Lovastatin (BioDeep_00000398731)

Main id: BioDeep_00000000231

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


Lovastatin (Mevacor)

化学式: C24H36O5 (404.2562606)
中文名称: 洛伐他汀
谱图信息: 最多检出来源 Homo sapiens(urine) 1.96%

分子结构信息

SMILES: C1[C@H](C=C2[C@]([C@@H]1OC(=O)[C@H](CC)C)([C@@H]([C@H](C=C2)C)CC[C@H]3OC(C[C@@H](C3)O)=O)[H])C
InChI: InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3

描述信息

C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AA - Hmg coa reductase inhibitors
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D004791 - Enzyme Inhibitors > D019161 - Hydroxymethylglutaryl-CoA Reductase Inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
C471 - Enzyme Inhibitor > C1655 - HMG-CoA Reductase Inhibitor
CONFIDENCE standard compound; INTERNAL_ID 2212
D009676 - Noxae > D000963 - Antimetabolites
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.415
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.416
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.421
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.419
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

同义名列表

3 个代谢物同义名

Lovastatin; Lovastatin (Mevacor); Mevinolin



数据库引用编号

55 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fei Liu, Xinyi Qiao, Qin Li, Jiajun Zhou, Jie Gao, Feng He, Peng Wu, Chunmei Chen, Weiguang Sun, Hucheng Zhu, Yonghui Zhang. Aculeatiols A-G: Lovastatin Derivatives Extracted from Aspergillus aculeatus. Journal of natural products. 2024 Apr; 87(4):753-763. doi: 10.1021/acs.jnatprod.3c00872. [PMID: 38372239]
  • Giuseppe Danilo Norata, Maciej Banach. The Impact of Red Yeast Rice Extract Use on the Occurrence of Muscle Symptoms and Liver Dysfunction: An Update from the Adverse Event Reporting Systems and Available Meta-Analyses. Nutrients. 2024 Feb; 16(3):. doi: 10.3390/nu16030444. [PMID: 38337728]
  • Yunxia Gong, Shengfa Li, Qianrui Liu, Fusheng Chen, Yanchun Shao. CRISPR/Cas9 system is a suitable gene targeting editing tool to filamentous fungus Monascus pilosus. Applied microbiology and biotechnology. 2024 Jan; 108(1):154. doi: 10.1007/s00253-023-12865-x. [PMID: 38240803]
  • Chanjuan Zheng, Hui Yao, Lu Lu, Hongqi Li, Lei Zhou, Xueyan He, Xi Xu, Hongzhuo Xia, Siyu Ding, Yiyuan Yang, Xinyu Wang, Muyao Wu, Lian Xue, Sisi Chen, Xiaojun Peng, Zhongyi Cheng, Yian Wang, Guangchun He, Shujun Fu, Evan T Keller, Suling Liu, Yi-Zhou Jiang, Xiyun Deng. Dysregulated Ribosome Biogenesis Is a Targetable Vulnerability in Triple-Negative Breast Cancer: MRPS27 as a Key Mediator of the Stemness-inhibitory Effect of Lovastatin. International journal of biological sciences. 2024; 20(6):2130-2148. doi: 10.7150/ijbs.94058. [PMID: 38617541]
  • Momoko Gyoten, Yi Luo, Rina Fujiwara-Tani, Shiori Mori, Ruiko Ogata, Shingo Kishi, Hiroki Kuniyasu. Lovastatin Treatment Inducing Apoptosis in Human Pancreatic Cancer Cells by Inhibiting Cholesterol Rafts in Plasma Membrane and Mitochondria. International journal of molecular sciences. 2023 Nov; 24(23):. doi: 10.3390/ijms242316814. [PMID: 38069135]
  • Siyuan Shen, Jun Wang, Chenchen Ma, Yanni Chen, Hao Ding, Jiachao Zhang. Understanding the "individual drug reaction" from the perspective of the interaction between probiotics and lovastatin in vitro and in vivo. Microbiome. 2023 Sep; 11(1):209. doi: 10.1186/s40168-023-01658-z. [PMID: 37749663]
  • Minghui Wu, Qiqi Wang, Han Zhang, Zhengyong Pan, Qilu Zeng, Weizhen Fang, Jilong Mao, Jianpeng Li, Han Wu, Zhongping Qiu. Performance and mechanism of co-culture of Monascus purpureus, Lacticaseibacillus casei, and Saccharomyces cerevisiae to enhance lovastatin production and lipid-lowering effects. Bioprocess and biosystems engineering. 2023 Sep; ?(?):. doi: 10.1007/s00449-023-02903-3. [PMID: 37688635]
  • Guangshan Yao, Na Han, Huawei Zheng, Lu Wang. The Histone Deacetylase HstD Regulates Fungal Growth, Development and Secondary Metabolite Biosynthesis in Aspergillus terreus. International journal of molecular sciences. 2023 Aug; 24(16):. doi: 10.3390/ijms241612569. [PMID: 37628749]
  • Aleksandar Kuzmanov, Souzan Salemi, Florian A Schmid, Irene A Burger, Daniel Eberli, Benedikt Kranzbühler. Improved Prostate-Specific Membrane Antigen (PSMA) Stimulation Using a Super Additive Effect of Dutasteride and Lovastatin In Vitro. International journal of molecular sciences. 2023 Aug; 24(15):. doi: 10.3390/ijms241512338. [PMID: 37569712]
