Hibifolin (BioDeep_00000247969)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(2S,3S,4S,5R,6S)-6-((2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4-oxo-4H-chromen-8-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

化学式: C21H18O14 (494.0697)
中文名称: 棉皮素-8-O-β-D-葡萄糖醛酸苷, 棉花皮素-8-O-葡萄糖醛酸苷, 棉皮素-8-O-Β-D-葡萄糖醛酸苷
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 70.14%

分子结构信息

SMILES: C(C(C(O)=O)4)(O)C(C(C(O4)Oc(c(O)3)c(c(c(c3)O)1)OC(c(c2)cc(c(O)c2)O)=C(C1=O)O)O)O
InChI: InChI=1S/C21H18O14/c22-6-2-1-5(3-7(6)23)16-13(28)11(26)10-8(24)4-9(25)17(18(10)33-16)34-21-15(30)12(27)14(29)19(35-21)20(31)32/h1-4,12,14-15,19,21-25,27-30H,(H,31,32)/t12-,14-,15+,19-,21+/m0/s1

描述信息

Hibifolin is a natural product found in Helicteres isora, Abelmoschus manihot, and Sedum album with data available.
Hibifolin, a flavonol glycoside, is a potential inhibitor of adenosine deaminase (ADA), with a Ki of 49.92 μM. Hibifolin protects neurons against beta-amyloid-induced neurotoxicity[1][2].
Hibifolin, a flavonol glycoside, is a potential inhibitor of adenosine deaminase (ADA), with a Ki of 49.92 μM. Hibifolin protects neurons against beta-amyloid-induced neurotoxicity[1][2].

同义名列表

11 个代谢物同义名

(2S,3S,4S,5R,6S)-6-((2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4-oxo-4H-chromen-8-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4-oxochromen-8-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid; 2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-4-OXO-4H-1-BENZOPYRAN-8-YL .BETA.-D-GLUCOPYRANOSIDURONIC ACID; beta-D-Glucopyranosiduronic acid, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4-oxo-4H-1-benzopyran-8-yl; GOSSYPETIN 8-O-.BETA.-D-GLUCURONIDE; Gossypetin-8-glucuronide; UNII-JR6MS62GTB; JR6MS62GTB; Hibifolin; [ 2- (3,4-Dihydroxyphenyl) -3,5,7-trihydroxy-4-oxo-4H-1-benzopyran-8-yl ] beta-D-glucopyranosiduronic acid; Gossypetin 8-glucuronide



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • K G Arun, C S Sharanya, P M Sandeep, C Sadasivan. Inhibitory activity of hibifolin on adenosine deaminase- experimental and molecular modeling study. Computational biology and chemistry. 2016 10; 64(?):353-358. doi: 10.1016/j.compbiolchem.2016.08.005. [PMID: 27591790]
  • Jianming Guo, Caifu Xue, Jin-ao Duan, Dawei Qian, Yuping Tang, Yi You. Anticonvulsant, antidepressant-like activity of Abelmoschus manihot ethanol extract and its potential active components in vivo. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 Nov; 18(14):1250-4. doi: 10.1016/j.phymed.2011.06.012. [PMID: 21784623]
  • Cai-fu Xue, Jian-ming Guo, Da-wei Qian, Jin-ao Duan, Yan Shu. [Absorption of flavonoids from Abelmoschus manihot extract by in situ intestinal perfusion]. Yao xue xue bao = Acta pharmaceutica Sinica. 2011 Apr; 46(4):454-9. doi: . [PMID: 21751500]