THSG cpd (BioDeep_00000230146)

 

Secondary id: BioDeep_00000249003

PANOMIX_OTCML-2023


代谢物信息卡片


2,3,5,4-Tetrahydroxystilbene 2-O-AfAEA centa notA inverted exclamation markAfasAA|AfAEAdaggeratrade markAfA centA centasA notA em leaderA inverted exclamation mark-D-glucoside

化学式: C20H22O9 (406.1263762)
中文名称: 何首乌苷, 二苯乙烯苷, 2,3,5,4-四羟基二苯乙烯葡萄糖苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C=CC2=C(C(=CC(=C2)O)O)OC3C(C(C(C(O3)CO)O)O)O)O
InChI: InChI=1S/C20H22O9/c21-9-15-16(25)17(26)18(27)20(28-15)29-19-11(7-13(23)8-14(19)24)4-1-10-2-5-12(22)6-3-10/h1-8,15-18,20-27H,9H2/b4-1+/t15-,16-,17+,18-,20+/m1/s1

描述信息

(E)-2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside is a stilbenoid that is trans-stilbene which has been substituted by hydroxy groups at positions 2, 3, 5, and 4, and in which the hydroxy group at positon 2 has then been converted to the corresponding the beta-D-glucoside. It has a role as an antioxidant, a cyclooxygenase 2 inhibitor, an anti-inflammatory agent, a cardioprotective agent, a platelet aggregation inhibitor and an apoptosis inhibitor. It is a stilbenoid, a beta-D-glucoside and a member of resorcinols.
(2S,3R,4S,5S,6R)-2-[2,4-dihydroxy-6-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol is a natural product found in Euphorbia marschalliana, Hopea reticulata, and other organisms with data available.
See also: Reynoutria multiflora root (part of).
2,3,4',5-tetrahydroxystilbene 2-OD-glucoside is isolated from the roots of Polygonaceae species and inhibits the formation of 5-HETE, HHT and thromboxane B2.
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions[1][2].
2,3,4',5-tetrahydroxystilbene 2-OD-glucoside is isolated from the roots of Polygonaceae species and inhibits the formation of 5-HETE, HHT and thromboxane B2.