  • Saeid Mirzai, Luke J Laffin. Supplements for Lipid Lowering: What Does the Evidence Show?. Current cardiology reports. 2023 Jun; ?(?):. doi: 10.1007/s11886-023-01903-9. [PMID: 37300664]
  • Nicholas Angelopoulos, Rodis D Paparodis, Ioannis Androulakis, Anastasios Boniakos, Georgia Argyrakopoulou, Sarantis Livadas. Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial. Nutrients. 2023 Jun; 15(12):. doi: 10.3390/nu15122682. [PMID: 37375586]
  • Shaojun Chen, Jiahao Lv, Yiyuan Luo, Hongjiang Chen, Shuwei Ma, Lihua Zhang. Bioinformatic Analysis of Key Regulatory Genes in Adult Asthma and Prediction of Potential Drug Candidates. Molecules (Basel, Switzerland). 2023 May; 28(10):. doi: 10.3390/molecules28104100. [PMID: 37241840]
  • Arrigo F G Cicero, Federica Fogacci, Anca Pantea Stoian, Peter P Toth. Red Yeast Rice for the Improvement of Lipid Profiles in Mild-to-Moderate Hypercholesterolemia: A Narrative Review. Nutrients. 2023 May; 15(10):. doi: 10.3390/nu15102288. [PMID: 37242171]
  • Andrea Da Porto, Debora Donnini, Fabio Vanin, Arianna Romanin, Martina Antonello, Paolo Toritto, Eleonora Varisco, Gabriele Brosolo, Cristiana Catena, Leonardo A Sechi, Giorgio Soardo. Effects of Monacolin K in Nondiabetic Patients with NAFLD: A Pilot Study. Nutrients. 2023 Apr; 15(8):. doi: 10.3390/nu15081887. [PMID: 37111106]
  • Tzu-Shing Lin, Shih-Hau Chiu, Chien-Chi Chen, Chih-Hui Lin. Investigation of monacolin K, yellow pigments, and citrinin production capabilities of Monascus purpureus and Monascus ruber (Monascus pilosus). Journal of food and drug analysis. 2023 Mar; 31(1):85-94. doi: 10.38212/2224-6614.3438. [PMID: 37224553]
  • Shuai Wang, Yumei Feng, Yin Lou, Jingping Niu, Congcong Yin, Jinzhong Zhao, Weijun Du, Aiqin Yue. 3-Hydroxy-3-methylglutaryl coenzyme A reductase genes from Glycine max regulate plant growth and isoprenoid biosynthesis. Scientific reports. 2023 03; 13(1):3902. doi: 10.1038/s41598-023-30797-4. [PMID: 36890158]
  • Senthamarai Manogaran, Kannan Kilavan Packiam, P Senthil Kumar, Gayathri Rangasamy, A Saravanan. Utilization of industrial waste - Liquid cheese whey for the batch fermentation of lovastatin using Fusarium nectrioides (MH173849) an endophytic fungus: Screening, production and characterization. Chemosphere. 2023 Mar; 318(?):137947. doi: 10.1016/j.chemosphere.2023.137947. [PMID: 36706809]
  • Carlo Cervellati, Alessandro Trentini, Valentina Rosta, Giovanni Zuliani, Francesco Vieceli Dalla Sega, Francesca Fortini, Paola Rizzo, Paolo Cimaglia, Gianluca Campo. A Nutraceutical Compound Containing a Low Dose of Monacolin K, Polymethoxyflavones, Phenolic Acids, Flavonoids, and Hydroxytyrosol Improves HDL Functionality. Current vascular pharmacology. 2023 Feb; ?(?):. doi: 10.2174/1570161121666230221142131. [PMID: 36824007]
  • Qiu-Wan Sun, Hou-Sheng Hong. Research Progress on Gene Synthesis and Anticancer and Lipid-lowering Mechanism of Monacolin K. Anti-cancer agents in medicinal chemistry. 2023 Feb; ?(?):. doi: 10.2174/1871520623666230207122157. [PMID: 36748820]
  • Janani Balraj, Thandeeswaran Murugesan, Anand Raj Dhanapal, Vidhya Kalieswaran, Karunyadevi Jairaman, Govindaraju Archunan, Angayarkanni Jayaraman. Bioconversion of lovastatin to simvastatin by Streptomyces carpaticus toward the inhibition of HMG-CoA activity. Biotechnology and applied biochemistry. 2022 Dec; ?(?):. doi: 10.1002/bab.2429. [PMID: 36524308]
  • Xinyu Yang, Qifeng Huang, Jitao Xu, Zhen Gao, Xue Jiang, Yuanhua Wu, Wenwu Ye, Yue Liang. Transcriptome reveals BCAAs biosynthesis pathway is influenced by lovastatin and can act as a potential control target in Phytophthora sojae. Journal of applied microbiology. 2022 Dec; 133(6):3585-3595. doi: 10.1111/jam.15792. [PMID: 36000236]
  • Nan Sheng, Yun-Qiu Wang, Cun-Fu Wang, Meng-Qi Jia, Huan-Min Niu, Qi-Qi Lu, Ya-Nan Wang, Dan Feng, Xiao-Xue Zheng, Hui-Qing Yuan. AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin. Acta pharmacologica Sinica. 2022 Nov; 43(11):2905-2916. doi: 10.1038/s41401-022-00909-3. [PMID: 35459869]
  • Shi-You Jiang, Xinglin Yang, Zimo Yang, Jue-Wan Li, Meng-Qiang Xu, Yu-Xiu Qu, Jing-Jie Tang, Yun-Feng Li, Liguo Wang, Yi-Wen Shao, Xin-Yuan Meng, Huili Hu, Bao-Liang Song, Yu Rao, Wei Qi. Discovery of an insulin-induced gene binding compound that ameliorates nonalcoholic steatohepatitis by inhibiting sterol regulatory element-binding protein-mediated lipogenesis. Hepatology (Baltimore, Md.). 2022 11; 76(5):1466-1481. doi: 10.1002/hep.32381. [PMID: 35102596]
