Scutellarin (BioDeep_00000230284)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3S,4S,5R,6S)-6-((5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

化学式: C21H18O12 (462.0798228)
中文名称: 灯盏花乙素, 高黄芩甙, 野黄芩苷, 高黄芩苷, 印黄芩苷, 野黄芩甙, 黃芹素
谱图信息: 最多检出来源 Viridiplantae(plant) 0.78%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc(cc2=O)c1ccc(cc1)O)O)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@@H](O1)C(=O)O)O)O)O
InChI: InChI=1S/C21H18O12/c22-8-3-1-7(2-4-8)10-5-9(23)13-11(31-10)6-12(14(24)15(13)25)32-21-18(28)16(26)17(27)19(33-21)20(29)30/h1-6,16-19,21-22,24-28H,(H,29,30)/t16-,17-,18+,19+,21+/m0/s1

描述信息

Scutellarin is the glycosyloxyflavone which is the 7-O-glucuronide of scutellarein. It has a role as an antineoplastic agent and a proteasome inhibitor. It is a glycosyloxyflavone, a glucosiduronic acid, a trihydroxyflavone and a monosaccharide derivative. It is functionally related to a scutellarein. It is a conjugate acid of a scutellarin(1-).
Scutellarin is a natural product found in Scoparia dulcis, Sempervivum ruthenicum, and other organisms with data available.
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively.
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively.
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively.

同义名列表

45 个代谢物同义名

(2S,3S,4S,5R,6S)-6-((5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-chromen-7-yl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-[5,6-DIHYDROXY-2-(4-HYDROXYPHENYL)-4-OXO-CHROMEN-7-YL]OXY-3,4,5-TRIHYDROXY-OXANE-2-CARBOXYLIC ACID; (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid; GLUCOPYRANOSIDURONIC ACID, 5,6-DIHYDROXY-2-(P-HYDROXYPHENYL)-4-OXO-4H-1-BENZOPYRAN-7-YL, .BETA.-D-; .BETA.-D-GLUCOPYRANOSIDURONIC ACID, 5,6-DIHYDROXY-2-(4-HYDROXYPHENYL)-4-OXO-4H-1-BENZOPYRAN-7-YL; Glucopyranosiduronic acid, 5,6-dihydroxy-2-(p-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, beta-D-; beta-D-glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl; 4H-1-Benzopyran-4-one, 7-(.beta.-D-glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-; 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranosiduronic acid; 7-(beta-d-glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one; FLAVONE, 4,5,6,7-TETRAHYDROXY-, 7-.BETA.-D-GLUCOPYRANURONOSIDE; flavone, 4,5,6,7-tetrahydroxy-, 7-beta-D-glucopyranuronoside; Breviscapin;Scutellarein-7-glucuronide;Scutellarin B; SCUTELLAREIN 7-.BETA.-D-GLUCURONOSIDE; SCUTELLAREIN 7-O-.BETA.-D-GLUCURONIDE; SCUTELLAREIN 7-O-.BETA.-GLUCURONIDE; scutellarein 7-beta-D-glucuronoside; Scutellarein-7-O-beta-D-glucuronide; scutellarein 7-O-beta-D-glucuronide; SCUTELLAREIN 7-.BETA.-D-GLUCURONIDE; Scutellarein-7beta-D-glucuronoside; SCUTELLAREIN GLUCURONIDE [WHO-DD]; scutellarein-7-O-beta-glucuronide; scutellarein 7-beta-D-glucuronide; Scutellarein-7beta-D-glucuronide; Scutellarin, analytical standard; SCUTELLAREIN GLUCURONIDE [MI]; SCUTELLAREIN 7-O-GLUCURONIDE; scutellarein-7-O-glucuronide; Scutellarein-7-glucuronide; scutellarein 7-glucuronide; new-breviscapine; Scutellarin,(S); UNII-16IGP0ML9A; scutellarin B; MEGxp0_000554; Scutellarine; Breviscapine; Breviscapin; dengzhanhua; Scutellarin; 16IGP0ML9A; S-7-G



