Poliumoside (BioDeep_00000230613)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


6-[2-(3,4-DIHYDROXYPHENYL)ETHOXY]-5-HYDROXY-4-[(3,4,5-TRIHYDROXY-6-METHYLOXAN-2-YL)OXY]-2-{[(3,4,5-TRIHYDROXY-6-METHYLOXAN-2-YL)OXY]METHYL}OXAN-3-YL (2E)-3-(3,4-DIHYDROXYPHENYL)PROP-2-ENOATE

化学式: C35H46O19 (770.2633)
中文名称: 金石蚕甙, 金石蚕苷
谱图信息: 最多检出来源 Viridiplantae(plant) 55.1%

分子结构信息

SMILES: CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OCCC3=CC(=C(C=C3)O)O)O)OC4C(C(C(C(O4)C)O)O)O)OC(=O)C=CC5=CC(=C(C=C5)O)O)O)O)O
InChI: InChI=1S/C35H46O19/c1-14-24(41)26(43)28(45)33(50-14)49-13-22-31(53-23(40)8-5-16-3-6-18(36)20(38)11-16)32(54-35-29(46)27(44)25(42)15(2)51-35)30(47)34(52-22)48-10-9-17-4-7-19(37)21(39)12-17/h3-8,11-12,14-15,22,24-39,41-47H,9-10,13H2,1-2H3/b8-5+

描述信息

Poliumoside is an oligosaccharide.
Poliumoside is a natural product found in Barleria lupulina, Teucrium polium, and other organisms with data available.
Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC50s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity[1][2][3].
Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC50s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity[1][2][3].

同义名列表

3 个代谢物同义名

6-[2-(3,4-DIHYDROXYPHENYL)ETHOXY]-5-HYDROXY-4-[(3,4,5-TRIHYDROXY-6-METHYLOXAN-2-YL)OXY]-2-{[(3,4,5-TRIHYDROXY-6-METHYLOXAN-2-YL)OXY]METHYL}OXAN-3-YL (2E)-3-(3,4-DIHYDROXYPHENYL)PROP-2-ENOATE; [6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-2-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate; Poliumoside



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Chao-Yi Xu, Chun Xu, Yi-Ning Xu, Shi-Qi Du, Zi-Han Dai, Shu-Qing Jin, Gang Zheng, Cheng-Long Xie, Wen-Lai Fang. Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Mar; 125(?):155342. doi: 10.1016/j.phymed.2024.155342. [PMID: 38295665]
  • Samed Şimşek, Hüseyin Akşit, Ali Aydın, Ekrem Köksal. Ferruginoside D: A Novel Phenylethanoid from Verbascum leiocarpum. Chemistry & biodiversity. 2023 Dec; 20(12):e202301200. doi: 10.1002/cbdv.202301200. [PMID: 37909246]
  • Gabriel R Martins, Thamirys Silva da Fonseca, Lucero Martínez-Fructuoso, Rosineide Costa Simas, Fabio T Silva, Fatima Regina G Salimena, Daniela S Alviano, Celuta Sales Alviano, Gilda Guimarães Leitão, Rogelio Pereda-Miranda, Suzana G Leitão. Antifungal Phenylpropanoid Glycosides from Lippia rubella. Journal of natural products. 2019 03; 82(3):566-572. doi: 10.1021/acs.jnatprod.8b00975. [PMID: 30817148]
  • Hao Qian, Fang-Jun Yu, Dan-Yi Lu, Bao-Jian Wu, Xing-Wang Zhang, Huan Wang, Zhi-Guo Ma. Identification of poliumoside metabolites in rat plasma, urine, bile, and intestinal bacteria with UPLC/Q-TOF-MS. Chinese journal of natural medicines. 2018 Nov; 16(11):871-880. doi: 10.1016/s1875-5364(18)30129-8. [PMID: 30502769]
  • Rui Deng, Yunhui Xu, Feng Feng, Wenyuan Liu. Identification of poliumoside metabolites in rat feces by high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Oct; 969(?):285-96. doi: 10.1016/j.jchromb.2014.08.032. [PMID: 25215644]
  • Xiao Hu, Li Li, Yi-Fang Yang, Chun-Yue Huang, Guang-Lei Huang. [Caffeoyl phenylethanoid glycosides from Callicarpa kwangtungensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 May; 39(9):1630-4. doi: ". [PMID: 25095374]
  • Can-Huang Liu, Ta-Si Liu, Chen-Qu Luo, Ji Zhang, Xiao-Yan Zeng, Lei Cui, Li-Juan Xie. [Determination of forsythiaside B and poliumoside in different origin and parts from Callicarpa kwangtungensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Oct; 38(19):3324-6. doi: . [PMID: 24422401]
  • Xiuman Sun, Qiongfeng Liao, Guanghui Liu, Hao Cai, Lei Zhang, Chenchen Zhu, Zhiyong Xie. Simultaneous determination of three phenylethanoid glycosides from Callicarpae Caulis et Folium in rat plasma by LC-MS/MS and its application to PK study. Bioanalysis. 2013 Aug; 5(15):1883-95. doi: 10.4155/bio.13.124. [PMID: 23905862]
  • Bui Huu Tai, Nguyen Xuan Nhiem, Tran Hong Quang, Nguyen Thi Thanh Ngan, Nguyen Huu Tung, Yohan Kim, Jung-Jin Lee, Chang-Seon Myung, Nguyen Manh Cuong, Young Ho Kim. A new iridoid and effect on the rat aortic vascular smooth muscle cell proliferation of isolated compounds from Buddleja officinalis. Bioorganic & medicinal chemistry letters. 2011 Jun; 21(11):3462-6. doi: 10.1016/j.bmcl.2011.03.078. [PMID: 21524582]