Chalcone, 3 (BioDeep_00000395478)

Main id: BioDeep_00000009772

 

PANOMIX_OTCML-2023 Cytotoxicity Volatile Flavor Compounds


代谢物信息卡片


2-Propen-1-one, 3-(4-hydroxyphenyl)-1-phenyl-, (2E)-

化学式: C15H12O2 (224.0837252)
中文名称: 2-羟基查耳酮, 4-羟基查耳酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)C(=O)C=CC2=CC=C(C=C2)O
InChI: InChI=1S/C15H12O2/c16-14-9-6-12(7-10-14)8-11-15(17)13-4-2-1-3-5-13/h1-11,16H/b11-8+

描述信息

4-hydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4. It has a role as a plant metabolite and an antihypertensive agent. It is a member of chalcones and a member of phenols. It is functionally related to a trans-chalcone.
A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4.
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].

同义名列表

35 个代谢物同义名

2-Propen-1-one, 3-(4-hydroxyphenyl)-1-phenyl-, (2E)-; 2-PROPEN-1-ONE, 3-(4-HYDROXYPHENYL)-1-PHENYL-, (E)-; (2E)-3-(4-Hydroxyphenyl)-1-phenyl-2-propen-1-one #; (2E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one; (E)-3-(4-hydroxyphenyl)-1-phenyl-prop-2-en-1-one; (E)-3-(4-hydroxyphenyl)-1-phenyl-2-propen-1-one; (E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one; 3-(4-hydroxy-phenyl)-1-phenyl-prop-2-en-1-one; 2-Propen-1-one, 3-(4-hydroxyphenyl)-1-phenyl-; 3-(4-hydroxyphenyl)-1-phenyl-2-propen-1-one; (E)-3-(4-Hydroxy-phenyl)-1-phenyl-propenone; 3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one; 1-phenyl-3-(4-hydroxyphenyl)-2-propen-1-one; 2-(4-Hydroxybenzylidene)acetophenone; (4-Hydroxybenzylidene) acetophenone; (4-HYDROXYBENZYLIDENE)ACETOPHENONE; 4-Hydroxybenzylidene acetophenone; N-a-Boc-L-Tryptophanbenzylester; 2-(4-Hydroxybenzal)acetophenone; 4-Hydroxystyryl phenyll ketone; (4-Hydroxybenzal)acetophenone; TRANS-4-HYDROXYCHALCONE; (E)-4-Hydroxychalcone; Chalcone, 4-hydroxy-; 4-hydroxy chalcone; 4-hydroxy-chalcone; 4-Hydroxychalcone; UNII-JO97Q47VBU; Chalcone, 3; Chalcone 2; JO97Q47VBU; YISI; IPJ; 4-Hydroxychalcone; 4-Hydroxychalcone



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhaodi Xie, Xiaoting Luo, Zhuan Zou, Xiao Zhang, Feifei Huang, Ruishan Li, Shijie Liao, Yun Liu. Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia. Bioorganic & medicinal chemistry letters. 2017 08; 27(15):3602-3606. doi: 10.1016/j.bmcl.2017.01.053. [PMID: 28655421]
  • Huixiao Hong, William S Branham, Hui Wen Ng, Carrie L Moland, Stacey L Dial, Hong Fang, Roger Perkins, Daniel Sheehan, Weida Tong. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Feb; 143(2):333-48. doi: 10.1093/toxsci/kfu231. [PMID: 25349334]
  • Qi Qu, Bingguang Dai, Bo Yang, Xuelian Li, Yimin Liu, Fuling Zhang. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. BioMed research international. 2014; 2014(?):603415. doi: 10.1155/2014/603415. [PMID: 25003119]
  • Huixiao Hong, William S Branham, Stacey L Dial, Carrie L Moland, Hong Fang, Jie Shen, Roger Perkins, Daniel Sheehan, Weida Tong. Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities. Chemical research in toxicology. 2012 Nov; 25(11):2553-66. doi: 10.1021/tx3003406. [PMID: 23013281]
  • Lei Ma, Zhengyi Yang, Chenjing Li, Zhiyuan Zhu, Xu Shen, Lihong Hu. Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1). Journal of enzyme inhibition and medicinal chemistry. 2011 Oct; 26(5):643-8. doi: 10.3109/14756366.2010.543420. [PMID: 21222511]
  • Hong Fang, Weida Tong, William S Branham, Carrie L Moland, Stacy L Dial, Huixiao Hong, Qian Xie, Roger Perkins, William Owens, Daniel M Sheehan. Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. Chemical research in toxicology. 2003 Oct; 16(10):1338-58. doi: 10.1021/tx030011g. [PMID: 14565775]