sappanol B (BioDeep_00000395502)
Secondary id: BioDeep_00000297667
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C15H12O5 (272.0684702)
中文名称: 原苏木素A
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(=O)COC2=C(C=CC(=C2)O)C3=CC(=C(C=C31)O)O
InChI: InChI=1S/C15H12O5/c16-9-1-2-11-12-6-14(19)13(18)4-8(12)3-10(17)7-20-15(11)5-9/h1-2,4-6,16,18-19H,3,7H2
描述信息
Protosappanin A is a member of catechols. It has a role as a metabolite.
Protosappanin A is a natural product found in Alpinia japonica, Biancaea decapetala, and Biancaea sappan with data available.
A natural product found in Caesalpinia sappan.
Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3[1].
Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3[1].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:69202
- PubChem: 128001
- ChEMBL: CHEMBL447427
- MeSH: protosappanin A
- ChemIDplus: 0102036282
- CAS: 102036-28-2
- medchemexpress: HY-113573
- MetaboLights: MTBLC69202
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 105674 - Alpinia japonica: 10.1248/CPB.35.3568
- 191885 - Biancaea decapetala: 10.1248/CPB.35.3568
- 483143 - Biancaea sappan:
- 33090 - Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuhan Ding, Qian Xiang, Peiyuan Zhu, Manlu Fan, Huaqin Tong, Mengxi Wang, Songyi Cheng, Peng Yu, Haibo Shi, Haowen Zhang, Xiaohu Chen. Qihuang Zhuyu formula alleviates coronary microthrombosis by inhibiting PI3K/Akt/αIIbβ3-mediated platelet activation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Mar; 125(?):155276. doi:
10.1016/j.phymed.2023.155276. [PMID: 38295661] - Xiaodan Zheng, Jingqiu Chen, Nanquan Rao, Chun Yang, Juan Liu, Jun Zhang, Yanhong Li. The Effect of an Extract of Sappanwood, Protosappanin A and Protosappanin B on Osteogenesis in Periodontitis.
Frontiers in bioscience (Landmark edition).
2023 08; 28(8):172. doi:
10.31083/j.fbl2808172. [PMID: 37664926] - Golam Mezbah Uddin, Chul Young Kim, Donghwa Chung, Kyung-A Kim, Sang Hoon Jung. One-step isolation of sappanol and brazilin from Caesalpinia sappan and their effects on oxidative stress-induced retinal death.
BMB reports.
2015 May; 48(5):289-94. doi:
10.5483/bmbrep.2015.48.5.189. [PMID: 25248564] - Supinya Tewtrakul, Prapaporn Chaniad, Somsak Pianwanit, Chatchanok Karalai, Chanita Ponglimanont, Orapun Yodsaoue. Anti-HIV-1 Integrase Activity and Molecular Docking Study of Compounds from Caesalpinia sappan L.
Phytotherapy research : PTR.
2015 May; 29(5):724-9. doi:
10.1002/ptr.5307. [PMID: 25676492] - Zheng Wang, Jian-Bo Sun, Wei Qu, Fu-Qin Guan, Lin-Zhen Li, Jing-Yu Liang. Caesappin A and B, two novel protosappanins from Caesalpinia sappan L.
Fitoterapia.
2014 Jan; 92(?):280-4. doi:
10.1016/j.fitote.2013.12.004. [PMID: 24334102] - Ke-Wu Zeng, Ming-Bo Zhao, Zhi-Zhong Ma, Yong Jiang, Peng-Fei Tu. Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia.
International immunopharmacology.
2012 Dec; 14(4):558-69. doi:
10.1016/j.intimp.2012.09.004. [PMID: 23000519] - Wan-Chun Lai, Hui-Chun Wang, Guan-Yu Chen, Juan-Cheng Yang, Michal Korinek, Chia-Jung Hsieh, Hiroshi Nozaki, Ken-Ichiro Hayashi, Chih-Chung Wu, Yang-Chang Wu, Fang-Rong Chang. Using the pER8:GUS reporter system to screen for phytoestrogens from Caesalpinia sappan.
Journal of natural products.
2011 Aug; 74(8):1698-706. doi:
10.1021/np100920q. [PMID: 21800859] - Yohei Sasaki, Maemi Suzuki, Takayuki Matsumoto, Tomokazu Hosokawa, Tsuneo Kobayashi, Katsuo Kamata, Seiji Nagumo. Vasorelaxant activity of Sappan Lignum constituents and extracts on rat aorta and mesenteric artery.
Biological & pharmaceutical bulletin.
2010; 33(9):1555-60. doi:
10.1248/bpb.33.1555. [PMID: 20823574] - Lin-chun Fu, Xin-an Huang, Zhen-yuan Lai, Ying-jie Hu, Hong-jiao Liu, Xiao-ling Cai. A new 3-benzylchroman derivative from Sappan Lignum (Caesalpinia sappan).
Molecules (Basel, Switzerland).
2008 Aug; 13(8):1923-30. doi:
10.3390/molecules13081923. [PMID: 18794793] - Yohei Sasaki, Tomokazu Hosokawa, Masahiro Nagai, Seiji Nagumo. In vitro study for inhibition of NO production about constituents of Sappan Lignum.
Biological & pharmaceutical bulletin.
2007 Jan; 30(1):193-6. doi:
10.1248/bpb.30.193. [PMID: 17202686]
