Echinacoside (BioDeep_00000230630)

PANOMIX_OTCML-2023

代谢物信息卡片

化学式: C35H46O20 (786.2582316)
中文名称: 松果菊甙, 紫锥花苷, 松果菊苷, 紫锥菊苷, 海胆苷
谱图信息: 最多检出来源 Viridiplantae(plant) 1.01%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)COC4C(C(C(C(O4)CO)O)O)O)OCCC5=CC(=C(C=C5)O)O)O)O)O)O
InChI: InChI=1S/C35H46O20/c1-14-24(42)26(44)29(47)35(51-14)55-32-30(48)34(49-9-8-16-3-6-18(38)20(40)11-16)53-22(13-50-33-28(46)27(45)25(43)21(12-36)52-33)31(32)54-23(41)7-4-15-2-5-17(37)19(39)10-15/h2-7,10-11,14,21-22,24-40,42-48H,8-9,12-13H2,1H3/b7-4+/t14-,21+,22+,24-,25+,26+,27-,28+,29+,30+,31+,32+,33+,34+,35-/m0/s1

描述信息

Echinacoside is an oligosaccharide.
Echinacoside is a phenylethanoid glycoside isolated from Echinacea angustifolia in 1950, and currently being investigated for the treatment of Parkinsons, Alzheimers, atherosclerosis, osteoporosis, acute colitis, wound treatment, and hepatitis. Echinacoside has demonstrated inhibition of apoptosis in neural cell lines, demonstrating potential for use in the treatment of neurological conditions.
Echinacoside is a natural product found in Jasminum mesnyi, Pedicularis plicata, and other organisms with data available.
Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits Wnt/β-catenin signaling. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity[1][2][3].
Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits Wnt/β-catenin signaling. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity[1][2][3].

同义名列表

18 个代谢物同义名

[(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxymethyl]-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-tetrahydropyran-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate; (2R,3R,4R,5R,6R)-6-(3,4-Dihydroxyphenethoxy)-5-hydroxy-2-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)-4-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl 3-(3,4-dihydroxyphenyl)acrylate; [(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate; .BETA.-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL O-6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL-(1->3)-O-(.BETA.-D-GLUCOPYRANOSYL-(1->6))-, 4-(3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE); Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl O-6-deoxy-alpha-L-mannopyranosyl-(1-3)-O-(beta-D-glucopyranosyl-(1-6))-, 4-(3-(3,4-dihydroxyphenyl)-2-propenoate), beta-D-; 2-(3,4-dihydroxyphenyl)ethyl 6-deoxy-alpha-L-mannopyranosyl-(1-3)-[beta-D-glucopyranosyl-(1-6)]-4-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-beta-D-glucopyranoside; Echinacoside, United States Pharmacopeia (USP) Reference Standard; Echinacoside, primary pharmaceutical reference standard; Echinacoside, analytical standard; Echinacoside, 98\\% (HPLC); ECHINACOSIDE [USP-RS]; Echinacoside,(S); UNII-I04O1DT48T; MEGxp0_001773; echinacoside; Tox21_200945; I04O1DT48T; AC1NQZ1Q

数据库引用编号

15 个数据库交叉引用编号

ChEBI: CHEBI:4745
KEGG: C10450
PubChem: 5281771
DrugBank: DB15488
ChEMBL: CHEMBL510539
Wikipedia: Echinacoside
MeSH: echinacoside
ChemIDplus: 0082854373
KNApSAcK: C00002738
CAS: 737806-07-4
CAS: 82854-37-3
medchemexpress: HY-N0020
PubChem: 12633
3DMET: B03856
NIKKAJI: J362.655E