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

73 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hui Ma, Grace Gar-Lee Yue, Julia Kin-Ming Lee, Si Gao, Ka-Ki Yuen, Wen Cheng, Xiang Li, Clara Bik-San Lau. Scutellarin, a flavonoid compound from Scutellaria barbata, suppresses growth of breast cancer stem cells in vitro and in tumor-bearing mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155418. doi: 10.1016/j.phymed.2024.155418. [PMID: 38518647]
  • Zhao Cui, Caifeng Li, Wei Liu, Mo Sun, Shiwen Deng, Junxian Cao, Hongjun Yang, Peng Chen. Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression. Cell death & disease. 2024 Apr; 15(4):267. doi: 10.1038/s41419-024-06625-6. [PMID: 38622131]
  • Wen-Cong Gao, Tie-Hua Yang, Bin-Bao Wang, Qian Liu, Qing Li, Xiao-Huan Zhou, Chang-Bo Zheng, Peng Chen. Scutellarin inhibits oleic acid induced vascular smooth muscle foam cell formation via activating autophagy and inhibiting NLRP3 inflammasome activation. Clinical and experimental pharmacology & physiology. 2024 04; 51(4):e13845. doi: 10.1111/1440-1681.13845. [PMID: 38382550]
  • Marika Mróz, Barbara Kusznierewicz. Phytochemical screening and biological evaluation of Greek sage (Salvia fruticosa Mill.) extracts. Scientific reports. 2023 12; 13(1):22309. doi: 10.1038/s41598-023-49695-w. [PMID: 38102229]
  • Xueheng Xie, Fan Wang, Wenxiu Ge, Xiangbao Meng, Lijuan Fan, Wei Zhang, Zhen Wang, Meng Ding, Shengliang Gu, Xiaoyan Xing, Xiaobo Sun. Scutellarin attenuates oxidative stress and neuroinflammation in cerebral ischemia/reperfusion injury through PI3K/Akt-mediated Nrf2 signaling pathways. European journal of pharmacology. 2023 Oct; 957(?):175979. doi: 10.1016/j.ejphar.2023.175979. [PMID: 37611841]
  • Yong-Jing Liu, Li Lou, Qun Huang, Wei Xu, Hua Li. Ultrasonic extraction and purification of scutellarin from Erigerontis Herba using deep eutectic solvent. Ultrasonics sonochemistry. 2023 Oct; 99(?):106560. doi: 10.1016/j.ultsonch.2023.106560. [PMID: 37625256]
  • Xiyu Mei, Hao Ouyang, Hong Zhang, Wangya Jia, Bin Lu, Jingnan Zhang, Lili Ji. Scutellarin suppresses the metastasis of triple-negative breast cancer via targeting TNFα/TNFR2-RUNX1-triggered G-CSF expression in endothelial cells. Biochemical pharmacology. 2023 Sep; ?(?):115808. doi: 10.1016/j.bcp.2023.115808. [PMID: 37716622]
  • Linlin Li, Yifang Zou, Lingzhi Wang, Leilei Yang, Yutong Li, Anqi Liao, Zheng Chen, Zhuo Yu, Jianfeng Guo, Shulan Han. Nanodelivery of scutellarin induces immunogenic cell death for treating hepatocellular carcinoma. International journal of pharmaceutics. 2023 Jul; 642(?):123114. doi: 10.1016/j.ijpharm.2023.123114. [PMID: 37301243]
  • Shadi Vesaghhamedani, Seyedeh Shabnam Mazloumi Kiapey, Arezoo Gowhari Shabgah, Sedigheh Amiresmaili, Abbas Jahanara, Maziar Oveisee, Aliakbar Shekarchi, Seyed Mohammad Gheibihayat, Farhad Jadidi-Niaragh, Jamshid Gholizadeh Navashenaq. From traditional medicine to modern oncology: Scutellarin, a promising natural compound in cancer treatment. Progress in biophysics and molecular biology. 2023 Jul; 180-181(?):19-27. doi: 10.1016/j.pbiomolbio.2023.04.006. [PMID: 37080435]
