Sophoricoside (BioDeep_00000230216)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3-{4-[(2S,4S,5S,3R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)(2H-3,4,5,6-tetrahydr opyran-2-yloxy)]phenyl}-5,7-dihydroxychromen-4-one

化学式: C21H20O10 (432.1056)
中文名称: 槐角苷
谱图信息: 最多检出来源 Viridiplantae(plant) 60.61%

分子结构信息

SMILES: c(c1C(C(=O)3)=COc(c4)c3c(cc(O)4)O)cc(OC(O2)C(O)C(O)C(O)C2CO)cc1
InChI: InChI=1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-3-1-9(2-4-11)12-8-29-14-6-10(23)5-13(24)16(14)17(12)25/h1-6,8,15,18-24,26-28H,7H2

描述信息

Sophoricoside is an isoflavonoid and an acrovestone.
Sophoricoside is a natural product found in Oxytropis falcata, Lupinus polyphyllus, and other organisms with data available.
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.780
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.782
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.779
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.777
Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.
Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.

同义名列表

26 个代谢物同义名

3-{4-[(2S,4S,5S,3R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)(2H-3,4,5,6-tetrahydr opyran-2-yloxy)]phenyl}-5,7-dihydroxychromen-4-one; 5,7-dihydroxy-3-(4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-4H-chromen-4-one; 5,7-dihydroxy-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-4-one; 4H-1-BENZOPYRAN-4-ONE, 3-(4-(.BETA.-D-GLUCOPYRANOSYLOXY)PHENYL)-5,7-DIHYDROXY- SOPHORICOSIDE; 4H-1-Benzopyran-4-one, 3-(4-(beta-D-glucopyranosyloxy)phenyl)-5,7-dihydroxy- sophoricoside; tetrahydro-2H-pyran-2-yloxy)phenyl)-4H-chromen-4-one; (2S)-N-Boc-5-methylpyrrolidine-2-carboxylicacid; GENISTEIN, 4-.BETA.-D-GLUCOPYRANOSIDE; 5,7-dihydroxy-3-(4-((2S,3R,4S,5S,6R)-; 5,7-Dihydroxy-4-glucosyloxyisoflavone; Genistein, 4-beta-D-glucopyranoside; 3,4,5-trihydroxy-6-(hydroxymethyl); Genistein sophoricoside [MI]; Genistein-4?-O-glucoside; Genistein 4-O-glucoside; Genistein sophoricoside; GENISTEIN-4-O-GLUCOSIDE; Sophoricoside,(S); Sophoricoside; 5,7-dihydroxy-3-[4-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]phenyl]-4-chromenone; 5,7-dihydroxy-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxyphenyl]chromen-4-one; 5,7-dihydroxy-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxyphenyl]chromone; NCGC00142616-01; ZINC04136964; SBB015797; 3- [ 4- (beta-D-Glucopyranosyloxy) phenyl ] -5,7-dihydroxy-4H-1-benzopyran-4-one



