2'-Aminoacetophenone (BioDeep_00000025229)

 

Secondary id: BioDeep_00000018435, BioDeep_00000405662, BioDeep_00000617799, BioDeep_00001871712

human metabolite PANOMIX_OTCML-2023 Endogenous Volatile Flavor Compounds


代谢物信息卡片


2-Aminoacetophenone hydrochloride

化学式: C8H9NO (135.0684104)
中文名称: 2-氨基苯乙酮, 2'-氨基苯乙酮
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 2.15%

分子结构信息

SMILES: CC(=O)C1=CC=CC=C1N
InChI: InChI=1S/C8H9NO/c1-6(10)7-4-2-3-5-8(7)9/h2-5H,9H2,1H3

描述信息

2-Aminoacetophenone, also known as O-acetylaniline or 1-acetyl-2-aminobenzene, belongs to the class of organic compounds known as alkyl-phenylketones. These are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group. 2-Aminoacetophenone exists as a solid, slightly soluble (in water), and an extremely weak acidic (essentially neutral) compound (based on its pKa). Within the cell, 2-aminoacetophenone is primarily located in the cytoplasm. 2-Aminoacetophenone is a sweet, foxy, and grape tasting compound that can be found in fruits and milk and milk products. This makes 2-aminoacetophenone a potential biomarker for the consumption of these food products.
2'-Aminoacetophenone is an aromatic compound containing a ketone substituted by one alkyl group, and a phenyl group. 2'-Aminoacetophenone can be used as a breath biomarker for the detection of Ps. Aeruginosa infections in the cystic fibrosis lung[1].

同义名列表

19 个代谢物同义名

2-Aminoacetophenone hydrochloride; 1-(2-Aminophenyl)ethanone, 9ci; 1-(2-aminophenyl)ethan-1-one; O-Aminophenyl methyl ketone; 1-(2-Aminophenyl)-ethanone; 1-(Aminophenyl)-ethanone; Ortho-aminoacetophenone; 1-Acetyl-2-aminobenzene; 2-Amonioacetophenone; O-Aminoacetylbenzene; 2-Aminoacetophenone; O-Aminoacetophenone; 2-Acetylphenylamine; 2-Acetylaniline; O-Acetylaniline; FEMA 3906; 5 Kaal; 2'-Aminoacetophenone; 2'-Aminoacetophenone



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Arijit Chakraborty, Asel Kabashi, Samuel Wilk, Laurence G Rahme. Quorum-Sensing Signaling Molecule 2-Aminoacetophenone Mediates the Persistence of Pseudomonas aeruginosa in Macrophages by Interference with Autophagy through Epigenetic Regulation of Lipid Biosynthesis. mBio. 2023 Apr; ?(?):e0015923. doi: 10.1128/mbio.00159-23. [PMID: 37010415]
  • I Kviatkovski, T Yarnitzky, S Shushan, O Schwartz-Harari, R Nir-Paz, Y Helman. A bacterial biosensor encoding a genetically modified LuxR receptor exhibits improved detection of Pseudomonas aeruginosa's biomarker molecule 2-aminoacetophenone. Chemical communications (Cambridge, England). 2018 Aug; 54(66):9218-9221. doi: 10.1039/c8cc03540g. [PMID: 30065984]
  • Igor Kviatkovski, Sagit Shushan, Yahav Oron, Idan Frumin, Daniel Amir, Lavi Secundo, Eitan Livne, Aharon Weissbrod, Noam Sobel, Yael Helman. Smelling Pseudomonas aeruginosa infections using a whole-cell biosensor - An alternative for the gold-standard culturing assay. Journal of biotechnology. 2018 Feb; 267(?):45-49. doi: 10.1016/j.jbiotec.2017.12.023. [PMID: 29292129]
  • Kazutoshi Sakurai, Kenichi Tomiyama, Yukihiro Kawakami, Yoshihiro Yaguchi, Yoshinori Asakawa. Characteristic Scent from the Tahitian Liverwort, Cyathodium foetidissimum. Journal of oleo science. 2018; 67(10):1265-1269. doi: 10.5650/jos.ess18160. [PMID: 30305559]
  • C Brunius, J K Vidanarachchi, J Tomankova, K Lundström, K Andersson, G Zamaratskaia. Skatole metabolites in urine as a biological marker of pigs with enhanced hepatic metabolism. Animal : an international journal of animal bioscience. 2016 Oct; 10(10):1734-40. doi: 10.1017/s1751731116000574. [PMID: 27080076]
  • I Kviatkovski, L Chernin, T Yarnitzky, I Frumin, N Sobel, Y Helman. Pseudomonas aeruginosa activates the quorum sensing LuxR response regulator through secretion of 2-aminoacetophenone. Chemical communications (Cambridge, England). 2015 Feb; 51(15):3258-61. doi: 10.1039/c4cc10393a. [PMID: 25614099]
  • D L Nolte, J R Mason. Maternal ingestion of ortho-aminoacetophenone during gestation affects intake by offspring. Physiology & behavior. 1995 Nov; 58(5):925-8. doi: 10.1016/0031-9384(95)00152-9. [PMID: 8577889]
  • W Y Li, S K Seah, R T Koda. Determination of mitomycin C in human aqueous humor and serum by high-performance liquid chromatography. Journal of chromatography. 1993 Sep; 619(1):148-53. doi: 10.1016/0378-4347(93)80459-h. [PMID: 8245155]
  • R E Page, M S Blum, H M Fales. o-Aminoacetophenone, a pheromone that repels honeybees (Apis mellifera L.). Experientia. 1988 Mar; 44(3):270-1. doi: 10.1007/bf01941735. [PMID: 3350140]