midecamycin (BioDeep_00000238384)

Chemicals and Drugs natural product

代谢物信息卡片

Midecamicina

化学式: C41H67NO15 (813.451)
中文名称: 麦迪霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(=O)OC1CC(=O)OC(C)C/C=C/C=C\C(O)C(C)CC(CC=O)C(O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@H](OC(=O)CC)[C@@H](C)O3)[C@H](N(C)C)[C@H]2O)C1OC
InChI: InChI=1S/C41H67NO15/c1-11-30(45)54-29-21-32(47)51-24(4)16-14-13-15-17-28(44)23(3)20-27(18-19-43)37(38(29)50-10)57-40-35(48)34(42(8)9)36(25(5)53-40)56-33-22-41(7,49)39(26(6)52-33)55-31(46)12-2/h13-15,17,19,23-29,33-40,44,48-49H,11-12,16,18,20-22H2,1-10H3/b14-13-,17-15+

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01F - Macrolides, lincosamides and streptogramins > J01FA - Macrolides
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007933 - Leucomycins
C784 - Protein Synthesis Inhibitor > C261 - Macrolide Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic
Midecamycin, an acetoxy-substituted macrolide antibiotic, is tested against gram-positive and gram-negative bacteria.

同义名列表

4 个代谢物同义名

midecamycin; Midecamicina; SF-837; Antibiotic SF-837

数据库引用编号

12 个数据库交叉引用编号

ChEBI: CHEBI:31845
KEGGdrug: D01339
PubChem: 5282169
PubChem: 6392391
PubChem: 5128452
DrugBank: DB13456
ChEMBL: CHEMBL444963
KNApSAcK: C00018233
CAS: 35457-80-8
PMhub: MS000061320
medchemexpress: HY-B1908
LOTUS: LTS0226930

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

2 - Bacteria: LTS0226930
1883 - Streptomyces: LTS0226930
1906 - Streptomyces fradiae: 10.1007/S00253-004-1658-7
1906 - Streptomyces fradiae: 10.1111/J.1745-7270.2007.00265.X
1906 - Streptomyces fradiae: 10.1128/JB.174.15.5141-5144.1992
1906 - Streptomyces fradiae: LTS0226930
1906 - Streptomyces fradiae: NA
1949 - Streptomyces mycarofaciens: 10.1007/S00253-004-1658-7
1949 - Streptomyces mycarofaciens: 10.1111/J.1745-7270.2007.00265.X
1949 - Streptomyces mycarofaciens: 10.1128/JB.174.15.5141-5144.1992
1949 - Streptomyces mycarofaciens: LTS0226930
1949 - Streptomyces mycarofaciens: NA
2062 - Streptomycetaceae: LTS0226930