  • Lijie Jia, Wei Fan, Peili Wang, Yu Chen, Ping Zhao, Shengchao Yang, Guangqiang Long. Attapulgite amendment favors the utilization of high cadmium-contaminated soil for Erigeron breviscapus cultivation. Chemosphere. 2023 Jun; 326(?):138490. doi: 10.1016/j.chemosphere.2023.138490. [PMID: 36965533]
  • Ümit Yırtıcı, Aysun Ergene, Şevki Adem, Mehmet Nuri Atalar, Volkan Eyüpoğlu, Ravi Rawat, Esra Arat, Ergin Hamzaoğlu. Centaurea mersinensis phytochemical composition and multi-dimensional bioactivity properties supported by molecular modeling. Journal of biomolecular structure & dynamics. 2023 Apr; ?(?):1-17. doi: 10.1080/07391102.2023.2204496. [PMID: 37098809]
  • Shiyu Chen, Fangfang Fan, Yingrui Zhang, Jiuseng Zeng, Yuxuan Li, Ning Xu, Yi Zhang, Xian-Li Meng, Jin-Ming Lin. Metabolites from scutellarin alleviating deferoxamine-induced hypoxia injury in BV2 cells cultured on microfluidic chip combined with a mass spectrometer. Talanta. 2023 Mar; 259(?):124478. doi: 10.1016/j.talanta.2023.124478. [PMID: 36989966]
  • Fabiana de Freitas Figueiredo, Amilcar Sabino Damazoa, Karuppusamy Arunachalam, Marcelo José Dias Silva, Eduarda Pavan, Joaquim Corsino da Silva Lima, Domingos Tabajara de Oliveira Martins. Evaluation of the gastroprotective and ulcer healing properties by Fridericia chica (Bonpl.) L.G. Lohmann hydroethanolic extract of leaves. Journal of ethnopharmacology. 2023 Mar; ?(?):116338. doi: 10.1016/j.jep.2023.116338. [PMID: 36870462]
  • Hardeep Singh Tuli, Sakshi Bhushan, Ajay Kumar, Poonam Aggarwal, Katrin Sak, Seema Ramniwas, Kanupriya Vashishth, Tapan Behl, Rashmi Rana, Shafiul Haque, Miguel A Prieto. Autophagy Induction by Scutellaria Flavones in Cancer: Recent Advances. Pharmaceuticals (Basel, Switzerland). 2023 Feb; 16(2):. doi: 10.3390/ph16020302. [PMID: 37259445]
  • Peng Yu, Jingyang Li, Yanqing Luo, Jiayi Sun, Yingfan Hu, Bo Lin, Xianli Meng, Li Xiang. Mechanistic Role of Scutellaria baicalensis Georgi in Breast Cancer Therapy. The American journal of Chinese medicine. 2023 Jan; ?(?):1-30. doi: 10.1142/s0192415x23500155. [PMID: 36655686]
  • Hangxing Huang, Change Cao, Zhimin Miao, Xiaoli Yang, Yong Lai. Scutellarin Mediates Cytochrome P450 3A4 and 2C19 Expression via Pregnane X Receptor and Constitutive Androstane Receptor. Current molecular pharmacology. 2023; 16(6):640-653. doi: 10.2174/1874467215666220823123852. [PMID: 36017831]
  • Jie Zhang, Yumei Yan, Fang Cheng, Feixiang Huang, Xingliang Xie, Yanmei Sheng. Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells. Journal of visualized experiments : JoVE. 2022 11; ?(189):. doi: 10.3791/64721. [PMID: 36468713]
  • Huan Yang, Zhengting Wang, Lihuan Wang, Yijie Li, Jiadong Guo, Xiao Yang, Jie Zhao, Kewei Rong, Pu Zhang, Bin Ye, Kai Zhang, Hui Ma. Scutellarin ameliorates osteoarthritis by protecting chondrocytes and subchondral bone microstructure by inactivating NF-κB/MAPK signal transduction. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Nov; 155(?):113781. doi: 10.1016/j.biopha.2022.113781. [PMID: 36271561]