同义名列表

59 个代谢物同义名

2,3,5,4-Tetrahydroxystilbene 2-O-AfAEA centa notA inverted exclamation markAfasAA|AfAEAdaggeratrade markAfA centA centasA notA em leaderA inverted exclamation mark-D-glucoside; (2S,3R,4S,5S,6R)-2-[2,4-dihydroxy-6-[(E)-2-(4-hydroxyphenyl)vinyl]phenoxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol; (2S,3R,4S,5S,6R)-2-(2,4-dihydroxy-6-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; (2S,3R,4S,5S,6R)-2-[2,4-dihydroxy-6-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol; .BETA.-D-GLUCOPYRANOSIDE, 2,4-DIHYDROXY-6-(2-(4-HYDROXYPHENYL)ETHENYL)PHENYL, (E)-; .BETA.-D-GLUCOPYRANOSIDE, 2,4-DIHYDROXY-6-((1E)-2-(4-HYDROXYPHENYL)ETHENYL)PHENYL; 2,4-DIHYDROXY-6-((1E)-2-(4-HYDROXYPHENYL)ETHENYL)PHENYL .BETA.-D-GLUCOPYRANOSIDE; beta-D-Glucopyranoside, 2,4-dihydroxy-6-(2-(4-hydroxyphenyl)ethenyl)phenyl, (E)-; beta-D-Glucopyranoside, 2,4-dihydroxy-6-((1E)-2-(4-hydroxyphenyl)ethenyl)phenyl; 2,4-Dihydroxy-6-((1E)-2-(4-hydroxyphenyl)ethenyl)phenyl beta-D-glucopyranoside; 2,4-dihydroxy-6-[(E)-2-(4-hydroxyphenyl)ethenyl]phenyl beta-D-glucopyranoside; beta-D-Glucopyranoside, 2,4-dihydroxy-6-(2-(4-hydroxyphenyl)ethenyl)phenyl; B-D-GLUCOPYRANOSIDE,2,4-DIHYDROXY-6-[2-(4-HYDROXYPHENYL)ETHENYL]PHENYL; (E)-2,3,4,5-beta-tetrahydroxystilbene-2-beta-D-glucopyranoside; 2,3,5,4-Tetrahydroxyl-diphenylethylene-2-O-beta-D-glucoside; 2,3,5,4-TETRAHYDROXYSTILBENE-2-O-BETA-D-GLUCOSIDE (USP-RS); 2,3,5,4-TETRAHYDROXYSTILBENE-2-O-BETA-D-GLUCOSIDE [USP-RS]; 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucopyranoside; 2,3,5,4-Tetrahydroxy stilbene-2-Omicron-beta-D-glucoside; 2,3,5,4-tetrahydroxystilbene-2-o-beta-d-glucopyranoside; trans-2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside; 2,3,5,4-Tetrahydroxytoluylene-2-beta-D-glucopyranoside; (E)-2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside; 2,3,5,4-Tetrahydroxystilbene-2-O-b-D-glucopyranoside; 2,3,5,4-Tetrahydroxyl diphenylethylene-2-O-glucoside; 2,3,5,4-tetrahydroxyl-diphenylethylene-2-o-glucoside; 2,3,5,4-tetrahydroxyl diphenylethylene-2-o-glucoside; 2,3,5,4-TETRAHYDROXYSTILBENE-2-O-.BETA.-D-GLUCOSIDE; 2,3,4,5-tetrahydroxystilbene-2-O-beta-D-glucoside; 2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside; 2,3,5,4-tetrahydroxystilbene 2-O-beta-D-glucoside; 2,3,5,4-Tetrahydroxytoluylene-2-beta-D-glucoside; 2,3,5,4-tetrahydroxystilbene 2-O-glucopyranoside; 2,3,5,4-Tetrahydroxystilbene-2-O-ss-D-glucoside; 2,3,5,4-Tetrahydroxystilbene 2-O-fA-D-Glucoside; 2,3,5,4-Tetrahydroxy stilbene 2-Ο-β-D-glucoside; (E)-2,3,5,4-Tetrahydroxy stilbene-2-O-glucoside; 2,3,5,4-Tetrahydroxystilbene 2-O-b-D-glucoside; 2,3,5,4-tetrahydroxystilbene-2-O-?-D-glucoside; 2,3,5,4-Tetrahydroxystilbene 2-O-β-D-glucoside; 2,3,5,4-Tetrahydroxy stilbene-2-o-D-glucoside; 2,3,5,4-Tetrahydroxystilbene 2-O--D-glucoside; 2,3,5,4-Tetrahydroxy stilbene-2---D-glucoside; 2,3,4,5-Tetrahydroxystilbene 2-o-D-glucoside; 2,3,5,4-tetrahydroxystilbene-2-O-D-glucoside; tetrahydroxyldiphenylethylene-2-o-glucoside; 2,3,5,4-Tetrahydroxystilbene 2-O-glucoside; 2,3,5,4-tetrahydroxystilbene-2-O-glucoside; 2,3,4,5-Tetrahydroxystilbene 2-O-Glucoside; 2,3,5,4-Tetrahydroxystilbene 2-O-glucosid; tetrahydroxyl diphenylethylene-2-o-gluco; Tetrahydroxystilbene-2-O-??-D-glucoside; tetrahydroxystilbene glucoside; 4OH-stil-2-O-Glu; UNII-54QRI6OKJ5; 54QRI6OKJ5; THSG cpd; 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside; 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cheng-Yu Wang, Ying-Huan Hu, Zhen-Xiao Sun. Hepatic Effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, the Signature Component of Traditional Chinese Medicine Heshouwu: Advances and Prospects. Current drug metabolism. 2023; 24(1):16-27. doi: 10.2174/1389200224666230223144826. [PMID: 36825731]
  • Juan Huang, Shuyi Huang, Jing Zhang, Youling Liang, Junqi Bai, Wen Xu, Lu Gong, He Su, Zhihai Huang, Xiaohui Qiu. A Systematic Strategy for the Characterization of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside Metabolites In Vivo by Ultrahigh Performance Liquid Chromatography Coupled with a Q Exactive-Orbitrap Mass System. Journal of agricultural and food chemistry. 2022 Jun; 70(25):7773-7785. doi: 10.1021/acs.jafc.2c00572. [PMID: 35713646]