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表

文献列表

Dan Deng, Zizi Mu, Xiaoyan Lv, Xincheng Jiang, Jiang Zhou, Huizhi Guo, Wenbing Zhang, Bei Wang, Yishan Lu, Jinping Wu, Hao Du, Shuhuan Zhang, Qiaoqing Xu, Qiwei Wei. Pathogenicity of Plesiomonas shigelloides and Citrobacter freundii isolated from the endangered Chinese sturgeon (Acipenser sinensis). Microbial pathogenesis. 2022 Dec; 173(Pt A):105818. doi: 10.1016/j.micpath.2022.105818. [PMID: 36216208]
Daxing Liu, Wenrui Jin. Determination of midecamycin by capillary zone electrophoresis with electrochemical detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jan; 783(2):509-15. doi: 10.1016/s1570-0232(02)00675-x. [PMID: 12482494]
G P Ahern, P R Junankar, S M Pace, S Curtis, J A Mould, A F Dulhunty. Effects of ivermectin and midecamycin on ryanodine receptors and the Ca2+-ATPase in sarcoplasmic reticulum of rabbit and rat skeletal muscle. The Journal of physiology. 1999 Jan; 514 ( Pt 2)(?):313-26. doi: 10.1111/j.1469-7793.1999.313ae.x. [PMID: 9852316]
K Kurihara, K Ajito, S Shibahara, T Ishizuka, O Hara, M Araake, S Omoto. Cladinose analogues of sixteen-membered macrolide antibiotics. I. Synthesis of 4-O-alkyl-L-cladinose analogues via glycosylation. The Journal of antibiotics. 1996 Jun; 49(6):582-92. doi: 10.7164/antibiotics.49.582. [PMID: 8698643]
P Finielz, J M Mondon, C Chuet, J Guiserix. Drug interaction between midecamycin and cyclosporin. Nephron. 1995; 70(1):136. doi: 10.1159/000188572. [PMID: 7617108]
P Periti, T Mazzei, E Mini, A Novelli. Clinical pharmacokinetic properties of the macrolide antibiotics. Effects of age and various pathophysiological states (Part I). Clinical pharmacokinetics. 1989 Apr; 16(4):193-214. doi: 10.2165/00003088-198916040-00001. [PMID: 2656049]
T Suzuki, A Sakai, K Ohta, S Endo, N Yasuda, M Morishita, T Ishioka. [Studies on absorption and excretion of rokitamycin dry syrup in healthy volunteers]. The Japanese journal of antibiotics. 1988 Jul; 41(7):813-22. doi: NULL. [PMID: 3172454]
T Suzuki, A Sakai, M Morishita, T Ishioka, K Shimizu. [Studies on concentrations in body fluids of 16-membered ring macrolide antibiotics upon oral administration to healthy volunteers. Effects of their metabolites on bioassay values]. The Japanese journal of antibiotics. 1988 May; 41(5):510-22. doi: NULL. [PMID: 3216473]
K Deguchi, N Yokota, S Tanaka, S Fukayama, Y Nishimura, H Yoshihara, S Oda, Y Matsumoto, R Ikegami, K Sato. [Midecamycin acetate-susceptibility of clinical isolates from dental and oral surgical infections]. The Japanese journal of antibiotics. 1986 Oct; 39(10):2595-600. doi: NULL. [PMID: 3643285]
A Inoue, T Deguchi. [The pharmacokinetic studies on spiramycin and acetylspiramycin in rats]. The Japanese journal of antibiotics. 1982 Aug; 35(8):1998-2004. doi: . [PMID: 7154248]
T Yoshida, T Watanabe, T Shomura, S Someya, R Okamoto, S Ishihara, K Miyauchi, Y Kazuno. Bacteriological evaluation of midecamycin acetate and its metabolites. The Japanese journal of antibiotics. 1982 Jun; 35(6):1462-74. doi: NULL. [PMID: 6982352]
M Morikawa, M Inoue, M Tsuboi, T Shomura, S Someya, S Murata, K Umemura, M Sugiura. A study of esterase--its application to biotransformation of midecamycin derivatives. Journal of pharmacobio-dynamics. 1982 May; 5(5):314-8. doi: 10.1248/bpb1978.5.314. [PMID: 7120031]
Y Iwasaki, S Iwata, T Kanemitsu, K Jozaki, H Hattori, R Wakabayashi, Y Kojima, K Sunakawa, T Oikawa, M Osano, Y Ichihashi, T Kuratsuji. [Fundamental and clinical evaluation of 9,3'-diacetylmidecamycin in pediatric field (author's transl)]. The Japanese journal of antibiotics. 1982 Feb; 35(2):429-37. doi: NULL. [PMID: 6979642]
H Sakakibara, O Okekawa, T Fujiwara, M Aizawa, S Omura. Acyl derivatives of 16-membered macrolides. II. Antibacterial activities and serum levels of 3"-O-acyl derivatives of leucomycin. The Journal of antibiotics. 1981 Aug; 34(8):1011-8. doi: 10.7164/antibiotics.34.1011. [PMID: 7319916]