  • Qiankun Yang, Yan Wang, Huizhen Chen, Hui Fan, Xiao Zhang, Babatunde Kazeem Bello, Gang Liu, Xin Feng, Daoyang Teng, Yi Chen, Panpan Zhao, Jingquan Dong. Protective Activities of Scutellarin against Alcohol-Induced Acute Kidney Injury. Chemistry & biodiversity. 2022 Nov; 19(11):e202200254. doi: 10.1002/cbdv.202200254. [PMID: 36177678]
  • Xi-Yu Mei, Jing-Nan Zhang, Wang-Ya Jia, Bin Lu, Meng-Na Wang, Tian-Yu Zhang, Li-Li Ji. Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown. Acta pharmacologica Sinica. 2022 Oct; 43(10):2666-2677. doi: 10.1038/s41401-022-00873-y. [PMID: 35228654]
  • Minzhen Deng, Jingbo Sun, Lilin Peng, Yan Huang, Wen Jiang, Shuang Wu, Lihua Zhou, Sookja Kim Chung, Xiao Cheng. Scutellarin acts on the AR-NOX axis to remediate oxidative stress injury in a mouse model of cerebral ischemia/reperfusion injury. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Aug; 103(?):154214. doi: 10.1016/j.phymed.2022.154214. [PMID: 35689902]
  • Jie Dai, Chenyu Li, Long Zhao, Chen Guan, Chengyu Yang, Ningxin Zhang, Bin Zhou, Yue Zhang, Lin Wang, Wei Jiang, Congjuan Luo, Yan Xu. Scutellarin protects the kidney from ischemia/reperfusion injury by targeting Nrf2. Nephrology (Carlton, Vic.). 2022 Aug; 27(8):690-700. doi: 10.1111/nep.14069. [PMID: 35638402]
  • Chang Yang, Qing Zhao, Shanshan Yang, Libin Wang, Xingyuan Xu, Lisu Li, Wafa T Al-Jamal. Intravenous Administration of Scutellarin Nanoparticles Augments the Protective Effect against Cerebral Ischemia-Reperfusion Injury in Rats. Molecular pharmaceutics. 2022 05; 19(5):1410-1421. doi: 10.1021/acs.molpharmaceut.1c00942. [PMID: 35441510]
  • Xue Liu, Zhenzhi Qin, Chen Guan, Lingyu Xu, Jie Dai, Chengyu Yang, Bin Zhou, Hong Luan, Long Zhao, Wei Zhang, Congjuan Luo, Yan Xu. [Scutellarin alleviates lipopolysaccharide-induced renal injury via mediating cysteine-rich protein 61-connective tissue growth factor-nephroblastoma overexpressed gene 1 expression to inhibit nuclear factor-κB signaling pathway]. Zhonghua wei zhong bing ji jiu yi xue. 2022 Apr; 34(4):400-406. doi: 10.3760/cma.j.cn121430-20210401-00767. [PMID: 35692206]
  • Feixue Liu, Xuzhu Gao, Zhixing Li, Xiao Zhang, Hui Fan, Guili Yu, Babatunde Kazeem Bello, Xin Feng, Debang Li, Daoyang Teng, Yi Chen, PanPan Zhao, Mian Fu, Jingquan Dong. Protective Effects of Scutellarin on Acute Alcohol Intestinal Injury. Chemistry & biodiversity. 2022 Apr; 19(4):e202100856. doi: 10.1002/cbdv.202100856. [PMID: 35263019]
  • Xueying Zhang, Zhaojiong Huo, Huiling Luan, Yihai Huang, Yanhui Shen, Liang Sheng, Jiangyu Liang, Feihua Wu. Scutellarin ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing IRE1α/XBP1 pathway. Phytotherapy research : PTR. 2022 Jan; 36(1):433-447. doi: 10.1002/ptr.7344. [PMID: 34859513]
  • Yan Huo, Abudureheman Mijiti, Ruonan Cai, Zhaohua Gao, Maierpu Aini, Abudukadier Mijiti, Zhaoling Wang, Rui Qie. Scutellarin alleviates type 2 diabetes (HFD/low dose STZ)-induced cardiac injury through modulation of oxidative stress, inflammation, apoptosis and fibrosis in mice. Human & experimental toxicology. 2021 Dec; 40(12_suppl):S460-S474. doi: 10.1177/09603271211045948. [PMID: 34610774]
