8-Hydroxy-deoxyguanosine (BioDeep_00000027869)

 

Secondary id: BioDeep_00000399622, BioDeep_00001871415

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Toxin


代谢物信息卡片


2-amino-8-hydroxy-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one

化学式: C10H13N5O5 (283.09166480000005)
中文名称: 2-脱氧-7,8-二氢-8-氧代鸟苷
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 43.87%

分子结构信息

SMILES: C1C(C(OC1N2C3=C(C(=O)NC(=N3)N)NC2=O)CO)O
InChI: InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1

描述信息

8-hydroxy-deoxyguanosine (8-OHdG) is a sensitive marker of the DNA damage due to hydroxyl radical attack at the C8 of guanine. This damage, if left unrepaired, has been proposed to contribute to mutagenicity and cancer promotion. 8-OHdG has also been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821).
8-hydroxy-deoxyguanosine (8-OHdG) is a sensitive marker of the DNA damage due to hydroxyl radical attack at the C8 of guanine. This damage, if left unrepaired, has been proposed to contribute to mutagenicity and cancer promotion. [HMDB]
8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis.
8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis.

同义名列表

33 个代谢物同义名

2-amino-8-hydroxy-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one; 8-oxo-7,8-Dihydro-2-deoxyguanosine; 7,8-Dihydro-2-deoxy-8-oxoguanosine; 2-Deoxy-8-oxo-7,8-dihydroguanosine; 2-Deoxy-7,8-dihydro-8-oxoguanosine; 7,8-dihydro-8-oxo-2-Deoxyguanosine; 8-oxo-7,8-Dihydrodeoxyguanosine; 7,8-dihydro-8-Oxodeoxyguanosine; 7-hydro-8-Oxodeoxyguanosine; 8-oxo-7-Hydrodeoxyguanosine; 2-Deoxy-8-hydroxyguanosine; 8-hydroxy-2-deoxyguanosine; 8-Hydroxy-2-deoxyguanosine; 8-Hydroxy-2deoxyguanosine; 8-Hydroxy-deoxyguanosine; 8-Hydroxydeoxy-guanosine; 8-Hydroxydeoxyguanosine; 2-Deoxy-8-oxoguanosine; 8-oxo-2-Deoxyguanosine; 8-Hydroxydeoxyguanine; 8-oxo-2-Deoxyguanine; 8-OHdG compound; 8-Oxoguanosine; 8-oxo-DGuo; 8-oxo-2-DG; 8-OxodGuo; 8-oxo-DG; 8-OH-DG; 8-Oxodg; 8-OHdG; O-D-DG; OH8Dg; 8-Hydroxy-2'-deoxyguanosine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shiming Song, Yanxia Gao, Shuai Feng, Zhipeng Cheng, Haibao Huang, Jingchuan Xue, Tao Zhang, Hongwen Sun. Widespread occurrence of two typical N, N'-substituted p-phenylenediamines and their quinones in humans: Association with oxidative stress and liver damage. Journal of hazardous materials. 2024 Apr; 468(?):133835. doi: 10.1016/j.jhazmat.2024.133835. [PMID: 38394895]
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  • Mahsa Zare, Niloofar Shoaei, Jahangir Karimian, Mehran Nouri, Sahar Zare, Kimia Leilami, Zainab Shateri, Parvin Sarbakhsh, Mohammad Hasan Eftekhari, Bahram Pourghassem Gargari. Effect of a plant-based diet on oxidative stress biomarkers in male footballers. Scientific reports. 2024 02; 14(1):3700. doi: 10.1038/s41598-024-54198-3. [PMID: 38355662]
  • Jia Zhicheng, Li Yongqian, Wang Peixuan, Yang Kai, Shi Mengyu, Chen Wen, Liang Qihui, Guo Ying. ErZhiTianGui Decoction alleviates age-related ovarian aging by regulating mitochondrial homeostasis and inhibiting ferroptosis. Journal of ovarian research. 2024 Jan; 17(1):12. doi: 10.1186/s13048-023-01341-9. [PMID: 38200521]
  • Enas A Saad, Hanaa A Hassan, Mamdooh H Ghoneum, Mai Alaa El-Dein. Edible wild plants, chicory and purslane, alleviated diabetic testicular dysfunction, and insulin resistance via suppression 8OHdg and oxidative stress in rats. PloS one. 2024; 19(4):e0301454. doi: 10.1371/journal.pone.0301454. [PMID: 38603728]
  • Hui-Yi Lin, Xiaodan Zhu, Harun Or Rashid Mazumder, Martin Ronis, Kim Brint Pedersen, Michael Hagensee. Serum oxidative biomarkers associated with genital HPV infection and cervical lesions in women. Journal of medical virology. 2024 01; 96(1):e29362. doi: 10.1002/jmv.29362. [PMID: 38180249]
  • Weidong Hu, Zhengke He, Lin Du, Li Zhang, Jun Li, Yue Ma, Shicheng Bi. Biomarkers of oxidative stress in broiler chickens attacked by lipopolysaccharide: A systematic review and meta-analysis. Ecotoxicology and environmental safety. 2023 Nov; 266(?):115606. doi: 10.1016/j.ecoenv.2023.115606. [PMID: 37866038]
