Spectrum5_000333 (BioDeep_00000396891)
Secondary id: BioDeep_00000003812
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C15H12O2 (224.0837)
中文名称: 4-羟基查耳酮
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 100%
分子结构信息
SMILES: C1=CC=C(C=C1)C=CC(=O)C2=CC=C(C=C2)O
InChI: InChI=1S/C15H12O2/c16-14-9-7-13(8-10-14)15(17)11-6-12-4-2-1-3-5-12/h1-11,16H/b11-6+
描述信息
4-hydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4. It has a role as an anti-inflammatory agent and an antineoplastic agent. It is a member of chalcones and a member of phenols.
4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria[1][2][3].
同义名列表
36 个代谢物同义名
2-Propen-1-one, 1-(4-hydroxyphenyl)-3-phenyl-, (2E)-; 2-Propen-1-one, 1-(4-hydroxyphenyl)-3-phenyl-, (E)-; (2E)-1-(4-Hydroxyphenyl)-3-phenyl-2-propen-1-one #; (E)-1-(4-hydroxyphenyl)-3-phenyl-prop-2-en-1-one; (2E)-1-(4-Hydroxyphenyl)-3-phenyl-2-propen-1-one; (2E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one; (E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one; (E)-1-(4-hydroxyphenyl)-3-phenyl-2-propen-1-one; 2-Propen-1-one, 1-(4-hydroxyphenyl)-3-phenyl-; 1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one; (E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone; 1-(4-Hydroxyphenyl)-3-phenyl-2-propen-1-one; 1-(4-Hydroxy-phenyl)-3-phenyl-propenone; 1-(4-Hydroxyphenyl)-3-phenyl-2-propenal; 1-(4-Hydroxyphenyl)-3-phenylpropenone; 2-Benzylidene-4-hydroxyacetophenone; 2-Benzal-4-Hydroxyacetophenone; 2-Benzal-4-hydroxyacetophenone; 4-hydroxychalcone, AldrichCPR; 4-Hydroxyphenyl styryl ketone; UAHGNXFYLAJDIN-IZZDOVSWSA-N; 4-Hydroxychalcone, (E)-; trans-4-Hydroxychalcone; (E)-4-Hydroxychalcone; Chalcone, 4-hydroxy-; 4-hydroxy Chalcone; 4/-Hydroxychalcone; 4-Cinnamoylphenol; p-Cinnamoylphenol; 4-Hydroxychalcone; Spectrum5_000333; UNII-2K338K8UOA; 2K338K8UOA; 4'-Hydroxychalcone; 4'-Hydroxychalcone; 4'-Hydroxychalcone
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:34360
- KEGG: C14232
- PubChem: 5282362
- ChEMBL: CHEMBL276473
- MeSH: 4-hydroxychalcone
- ChemIDplus: 0002657252
- CAS: 38239-52-0
- CAS: 2657-25-2
- medchemexpress: HY-N7056
- PubChem: 7847042
- NIKKAJI: J23.024C
- KNApSAcK: 34360
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
---|
文献列表
- Svetlana S Efimova, Anastasiia A Zakharova, Roman Ya Medvedev, Olga S Ostroumova. Ion Channels Induced by Antimicrobial Agents in Model Lipid Membranes are Modulated by Plant Polyphenols Through Surrounding Lipid Media.
The Journal of membrane biology.
2018 08; 251(4):551-562. doi:
10.1007/s00232-018-0031-1
. [PMID: 29549386] - Zhaodi Xie, Xiaoting Luo, Zhuan Zou, Xiao Zhang, Feifei Huang, Ruishan Li, Shijie Liao, Yun Liu. Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia.
Bioorganic & medicinal chemistry letters.
2017 08; 27(15):3602-3606. doi:
10.1016/j.bmcl.2017.01.053
. [PMID: 28655421] - Huixiao Hong, William S Branham, Hui Wen Ng, Carrie L Moland, Stacey L Dial, Hong Fang, Roger Perkins, Daniel Sheehan, Weida Tong. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.
Toxicological sciences : an official journal of the Society of Toxicology.
2015 Feb; 143(2):333-48. doi:
10.1093/toxsci/kfu231
. [PMID: 25349334] - Hao-ran Liu, Xian-jun Liu, Hao-qun Fan, Jing-jing Tang, Xiao-hui Gao, Wu-Kun Liu. Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors.
Bioorganic & medicinal chemistry.
2014 Nov; 22(21):6124-33. doi:
10.1016/j.bmc.2014.08.033
. [PMID: 25260958] - Santosh N Mokale, Manjusha C Nevase, Nikhil S Sakle, Pritam N Dube, Vishakha R Shelke, Swati A Bhavale, Afreen Begum. Synthesis and in-vivo hypolipidemic activity of some novel substituted phenyl isoxazol phenoxy acetic acid derivatives.
Bioorganic & medicinal chemistry letters.
2014 May; 24(9):2155-8. doi:
10.1016/j.bmcl.2014.03.030
. [PMID: 24703232] - Huixiao Hong, William S Branham, Stacey L Dial, Carrie L Moland, Hong Fang, Jie Shen, Roger Perkins, Daniel Sheehan, Weida Tong. Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities.
Chemical research in toxicology.
2012 Nov; 25(11):2553-66. doi:
10.1021/tx3003406
. [PMID: 23013281] - S Sogawa, Y Nihro, H Ueda, A Izumi, T Miki, H Matsumoto, T Satoh. 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.
Journal of medicinal chemistry.
1993 Nov; 36(24):3904-9. doi:
10.1021/jm00076a019
. [PMID: 8254620]