuan. Resin glycosides from the seeds of Ipomoea muricata and their multidrug resistance reversal activities. Phytochemistry. 2018 May; 149(?):24-30. doi: 10.1016/j.phytochem.2018.01.020. [PMID: 29448078]
  • Caroline J Reddel, Gabrielle J Pennings, Jennifer L Curnow, Vivien M Chen, Leonard Kritharides. Procoagulant Effects of Low-Level Platelet Activation and Its Inhibition by Colchicine. Thrombosis and haemostasis. 2018 04; 118(4):723-733. doi: 10.1055/s-0038-1636915. [PMID: 29554700]
  • Yu Zhang, Yu-Xi Yuan, Masuo Goto, Ling-Li Guo, Xiao-Nian Li, Susan L Morris-Natschke, Kuo-Hsiung Lee, Xiao-Jiang Hao. Taburnaemines A-I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa. Journal of natural products. 2018 03; 81(3):562-571. doi: 10.1021/acs.jnatprod.7b00949. [PMID: 29319316]
  • Yang Qu, Antje M K Thamm, Matthew Czerwinski, Sayaka Masada, Kyung Hee Kim, Graham Jones, Ping Liang, Vincenzo De Luca. Geissoschizine synthase controls flux in the formation of monoterpenoid indole alkaloids in a Catharanthus roseus mutant. Planta. 2018 Mar; 247(3):625-634. doi: 10.1007/s00425-017-2812-7. [PMID: 29147812]
  • Xiao-Ning Zhang, Jia Liu, Yang Liu, Yu Wang, Ann Abozeid, Zhi-Guo Yu, Zhong-Hua Tang. Metabolomics Analysis Reveals that Ethylene and Methyl Jasmonate Regulate Different Branch Pathways to Promote the Accumulation of Terpenoid Indole Alkaloids in Catharanthus roseus. Journal of natural products. 2018 02; 81(2):335-342. doi: 10.1021/acs.jnatprod.7b00782. [PMID: 29406718]
  • Bilal Ahmad, Anindyajit Banerjee, Harshita Tiwari, Shrabasti Jana, Sudeshna Bose, Saikat Chakrabarti. Structural and functional characterization of the Vindoline biosynthesis pathway enzymes of Catharanthus roseus. Journal of molecular modeling. 2018 Feb; 24(3):53. doi: 10.1007/s00894-018-3590-2. [PMID: 29442186]
  • Lakshmi, Sanjay Singh, Mahalingam Rajamanickam Vijayakumar, Hitesh Kumar Dewangan. Lipid Based Aqueous Core Nanocapsules (ACNs) for Encapsulating Hydrophillic Vinorelbine Bitartrate: Preparation, Optimization, Characterization and In vitro Safety Assessment for Intravenous Administration. Current drug delivery. 2018; 15(9):1284-1293. doi: 10.2174/1567201815666180716112457. [PMID: 30009708]
  • Alison Edge, Yang Qu, Michael L A E Easson, Antje M K Thamm, Kyung Hee Kim, Vincenzo De Luca. A tabersonine 3-reductase Catharanthus roseus mutant accumulates vindoline pathway intermediates. Planta. 2018 Jan; 247(1):155-169. doi: 10.1007/s00425-017-2775-8. [PMID: 28894945]
  • Lakshmi Maurya, Sanjay Singh, Vijayakumar M Rajamanickam, Gopeshwar Narayan. Vitamin E TPGS Emulsified Vinorelbine Bitartrate Loaded Solid Lipid Nanoparticles (SLN): Formulation Development, Optimization and In vitro Characterization. Current drug delivery. 2018; 15(8):1135-1145. doi: 10.2174/1567201815666180409105410. [PMID: 29629662]
  • Charlotte Luchsinger, Marcelo Aguilar, Patricia V Burgos, Pamela Ehrenfeld, Gonzalo A Mardones. Functional disruption of the Golgi apparatus protein ARF1 sensitizes MDA-MB-231 breast cancer cells to the antitumor drugs Actinomycin D and Vinblastine through ERK and AKT signaling. PloS one. 2018; 13(4):e0195401. doi: 10.1371/journal.pone.0195401. [PMID: 29614107]
  • Xiaoliang Zhao, Xiaohua Wen, Wei Wei, Yanjun Su, Jian You, Liqun Gong, Zhenfa Zhang, Meng Wang, Jianyu Xiao, Xiyin Wei, Changli Wang. Predictors for the efficacy of Endostar combined with neoadjuvant chemotherapy for stage IIIA (N2) NSCLC. Cancer biomarkers : section A of Disease markers. 2017 Dec; 21(1):169-177. doi: 10.3233/cbm-170565. [PMID: 29036790]
  • Agnieszka Krawczyk, Dariusz Nowak, Piotr Jan Nowak, Gianluca Padula, Sylwia Kwiatkowska. Elevated exhalation of hydrogen peroxide in patients with non-small cell lung cancer is not affected by chemotherapy. Redox report : communications in free radical research. 2017 Nov; 22(6):308-314. doi: 10.1080/13510002.2016.1229885. [PMID: 27611345]
  • A Guidetti, A Mazzocchi, R Miceli, E Paterno', F Taverna, F Spina, F Crippa, L Farina, P Corradini, A M Gianni, S Viviani. Early reduction of serum TARC levels may predict for success of ABVD as frontline treatment in patients with Hodgkin Lymphoma. Leukemia research. 2017 11; 62(?):91-97. doi: 10.1016/j.leukres.2017.09.018. [PMID: 28992524]