  • Jennifer Maccarone, Stephanie T Grady, Marilyn L Moy, Jaime E Hart, Choong-Min Kang, Brent A Coull, Joel D Schwartz, Petros Koutrakis, Junfeng Zhang, Eric Garshick. Indoor (residential) and ambient particulate matter associations with urinary oxidative stress biomarkers in a COPD cohort. The Science of the total environment. 2023 Nov; 897(?):165352. doi: 10.1016/j.scitotenv.2023.165352. [PMID: 37419349]
  • Peng Peng, Mincong He, Weihua Fang, Mengqi Lai, Fangjun Xiao, Wei He, Huan Xiao, Qiushi Wei. Plasma 8-OHdG act as a biomarker for steroid-induced osteonecrosis of the femoral head. BMC musculoskeletal disorders. 2023 Oct; 24(1):808. doi: 10.1186/s12891-023-06804-0. [PMID: 37828532]
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  • Bin Wang, Lieyang Fan, Shijie Yang, Min Zhou, Ge Mu, Wei Liu, Linling Yu, Meng Yang, Man Cheng, Xing Wang, Weihong Qiu, Tingming Shi, Weihong Chen. Cross-sectional and longitudinal relationships between urinary 1-bromopropane metabolite and pulmonary function and underlying role of oxidative damage among urban adults in the Wuhan-Zhuhai cohort in China. Environmental pollution (Barking, Essex : 1987). 2022 Nov; 313(?):120147. doi: 10.1016/j.envpol.2022.120147. [PMID: 36096263]
  • Dhimiter Bello, Lucia Chanetsa, Costas A Christophi, Dilpreet Singh, Magdiel Inggrid Setyawati, David C Christiani, Sanjay H Chotirmall, Kee Woei Ng, Philip Demokritou. Biomarkers of oxidative stress in urine and plasma of operators at six Singapore printing centers and their association with several metrics of printer-emitted nanoparticle exposures. Nanotoxicology. 2022 Nov; 16(9-10):913-934. doi: 10.1080/17435390.2023.2175735. [PMID: 36774544]
  • Pan-Pan Chen, Pan Yang, Chong Liu, Yan-Ling Deng, Qiong Luo, Yu Miao, Min Zhang, Fei-Peng Cui, Jia-Yue Zeng, Tian Shi, Ting-Ting Lu, Da Chen, Long-Qiang Wang, Chun-Ping Liu, Ming Jiang, Qiang Zeng. Urinary concentrations of phenols, oxidative stress biomarkers and thyroid cancer: Exploring associations and mediation effects. Journal of environmental sciences (China). 2022 Oct; 120(?):30-40. doi: 10.1016/j.jes.2022.01.009. [PMID: 35623770]
  • Iriny M Ayoub, Marawan A El-Baset, Mai M Elghonemy, Samir A E Bashandy, Fatma A A Ibrahim, Omar A H Ahmed-Farid, Abd El-Nasser G El Gendy, Sherif M Afifi, Tuba Esatbeyoglu, Abdel Razik H Farrag, Mohamed A Farag, Abdelsamed I Elshamy. Chemical Profile of Cyperus laevigatus and Its Protective Effects against Thioacetamide-Induced Hepatorenal Toxicity in Rats. Molecules (Basel, Switzerland). 2022 Oct; 27(19):. doi: 10.3390/molecules27196470. [PMID: 36235007]
  • Yan Wang, Yanjian Wan, Meiling Cao, Aizhen Wang, Gaga Mahai, Zhenyu He, Shunqing Xu, Wei Xia. Urinary 2,4-dichlorophenoxyacetic acid in Chinese pregnant women at three trimesters: Variability, exposure characteristics, and association with oxidative stress biomarkers. Chemosphere. 2022 Oct; 304(?):135266. doi: 10.1016/j.chemosphere.2022.135266. [PMID: 35688197]
  • Mizanur Rahman, Martin Irmler, Micol Introna, Johannes Beckers, Lena Palmberg, Gunnar Johanson, Swapna Upadhyay, Koustav Ganguly. Insight into the pulmonary molecular toxicity of heated tobacco products using human bronchial and alveolar mucosa models at air-liquid interface. Scientific reports. 2022 09; 12(1):16396. doi: 10.1038/s41598-022-20657-y. [PMID: 36180488]
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  • Manassanan Jitjumnong, Pornpan Chalermkitpanit, Tanyawan Suantawee, Sinsuda Dechsupa, Ladawan Vajarintarangoon, Sittisak Honsawek. Telomere Shortening and Increased Oxidative Stress in Lumbar Disc Degeneration. International journal of molecular sciences. 2022 Sep; 23(17):. doi: 10.3390/ijms231710125. [PMID: 36077523]
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