  • Antonio Cibelli, Eliana Scemes, David C Spray. Activity and Stability of Panx1 Channels in Astrocytes and Neuroblastoma Cells Are Enhanced by Cholesterol Depletion. Cells. 2022 10; 11(20):. doi: 10.3390/cells11203219. [PMID: 36291086]
  • Li-Juan Lang, Min Wang, Chang Lei, Yi Shen, Qi-Jie Zhu, Hong-Mei Diao, Hao Chen, Lei Shen, Xiang Dong, Bei Jiang, Chao-Jiang Xiao. Phloridzin Highly Accumulated in Malus rockii Rehder and Its Structure Revision and Hypolipidemic Activity. Planta medica. 2022 Oct; 88(13):1190-1198. doi: 10.1055/a-1716-0958. [PMID: 34875697]
  • Liwei Zhang, Yan Shi, Mingzhu Yan, Guangping Zhang. Modulatory action of withaferin-A on oxidative damage through regulation of inflammatory mediators and apoptosis via PI3K/AKT signaling pathway in high cholesterol-induced atherosclerosis in experimental rats. Journal of biochemical and molecular toxicology. 2022 Oct; 36(10):e23154. doi: 10.1002/jbt.23154. [PMID: 35734936]
  • Xianchen Geng, Chun Zhang, Lida Wei, Kai Lin, Zeng-Fu Xu. Genome-Wide Identification and Expression Analysis of Cytokinin Response Regulator (RR) Genes in the Woody Plant Jatropha curcas and Functional Analysis of JcRR12 in Arabidopsis. International journal of molecular sciences. 2022 Sep; 23(19):. doi: 10.3390/ijms231911388. [PMID: 36232689]
  • Maciej Banach, Alberico L Catapano, Arrigo F G Cicero, Carlos Escobar, Bernhard Foger, Niki Katsiki, Gustavs Latkovskis, Michal Rakowski, Zeljko Reiner, Amirhossein Sahebkar, Geeta Sikand, Peter E Penson, On Behalf Of The International Lipid Expert Panel Ilep. Red yeast rice for dyslipidaemias and cardiovascular risk reduction: A position paper of the International Lipid Expert Panel. Pharmacological research. 2022 09; 183(?):106370. doi: 10.1016/j.phrs.2022.106370. [PMID: 35901940]
  • F Martinez-Martin, E Corbella, I Sarasa, F Trias, D Petitbò, M Licerán, R M Sánchez-Hernández, D Martin, A Sánchez, C Arnás, S de Dios, M Florido, X Pintó. Effects of treatment with monacolin K, berberine and coenzyme Q10 on lipid metabolism in patients with moderate cardiovascular risk. Semergen. 2022 Sep; 48(6):403-410. doi: 10.1016/j.semerg.2022.04.005. [PMID: 35606250]
  • Ines Villano, Marco La Marra, Salvatore Allocca, Ciro Rosario Ilardi, Rita Polito, Chiara Porro, Sergio Chieffi, Giovanni Messina, Vincenzo Monda, Girolamo Di Maio, Antonietta Messina. The Role of Nutraceutical Supplements, Monacolin K and Astaxanthin, and Diet in Blood Cholesterol Homeostasis in Patients with Myopathy. Biomolecules. 2022 08; 12(8):. doi: 10.3390/biom12081118. [PMID: 36009012]
  • Olga Protic, Raffaele Di Pillo, Alberto Montesanto, Roberta Galeazzi, Giulia Matacchione, Angelica Giuliani, Jacopo Sabbatinelli, Felicia Gurău, Andrea Silvestrini, Fabiola Olivieri, Roberto Antonicelli, Anna Rita Bonfigli. Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia. Nutrients. 2022 Jul; 14(14):. doi: 10.3390/nu14142812. [PMID: 35889769]
  • Jia Chen, Qi Zheng, Zhenxing Zheng, Yirou Li, Hailang Liao, Hui Zhao, Dale Guo, Yuntong Ma. Analysis of the differences in the chemical composition of monascus rice and highland barley monascus. Food & function. 2022 Jul; 13(13):7000-7019. doi: 10.1039/d2fo00402j. [PMID: 35723016]
  • K S Abdelkawy, Fathalla Belal, AbdelazizE Abdelaziz, H A Elmekawy, M Y Abdelgaied, N M El-Khodary. Statins Increase the Bioavailability of Fixed-Dose Combination of Sofosbuvir/Ledipasvir by Inhibition of P-glycoprotein. Drug research. 2022 Jul; 72(6):319-326. doi: 10.1055/a-1835-1690. [PMID: 35724670]
  • Anan Liu, Amanda Juan Chen, Bingyu Liu, Qian Wei, Jian Bai, Youcai Hu. Investigation of citrinin and monacolin K gene clusters variation among pigment producer Monascus species. Fungal genetics and biology : FG & B. 2022 05; 160(?):103687. doi: 10.1016/j.fgb.2022.103687. [PMID: 35315337]
  • Dinesh Suram, Kishan Veerabrahma. Design and Development of Solid SMEDDS and Liquisolid Formulations of Lovastatin, for Improved Drug Dissolution and In vivo Effects-a Pharmacokinetic and Pharmacodynamic Assessment. AAPS PharmSciTech. 2022 Apr; 23(5):123. doi: 10.1208/s12249-022-02272-2. [PMID: 35460060]
