Trihydroxycoprostanoic acid (BioDeep_00000027776)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


(1S,2R,5R,7R,9R,10R,11S,14R,15R,16S)-5,9,16-trihydroxy-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-7-carboxylic acid

化学式: C28H48O5 (464.3501558)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 20%

分子结构信息

SMILES: CC(C)CCCC(C)C1CCC2C1(C(CC3C2C(CC4(C3(CCC(C4)O)C)C(=O)O)O)O)C
InChI: InChI=1S/C28H48O5/c1-16(2)7-6-8-17(3)19-9-10-20-24-21(13-23(31)27(19,20)5)26(4)12-11-18(29)14-28(26,25(32)33)15-22(24)30/h16-24,29-31H,6-15H2,1-5H3,(H,32,33)/t17-,18-,19-,20+,21+,22-,23+,24+,26-,27-,28+/m1/s1

描述信息

Trihydroxycoprostanoic acid is excreted in the urine of patients with Zellweger syndrome (PMID 7347441), a genetic disorder. The oxidation trihydroxycoprostanic acid is deficient in liver homogenates from patients with peroxisomal diseases (PMID 2576087). Trihydroxycoprostanoic acid is found to be associated with adrenoleukodystrophy (ALD), which is also an inborn error of metabolism.
Trihydroxycoprostanoic acid is excreted in the urine of patients with Zellweger syndrome (PMID 7347441 )
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids

同义名列表

17 个代谢物同义名

(1S,2R,5R,7R,9R,10R,11S,14R,15R,16S)-5,9,16-trihydroxy-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-7-carboxylic acid; (1S,2R,5R,7R,9R,10R,11S,14R,15R,16S)-5,9,16-Trihydroxy-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-7-carboxylate; (3alpha,5beta,7alpha,12alpha)-3,7,12-Trihydroxycholestane-5-carboxylic acid; (3alpha,5beta,7alpha,12alpha)-3,7,12-Trihydroxycholestane-5-carboxylate; (3a,5b,7a,12a)-3,7,12-Trihydroxy-cholestane-5-carboxylic acid; 3 alpha,7 alpha,12 alpha-Trihydroxy-5 beta-cholestanoic acid; (3a,5b,7a,12a)-3,7,12-Trihydroxy-cholestane-5-carboxylate; 3 alpha,7 alpha,12 alpha-Trihydroxycoprostanic acid; 3alpha,7alpha,12alpha-Trihydroxycoprostanic acid; 3alpha,7alpha,12alpha-Trihydroxycoprostanate; 3,7,12-Trihydroxycoprostanic acid; 3,7,12-Trihydroxycoprostanate; Trihydroxycoprostanoic acid; Tryhydroxycoprostanic acid; Trihydroxycoprostanoate; Tryhydroxycoprostanate; 5-Thca



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • P A Watkins, W W Chen, C J Harris, G Hoefler, S Hoefler, D C Blake, A Balfe, R I Kelley, A B Moser, M E Beard. Peroxisomal bifunctional enzyme deficiency. The Journal of clinical investigation. 1989 Mar; 83(3):771-7. doi: 10.1172/jci113956. [PMID: 2921319]
  • M Casteels, C W Van Roermund, L Schepers, L Govaert, H J Eyssen, G P Mannaerts, R J Wanders. Deficient oxidation of trihydroxycoprostanic acid in liver homogenates from patients with peroxisomal diseases. Journal of inherited metabolic disease. 1989; 12(4):415-22. doi: 10.1007/bf01802036. [PMID: 2576087]
  • R J Wanders, H S Heymans, R B Schutgens, B T Poll-Thé, J M Saudubray, J M Tager, G Schrakamp, H van den Bosch. Peroxisomal functions in classical Refsum's disease: comparison with the infantile form of Refsum's disease. Journal of the neurological sciences. 1988 Apr; 84(2-3):147-55. doi: 10.1016/0022-510x(88)90120-7. [PMID: 2454298]
  • M Une, Y Tazawa, K Tada, T Hoshita. Occurrence of both (25R)- and (25S)-3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acids in urine from an infant with Zellweger's syndrome. Journal of biochemistry. 1987 Dec; 102(6):1525-30. doi: 10.1093/oxfordjournals.jbchem.a122200. [PMID: 3448094]
  • B F Kase, J I Pedersen, B Strandvik, I Björkhem. In vivo and vitro studies on formation of bile acids in patients with Zellweger syndrome. Evidence that peroxisomes are of importance in the normal biosynthesis of both cholic and chenodeoxycholic acid. The Journal of clinical investigation. 1985 Dec; 76(6):2393-402. doi: 10.1172/jci112252. [PMID: 4077985]
  • B F Kase, I Björkhem, P Hågå, J I Pedersen. Defective peroxisomal cleavage of the C27-steroid side chain in the cerebro-hepato-renal syndrome of Zellweger. The Journal of clinical investigation. 1985 Feb; 75(2):427-35. doi: 10.1172/jci111717. [PMID: 3973012]
  • N J Willson, M J Kogan, D J Pierson, E Newman. Confirmation of EMIT cannabinoid assay results by bonded phase adsorption with thin layer chromatography. Journal of toxicology. Clinical toxicology. 1983 Jul; 20(5):465-73. doi: 10.3109/15563658308990612. [PMID: 6366244]
  • A K Batta, G Salen, S Shefer, B Dayal, G S Tint. Configuration at C-25 in 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestan-26-oic acid isolated from human bile. Journal of lipid research. 1983 Jan; 24(1):94-6. doi: ". [PMID: 6833885]