  • Liang Lu, Liu-Kun Yang, Jiao Yue, Xin-Shang Wang, Jing-Yu Qi, Fan Yang, Ban Feng, Shui-Bing Liu. Scutellarin alleviates depression-like behaviors induced by LPS in mice partially through inhibition of astrocyte-mediated neuroinflammation. Neuroscience letters. 2021 11; 765(?):136284. doi: 10.1016/j.neulet.2021.136284. [PMID: 34624394]
  • Guangli Liu, Yan Liang, Min Xu, Ming Sun, Weijun Sun, You Zhou, Xiaojuan Huang, Wenjie Song, Yuan Liang, Zhang Wang. Protective mechanism of Erigeron breviscapus injection on blood-brain barrier injury induced by cerebral ischemia in rats. Scientific reports. 2021 09; 11(1):18451. doi: 10.1038/s41598-021-97908-x. [PMID: 34531475]
  • Sha Zeng, Li Chen, Qiang Sun, Hui Zhao, Han Yang, Shan Ren, Maolun Liu, Xianli Meng, Haibo Xu. Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade. European journal of pharmacology. 2021 Sep; 906(?):174253. doi: 10.1016/j.ejphar.2021.174253. [PMID: 34118224]
  • Lijiao Xu, Rongchang Chen, Xu Zhang, Yue Zhu, Xiaoyu Ma, Guibo Sun, Xiaobo Sun. Scutellarin protects against diabetic cardiomyopathy via inhibiting oxidative stress and inflammatory response in mice. Annals of palliative medicine. 2021 Mar; 10(3):2481-2493. doi: 10.21037/apm-19-516. [PMID: 33549002]
  • Guangli Liu, Guangmin Tang, Weiwen Liang, Zhang Wang, Wenlong Xu, Gang Fan, Yujie Wang, Mingming Zhao. PK-PD Correlation of Erigeron Breviscapus Injection in the Treatment of Cerebral Ischemia-Reperfusion Injury Model Rats. Journal of molecular neuroscience : MN. 2021 Feb; 71(2):302-324. doi: 10.1007/s12031-020-01651-3. [PMID: 32757108]
  • Tao Wang, Hin Kiu Lee, Grace Gar Lee Yue, Arthur Chi Kong Chung, Clara Bik San Lau, Zongwei Cai. A novel binary matrix consisting of graphene oxide and caffeic acid for the analysis of scutellarin and its metabolites in mouse kidney by MALDI imaging. The Analyst. 2021 Jan; 146(1):289-295. doi: 10.1039/d0an01539c. [PMID: 33140762]
  • Yuba Raj Gaihre, Keisuke Tsuge, Hiroshi Hamajima, Yasuo Nagata, Teruyoshi Yanagita. The Contents of Polyphenols in Perilla frutescens (L.) Britton var. frutescens (Egoma) Leaves are Determined by Vegetative Stage, Spatial Leaf Position, and Timing of Harvesting during the Day. Journal of oleo science. 2021; 70(6):855-859. doi: 10.5650/jos.ess20291. [PMID: 34078762]
  • Grace Gar-Lee Yue, Yuk-Yu Chan, Wenjing Liu, Si Gao, Chun-Wai Wong, Julia Kin-Ming Lee, Kit-Man Lau, Clara Bik-San Lau. Effectiveness of Scutellaria barbata water extract on inhibiting colon tumor growth and metastasis in tumor-bearing mice. Phytotherapy research : PTR. 2021 Jan; 35(1):361-373. doi: 10.1002/ptr.6808. [PMID: 32869911]
  • Hua Fan, Peng Lin, Qiang Kang, Zhi-Long Zhao, Ji Wang, Jia-Yi Cheng. Metabolism and Pharmacological Mechanisms of Active Ingredients in Erigeron breviscapus. Current drug metabolism. 2021; 22(1):24-39. doi: 10.2174/1389200221666201217093255. [PMID: 33334284]
  • Shao-Hua Ju, Li-Rong Tan, Pan-Wang Liu, You-Li Tan, Yuan-Ting Zhang, Xiao-Hong Li, Ming-Jian Wang, Ben-Xiang He. Scutellarin regulates osteoarthritis in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway. Molecular medicine reports. 2021 01; 23(1):. doi: 10.3892/mmr.2020.11722. [PMID: 33236146]