  • Joanna Niedbalska-Tarnowska, Katarzyna Ochenkowska, Marta Migocka-Patrzałek, Magda Dubińska-Magiera. Assessment of the Preventive Effect of L-carnitine on Post-statin Muscle Damage in a Zebrafish Model. Cells. 2022 04; 11(8):. doi: 10.3390/cells11081297. [PMID: 35455976]
  • Chen Benjian, Huang Xiaodan, Peng Huiting, L I Yishi, Cao Yongtao, W U Huanlin, X U Danping. Effectiveness and safety of red yeast rice predominated by monacolin K β-hydroxy acid form for hyperlipidemia treatment and management. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 04; 42(2):264-271. doi: 10.19852/j.cnki.jtcm.2022.02.007. [PMID: 35473348]
  • Andy Wijaya, Yi Wang, Dan Tang, Yuan Zhong, Boyan Liu, Meng Yan, Quhui Jiu, Wei Wu, Guixue Wang. A study of lovastatin and L-arginine co-loaded PLGA nanomedicine for enhancing nitric oxide production and eNOS expression. Journal of materials chemistry. B. 2022 01; 10(4):607-624. doi: 10.1039/d1tb01455b. [PMID: 34994373]
  • Efosa Amadasu, Richard Kang, Ahsan Usmani, Cesario V Borlongan. Effects of Lovastatin on Brain Cancer Cells. Cell transplantation. 2022 Jan; 31(?):9636897221102903. doi: 10.1177/09636897221102903. [PMID: 35670207]
  • Yi Xiao, Qin Liu, Nanyin Peng, Yuzhang Li, Danyang Qiu, Tianlun Yang, Richard Kang, Ahsan Usmani, Efosa Amadasu, Cesario V Borlongan, Guolong Yu. Lovastatin Inhibits RhoA to Suppress Canonical Wnt/β-Catenin Signaling and Alternative Wnt-YAP/TAZ Signaling in Colon Cancer. Cell transplantation. 2022 Jan; 31(?):9636897221075749. doi: 10.1177/09636897221075749. [PMID: 35168393]
  • Shanshan Gao, Fraser Soares, Shiyan Wang, Chi Chun Wong, Huarong Chen, Zhenjie Yang, Weixin Liu, Minnie Y Y Go, Musaddeque Ahmed, Yong Zeng, Catherine Adell O'Brien, Joseph J Y Sung, Housheng Hansen He, Jun Yu. CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer. Oncogene. 2021 12; 40(48):6601-6613. doi: 10.1038/s41388-021-01882-7. [PMID: 34621019]
  • Sajad Karampoor, Khashayar Hesamizadeh, Zinat Shams, Arefeh Ghafari Novin, Mohammad Farahmand, Hamid Zahednasab, Rasoul Mirzaei, Farhad Zamani, Marzieh Hajibaba, Behnaz Bouzari, Azadeh Laali, Alireza Tabibzadeh, Mohammad Hadi Karbalaie Niya, Hossein Keyvani. The role of lovastatin in the attenuation of COVID-19. International immunopharmacology. 2021 Dec; 101(Pt A):108192. doi: 10.1016/j.intimp.2021.108192. [PMID: 34607230]
  • A Hosseinzadeh, S Mehrzadi, M Rezaei, M Badavi, A Nesari, M Goudarzi. Lovastatin attenuates glyoxal-induced toxicity on rat liver mitochondria. Human & experimental toxicology. 2021 Dec; 40(12):2215-2222. doi: 10.1177/09603271211027939. [PMID: 34165024]
  • Firoozeh Farahmand, Akshi Malik, Anita Sharma, Ashim K Bagchi, Pawan K Singal. Role of oxidative stress versus lipids in monocrotaline-induced pulmonary hypertension and right heart failure. Physiological reports. 2021 11; 9(22):e15090. doi: 10.14814/phy2.15090. [PMID: 34816616]
  • Liguo Xie, Guodong Zhu, Junjie Shang, Xuemei Chen, Chunting Zhang, Xiuling Ji, Qi Zhang, Yunlin Wei. An overview on the biological activity and anti-cancer mechanism of lovastatin. Cellular signalling. 2021 11; 87(?):110122. doi: 10.1016/j.cellsig.2021.110122. [PMID: 34438015]
  • Matthew Stephens, Simon Roizes, Pierre-Yves von der Weid. Off-Target Effect of Lovastatin Disrupts Dietary Lipid Uptake and Dissemination through Pro-Drug Inhibition of the Mesenteric Lymphatic Smooth Muscle Cell Contractile Apparatus. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111756. [PMID: 34769187]
  • T Gojkovic, S Vladimirov, J Kotur-Stevuljevic, N Bogavac-Stanojevic, A Zeljkovic, J Vekic, T Antonic, V Spasojevic-Kalimanovska. Effects of monacolin K-containing nutraceutical on cholesterol homeostasis re-establishment and CVD risk reduction in hypercholesterolemic subjects. European review for medical and pharmacological sciences. 2021 Aug; 25(16):5261-5267. doi: 10.26355/eurrev_202108_26546. [PMID: 34486702]
  • Lai Wang, Zu-Guo Zheng, Lingchang Meng, Lijun Zhu, Ping Li, Jun Chen, Hua Yang. Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue. Cell biology and toxicology. 2021 06; 37(3):441-460. doi: 10.1007/s10565-020-09558-w. [PMID: 33034787]
  • Staci L Haney, Michelle L Varney, Yashpal Chhonker, Geoffrey Talmon, Lynette M Smith, Daryl J Murry, Sarah A Holstein. In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway. Pharmacological research. 2021 05; 167(?):105528. doi: 10.1016/j.phrs.2021.105528. [PMID: 33667685]