  • Xueling He, Jiayan Liu, Guohao Long, Xin-Hua Xia, Mei Liu. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside, a major bioactive component from Polygoni multiflori Radix (Heshouwu) suppresses DSS induced acute colitis in BALb/c mice by modulating gut microbiota. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 May; 137(?):111420. doi: 10.1016/j.biopha.2021.111420. [PMID: 33761623]
  • Qian Bi, Wen Gu, Fanying Meng, Xingxin Yang, Linxi Zeng, Li Liang, Min Yang, Ting Zhang, Jie Yu. Pharmacological and metagenomics evidence of polysaccharide from Polygonum multiflorum in the alleviation of insulin resistance. International journal of biological macromolecules. 2020 Dec; 164(?):1070-1079. doi: 10.1016/j.ijbiomac.2020.07.085. [PMID: 32687904]
  • Cheng Wang, Nai-Hua Hu, Lin-Yuan Yu, Li-Hong Gong, Xu-Yang Dai, Cheng Peng, Yun-Xia Li. 2,3,5,4'-tetrahydroxystilbence-2-O-β-D-glucoside attenuates hepatic steatosis via IKKβ/NF-κB and Keap1-Nrf2 pathways in larval zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Jul; 127(?):110138. doi: 10.1016/j.biopha.2020.110138. [PMID: 32387861]
  • Xuanbin Wang, Jing Zeng, Xiao Wang, Ju Li, Jin Chen, Ning Wang, Miao Zhang, Yibin Feng, Huailan Guo. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside induces autophagy of liver by activating PI3K/Akt and Erk pathway in prediabetic rats. BMC complementary medicine and therapies. 2020 Jun; 20(1):177. doi: 10.1186/s12906-020-02949-w. [PMID: 32513151]
  • Ni-Man Bao, Jin Dai, Ning-Ling Liao, Wen-Feng Ying, Rong-Hua Zhao. Water-Assisted/Water-Accelerated Photoreaction of trans-2,3,4',5-Tetrahydroxystilbene-2-O-β-d-glucoside from the Roots of Polygonum multiflorum. Journal of agricultural and food chemistry. 2020 May; 68(18):5086-5092. doi: 10.1021/acs.jafc.9b04922. [PMID: 31610119]
  • Jin Qian, Mingqi Hou, Xian Wu, Chuanying Dai, Jiaqiang Sun, Liuyi Dong. A review on the extraction, purification, detection, and pharmacological effects of 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside from Polygonum multiflorum. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Apr; 124(?):109923. doi: 10.1016/j.biopha.2020.109923. [PMID: 31986418]
  • Thi-Thuy An Nguyen, Manh Tuan Ha, Se-Eun Park, Jae Sue Choi, Byung Sun Min, Jeong Ah Kim. Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of Polygonum multiflorum. Journal of natural products. 2020 02; 83(2):323-332. doi: 10.1021/acs.jnatprod.9b00777. [PMID: 31944695]
  • Fengjiao Li, Ting Zhang, Yanran He, Wen Gu, Xingxin Yang, Ronghua Zhao, Jie Yu. Inflammation inhibition and gut microbiota regulation by TSG to combat atherosclerosis in ApoE-/- mice. Journal of ethnopharmacology. 2020 Jan; 247(?):112232. doi: 10.1016/j.jep.2019.112232. [PMID: 31606534]
  • Cheng Wang, Yimeng Zhou, Xiaohong Gong, Li Zheng, Yunxia Li. In vitro and in situ study on characterization and mechanism of the intestinal absorption of 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside. BMC pharmacology & toxicology. 2020 01; 21(1):7. doi: 10.1186/s40360-020-0384-9. [PMID: 31969193]
  • Jin Xu, Yi Peng, Yi Zeng, Yi-Qiao Hua, Xiao-le Xu. 2, 3, 4', 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and Diet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDL Receptor Knockout Mice and Its Possible Mechanisms. International journal of molecular sciences. 2019 Apr; 20(7):. doi: 10.3390/ijms20071617. [PMID: 30939745]
  • Anling Hu, Juan Huang, Shiyue Li, Yang Gao, Li Wu, Jiang Deng, Jie Liu, Qihai Gong, Lisheng Li, Shangfu Xu. Involvement of stromal cell-derived factor-1α (SDF-1α), stem cell factor (SCF), fractalkine (FKN) and VEGF in TSG protection against intimal hyperplasia in rat balloon injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Feb; 110(?):887-894. doi: 10.1016/j.biopha.2018.12.030. [PMID: 30572193]
  • Yun-Ho Hwang, Su-Jin Kim, Hangun Kim, Sung-Tae Yee. The Protective Effects of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-Glucoside in the OVA-Induced Asthma Mice Model. International journal of molecular sciences. 2018 Dec; 19(12):. doi: 10.3390/ijms19124013. [PMID: 30545126]
