Tenuifolin (BioDeep_00000230558)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C36H56O12 (680.3771576)
中文名称: 细叶远志皂苷
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 2.13%
分子结构信息
SMILES: CC1(C)CCC2(C(=O)O)CCC3(CO)C(=CCC4C5(C)CC(O)C(OC6OC(CO)C(O)C(O)C6O)C(C)(C(=O)O)C5CCC43C)C2C1
InChI: InChI=1S/C36H56O12/c1-31(2)10-11-35(30(45)46)12-13-36(17-38)18(19(35)14-31)6-7-22-32(3)15-20(39)27(34(5,29(43)44)23(32)8-9-33(22,36)4)48-28-26(42)25(41)24(40)21(16-37)47-28/h6,19-28,37-42H,7-17H2,1-5H3,(H,43,44)(H,45,46)/t19-,20-,21+,22+,23+,24+,25-,26+,27-,28-,32+,33+,34-,35-,36-/m0/s1
描述信息
Tenuifolin is a natural product found in Polygala comosa, Muraltia spinosa, and other organisms with data available.
Tenuifolin is a triterpene isolated from Polygala tenuifolia?Willd, has neuroprotective effects. Tenuifolin reduces Aβ secretion by inhibiting β-secretase. Tenuifolin improves learning and memory in aged mice by decreasing AChE activity and has the potential for Alzheimer’s disease (AD) treatment[1].
Tenuifolin is a triterpene isolated from Polygala tenuifolia?Willd, has neuroprotective effects. Tenuifolin reduces Aβ secretion by inhibiting β-secretase. Tenuifolin improves learning and memory in aged mice by decreasing AChE activity and has the potential for Alzheimer’s disease (AD) treatment[1].
同义名列表
4 个代谢物同义名
(2S,3R,4S,4aR,6aR,6bR,8aS,12aS,14aR,14bR)-2-hydroxy-6b-(hydroxymethyl)-4,6a,11,11,14b-pentamethyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4,8a-dicarboxylic acid; Olean-12-ene-23,28-dioic acid, 3-(beta-D-glucopyranosyloxy)-2,27-dihydroxy-, (2beta,3beta,4alpha)-; tenuifolin diterpene; Tenuifolin
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 21588226
- PubChem: 71307577
- MeSH: tenuifolin diterpene
- KNApSAcK: C00032301
- chemspider: 10205970
- CAS: 20183-47-5
- medchemexpress: HY-N0702
- PMhub: MS000082622
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Heng Kong, Yuan-Yuan Han, Gai-Ling Yang, Kang Li, Lu Yu, Xun-Kai Xie, Guang-Yuan Xia, Peng-Ju Wei, Wan-Rong Zhang, Chu-Hua Li. Tenuifolin improves learning and memory by regulating long-term potentiation and dendritic structure of hippocampal CA1 area in healthy female mice but not male mice.
Behavioural brain research.
2024 May; 466(?):114974. doi:
10.1016/j.bbr.2024.114974. [PMID: 38554850] - Ning Jiang, Yiwen Zhang, Caihong Yao, Yupei Liu, Yuzhen Chen, Fang Chen, Yan Wang, Muhammad Iqbal Choudhary, Xinmin Liu. Tenuifolin ameliorates the sleep deprivation-induced cognitive deficits.
Phytotherapy research : PTR.
2023 Feb; 37(2):464-476. doi:
10.1002/ptr.7627. [PMID: 36608695] - Shaojie Yang, Yan Qu, Juan Wang, Feng Gao, Manman Ji, Pan Xie, Aisong Zhu, Bei Tan, Xuncui Wang, Guoqi Zhu. Anshen Dingzhi prescription in the treatment of PTSD in mice: Investigation of the underlying mechanism from the perspective of hippocampal synaptic function.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jul; 101(?):154139. doi:
10.1016/j.phymed.2022.154139. [PMID: 35523115] - Haixia Wang, Hong Huang, Ning Jiang, Yiwen Zhang, Jingwei Lv, Xinmin Liu. Tenuifolin ameliorates chronic restraint stress-induced cognitive impairment in C57BL/6J mice.
Phytotherapy research : PTR.
2022 Mar; 36(3):1402-1412. doi:
10.1002/ptr.7402. [PMID: 35129236] - Tatsuya Shirahata, Rintaro Miyaishi, Tatsuki Kitazoe, Masaya Saito, Yuki Taneoka, Shuhei Hidaka, Masaki Yokoyama, Takayori Tojima, Tatsuya Katsumi, Nozomu Hirata, Takashi Nishino, Eisuke Kaji, Haruki Yamada, Takayuki Nagai, Hiroaki Kiyohara, Shunsuke Nakamori, Naruki Konishi, Yoshinori Kobayashi. Preparation of Tenuifolin from Polygala senega L. Root Using a Hydrolytic Continuous Flow System under High-Temperature, High-Pressure Conditions.
The Journal of organic chemistry.
2021 12; 86(23):16268-16277. doi:
10.1021/acs.joc.1c01125. [PMID: 34730980] - Fang Peng, Linyu Lu, Fei Wei, Die Wu, Kai Wang, Juanjuan Tang. The onjisaponin B metabolite tenuifolin ameliorates dopaminergic neurodegeneration in a mouse model of Parkinson's disease.
Neuroreport.
2020 04; 31(6):456-465. doi:
10.1097/wnr.0000000000001428. [PMID: 32168102] - Hui Yan, Zhuan-Di Zheng, Hong-Fei Wu, Xiao-Chuang Liu, An Zhou. A microemulsion high-performance liquid chromatography (MELC) method for the separation and determination of hydrolyzed tenuifolin in Radix Polygalae.
Scientific reports.