  • Hatice Nurdan Aksoy, Cagatay Ceylan. Comparison of the Effects of Statins on A549 Nonsmall-Cell Lung Cancer Cell Line Lipids Using Fourier Transform Infrared Spectroscopy: Rosuvastatin Stands Out. Lipids. 2021 05; 56(3):289-299. doi: 10.1002/lipd.12296. [PMID: 33611813]
  • Sara Marcheluzzo, Marta Faggian, Mirella Zancato, Gregorio Peron. Analysis of Monacolins and Berberine in Food Supplements for Lipid Control: An Overview of Products Sold on the Italian Market. Molecules (Basel, Switzerland). 2021 Apr; 26(8):. doi: 10.3390/molecules26082222. [PMID: 33921464]
  • Rafael Guerrero-Bonmatty, Guadalupe Gil-Fernández, Francisco José Rodríguez-Velasco, Jordi Espadaler-Mazo. A Combination of Lactoplantibacillus plantarum Strains CECT7527, CECT7528, and CECT7529 Plus Monacolin K Reduces Blood Cholesterol: Results from a Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2021 Apr; 13(4):. doi: 10.3390/nu13041206. [PMID: 33917503]
  • Giuseppe Mannino, Piera Iovino, Antonino Lauria, Tullio Genova, Alberto Asteggiano, Monica Notarbartolo, Alessandra Porcu, Graziella Serio, Giorgia Chinigò, Andrea Occhipinti, Andrea Capuzzo, Claudio Medana, Luca Munaron, Carla Gentile. Bioactive Triterpenes of Protium heptaphyllum Gum Resin Extract Display Cholesterol-Lowering Potential. International journal of molecular sciences. 2021 Mar; 22(5):. doi: 10.3390/ijms22052664. [PMID: 33800828]
  • Alireza P Shabanzadeh, Jason Charish, Nardos G Tassew, Nahal Farhani, Jinzhou Feng, Xinjue Qin, Shuzo Sugita, Andrea J Mothe, Thomas Wälchli, Paulo D Koeberle, Philippe P Monnier. Cholesterol synthesis inhibition promotes axonal regeneration in the injured central nervous system. Neurobiology of disease. 2021 03; 150(?):105259. doi: 10.1016/j.nbd.2021.105259. [PMID: 33434618]
  • Haruka Ajima, Yuko Kai, Junya Fujimaki, Shiori Akashi, Akihito Morita, Osamu Ezaki, Yasutomi Kamei, Shinji Miura. Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy, including FoxO1 and its targets. The Journal of toxicological sciences. 2021; 46(1):11-24. doi: 10.2131/jts.46.11. [PMID: 33408297]
  • Aaser M Abdelazim, Tamer Ahmed Ismail, Mosleh M Abumaghaid, Islam M Saadaldin. Synergetic Action of Forskolin and Mevastatin Induce Normalization of Lipids Profile in Dyslipidemic Rats through Adenosine Monophosphate Kinase Upregulation. BioMed research international. 2021; 2021(?):6687551. doi: 10.1155/2021/6687551. [PMID: 34104650]
  • Sarah A Long, Shan Huang, Anusha Kambala, Ling Ren, Jennifer Wilson, Michael Goetz, Xiaojiang Hao, Xiaosheng Yang, Ekaterina I Goncharova, Libin Jia, Amy LeBlanc, Chand Khanna, Curtis J Henrich, John A Beutler. Identification of potential modulators of osteosarcoma metastasis by high-throughput cellular screening of natural products. Chemical biology & drug design. 2021 01; 97(1):77-86. doi: 10.1111/cbdd.13762. [PMID: 32666679]
  • Chongyan Zhao, Fang Yang, Feng Lin, Qingsong Qu, Zhixun Li, Xing Liu, Lu Han, Xinyuan Shi. Process optimization in ginseng fermentation by Monascus ruber and study on bile acid-binding ability of fermentation products in vitro. Preparative biochemistry & biotechnology. 2021; 51(2):120-126. doi: 10.1080/10826068.2020.1799389. [PMID: 33342390]
  • G Kumaravel Dinesh, Malavika Pramod, Sankar Chakma. Sonochemical synthesis of amphoteric Cu0-Nanoparticles using Hibiscus rosa-sinensis extract and their applications for degradation of 5-fluorouracil and lovastatin drugs. Journal of hazardous materials. 2020 11; 399(?):123035. doi: 10.1016/j.jhazmat.2020.123035. [PMID: 32512280]
  • A B Sioofy-Khojine, A Honkimaa, H Hyöty. A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses. Diabetic medicine : a journal of the British Diabetic Association. 2020 11; 37(11):1849-1853. doi: 10.1111/dme.14175. [PMID: 31705692]
  • Mengdi Zhang, Zhaoxin Wang, Siyu Hao, Lei Hao, Xinying Zhang, Peng Yu, Hua Sun. Synthesis of natural 3'-Prenylchalconaringenin and biological evaluation of ameliorating non-alcoholic fatty liver disease and metabolic syndrome. European journal of medicinal chemistry. 2020 Nov; 205(?):112649. doi: 10.1016/j.ejmech.2020.112649. [PMID: 32791402]
  • Xiangnan Ren, Zixing Shao, Wu Fan, Zixuan Wang, Kaiyun Chen, Xuefeng Yu. Untargeted metabolomics reveals the effect of lovastatin on steroid-induced necrosis of the femoral head in rabbits. Journal of orthopaedic surgery and research. 2020 Oct; 15(1):497. doi: 10.1186/s13018-020-02026-5. [PMID: 33115522]
