C17H14O6 (BioDeep_00000396358)

Main id: BioDeep_00000266209

 

PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 3,5-dihydroxy-7-methoxy-2-(4-methoxyphenyl)-

化学式: C17H14O6 (314.079)
中文名称: 3,5-二羟基-4,7-二甲氧基黄酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(OC)=CC2OC(C3C=CC(OC)=CC=3)=C(O)C(=O)C=2C(O)=C1
InChI: InChI=1S/C17H14O6/c1-21-10-5-3-9(4-6-10)17-16(20)15(19)14-12(18)7-11(22-2)8-13(14)23-17/h3-8,18,20H,1-2H3

描述信息

7,4-dimethylkaempferol is a dimethoxyflavone that is kaempferol in which the hydroxy groups at position 4 and 7 have been replaced by methoxy groups. It is a component of bee glue and has been isolated from several plant species including Betula exilis, Zingiber mekongense and Alpinia flabellata. It has a role as an antioxidant and a plant metabolite. It is a dimethoxyflavone, a dihydroxyflavone and a member of flavonols. It is functionally related to a kaempferol. It is a conjugate acid of a 7,4-O-dimethylkaempferol 3-olate.
3,5-Dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one is a natural product found in Spiranthes sinensis, Spiranthes vernalis, and other organisms with data available.
A dimethoxyflavone that is kaempferol in which the hydroxy groups at position 4 and 7 have been replaced by methoxy groups. It is a component of bee glue and has been isolated from several plant species including Betula exilis, Zingiber mekongense and Alpinia flabellata.
Kaempferol-7,4'-dimethyl ether is a PTP1B inhibitor, and also can inhibit the production of NO. Kaempferol-7,4'-dimethyl ether shows the inhibition rate of 46.1\\% at 100 μM. Kaempferol-7,4'-dimethyl ether inhibits PTP1B activity with IC50 value of 16.92 μM[1][2].
Kaempferol-7,4'-dimethyl ether is a PTP1B inhibitor, and also can inhibit the production of NO. Kaempferol-7,4'-dimethyl ether shows the inhibition rate of 46.1\% at 100 μM. Kaempferol-7,4'-dimethyl ether inhibits PTP1B activity with IC50 value of 16.92 μM[1][2].

同义名列表

25 个代谢物同义名

4H-1-Benzopyran-4-one, 3,5-dihydroxy-7-methoxy-2-(4-methoxyphenyl)-; 3,5-dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; 3,5-Dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one #; 3,5-Dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 3,5-DIHYDROXY-7-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE; 3,5-Dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4-benzopyrone; 3,5-dihydroxy-7-methoxy-2-(4-methoxyphenyl)chromen-4-one; FLAVONE, 3,5-DIHYDROXY-4,7-DIMETHOXY-; DIHYDROXY-4,7-DIMETHOXYFLAVONE, 3,5-; 3,5-Dihydroxy-7,4-dimethoxyflavone; 3,5-Dihydroxy-4,7-dimethoxyflavone; kaempferol 4,7-dimethyl ether; Kaempferol 7,4-dimethyl ether; Kaempferol-7,4-dimethyl ether; KZBAXKKOXPLOBX-UHFFFAOYSA-N; 4-O,7-O-Dimethylkaempferol; 7,4-DI-O-METHYLKAEMPFEROL; 7,4-DIMETHOXYKAEMPFEROL; 4,7-DIMETHOXYKAEMPFEROL; 4,7-dimethylkaempferol; 7,4-dimethylkaempferol; UNII-Y4D3RA49HD; Y4D3RA49HD; C17H14O6; Kaempferol-7,4'-dimethyl ether



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Lei Zhao, Xue-jing Peng, Peng-fei Xia, Wen-da Duan. [Chemical constituents of Tamarix chinensis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Jan; 37(1):61-3. doi: ". [PMID: 25090705]
  • Catheleeya Mekjaruskul, Michael Jay, Bungorn Sripanidkulchai. Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2342-53. doi: 10.1124/dmd.112.047142. [PMID: 22961680]
  • T-Z Li, W-D Zhang, G-J Yang, W-Y Liu, R-H Liu, C Zhang, H-S Chen. New flavonol glycosides and new xanthone from Polygala japonica. Journal of Asian natural products research. 2006 Jul; 8(5):401-9. doi: 10.1080/10286020500172558. [PMID: 16864455]
  • Jian Zhang, Qing-hai Guo, Ling-yi Kong. [Flavonoids from rhizome of Alpinia tonkinensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2003 Jan; 28(1):41-3. doi: ". [PMID: 15015265]
  • H Kikuzaki, S Tesaki, S Yonemori, N Nakatani. Phenylbutanoid dimers from the leaves of Alpinia flabellata. Phytochemistry. 2001 Jan; 56(1):109-14. doi: 10.1016/s0031-9422(00)00360-5. [PMID: 11198817]
  • . . . . doi: . [PMID: 21343428]