Acetylcorynoline (BioDeep_00000230151)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


[(1R,12S,13R)-13,24-dimethyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-yl] acetate

化学式: C23H23NO6 (409.1525)
中文名称: 乙酰紫堇灵
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 67.39%

分子结构信息

SMILES: c12c(cc3c(c1)C[C@@H]([C@]1([C@@H]3N(Cc3c1ccc1c3OCO1)C)C)OC(=O)C)OCO2
InChI: InChI=1S/C23H23NO6/c1-12(25)30-20-7-13-6-18-19(28-10-27-18)8-14(13)22-23(20,2)16-4-5-17-21(29-11-26-17)15(16)9-24(22)3/h4-6,8,20,22H,7,9-11H2,1-3H3/t20-,22+,23-/m0/s1

描述信息

Acetylcorynoline is a benzophenanthridine alkaloid.
Acetylcorynoline is a natural product found in Corydalis bungeana, Corydalis remota, and other organisms with data available.
Acetylcorynoline is the major alkaloid component derived from Corydalis bungeana, and has anti-inflammatory properties[1].
Acetylcorynoline is the major alkaloid component derived from Corydalis bungeana, and has anti-inflammatory properties[1].

同义名列表

11 个代谢物同义名

[(1R,12S,13R)-13,24-dimethyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-yl] acetate; (1,3)BENZODIOXOLO(5,6-C)-1,3-DIOXOLO(4,5-I)PHENANTHRIDIN-6-OL, 5B,6,7,12B,13,14-HEXAHYDRO-5B,13-DIMETHYL-, ACETATE (ESTER), (5BR,6S,12BR)-; CHELIDONINE, 13-METHYL-, ACETATE (ESTER); Corynoline, acetate (ester); (+)-Corynoline acetate; ACETYLCORYNOLINE(P); O-Acetylcorynoline; Corynoline acetate; Acetylcorynoline; UNII-6ZFQ6Y9RZD; 6ZFQ6Y9RZD



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

24 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Qinning Li, Yan Xiang, Zhenxu Zhang, Xiaoyang Qu, Jie Wu, Jun Fu, Fenxia Zhu, Hao Tang. An integrated RNA-Seq and network pharmacology approach for exploring the preventive effect of Corydalis bungeana Turcz. Extract and Acetylcorynoline on LPS-induced acute lung injury. Journal of ethnopharmacology. 2024 Jan; 318(Pt B):117048. doi: 10.1016/j.jep.2023.117048. [PMID: 37586441]
  • Chang Gao, Yue Du, Xin Wang, Huikun Cao, Bin Lin, Youping Liu, Xin Di. Hexahydrobenzophenanthridine alkaloids from Corydalis bungeana Turcz. and their anti-inflammatory activity. Bioorganic & medicinal chemistry letters. 2018 07; 28(13):2265-2269. doi: 10.1016/j.bmcl.2018.05.039. [PMID: 29853329]
  • Ruijuan Liu, Lu Zheng, Minlu Cheng, Yao Wu, Pan Gu, Yujie Liu, Pengcheng Ma, Li Ding. Simultaneous determination of corynoline and acetylcorynoline in human urine by LC-MS/MS and its application to a urinary excretion study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Mar; 1014(?):83-9. doi: 10.1016/j.jchromb.2016.01.046. [PMID: 26882127]
  • Congcong Wen, Jinzhang Cai, Chongliang Lin, Jianshe Ma, Xianqin Wang. Gradient elution liquid chromatography mass spectrometry determination of acetylcorynoline in rat plasma and its application to a pharmacokinetic study. Xenobiotica; the fate of foreign compounds in biological systems. 2014 Aug; 44(8):743-8. doi: 10.3109/00498254.2014.887802. [PMID: 24512634]
  • Ru-Huei Fu, Yu-Chi Wang, Chang-Shi Chen, Rong-Tzong Tsai, Shih-Ping Liu, Wen-Lin Chang, Hsin-Lien Lin, Chia-Hui Lu, Jing-Rong Wei, Zih-Wan Wang, Woei-Cherng Shyu, Shinn-Zong Lin. Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease. Neuropharmacology. 2014 Jul; 82(?):108-20. doi: 10.1016/j.neuropharm.2013.08.007. [PMID: 23973292]
  • Ru-Huei Fu, Yu-Chi Wang, Shih-Ping Liu, Ching-Liang Chu, Rong-Tzong Tsai, Yu-Chen Ho, Wen-Lin Chang, Shao-Chih Chiu, Horng-Jyh Harn, Woei-Cherng Shyu, Shinn-Zong Lin. Acetylcorynoline impairs the maturation of mouse bone marrow-derived dendritic cells via suppression of IκB kinase and mitogen-activated protein kinase activities. PloS one. 2013; 8(3):e58398. doi: 10.1371/journal.pone.0058398. [PMID: 23472193]