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Zehui Li, Jiashan Li, Yuan Li, Li Guo, Panyu Xu, Hanqian Du, Na Lin, Ying Xu. The role of Cistanches Herba and its ingredients in improving reproductive outcomes: A comprehensive review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155681. doi: 10.1016/j.phymed.2024.155681. [PMID: 38718638]
Zhou Yang, Yalin Zhao, Yanling Wang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Tingyu Liu, Yue Hu, Hui Chang. Echinacoside ameliorates post-stroke depression by activating BDNF signaling through modulation of Nrf2 acetylation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155433. doi: 10.1016/j.phymed.2024.155433. [PMID: 38547621]
Kiros Haddish, Jong Won Yun. Echinacoside stimulates myogenesis and ATP-dependent thermogenesis in the skeletal muscle via the activation of D1-like dopaminergic receptors. Archives of biochemistry and biophysics. 2024 Feb; 752(?):109886. doi: 10.1016/j.abb.2024.109886. [PMID: 38215960]
Jiao Wei, Zongmei Zheng, Xinxin Hou, Fengjing Jia, Yuan Yuan, Fuwen Yuan, Feng He, Liang Hu, Ling Zhao. Echinacoside inhibits colorectal cancer metastasis via modulating the gut microbiota and suppressing the PI3K/AKT signaling pathway. Journal of ethnopharmacology. 2024 Jan; 318(Pt A):116866. doi: 10.1016/j.jep.2023.116866. [PMID: 37429503]
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu. Echinacoside exerts neuroprotection via suppressing microglial α-synuclein/TLR2/NF-κB/NLRP3 axis in parkinsonian models. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155230. doi: 10.1016/j.phymed.2023.155230. [PMID: 38000105]
Hongyi Liang, Guoliang Yin, Guangxi Shi, Zhiyong Liu, Xiaofei Liu, Jingwei Li. Echinacoside regulates PI3K/AKT/HIF-1α/VEGF cross signaling axis in proliferation and apoptosis of breast cancer. Analytical biochemistry. 2024 01; 684(?):115360. doi: 10.1016/j.ab.2023.115360. [PMID: 37865269]
Wang Wang, Shujun Jiang, Yang Zhao, Guoxue Zhu. Echinacoside: A promising active natural products and pharmacological agents. Pharmacological research. 2023 Nov; 197(?):106951. doi: 10.1016/j.phrs.2023.106951. [PMID: 37804927]
Guo Ziliang, Qian Qingyuan, L I Xiaolin, Zhu Yuting, Ren Jun, L I Maoxing. Efficacy of verbascoside, echinacoside, crenatoside on altitude-induced fatigue in rats and possible mechanism. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2023 10; 43(5):934-943. doi: 10.19852/j.cnki.jtcm.20230630.001. [PMID: 37679981]
Yiming Li, Yingbiao Wu, Zhongping Ning, Xinming Li. Echinacoside ameliorates 5-fluorouracil-induced endothelial injury and senescence through SIRT1 activation. International immunopharmacology. 2023 May; 120(?):110279. doi: 10.1016/j.intimp.2023.110279. [PMID: 37187128]
Yuhao Ding, Yuan Zhang, Zhonghao Wang, Fanle Zeng, Qianzhen Zhen, Huizi Zhao, Jun Li, Taotao Ma, Cheng Huang. Echinacoside from Cistanche tubulosa ameliorates alcohol-induced liver injury and oxidative stress by targeting Nrf2. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023 03; 37(3):e22792. doi: 10.1096/fj.202201430r. [PMID: 36723904]
Qian-Ting Wang, Yan Jiang, Liang-Hui Xu, Jia-Li Chen. [Echinacoside hampers malignant progression of breast cancer MCF-7 cells by modulating AKR1B10/ERK signal transduction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Feb; 48(3):744-751. doi: 10.19540/j.cnki.cjcmm.20221102.702. [PMID: 36872238]