  • Agata Krakowska, Piotr Zięba, Anna Włodarczyk, Katarzyna Kała, Katarzyna Sułkowska-Ziaja, Emilia Bernaś, Agnieszka Sękara, Beata Ostachowicz, Bożena Muszyńska. Selected edible medicinal mushrooms from Pleurotus genus as an answer for human civilization diseases. Food chemistry. 2020 Oct; 327(?):127084. doi: 10.1016/j.foodchem.2020.127084. [PMID: 32446029]
  • Florian Padberg, Henrik Hering, Andreas Luch, Sebastian Zellmer. Indirect co-cultivation of HepG2 with differentiated THP-1 cells induces AHR signalling and release of pro-inflammatory cytokines. Toxicology in vitro : an international journal published in association with BIBRA. 2020 Oct; 68(?):104957. doi: 10.1016/j.tiv.2020.104957. [PMID: 32739440]
  • Daniel F Alonso, Hernán G Farina. Repurposing of host-based therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19): a link between antiviral and anticancer mechanisms?. International journal of antimicrobial agents. 2020 Sep; 56(3):106125. doi: 10.1016/j.ijantimicag.2020.106125. [PMID: 32739476]
  • Brandon Christophe, Maham Karatela, Joanly Sanchez, Josephine Pucci, E Sander Connolly. Statin Therapy in Ischemic Stroke Models: A Meta-Analysis. Translational stroke research. 2020 08; 11(4):590-600. doi: 10.1007/s12975-019-00750-7. [PMID: 31788761]
  • Ya-Ping Huang, Ping Li, Ting Du, Xin-Jun Du, Shuo Wang. Protective effect and mechanism of Monascus-fermented red yeast rice against colitis caused by Salmonella enterica serotype Typhimurium ATCC 14028. Food & function. 2020 Jul; 11(7):6363-6375. doi: 10.1039/d0fo01017k. [PMID: 32609139]
  • Yaru Zhang, Zhiting Chen, Qinyou Wen, Zixiao Xiong, Xiaohua Cao, Zhenghuai Zheng, Yangxin Zhang, Zhiwei Huang. An overview on the biosynthesis and metabolic regulation of monacolin K/lovastatin. Food & function. 2020 Jul; 11(7):5738-5748. doi: 10.1039/d0fo00691b. [PMID: 32555902]
  • Cynthia Aranow, John Cush, Marcy B Bolster, Christopher C Striebich, Maria Dall'era, Meggan Mackay, Ewa Olech, Tracy Frech, Jane Box, Richard Keating, Mary Chester Wasko, William St Clair, Alan Kivitz, Weiquang Huang, PetaGay Ricketts, Beverly Welch, Sherrie Callahan, Meagan Spychala, Karen Boyle, Kate York, Lynette Keyes-Elstein, Ellen Goldmuntz, Betty Diamond, Anne Davidson. A double-blind, placebo-controlled, phase II, randomized study of lovastatin therapy in the treatment of mildly active rheumatoid arthritis. Rheumatology (Oxford, England). 2020 07; 59(7):1505-1513. doi: 10.1093/rheumatology/kez471. [PMID: 31628482]
  • Guoren He, Panpan Yang, Yuchao Tang, Yuwei Cao, Xianyu Qi, Leifeng Xu, Jun Ming. Mechanism of exogenous cytokinins inducing bulbil formation in Lilium lancifolium in vitro. Plant cell reports. 2020 Jul; 39(7):861-872. doi: 10.1007/s00299-020-02535-x. [PMID: 32270280]
  • Elena Formisano, Andrea Pasta, Anna L Cremonini, Elda Favari, Annalisa Ronca, Federico Carbone, Tommaso Semino, Francesco Di Pierro, Samir G Sukkar, Livia Pisciotta. Efficacy of Nutraceutical Combination of Monacolin K, Berberine, and Silymarin on Lipid Profile and PCSK9 Plasma Level in a Cohort of Hypercholesterolemic Patients. Journal of medicinal food. 2020 Jun; 23(6):658-666. doi: 10.1089/jmf.2019.0168. [PMID: 31663806]
  • Lea Wagmann, Selina Hemmer, Achim T Caspar, Markus R Meyer. Method development for quantitative determination of seven statins including four active metabolites by means of high-resolution tandem mass spectrometry applicable for adherence testing and therapeutic drug monitoring. Clinical chemistry and laboratory medicine. 2020 04; 58(5):664-672. doi: 10.1515/cclm-2019-0763. [PMID: 31665111]
  • Souty M Z Sharkawi, Ehab A M El-Shoura, Amira M Abo-Youssef, Ramadan A M Hemeida. The potential hepatoprotective effects of lovastatin combined with oral hypoglycemic agents in streptozotocin-induced diabetes in rats. Immunopharmacology and immunotoxicology. 2020 Apr; 42(2):165-173. doi: 10.1080/08923973.2020.1733013. [PMID: 32114843]
  • Chuen-Mao Yang, Chih-Chung Lin, Chien-Chung Yang, Rou-Ling Cho, Li-Der Hsiao. Mevastatin-Induced AP-1-Dependent HO-1 Expression Suppresses Vascular Cell Adhesion Molecule-1 Expression and Monocyte Adhesion on Human Pulmonary Alveolar Epithelial Cells Challenged with TNF-α. Biomolecules. 2020 03; 10(3):. doi: 10.3390/biom10030381. [PMID: 32121588]