  • Xiaobin Gong, Le Yang, Feng Zhang, Youtian Liang, Shouhong Gao, Ke Liu, Wansheng Chen. Validated UHPLC-MS/MS assay for quantitative determination of etoposide, gemcitabine, vinorelbine and their metabolites in patients with lung cancer. Biomedical chromatography : BMC. 2017 Nov; 31(11):. doi: 10.1002/bmc.3989. [PMID: 28409868]
  • Minfeng Chen, Xueping Lei, Changzheng Shi, Maohua Huang, Xiaobo Li, Baojian Wu, Zhengqiu Li, Weili Han, Bin Du, Jianyang Hu, Qiulin Nie, Weiqian Mai, Nan Ma, Nanhui Xu, Xinyi Zhang, Chunlin Fan, Aihua Hong, Minghan Xia, Liangping Luo, Ande Ma, Hongsheng Li, Qiang Yu, Heru Chen, Dongmei Zhang, Wencai Ye. Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. The Journal of clinical investigation. 2017 Oct; 127(10):3689-3701. doi: 10.1172/jci94258. [PMID: 28846068]
  • Ezequiel Cordova, Laura Morganti, Andrea Odzak, Florencia Arcondo, Mariana Silva, Marcelo Zylberman, Claudia Rodriguez. Severe hypokalemia due to a possible drug-drug interaction between vinblastine and antiretrovirals in a HIV-infected patient with Hodgkin's lymphoma. International journal of STD & AIDS. 2017 10; 28(12):1259-1262. doi: 10.1177/0956462417703026. [PMID: 28403692]
  • Kewen He, Xinzhao Wang, Xiyun Guan, Qian Yu, Qinghua Ma, Zhaoyun Liu, Zhiyong Yu. Vinorelbine Plus Gemcitabine or Cisplatin as First-line Treatment of HER2-negative Advanced Breast Cancer. Anticancer research. 2017 10; 37(10):5647-5653. doi: 10.21873/anticanres.12000. [PMID: 28982882]
  • Esmaeel Haghshenas, Tayyebeh Madrakian, Abbas Afkhami, Haidar Saify Nabiabad. A label-free electrochemical biosensor based on tubulin immobilized on gold nanoparticle/glassy carbon electrode for the determination of vinblastine. Analytical and bioanalytical chemistry. 2017 Sep; 409(22):5269-5278. doi: 10.1007/s00216-017-0471-y. [PMID: 28667386]
  • Yuqian Zhang, Yupeng Sun, Xiyan Mu, Lin Yuan, Qiao Wang, Lantong Zhang. Identification of metabolites of vindoline in rats using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Aug; 1060(?):126-137. doi: 10.1016/j.jchromb.2017.05.038. [PMID: 28609700]
  • Jesús Muñoz-Rojas. Importance of producing economic compounds to combat cancer. Microbial biotechnology. 2017 07; 10(4):683-684. doi: 10.1111/1751-7915.12491. [PMID: 28127869]
  • Jun-Jie Ma, Hui-Ping Liu. Efficacy of Aidi Injection () on overexpression of P-glycoprotein induced by vinorelbine and cisplatin regimen in patients with non-small cell lung cancer. Chinese journal of integrative medicine. 2017 Jul; 23(7):504-509. doi: 10.1007/s11655-016-2511-4. [PMID: 27484766]
  • Farah Wahida Ayob, Khanom Simarani, Nurhayati Zainal Abidin, Jamaludin Mohamad. First report on a novel Nigrospora sphaerica isolated from Catharanthus roseus plant with anticarcinogenic properties. Microbial biotechnology. 2017 07; 10(4):926-932. doi: 10.1111/1751-7915.12603. [PMID: 28612376]
  • Jia-Shuan Wu, Li-Min Mu, Ying-Zi Bu, Lei Liu, Yan Yan, Ying-Jie Hu, Jing Bai, Jing-Ying Zhang, Weiyue Lu, Wan-Liang Lu. C-type natriuretic peptide-modified lipid vesicles: fabrication and use for the treatment of brain glioma. Oncotarget. 2017 Jun; 8(25):40906-40921. doi: 10.18632/oncotarget.16641. [PMID: 28402948]
  • Li-Min Mu, Ying-Zi Bu, Lei Liu, Hong-Jun Xie, Rui-Jun Ju, Jia-Shuan Wu, Fan Zeng, Yao Zhao, Jing-Ying Zhang, Wan-Liang Lu. Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells. Scientific reports. 2017 06; 7(1):3487. doi: 10.1038/s41598-017-03805-7. [PMID: 28615716]
  • Daniel G Rosas-Ramírez, Mabel Fragoso-Serrano, Sonia Escandón-Rivera, Alba L Vargas-Ramírez, Juan P Reyes-Grajeda, Manuel Soriano-García. Resistance-modifying Activity in Vinblastine-resistant Human Breast Cancer Cells by Oligosaccharides Obtained from Mucilage of Chia Seeds (Salvia hispanica). Phytotherapy research : PTR. 2017 Jun; 31(6):906-914. doi: 10.1002/ptr.5815. [PMID: 28425219]
  • Mavis Jiarong Li, Abhinav Nath, William M Atkins. Differential Coupling of Binding, ATP Hydrolysis, and Transport of Fluorescent Probes with P-Glycoprotein in Lipid Nanodiscs. Biochemistry. 2017 05; 56(19):2506-2517. doi: 10.1021/acs.biochem.6b01245. [PMID: 28441502]
  • Hongyang Li, Li Sun, Hang Li, Xiaodan Lv, Herve Semukunzi, Ruiming Li, Jun Yu, Shengtao Yuan, Sensen Lin. DT-13, a saponin monomer 13 of the Dwarf lilyturf tuber, synergized with vinorelbine to induce mitotic arrest via activation of ERK signaling pathway in NCI-H1299 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 May; 89(?):1277-1285. doi: 10.1016/j.biopha.2017.02.104. [PMID: 28320095]