Cudraflavone B (BioDeep_00000268730)

   

PANOMIX_OTCML-2023


代谢物信息卡片


8-(2,4-dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-2H,6H-pyrano[3,2-g]chromen-6-one

化学式: C25H24O6 (420.1572804)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCC1=C(OC2=CC3=C(C=CC(O3)(C)C)C(=C2C1=O)O)C4=C(C=C(C=C4)O)O)C
InChI: InChI=1S/C25H24O6/c1-13(2)5-7-17-23(29)21-20(30-24(17)15-8-6-14(26)11-18(15)27)12-19-16(22(21)28)9-10-25(3,4)31-19/h5-6,8-12,26-28H,7H2,1-4H3

描述信息

Cudraflavone B is an extended flavonoid that consists of a pyranochromane skeleton that is 2H,6H-pyrano[3,2-g]chromen-6-one substituted by geminal methyl groups at position 2, a 2,4-dihydroxyphenyl group at position 8, a hydroxy group at position 5 and a prenyl group at position 7. Isolated from Morus alba and Morus species it exhibits anti-inflammatory activity. It has a role as an anti-inflammatory agent and a plant metabolite. It is an extended flavonoid, a pyranochromane and a trihydroxyflavone.
cudraflavone B is a natural product found in Artocarpus altilis, Maclura tricuspidata, and other organisms with data available.
An extended flavonoid that consists of a pyranochromane skeleton that is 2H,6H-pyrano[3,2-g]chromen-6-one substituted by geminal methyl groups at position 2, a 2,4-dihydroxyphenyl group at position 8, a hydroxy group at position 5 and a prenyl group at position 7. Isolated from Morus alba and Morus species it exhibits anti-inflammatory activity.

同义名列表

7 个代谢物同义名

8-(2,4-dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-2H,6H-pyrano[3,2-g]chromen-6-one; 2-(2,4-dihydroxy-phenyl)-5-hydroxy-8,8-dimethyl-3-(3-methyl-but-2-enyl)-8H-pyrano[3,2-g]chromen-4-one; 2-(2,4-Dihydroxyphenyl)-3-(3-methyl-2-butenyl)-5-hydroxy-8,8-dimethyl-4H,8H-benzo[1,2-b:5,4-b/]dipy; 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-4(8H)-one; 8-(2,4-dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-7-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-6-one; 2-(2,4-Dihydroxyphenyl)-3-(3-methyl-2-butenyl)-5-hydroxy-8,8-dimethyl-4H,8H-benzo[1,2-b; Cudraflavone B



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hongbo Dong, Min Wu, Shengwei Xiang, Tao Song, Ying Li, Bin Long, Chuanling Feng, Zheng Shi. Total Syntheses and Antibacterial Evaluations of Neocyclomorusin and Related Flavones. Journal of natural products. 2022 09; 85(9):2217-2225. doi: 10.1021/acs.jnatprod.2c00658. [PMID: 36062892]
  • Wonmin Ko, Kwan-Woo Kim, Tran Hong Quang, Chi-Su Yoon, Nayeon Kim, Hwan Lee, Sam-Cheol Kim, Eun-Rhan Woo, Youn-Chul Kim, Hyuncheol Oh, Dong-Sung Lee. Cudraflavanone B Isolated from the Root Bark of Cudrania tricuspidata Alleviates Lipopolysaccharide-Induced Inflammatory Responses by Downregulating NF-κB and ERK MAPK Signaling Pathways in RAW264.7 Macrophages and BV2 Microglia. Inflammation. 2021 Feb; 44(1):104-115. doi: 10.1007/s10753-020-01312-y. [PMID: 32766955]
  • Navneet Kishore, Pradeep Kumar, Karuna Shanker, Akhilesh Kumar Verma. Human disorders associated with inflammation and the evolving role of natural products to overcome. European journal of medicinal chemistry. 2019 Oct; 179(?):272-309. doi: 10.1016/j.ejmech.2019.06.034. [PMID: 31255927]
  • Hana Zelová, Zuzana Hanáková, Zuzana Čermáková, Karel Šmejkal, Stefano Dalĺ Acqua, Petr Babula, Josef Cvačka, Jan Hošek. Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra. Journal of natural products. 2014 Jun; 77(6):1297-303. doi: 10.1021/np401025f. [PMID: 24901948]
  • Hwa-Jeong Lee, Q-Schick Auh, Young-Man Lee, Soo-Kyung Kang, Seok-Woo Chang, Dong-Sung Lee, Youn-Chul Kim, Eun-Cheol Kim. Growth inhibition and apoptosis-inducing effects of cudraflavone B in human oral cancer cells via MAPK, NF-κB, and SIRT1 signaling pathway. Planta medica. 2013 Sep; 79(14):1298-306. doi: 10.1055/s-0033-1350619. [PMID: 23881456]
  • Jan Hošek, Milan Bartos, Stanislav Chudík, Stefano Dall'Acqua, Gabbriella Innocenti, Murat Kartal, Ladislav Kokoška, Peter Kollár, Zsófia Kutil, Přemysl Landa, Radek Marek, Veronika Závalová, Milan Žemlička, Karel Šmejkal. Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro. Journal of natural products. 2011 Apr; 74(4):614-9. doi: 10.1021/np100638h. [PMID: 21319773]
  • Young Bae Ryu, Marcus J Curtis-Long, Ji Won Lee, Hyung Won Ryu, Jun Young Kim, Woo Song Lee, Ki Hun Park. Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition. Bioorganic & medicinal chemistry letters. 2009 Sep; 19(17):4912-5. doi: 10.1016/j.bmcl.2009.07.098. [PMID: 19660948]
  • Tack-Joong Kim, Hyeong-Jun Han, Yong Lim, Min-Cheol Song, Jihee Kim, Jin-Tae Hong, Hwan-Soo Yoo, Myoung-Yun Pyo, Bang-Yeon Hwang, Myoung-Koo Lee, Yeo-Pyo Yun. Antiproliferative action of cudraflavone B, isolated from Cudrania tricuspidata, through the downregulation of pRb phosphorylation in aortic smooth muscle cell proliferation signaling. Journal of cardiovascular pharmacology. 2009 Apr; 53(4):341-8. doi: 10.1097/fjc.0b013e31819fd4cb. [PMID: 19295442]
  • Ji Hye Hwang, Seong Su Hong, Xiang Hua Han, Ji Sang Hwang, Dongho Lee, Heesoon Lee, Yeo Pyo Yun, Youngsoo Kim, Jai Seup Ro, Bang Yeon Hwang. Prenylated xanthones from the root bark of Cudrania tricuspidata. Journal of natural products. 2007 Jul; 70(7):1207-9. doi: 10.1021/np070059k. [PMID: 17608532]
  • Ki Hun Park, Yong-Dae Park, Jong-Min Han, Kyung-Ran Im, Byong Won Lee, Il Yun Jeong, Tae-Sook Jeong, Woo Song Lee. Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata. Bioorganic & medicinal chemistry letters. 2006 Nov; 16(21):5580-3. doi: 10.1016/j.bmcl.2006.08.032. [PMID: 16919944]