  • Kang Uk Kim, Sung-Jin Lee, Inhyung Lee. Development of an Improved Menopausal Symptom-Alleviating Licorice (Glycyrrhiza uralensis) by Biotransformation Using Monascus albidulus. Journal of microbiology and biotechnology. 2020 Feb; 30(2):178-186. doi: 10.4014/jmb.1909.09037. [PMID: 31752065]
  • Shiu-Wen Huang, I-Tsu Chyuan, Ching Shiue, Meng-Chieh Yu, Ya-Fen Hsu, Ming-Jen Hsu. Lovastatin-mediated MCF-7 cancer cell death involves LKB1-AMPK-p38MAPK-p53-survivin signalling cascade. Journal of cellular and molecular medicine. 2020 01; 24(2):1822-1836. doi: 10.1111/jcmm.14879. [PMID: 31821701]
  • Andres Gaviria-Mendoza, Manuel E Machado-Duque, Jorge E Machado-Alba. Lipid-lowering drug prescriptions in a group of Colombian patients. Biomedica : revista del Instituto Nacional de Salud. 2019 12; 39(4):759-768. doi: 10.7705/biomedica.4801. [PMID: 31860186]
  • Maciej Banach, Eric Bruckert, Olivier S Descamps, Lars Ellegård, Marat Ezhov, Bernhard Föger, Zlatko Fras, Petri T Kovanen, Gustavs Latkovskis, Winfried März, Demosthenes B Panagiotakos, György Paragh, Daniel Pella, Angela Pirillo, Andrea Poli, Željko Reiner, Günter Silbernagel, Margus Viigimaa, Michal Vrablík, Alberico L Catapano. The role of red yeast rice (RYR) supplementation in plasma cholesterol control: A review and expert opinion. Atherosclerosis. Supplements. 2019 Dec; 39(?):e1-e8. doi: 10.1016/j.atherosclerosissup.2019.08.023. [PMID: 31451336]
  • K Esmeijer, Olaf M Dekkers, Johan W de Fijter, Friedo W Dekker, Ellen K Hoogeveen. Effect of different types of statins on kidney function decline and proteinuria: a network meta-analysis. Scientific reports. 2019 11; 9(1):16632. doi: 10.1038/s41598-019-53064-x. [PMID: 31719617]
  • Maria G Lupo, Chiara Macchi, Silvia Marchianò, Riccardo Cristofani, Maria F Greco, Stefano Dall'Acqua, Haixia Chen, Cesare R Sirtori, Alberto Corsini, Massimiliano Ruscica, Nicola Ferri. Differential effects of red yeast rice, Berberis aristata and Morus alba extracts on PCSK9 and LDL uptake. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2019 11; 29(11):1245-1253. doi: 10.1016/j.numecd.2019.06.001. [PMID: 31439394]
  • Yinghua Peng, Xiaozheng Zhang, Tianshu Zhang, Peter M Grace, Hongyuan Li, Yibo Wang, Hang Li, Hongqian Chen, Linda R Watkins, Mark R Hutchinson, Hang Yin, Xiaohui Wang. Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain. Brain, behavior, and immunity. 2019 11; 82(?):432-444. doi: 10.1016/j.bbi.2019.09.013. [PMID: 31542403]
  • Ines Klingelhöfer, Gertrud E Morlock. Lovastatin in lactone and hydroxy acid forms and citrinin in red yeast rice powders analyzed by HPTLC-UV/FLD. Analytical and bioanalytical chemistry. 2019 Oct; 411(25):6655-6665. doi: 10.1007/s00216-019-02039-y. [PMID: 31410535]
  • Syed Ali Faran, Sajid Asghar, Syed Haroon Khalid, Ikram Ullah Khan, Muhammad Asif, Ikrima Khalid, Umar Farooq Gohar, Tanveer Hussain. Hepatoprotective and Renoprotective Properties of Lovastatin-Loaded Ginger and Garlic Oil Nanoemulsomes: Insights into Serum Biological Parameters. Medicina (Kaunas, Lithuania). 2019 Sep; 55(9):. doi: 10.3390/medicina55090579. [PMID: 31505863]
  • Zixiao Xiong, Xiaohua Cao, Qinyou Wen, Zhiting Chen, Zuxin Cheng, Xinying Huang, Yangxin Zhang, Chuannan Long, Yi Zhang, Zhiwei Huang. An overview of the bioactivity of monacolin K / lovastatin. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Sep; 131(?):110585. doi: 10.1016/j.fct.2019.110585. [PMID: 31207306]
  • Ming-Ming Wu, Chen Liang, Xiao-Di Yu, Bin-Lin Song, Qiang Yue, Yu-Jia Zhai, Valerie Linck, Yong-Xu Cai, Na Niu, Xu Yang, Bao-Long Zhang, Qiu-Shi Wang, Li Zou, Shuai Zhang, Tiffany L Thai, Jing Ma, Roy L Sutliff, Zhi-Ren Zhang, He-Ping Ma. Lovastatin attenuates hypertension induced by renal tubule-specific knockout of ATP-binding cassette transporter A1, by inhibiting epithelial sodium channels. British journal of pharmacology. 2019 09; 176(18):3695-3711. doi: 10.1111/bph.14775. [PMID: 31222723]
  • Mengran Guo, Mengdi Wei, Wen Li, Meichen Guo, Chunlin Guo, Minchao Ma, Yu Wang, Zimeng Yang, Mo Li, Qiang Fu, Li Yang, Zhonggui He. Impacts of particle shapes on the oral delivery of drug nanocrystals: Mucus permeation, transepithelial transport and bioavailability. Journal of controlled release : official journal of the Controlled Release Society. 2019 08; 307(?):64-75. doi: 10.1016/j.jconrel.2019.06.015. [PMID: 31207275]