YaJuan Ni, Jing Zhang, Wenjing Zhu, Yixuan Duan, HongYuan Bai, Chunhong Luan. Echinacoside inhibited cardiomyocyte pyroptosis and improved heart function of HF rats induced by isoproterenol via suppressing NADPH/ROS/ER stress. Journal of cellular and molecular medicine. 2022 11; 26(21):5414-5425. doi: 10.1111/jcmm.17564. [PMID: 36201630]
Menghan Wang, Xing Ma, Guoyu Wang, Yanan Song, Miao Zhang, Zhongchao Mai, Borong Zhou, Ying Ye, Wei Xia. Targeting UBR5 in hepatocellular carcinoma cells and precise treatment via echinacoside nanodelivery. Cellular & molecular biology letters. 2022 Oct; 27(1):92. doi: 10.1186/s11658-022-00394-w. [PMID: 36224534]
Wan Shu, Ziwei Wang, Rong Zhao, Rui Shi, Jun Zhang, Wei Zhang, Hongbo Wang. Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification. Drug design, development and therapy. 2022; 16(?):1847-1863. doi: 10.2147/dddt.s361955. [PMID: 35734366]
Yingdan Zhao, Yang Yi, Bo Gu, Hanqing Wang, Jun Ma, Zhiyong Guo. Echinacoside protects adenine-induced uremic rats from sciatic nerve damage by up-regulating α-Klotho. Journal of musculoskeletal & neuronal interactions. 2021 09; 21(3):413-421. doi: . [PMID: 34465681]
Daniela Hanganu, Mihaela Niculae, Irina Ielciu, Neli-Kinga Olah, Melania Munteanu, Ramona Burtescu, Răzvan Ștefan, Loredana Olar, Emoke Pall, Sanda Andrei, Dan C Vodnar, Daniela Benedec, Ilioara Oniga. Chemical Profile, Cytotoxic Activity and Oxidative Stress Reduction of Different Syringa vulgaris L. Extracts. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113104. [PMID: 34067400]
Yang Tian, Shijie Jin, Vanessa Promes, Xuemei Liu, Yunling Zhang. Astragaloside IV and echinacoside benefit neuronal properties via direct effects and through upregulation of SOD1 astrocyte function in vitro. Naunyn-Schmiedeberg's archives of pharmacology. 2021 05; 394(5):1019-1029. doi: 10.1007/s00210-020-02022-w. [PMID: 33219470]
Luo Yang, Xiang Zhang, Min Liao, Yarong Hao. Echinacoside improves diabetic liver injury by regulating the AMPK/SIRT1 signaling pathway in db/db mice. Life sciences. 2021 Apr; 271(?):119237. doi: 10.1016/j.lfs.2021.119237. [PMID: 33600859]
Shiv Bharadwaj, Sherif Aly El-Kafrawy, Thamir A Alandijany, Leena Hussein Bajrai, Altaf Ahmad Shah, Amit Dubey, Amaresh Kumar Sahoo, Umesh Yadava, Mohammad Amjad Kamal, Esam Ibraheem Azhar, Sang Gu Kang, Vivek Dhar Dwivedi. Structure-Based Identification of Natural Products as SARS-CoV-2 Mpro Antagonist from Echinacea angustifolia Using Computational Approaches. Viruses. 2021 02; 13(2):. doi: 10.3390/v13020305. [PMID: 33672054]
Zhi Tao, Lihu Zhang, Tao Wu, Xianying Fang, Linguo Zhao. Echinacoside ameliorates alcohol-induced oxidative stress and hepatic steatosis by affecting SREBP1c/FASN pathway via PPARα. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Feb; 148(?):111956. doi: 10.1016/j.fct.2020.111956. [PMID: 33378712]
Yajuan Ni, Jie Deng, Xin Liu, Qing Li, Juanli Zhang, Hongyuan Bai, Jingwen Zhang. Echinacoside reverses myocardial remodeling and improves heart function via regulating SIRT1/FOXO3a/MnSOD axis in HF rats induced by isoproterenol. Journal of cellular and molecular medicine. 2021 01; 25(1):203-216. doi: 10.1111/jcmm.15904. [PMID: 33314649]