2019 12; 9(1):19108. doi:
10.1038/s41598-019-55416-z. [PMID: 31836776] - Lin Wang, Gui Fang Jin, He Han Yu, Xiao Hua Lu, Zhen Hua Zou, Jia Qi Liang, Hong Yang. Protective effects of tenuifolin isolated from Polygala tenuifolia Willd roots on neuronal apoptosis and learning and memory deficits in mice with Alzheimer's disease.
Food & function.
2019 Nov; 10(11):7453-7460. doi:
10.1039/c9fo00994a. [PMID: 31664284] - Qing Cao, Yong Jiang, Su-Ying Cui, Peng-Fei Tu, Yue-Mei Chen, Xiao-Li Ma, Xiang-Yu Cui, Yuan-Li Huang, Hui Ding, Jin-Zhi Song, Bin Yu, Zhao-Fu Sheng, Zi-Jun Wang, Ya-Ping Xu, Guang Yang, Hui Ye, Xiao Hu, Yong-He Zhang. Tenuifolin, a saponin derived from Radix Polygalae, exhibits sleep-enhancing effects in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2016 Dec; 23(14):1797-1805. doi:
10.1016/j.phymed.2016.10.015. [PMID: 27912882] - Dan-Dan Wang, Lu Bai, Xiao-Shuang Xu, Fu-Sheng Zhang, Jie Xing, Jin-Ping Jia, Hong-Ling Tian, Xue-Mei Qin. [Rationality of commodity criteria and traditional breeding of Polygala tenuifolia based on agronomic traits and determination of chemical components].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 Oct; 41(20):3733-3740. doi:
10.4268/cjcmm20162006. [PMID: 28929649] - Qian Wang, Bing-Xin Xiao, Rui-Le Pan, Xin-Min Liu, Yong-Hong Liao, Li Feng, Fang-Rui Cao, Qi Chang. An LC-MS/MS method for simultaneous determination of three Polygala saponin hydrolysates in rat plasma and its application to a pharmacokinetic study.
Journal of ethnopharmacology.
2015 Jul; 169(?):401-6. doi:
10.1016/j.jep.2015.04.033. [PMID: 25922266] - Yan-hua Zhang, Lu Bai, Zhen-yu Li, Fu-sheng Zhang, Xue-mei Qin. [HPLC Fingerprint and Active Components Determination of Polygala tenuifolia Root Bark and Root].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2015 Jul; 38(7):1408-12. doi:
". [PMID: 26946836] - Ya-min Liu, Zong-yang Li, Han Hu, Shu-ping Xu, Qi Chang, Yong-hong Liao, Rui-le Pan, Xin-min Liu. Tenuifolin, a secondary saponin from hydrolysates of polygalasaponins, counteracts the neurotoxicity induced by Aβ25-35 peptides in vitro and in vivo.
Pharmacology, biochemistry, and behavior.
2015 Jan; 128(?):14-22. doi:
10.1016/j.pbb.2014.11.010. [PMID: 25444865] - Yu-Hong Zhou, Shui-Ying Zhang, Qiang Guo, Xing-Yun Chai, Yong Jiang, Peng-Fei Tu. Chemical investigation of the roots of Polygala sibirica L.
Chinese journal of natural medicines.
2014 Mar; 12(3):225-8. doi:
10.1016/s1875-5364(14)60038-8. [PMID: 24702811] - Bo Ma, Xiaotian Li, Jing Li, Qi Zhang, Yinhui Liu, Xiaojing Yang, Jingjing Sun, Di Yao, Lei Liu, Xiaoxin Liu, Hanjie Ying. Quantitative analysis of tenuifolin concentrations in rat plasma and tissue using LC⬜MS/MS: application to pharmacokinetic and tissue distribution study.
Journal of pharmaceutical and biomedical analysis.
2014 Jan; 88(?):191-200. doi:
10.1016/j.jpba.2013.07.012. [PMID: 24055855] - Yi Yao, Min Jia, Jian-Guo Wu, Hong Zhang, Lian-Na Sun, Wan-Sheng Chen, Khalid Rahman. Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice.
Pharmaceutical biology.
2010 Jul; 48(7):801-7. doi:
10.3109/13880200903280042. [PMID: 20645780] - Rong-Jyh Lin, Ming-Jen Cheng, Jin-Cherng Huang, Wen-Li Lo, Yu-Ting Yeh, Chung-Min Yen, Chin-Mei Lu, Chung-Yi Chen. Cytotoxic compounds from the stems of Cinnamomum tenuifolium.
Journal of natural products.
2009 Oct; 72(10):1816-24. doi:
10.1021/np900225p. [PMID: 19754130] - J Lv, H Jia, Y Jiang, Y Ruan, Z Liu, W Yue, K Beyreuther, P Tu, D Zhang. Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-beta secretion in vitro.
Acta physiologica (Oxford, England).
2009 Aug; 196(4):419-25. doi:
10.1111/j.1748-1716.2009.01961.x. [PMID: 19208093] - Hong Zhang, Ting Han, Lei Zhang, Cheng-Hao Yu, De-Guang Wan, Khalid Rahman, Lu-Ping Qin, Cheng Peng. Effects of tenuifolin extracted from radix polygalae on learning and memory: a behavioral and biochemical study on aged and amnesic mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2008 Aug; 15(8):587-94. doi:
10.1016/j.phymed.2007.12.004. [PMID: 18289838] - D J Greenblatt, J A Knowles, W H Comer, R I Shader, J S Harmatz, H W Ruelius. Clinical pharmacokinetics of lorazepam. IV. Long-term oral administration.
Journal of clinical pharmacology.
1977 Aug; 17(8-9):495-500. doi:
10.1002/j.1552-4604.1977.tb05642.x. [PMID: 19509]