Methyl brevifolincarboxylate (BioDeep_00000304628)

 

Secondary id: BioDeep_00000268124

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Methyl 7,8,9-trihydroxy-3,5-dioxo-1,2,3,5-tetrahydrobenzo[d]cyclopenta[b]pyran-1-carboxylate

化学式: C14H10O8 (306.037566)
中文名称: 短叶苏木酚酸甲酯
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 2.67%

分子结构信息

SMILES: COC(=O)C1CC(=O)C2=C1C3=C(C(=C(C=C3C(=O)O2)O)O)O
InChI: InChI=1S/C14H10O8/c1-21-13(19)5-3-7(16)12-9(5)8-4(14(20)22-12)2-6(15)10(17)11(8)18/h2,5,15,17-18H,3H2,1H3

描述信息

Methyl brevifolincarboxylate is an organic heterotricyclic compound that is 1,2,3,5-tetrahydrocyclopenta[c]isochromene substituted by hydroxy groups at positions 7, 8 and 9, oxo groups at positions 3 and 5 and a methoxycarbonyl group at position 1. Isolated from Phyllanthus urinaria and Phyllanthus niruri, it exhibits vasorelaxant activity. It has a role as a metabolite, a vasodilator agent, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a radical scavenger and a platelet aggregation inhibitor. It is an organic heterotricyclic compound, a delta-lactone, a member of phenols and a cyclic ketone.
Methyl brevifolincarboxylate is a natural product found in Euphorbia maculata and Phyllanthus niruri with data available.
An organic heterotricyclic compound that is 1,2,3,5-tetrahydrocyclopenta[c]isochromene substituted by hydroxy groups at positions 7, 8 and 9, oxo groups at positions 3 and 5 and a methoxycarbonyl group at position 1. Isolated from Phyllanthus urinaria and Phyllanthus niruri, it exhibits vasorelaxant activity.

同义名列表

5 个代谢物同义名

Methyl 7,8,9-trihydroxy-3,5-dioxo-1,2,3,5-tetrahydrobenzo[d]cyclopenta[b]pyran-1-carboxylate; methyl 7,8,9-trihydroxy-3,5-dioxo-1,2,3,5-tetrahydrocyclopenta[c]isochromene-1-carboxylate; methyl 7,8,9-trihydroxy-3,5-dioxo-1,2-dihydrocyclopenta[c]isochromene-1-carboxylate; Methyl brevifolincarboxylate; methylbrevifolin carboxylate



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Madamanchi Geethangili, Chiao-Wei Lin, Harry J Mersmann, Shih-Torng Ding. Methyl Brevifolincarboxylate Attenuates Free Fatty Acid-Induced Lipid Metabolism and Inflammation in Hepatocytes through AMPK/NF-κB Signaling Pathway. International journal of molecular sciences. 2021 Sep; 22(18):. doi: 10.3390/ijms221810062. [PMID: 34576229]
  • Fangzhao Chen, Luoping Yang, Lingyan Zhai, Yingna Huang, Feimin Chen, Wenjun Duan, Jie Yang. Methyl brevifolincarboxylate, a novel influenza virus PB2 inhibitor from Canarium Album (Lour.) Raeusch. Chemical biology & drug design. 2020 11; 96(5):1280-1291. doi: 10.1111/cbdd.13740. [PMID: 32519462]
  • Hao-Chuan Zheng, Yan Lu, Dao-Feng Chen. Anticomplement compounds from Polygonum chinense. Bioorganic & medicinal chemistry letters. 2018 05; 28(9):1495-1500. doi: 10.1016/j.bmcl.2018.03.079. [PMID: 29631958]
  • Toru Iizuka, Hiroyoshi Moriyama, Masahiro Nagai. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biological & pharmaceutical bulletin. 2006 Jan; 29(1):177-9. doi: 10.1248/bpb.29.177. [PMID: 16394535]