Xiu-Yu Tian, Mao-Xing Li, Tong Lin, Yan Qiu, Yu-Ting Zhu, Xiao-Lin Li, Wen-Di Tao, Peng Wang, Xiao-Xia Ren, Li-Ping Chen. A review on the structure and pharmacological activity of phenylethanoid glycosides. European journal of medicinal chemistry. 2021 Jan; 209(?):112563. doi: 10.1016/j.ejmech.2020.112563. [PMID: 33038797]
Balasubramani Gl, Rinky Rajput, Manish Gupta, Pradeep Dahiya, Jitendra K Thakur, Rakesh Bhatnagar, Abhinav Grover. Structure-based drug repurposing to inhibit the DNA gyrase of Mycobacterium tuberculosis. The Biochemical journal. 2020 11; 477(21):4167-4190. doi: 10.1042/bcj20200462. [PMID: 33030198]
Yufan Zhang, Qinfang Wu, Limin Zhong, Lei Wang, Dongwei Gong. Echinacoside promotes the proliferation of human renal tubular epithelial cells by blocking the HBX/TREM2‑mediated NF‑κB signalling pathway. Molecular medicine reports. 2020 08; 22(2):1137-1144. doi: 10.3892/mmr.2020.11201. [PMID: 32626964]
Yi Chen, Ying-Qi Li, Jia-Yi Fang, Ping Li, Fei Li. Establishment of the concurrent experimental model of osteoporosis combined with Alzheimer's disease in rat and the dual-effects of echinacoside and acteoside from Cistanche tubulosa. Journal of ethnopharmacology. 2020 Jul; 257(?):112834. doi: 10.1016/j.jep.2020.112834. [PMID: 32278031]
Longyun Zhou, Min Yao, Zirui Tian, Yongjia Song, Yueli Sun, Jie Ye, Gan Li, Kim Sia Sng, Leqin Xu, Xuejun Cui, Yongjun Wang. Echinacoside attenuates inflammatory response in a rat model of cervical spondylotic myelopathy via inhibition of excessive mitochondrial fission. Free radical biology & medicine. 2020 05; 152(?):697-714. doi: 10.1016/j.freeradbiomed.2020.01.014. [PMID: 32014501]
Zhifei Fu, Lifeng Han, Peng Zhang, Haoping Mao, Han Zhang, Yuefei Wang, Xiumei Gao, Erwei Liu. Cistanche polysaccharides enhance echinacoside absorption in vivo and affect the gut microbiota. International journal of biological macromolecules. 2020 Apr; 149(?):732-740. doi: 10.1016/j.ijbiomac.2020.01.216. [PMID: 31987946]
F Tugce Guragac Dereli, Yasin Genc, Iclal Saracoglu, Esra Kupeli Akkol. Enzyme inhibitory assessment of the isolated constituents from Plantago holosteum Scop. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2020 Mar; 75(3-4):121-128. doi: 10.1515/znc-2020-0008. [PMID: 32267249]
Xiang Zhang, Yarong Hao. Beneficial Effects of Echinacoside on Diabetic Cardiomyopathy in Diabetic Db/Db Mice. Drug design, development and therapy. 2020; 14(?):5575-5587. doi: 10.2147/dddt.s276972. [PMID: 33376302]
Qingqing Song, Jun Li, Huixia Huo, Yan Cao, Yitao Wang, Yuelin Song, Pengfei Tu. Retention Time and Optimal Collision Energy Advance Structural Annotation Relied on LC-MS/MS: An Application in Metabolite Identification of an Antidementia Agent Namely Echinacoside. Analytical chemistry. 2019 12; 91(23):15040-15048. doi: 10.1021/acs.analchem.9b03720. [PMID: 31693341]
Yehong Guo, Limin Wang, Qian Li, Cheng Zhao, Ping He, Xudong Ma. Enhancement of Kidney Invigorating Function in Mouse Model by Cistanches Herba Dried Rapidly at a Medium High Temperature. Journal of medicinal food. 2019 Dec; 22(12):1246-1253. doi: 10.1089/jmf.2018.4354. [PMID: 31834844]