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

31 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Zhaoshuo Li, Mi Zhang, Lixia Yang, Ding Fan, Peng Zhang, Li Zhang, Jianqing Zhang, Zhigang Lu. Sophoricoside ameliorates cerebral ischemia-reperfusion injury dependent on activating AMPK. European journal of pharmacology. 2024 May; 971(?):176439. doi: 10.1016/j.ejphar.2024.176439. [PMID: 38401605]
  • Xinyu Bian, Xiaoyu Zhuang, Junpeng Xing, Shu Liu, Zhiqiang Liu, Fengrui Song. Native Mass Spectrometry Coupled to Spectroscopic Methods to Investigate the Effect of Soybean Isoflavones on Structural Stability and Aggregation of Zinc Deficient and Metal-Free Superoxide Dismutase. Molecules (Basel, Switzerland). 2022 Oct; 27(21):. doi: 10.3390/molecules27217303. [PMID: 36364128]
  • Evangelia Bampali, Stefan Germer, Rudolf Bauer, Žarko Kulić. HPLC-UV/HRMS methods for the unambiguous detection of adulterations of Ginkgo biloba leaves with Sophora japonica fruits on an extract level. Pharmaceutical biology. 2021 Dec; 59(1):438-443. doi: 10.1080/13880209.2021.1910717. [PMID: 33886418]
  • Shengjie Fan, Haiyan Zhang, Yahui Wang, Yuanyuan Zhao, Lingling Luo, Hongrun Wang, Gen Chen, Lianjun Xing, Peiyong Zheng, Cheng Huang. LXRα/β Antagonism Protects against Lipid Accumulation in the Liver but Increases Plasma Cholesterol in Rhesus Macaques. Chemical research in toxicology. 2021 03; 34(3):833-838. doi: 10.1021/acs.chemrestox.0c00445. [PMID: 33647205]
  • Byung-Hak Kim, Sanghyun Lee. Sophoricoside from Styphnolobium japonicum improves experimental atopic dermatitis in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Feb; 82(?):153463. doi: 10.1016/j.phymed.2021.153463. [PMID: 33545490]
  • Byung-Hak Kim, Sanghyun Lee. Sophoricoside from Sophora japonica ameliorates allergic asthma by preventing mast cell activation and CD4+ T cell differentiation in ovalbumin-induced mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jan; 133(?):111029. doi: 10.1016/j.biopha.2020.111029. [PMID: 33254020]
  • Yu Zhang, Fei Li, Xi Jiang, Xiqian Jiang, Yahui Wang, Haiyan Zhang, Li Zhang, Shengjie Fan, Lianjun Xin, Baican Yang, Guang Ji, Cheng Huang. Sophoricoside is a selective LXRβ antagonist with potent therapeutic effects on hepatic steatosis of mice. Phytotherapy research : PTR. 2020 Dec; 34(12):3168-3179. doi: 10.1002/ptr.6747. [PMID: 32592532]
  • Wenfeng Li, Yalong Lu. Hepatoprotective Effects of Sophoricoside against Fructose-Induced Liver Injury via Regulating Lipid Metabolism, Oxidation, and Inflammation in Mice. Journal of food science. 2018 Feb; 83(2):552-558. doi: 10.1111/1750-3841.14047. [PMID: 29350757]
  • Chen Feng, Shuang Jin, Xin-Xin Xia, Yue Guan, Meng Luo, Yuan-Gang Zu, Yu-Jie Fu. Effective bioconversion of sophoricoside to genistein from Fructus sophorae using immobilized Aspergillus niger and Yeast. World journal of microbiology & biotechnology. 2015 Jan; 31(1):187-97. doi: 10.1007/s11274-014-1777-y. [PMID: 25392205]
  • Ruby, R J Santosh Kumar, Rishi K Vishwakarma, Somesh Singh, Bashir M Khan. Molecular cloning and characterization of genistein 4'-O-glucoside specific glycosyltransferase from Bacopa monniera. Molecular biology reports. 2014 Jul; 41(7):4675-88. doi: 10.1007/s11033-014-3338-8. [PMID: 24664316]
  • Xuran Zhi, Ning Sheng, Lin Yuan, Zhiyong Zhang, Peipei Jia, Xiaoxu Zhang, Lantong Zhang. Pharmacokinetics and excretion study of sophoricoside and its metabolite in rats by liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Jan; 945-946(?):154-62. doi: 10.1016/j.jchromb.2013.11.049. [PMID: 24342508]
  • Hossam M Abdallah, Ahmed M Al-Abd, Gihan F Asaad, Ashraf B Abdel-Naim, Ali M El-halawany. Isolation of antiosteoporotic compounds from seeds of Sophora japonica. PloS one. 2014; 9(6):e98559. doi: 10.1371/journal.pone.0098559. [PMID: 24892557]
  • Chongming Wu, Hong Luan, Shuai Wang, Xue Zhang, Ran Wang, Lifeng Jin, Peng Guo, Xi Chen. Modulation of lipogenesis and glucose consumption in HepG2 cells and C2C12 myotubes by sophoricoside. Molecules (Basel, Switzerland). 2013 Dec; 18(12):15624-35. doi: 10.3390/molecules181215624. [PMID: 24352018]
  • Ali M El-Halawany, Mi Hwa Chung, Hossam M Abdallah, Tsutomu Nishihara, Masao Hattori. Estrogenic activity of a naringinase-treated extract of Sophora japonica cultivated in Egypt. Pharmaceutical biology. 2010 Feb; 48(2):177-81. doi: 10.3109/13880200903062663. [PMID: 20645836]
  • Rongning Luo, Zhangwan Li, Guangsheng Qian, Jia Lu, Chunmei Fu. Determination of sophoricoside in rat plasma by HPLC and its application to pharmacokinetic studies. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2009 Dec; 129(12):1545-9. doi: 10.1248/yakushi.129.1545. [PMID: 19952535]
  • Ai-Lin Liu, Hai-Di Wang, Simon MingYuen Lee, Yi-Tao Wang, Guan-Hua Du. Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities. Bioorganic & medicinal chemistry. 2008 Aug; 16(15):7141-7. doi: 10.1016/j.bmc.2008.06.049. [PMID: 18640042]
  • Byung Hak Kim, Eun Yong Chung, Jae-Chun Ryu, Sang-Hun Jung, Kyung Rak Min, Youngsoo Kim. Anti-inflammatory mode of isoflavone glycoside sophoricoside by inhibition of interleukin-6 and cyclooxygenase-2 in inflammatory response. Archives of pharmacal research. 2003 Apr; 26(4):306-11. doi: 10.1007/bf02976960. [PMID: 12735689]
  • B Min, S R Oh, H K Lee, K Takatsu, I M Chang, K R Min, Y Kim. Sophoricoside analogs as the IL-5 inhibitors from Sophora japonica. Planta medica. 1999 Jun; 65(5):408-12. doi: 10.1055/s-1999-14016. [PMID: 10418325]
  • M GABOR. [The hormonal effect of an isoflavone derivative (sophoricoside)]. Kiserletes orvostudomany. 1961 May; 13(?):133-4. doi: ". [PMID: 13702797]