  • Sani Garba, Awis Qurni Sazili, Mazrul Fahmi Mahadzir, Su Chui Len Candyrine, Mohammad Faseleh Jahromi, Mahdi Ebrahimi, Yong Meng Goh, Anjas Asmara Samsudin, Ron Ronimus, Stefan Meutzel, Juan Boo Liang. Effects of naturally-produced lovastatin on carcass characteristics, muscle physico-chemical properties and lipid oxidation and cholesterol content in goats. Meat science. 2019 Aug; 154(?):61-68. doi: 10.1016/j.meatsci.2019.04.008. [PMID: 31004941]
  • Karina Romero Sandoval, Maria Cecília Rivitti Machado, Zilda Najjar Prado de Oliveira, Marcello Menta Simonsen Nico. CHILD syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion. Anais brasileiros de dermatologia. 2019 07; 94(3):341-343. doi: 10.1590/abd1806-4841.20198789. [PMID: 31365666]
  • Arrigo F G Cicero, Federica Fogacci, Maciej Banach. Red Yeast Rice for Hypercholesterolemia. Methodist DeBakey cardiovascular journal. 2019 Jul; 15(3):192-199. doi: 10.14797/mdcj-15-3-192. [PMID: 31687098]
  • Jiajun Huang, Jingjing Du, Wanjun Lin, Ze Long, Na Zhang, Xiaoming Huang, Ying Xie, Liang Liu, Wenzhe Ma. Regulation of lactate production through p53/β-enolase axis contributes to statin-associated muscle symptoms. EBioMedicine. 2019 Jul; 45(?):251-260. doi: 10.1016/j.ebiom.2019.06.003. [PMID: 31201144]
  • Katsuhito Watanabe, Shingo Oda, Akiko Matsubara, Sho Akai, Tsuyoshi Yokoi. Establishment and characterization of a mouse model of rhabdomyolysis by coadministration of statin and fibrate. Toxicology letters. 2019 Jun; 307(?):49-58. doi: 10.1016/j.toxlet.2019.03.001. [PMID: 30853469]
  • Tiffany Frey, Katelyn Swade, Lindsey Zwecker, Tyler Llewellyn, Eric Vogt, Kim Monteferante, Heather English. Monocyte Production of IFN-γ Is Interleukin-12 Dependent in a Model of Mevalonate Kinase Deficiency. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2019 06; 39(6):364-374. doi: 10.1089/jir.2018.0126. [PMID: 31013450]
  • Ricardo Lorenzoni, Leticia Malgarim Cordenonsi, Samuel Davies, Michelli Barcelos Antonow, Aline Scheinder Medina Diedrich, Cayane Genro Santos, Graciela Schneider Vitalis, Gabriela Garrastazu, Francesca Buttini, Fabio Sonvico, Patrícia Gomes, Renata Platcheck Raffin. Lipid-core nanocapsules are an alternative to the pulmonary delivery and to increase the stability of statins. Journal of microencapsulation. 2019 Jun; 36(4):317-326. doi: 10.1080/02652048.2019.1624849. [PMID: 31159613]
  • Licai Liang, Weijing Shao, Tingting Shu, Yuhan Zhang, Shuang Xu, Lang Guo, Yuran Zhou, He Huang, Peng Sun. Xuezhikang improves the outcomes of cardiopulmonary resuscitation in rats by suppressing the inflammation response through TLR4/NF-κB pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jun; 114(?):108817. doi: 10.1016/j.biopha.2019.108817. [PMID: 30953818]
  • Jiawen Song, Jia Luo, Zubing Ma, Qiang Sun, Chunjie Wu, Xiaofang Li. Quality and Authenticity Control of Functional Red Yeast Rice-A Review. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24101944. [PMID: 31137594]
  • Jae H Chang, Xiaolin Zhang, Kirsten Messick, Yi-Chen Chen, Eugene Chen, Jonathan Cheong, Justin Ly. Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse. Xenobiotica; the fate of foreign compounds in biological systems. 2019 May; 49(5):602-610. doi: 10.1080/00498254.2018.1478167. [PMID: 29768081]
  • Reo Kawata, Tsuyoshi Yokoi. Analysis of a Skeletal Muscle Injury and Drug Interactions in Lovastatin- and Fenofibrate-Coadministered Dogs. International journal of toxicology. 2019 May; 38(3):192-201. doi: 10.1177/1091581819844793. [PMID: 31113311]
  • D Beltrán, M D Frutos-Lisón, J C Espín, R García-Villalba. Re-examining the role of the gut microbiota in the conversion of the lipid-lowering statin monacolin K (lovastatin) into its active β-hydroxy acid metabolite. Food & function. 2019 Apr; 10(4):1787-1791. doi: 10.1039/c8fo02594k. [PMID: 30882807]
  • Henock G Yebyo, Hélène E Aschmann, Marco Kaufmann, Milo A Puhan. Comparative effectiveness and safety of statins as a class and of specific statins for primary prevention of cardiovascular disease: A systematic review, meta-analysis, and network meta-analysis of randomized trials with 94,283 participants. American heart journal. 2019 04; 210(?):18-28. doi: 10.1016/j.ahj.2018.12.007. [PMID: 30716508]