Elham Sadat Beshamgan, Mohsen Sharifi, Fatemeh Zarinkamar. Crosstalk among polyamines, phytohormones, hydrogen peroxide, and phenylethanoid glycosides responses in Scrophularia striata to Cd stress. Plant physiology and biochemistry : PPB. 2019 Oct; 143(?):129-141. doi: 10.1016/j.plaphy.2019.08.028. [PMID: 31493673]
Ziyan Li, Chunhong Zhang, Guanyao Ren, Min Yang, Shoudong Zhu, Minhui Li. Ecological modeling of Cistanche deserticola Y.C. Ma in Alxa, China. Scientific reports. 2019 09; 9(1):13134. doi: 10.1038/s41598-019-48397-6. [PMID: 31511531]
Yan-Hang Wang, Xiao-Min Song, Yong Jiang, Peng-Fei Tu, Ke-Wu Zeng. [Method for active ingredients' in vivo target identification of traditional Chinese medicine using magnetic nanoparticles]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Jul; 44(13):2657-2661. doi: 10.19540/j.cnki.cjcmm.20190418.201. [PMID: 31359673]
Hongnan Zheng, Yuting Su, Yang Sun, Tianle Tang, Di Zhang, Xuefeng He, Jianbo Wang. Echinacoside alleviates hypobaric hypoxia-induced memory impairment in C57 mice. Phytotherapy research : PTR. 2019 Apr; 33(4):1150-1160. doi: 10.1002/ptr.6310. [PMID: 30768741]
Chieh-Ju Wu, Mei-Yin Chien, Nan-Hei Lin, Yi-Chiao Lin, Wen-Ying Chen, Chao-Hsiang Chen, Jason T C Tzen. Echinacoside Isolated from Cistanche tubulosa Putatively Stimulates Growth Hormone Secretion via Activation of the Ghrelin Receptor. Molecules (Basel, Switzerland). 2019 Feb; 24(4):. doi: 10.3390/molecules24040720. [PMID: 30781558]
Ying Ye, Yanan Song, Juhua Zhuang, Guoyu Wang, Jing Ni, Wei Xia. Anticancer effects of echinacoside in hepatocellular carcinoma mouse model and HepG2 cells. Journal of cellular physiology. 2019 02; 234(2):1880-1888. doi: 10.1002/jcp.27063. [PMID: 30067868]
Yan Liang, Chang Chen, Baomei Xia, Wei Wu, Juanjuan Tang, Qing Chen, Lili Tang, Hui Yang, Zhennian Zhang, Yan Lu, Ye Yang, Yang Zhao. Neuroprotective Effect of Echinacoside in Subacute Mouse Model of Parkinson's Disease. BioMed research international. 2019; 2019(?):4379639. doi: 10.1155/2019/4379639. [PMID: 30834264]
Fengwei He, Li Chen, Qian Liu, Xiao Wang, Jia Li, Jinqian Yu. Preparative Separation of Phenylethanoid and Secoiridoid Glycosides from Ligustri Lucidi Fructus by High-Speed Counter-Current Chromatography Coupled with Ultrahigh Pressure Extraction. Molecules (Basel, Switzerland). 2018 Dec; 23(12):. doi: 10.3390/molecules23123353. [PMID: 30567348]
Cheng Wei Lu, Hsi Lung Hsieh, Tzu Yu Lin, Ting Yang Hsieh, Shu Kuei Huang, Su Jane Wang. Echinacoside, an Active Constituent of Cistanche Herba, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/GSK3β Pathway. Biological & pharmaceutical bulletin. 2018 Nov; 41(11):1685-1693. doi: 10.1248/bpb.b18-00407. [PMID: 30197410]
Fangxue Xu, Hui Cao, Xiaowei Cui, Hong Guo, Chunchao Han. Optimization of Fermentation Condition for Echinacoside Yield Improvement with Penicillium sp. H1, an Endophytic Fungus Isolated from Ligustrum lucidum Ait Using Response Surface Methodology. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102586. [PMID: 30308945]
Monika E Czerwińska, Emilia Gąsińska, Anna Leśniak, Paulina Krawczyk, Anna K Kiss, Marek Naruszewicz, Magdalena Bujalska-Zadrożny. Inhibitory effect of Ligustrum vulgare leaf extract on the development of neuropathic pain in a streptozotocin-induced rat model of diabetes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Oct; 49(?):75-82. doi: 10.1016/j.phymed.2018.06.006. [PMID: 30217264]
