Didymin (BioDeep_00000230472)

 

Secondary id: BioDeep_00000019009

PANOMIX_OTCML-2023


代谢物信息卡片


(S)-5-Hydroxy-2-(4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-4-one

化学式: C28H34O14 (594.1948464)
中文名称: 香风草甙, 香蜂草苷
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 36.36%

分子结构信息

SMILES: c(O)(c3)c(C(=O)2)c(cc3OC(O4)C(O)C(O)C(O)C(COC(O5)C(O)C(C(C5C)O)O)4)OC(C2)c(c1)ccc(OC)c1
InChI: InChI=1S/C28H34O14/c1-11-21(31)23(33)25(35)27(39-11)38-10-19-22(32)24(34)26(36)28(42-19)40-14-7-15(29)20-16(30)9-17(41-18(20)8-14)12-3-5-13(37-2)6-4-12/h3-8,11,17,19,21-29,31-36H,9-10H2,1-2H3/t11-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

描述信息

Didymin is a member of flavonoids and a glycoside.
Didymin is a natural product found in Citrus latipes, Citrus hystrix, and other organisms with data available.
See also: Tangerine peel (part of).
Didymin, a dietary flavonoid glycoside from citrus fruits, possesses antioxidant properties. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma[1][2].
Didymin, a dietary flavonoid glycoside from citrus fruits, possesses antioxidant properties. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma[1][2].

同义名列表

31 个代谢物同义名

(S)-5-Hydroxy-2-(4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-4-one; (S)-5-hydroxy-2-(4-methoxyphenyl)-7-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)methyl)tetrahydro-2H-pyran-2-yloxy)chroman-4-one; (2S)-5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one; 4H-1-BENZOPYRAN-4-ONE, 7-((6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(4-METHOXYPHENYL)-, (2S)-; 4H-1-BENZOPYRAN-4-ONE, 7-((6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(4-METHOXYPHENYL)-, (S)-; (2S)-7-((6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(4-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; 4H-1-BENZOPYRAN-4-ONE, 7-((6-O-(6-DEOXY-alpha-L-MANNOPYRANOSYL)-beta-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(4-METHOXYPHENYL)-, (2S)-; 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(4-methoxyphenyl)-, (S)-; (2S)-7-((6-O-(6-DEOXY-alpha-L-MANNOPYRANOSYL)-beta-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(4-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; (S)-7-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one; (S)-7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one; FLAVANONE, 5,7-DIHYDROXY-4-METHOXY-, 7.BETA.-RUTINOSIDE; FLAVANONE, 5,7-DIHYDROXY-4-METHOXY-, 7beta-RUTINOSIDE; 4-METHOXY-5,7-DIHYDROXYFLAVANONE 7-O-RUTINOSIDE; Isosakuranetin-7-beta-rutinoside; Isosakuranetin-7-O-rutinoside; Isosakuranetin 7-O-rutinoside; Iso-sakuranetin-7-putinoside; Didymin, analytical standard; Isosakuranetin 7-rutinoside; CITRIFOLIOL-7-O-RUTINOSIDE; DIDYMIN (USP-RS); DIDYMIN [USP-RS]; UNII-02Q5OS3TU3; Neoponcirin; 02Q5OS3TU3; Didymine; Didymin; (S) -7- [ [ 6-O- (6-Deoxy-alpha-L-mannopyranosyl) -beta-D-glucopyranosyl ] oxy ] -2,3-dihydro-5-hydroxy-2- (4-methoxyphenyl) -4H-1-benzopyran-4-one; 5,7-Dihydroxy-4-methoxyflavanone 7-O-rutinoside; Isosakuranetin-7-rutinoside



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yan Li, Cuiyu Li, Yuhua Xiong, Bin Fang, Xing Lin, Quanfang Huang. Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics. Drug design, development and therapy. 2022; 16(?):1713-1729. doi: 10.2147/dddt.s351092. [PMID: 35698653]
  • Zhongwen Feng, Lijun Pang, Siyun Chen, Xiaohong Pang, Yushen Huang, Qian Qiao, Yinglian Wang, Sayyaphone Vonglorkham, Quanfang Huang, Xing Lin, Jinbin Wei. Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice. International immunopharmacology. 2020 Nov; 88(?):107003. doi: 10.1016/j.intimp.2020.107003. [PMID: 33182043]
  • Gopalsamy Rajiv Gandhi, Alan Bruno Silva Vasconcelos, Ding-Tao Wu, Hua-Bin Li, Poovathumkal James Antony, Hang Li, Fang Geng, Ricardo Queiroz Gurgel, Narendra Narain, Ren-You Gan. Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies. Nutrients. 2020 Sep; 12(10):. doi: 10.3390/nu12102907. [PMID: 32977511]
  • Kirtikar Shukla, Himangshu Sonowal, Ashish Saxena, Kota V Ramana. Didymin prevents hyperglycemia-induced human umbilical endothelial cells dysfunction and death. Biochemical pharmacology. 2018 06; 152(?):1-10. doi: 10.1016/j.bcp.2018.03.012. [PMID: 29548811]
  • Quanfang Huang, Facheng Bai, Jinlan Nie, Shengjuan Lu, Chunyuang Lu, Xunshuai Zhu, Lang Zhuo, Xing Lin. Didymin ameliorates hepatic injury through inhibition of MAPK and NF-κB pathways by up-regulating RKIP expression. International immunopharmacology. 2017 Jan; 42(?):130-138. doi: 10.1016/j.intimp.2016.11.028. [PMID: 27912149]
  • Mingliang Zhong, Guibo Sun, Xiaopo Zhang, Guangli Sun, Xudong Xu, Shichun Yu. A new prenylated naphthoquinoid from the aerial parts of Clinopodium chinense (Benth.) O. Kuntze. Molecules (Basel, Switzerland). 2012 Nov; 17(12):13910-6. doi: 10.3390/molecules171213910. [PMID: 23178306]
  • Ram M Uckoo, Guddadarangavvanahally K Jayaprakasha, V M Balasubramaniam, Bhimanagouda S Patil. Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques. Journal of food science. 2012 Sep; 77(9):C921-6. doi: 10.1111/j.1750-3841.2012.02865.x. [PMID: 22957912]
  • Jyotsana Singhal, Lokesh Dalasanur Nagaprashantha, Rit Vatsyayan, Ashutosh, Sanjay Awasthi, Sharad S Singhal. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Cancer prevention research (Philadelphia, Pa.). 2012 Mar; 5(3):473-83. doi: 10.1158/1940-6207.capr-11-0318. [PMID: 22174364]