  • Zi-Qi Meng, Jia-Rui Wu, Ying-Li Zhu, Wei Zhou, Chang-Geng Fu, Xin-Kui Liu, Shu-Yu Liu, Meng-Wei Ni, Si-Yu Guo. Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic Stroke Treatment via a Network Pharmacology Approach. Chinese journal of integrative medicine. 2021 Jan; 27(1):62-69. doi: 10.1007/s11655-020-2716-4. [PMID: 32447519]
  • Luan Wen, Ting He, AXiang Yu, Siqi Sun, Xiang Li, Jing Wei, Ruolan Song, Xin Yan, Ruiwen Li, Xueyang Ren, Yu Wang, Xiaoyun Liu, Ying Dong, Xueyan Fu, Gaimei She. Breviscapine: A Review on its Phytochemistry, Pharmacokinetics and Therapeutic Effects. The American journal of Chinese medicine. 2021; 49(6):1369-1397. doi: 10.1142/s0192415x21500646. [PMID: 34263720]
  • Weiyao Ding, Change Cao, Yangyang Gao, Xuan Zhou, Yong Lai. Inhibition of CYP3A4 and CYP3A5 expression by scutellarin is not mediated via the regulation of hsa-miR-27a, 27b, 148a, 298 and 451a levels. Xenobiotica; the fate of foreign compounds in biological systems. 2020 Nov; 50(11):1267-1274. doi: 10.1080/00498254.2018.1555344. [PMID: 30501535]
  • Jianming Liu, Yongmei Guo, Yanqi Xu, Li Yuan, Huiting Zhu. Scutellarin is Highly Likely to be Responsible for Drug-Drug Interactions Mediated by Hepatic Organic Anion-Transporting Polypeptide1B3. Pharmaceutical research. 2020 Oct; 37(12):232. doi: 10.1007/s11095-020-02950-5. [PMID: 33123800]
  • Ryosuke Tsumagari, Kenta Maruo, Sho Kakizawa, Shuji Ueda, Minoru Yamanoue, Hiromitsu Saito, Noboru Suzuki, Yasuhito Shirai. Precise Regulation of the Basal PKCγ Activity by DGKγ Is Crucial for Motor Coordination. International journal of molecular sciences. 2020 Oct; 21(21):. doi: 10.3390/ijms21217866. [PMID: 33114041]
  • Jinxin Shi, Chengpeng Sun, Huilian Huang, Wenhui Lin, Jian Gao, Yanhe Lin, Zhanjun Zhang, Xiaokui Huo, Xiangge Tian, Zhenlong Yu, Baojing Zhang, Xiaochi Ma. β-Glucuronidase- and OATP2B1-mediated drug interaction of scutellarin in Dengzhan Xixin Injection: A formulation aspect. Drug development research. 2020 08; 81(5):609-619. doi: 10.1002/ddr.21661. [PMID: 32220026]
  • Tao Li, Dirong Wu, Yang Yang, Tao Xiao, Yilin Han, Jing Li, Ting Liu, Li Li, Zeqin Dai, Yongjun Li, Xiaozhong Fu. Synthesis, pharmacological evaluation and mechanistic study of scutellarin methyl ester -4'-dipeptide conjugates for the treatment of hypoxic-ischemic encephalopathy (HIE) in rat pups. Bioorganic chemistry. 2020 08; 101(?):103980. doi: 10.1016/j.bioorg.2020.103980. [PMID: 32540782]
  • Lingyun Gao, Heng Tang, Qingfu Zeng, Ting Tang, Ming Chen, Peng Pu. The anti-insulin resistance effect of scutellarin may be related to antioxidant stress and AMPKα activation in diabetic mice. Obesity research & clinical practice. 2020 Jul; 14(4):368-374. doi: 10.1016/j.orcp.2020.06.005. [PMID: 32631803]
  • Huiling Luan, Zhaojiong Huo, Zifeng Zhao, Shoukang Zhang, Yihai Huang, Yanhui Shen, Pu Wang, Junxiao Xi, Jingyu Liang, Feihua Wu. Scutellarin, a modulator of mTOR, attenuates hepatic insulin resistance by regulating hepatocyte lipid metabolism via SREBP-1c suppression. Phytotherapy research : PTR. 2020 Jun; 34(6):1455-1466. doi: 10.1002/ptr.6582. [PMID: 31828866]
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