Yu Yan, Tong-Xiang Liu, Dan Bi, Wen-Jing Liu, Qing-Qing Song, Jun Li, Yue-Lin Song, Peng-Fei Tu, Yun-Fang Zhao. [Transformation pathways in methanol of echinacoside, a principal effective ingredient of Cistanches Herba]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Jun; 43(11):2321-2325. doi: 10.19540/j.cnki.cjcmm.20180309.001. [PMID: 29945385]
Jingjing Liu, Lingling Yang, Yanhong Dong, Bo Zhang, Xueqin Ma. Echinacoside, an Inestimable Natural Product in Treatment of Neurological and other Disorders. Molecules (Basel, Switzerland). 2018 May; 23(5):. doi: 10.3390/molecules23051213. [PMID: 29783690]
Gaosheng Hu, Tianran Wu, Yue Chang, Xinyi Zhan, Jingming Jia. Wound Stress, an Unheeded Factor for Echinacoside Accumulation in Cistanche deserticola Y. C. Ma. Molecules (Basel, Switzerland). 2018 Apr; 23(4):. doi: 10.3390/molecules23040893. [PMID: 29649140]
Qin Zheng, Yu Tang, Peng-Yi Hu, Dan Liu, Delin Zhang, Pengfei Yue, Yuanyuan Guo, Ming Yang. The influence and mechanism of ligustilide, senkyunolide I, and senkyunolide A on echinacoside transport through MDCK-MDR1 cells as blood-brain barrier in vitro model. Phytotherapy research : PTR. 2018 Mar; 32(3):426-435. doi: 10.1002/ptr.5985. [PMID: 29193364]
Zhihui Jiang, Bo Zhou, Xinping Li, Gordon M Kirby, Xiaoying Zhang. Echinacoside Increases Sperm Quantity in Rats by Targeting the Hypothalamic Androgen Receptor. Scientific reports. 2018 03; 8(1):3839. doi: 10.1038/s41598-018-22211-1. [PMID: 29497114]
Yu Yan, Qingqing Song, Xiaojia Chen, Jun Li, Peng Li, Yitao Wang, Tongxiang Liu, Yuelin Song, Pengfei Tu. Simultaneous determination of components with wide polarity and content ranges in Cistanche tubulosa using serially coupled reverse phase-hydrophilic interaction chromatography-tandem mass spectrometry. Journal of chromatography. A. 2017 Jun; 1501(?):39-50. doi: 10.1016/j.chroma.2017.04.034. [PMID: 28476319]
Xinhong Wang, Xiaoguang Wang, Yuhai Guo. Rapidly Simultaneous Determination of Six Effective Components in Cistanche tubulosa by Near Infrared Spectroscopy. Molecules (Basel, Switzerland). 2017 May; 22(5):. doi: 10.3390/molecules22050843. [PMID: 28534831]
Fengjuan Tang, Yarong Hao, Xue Zhang, Jian Qin. Effect of echinacoside on kidney fibrosis by inhibition of TGF-β1/Smads signaling pathway in the db/db mice model of diabetic nephropathy. Drug design, development and therapy. 2017; 11(?):2813-2826. doi: 10.2147/dddt.s143805. [PMID: 29033543]
Claudio Frezza, Alessandro Venditti, Mirella Di Cecco, Giampiero Ciaschetti, Mauro Serafini, Armandodoriano Bianco. Iridoids and phenylethanoid glycosides from the aerial parts of Ajuga tenorei, an endemic Italian species. Natural product research. 2017 Jan; 31(2):218-223. doi: 10.1080/14786419.2016.1218490. [PMID: 27492580]
Ling Zhang, Qiao-Yan Cai, Zhi-Xiong Cai, Yi Fang, Chun-Song Zheng, Li-Li Wang, Shan Lin, Da-Xin Chen, Jun Peng. Interactions of Bovine Serum Albumin with Anti-Cancer Compounds Using a ProteOn XPR36 Array Biosensor and Molecular Docking. Molecules (Basel, Switzerland). 2016 Dec; 21(12):. doi: 10.3390/molecules21121706. [PMID: 27973422]
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