  • Li-Li Sun, Meng Wang, Hui-Jie Zhang, Guang-Jiao You, Ya-Nan Liu, Xiao-Liang Ren, Yan-Ru Deng. The influence of polysaccharides from Ophiopogon japonicus on 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-d-glucoside about biopharmaceutical properties in vitro and pharmacokinetics in vivo. International journal of biological macromolecules. 2018 Nov; 119(?):677-682. doi: 10.1016/j.ijbiomac.2018.07.179. [PMID: 30067956]
  • Kun-Ze Du, Ying Chen, Jin Li, Ge Tang, Fei Tian, Jun He, Yanxu Chang. Quantification of eight active ingredients in crude and processed radix polygoni multiflori applying miniaturized matrix solid-phase dispersion microextraction followed by UHPLC. Journal of separation science. 2018 Sep; 41(17):3486-3495. doi: 10.1002/jssc.201800342. [PMID: 30028075]
  • Su-Jin Kim, Yun-Ho Hwang, Seul-Ki Mun, Seong-Gyeol Hong, Kwang-Jin Kim, Kyung-Yun Kang, Young-Jin Son, Sung-Tae Yee. Protective Effects of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside on Ovariectomy Induced Osteoporosis Mouse Model. International journal of molecular sciences. 2018 Aug; 19(9):. doi: 10.3390/ijms19092554. [PMID: 30154383]
  • Po-Wei Tsai, Yi-Hui Lee, Lih-Geeng Chen, Chia-Jung Lee, Ching-Chiung Wang. In Vitro and In Vivo Anti-Osteoarthritis Effects of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-Glucoside from Polygonum Multiflorum. Molecules (Basel, Switzerland). 2018 Mar; 23(3):. doi: 10.3390/molecules23030571. [PMID: 29510478]
  • Wenqiang Li, Ruifang Sun, Sumei Zhou, Jinluan Ma, Yingguang Xie, Bingcan Xu, Huibao Long, Keqin Luo, Kuaifa Fang. 2,3,5,4'‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside inhibits septic serum‑induced inflammatory injury via interfering with the ROS‑MAPK‑NF‑κB signaling pathway in pulmonary aortic endothelial cells. International journal of molecular medicine. 2018 Mar; 41(3):1643-1650. doi: 10.3892/ijmm.2017.3329. [PMID: 29286092]
  • Xuemeng Chen, Kun Tang, Yi Peng, XiaoLe Xu. 2,3,4',5-tetrahydroxystilbene-2-O-β-d-glycoside attenuates atherosclerosis in apolipoprotein E-deficient mice: role of reverse cholesterol transport. Canadian journal of physiology and pharmacology. 2018 Jan; 96(1):8-17. doi: 10.1139/cjpp-2017-0474. [PMID: 28863273]
  • En-Yuan Lin, Uyanga Bayarsengee, Ching-Chiung Wang, Yung-Hsiao Chiang, Chao-Wen Cheng. The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway. Environmental toxicology. 2018 Jan; 33(1):72-82. doi: 10.1002/tox.22496. [PMID: 29064158]
  • Cheng-Yong Jiang, Xiao-Yan Qin, Mi-Mi Yuan, Gui-Jiang Lu, Yong Cheng. 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside Reverses Stress-Induced Depression via Inflammatory and Oxidative Stress Pathways. Oxidative medicine and cellular longevity. 2018; 2018(?):9501427. doi: 10.1155/2018/9501427. [PMID: 30327715]
  • Zhaochen Ning, Yihan Li, Dongyan Liu, John Owoicho Orgah, Jie Zhu, Yan Wang, Yan Zhu. Tetrahydroxystilbene Glucoside Delayed Senile Symptoms in Old Mice via Regulation of the AMPK/SIRT1/PGC-1α Signaling Cascade. Gerontology. 2018; 64(5):457-465. doi: 10.1159/000487360. [PMID: 29804119]
  • Lingling Zhang, Jianzong Chen. Biological Effects of Tetrahydroxystilbene Glucoside: An Active Component of a Rhizome Extracted from Polygonum multiflorum. Oxidative medicine and cellular longevity. 2018; 2018(?):3641960. doi: 10.1155/2018/3641960. [PMID: 30524653]
  • Lingling Zhang, Linhong Huang, Xiaobing Li, Cuicui Liu, Xin Sun, Leitao Wu, Tao Li, Hao Yang, Jianzong Chen. Potential molecular mechanisms mediating the protective effects of tetrahydroxystilbene glucoside on MPP+-induced PC12 cell apoptosis. Molecular and cellular biochemistry. 2017 Dec; 436(1-2):203-213. doi: 10.1007/s11010-017-3169-8. [PMID: 28852926]
  • Jingjing Wu, Wenfeng Hu, Yu Gong, Peng Wang, Lijuan Tong, Xiangfan Chen, Zhuo Chen, Xiaole Xu, Wenjuan Yao, Wei Zhang, Chao Huang. Current pharmacological developments in 2,3,4',5-tetrahydroxystilbene 2-O-β-D-glucoside (TSG). European journal of pharmacology. 2017 Sep; 811(?):21-29. doi: 10.1016/j.ejphar.2017.05.037. [PMID: 28545778]
  • Qiong Yu, Li-Long Jiang, Na Luo, Ya-Xi Fan, Jiang Ma, Ping Li, Hui-Jun Li. Enhanced absorption and inhibited metabolism of emodin by 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside: Possible mechanisms for Polygoni Multiflori Radix-induced liver injury. Chinese journal of natural medicines. 2017 Jun; 15(6):451-457. doi: 10.1016/s1875-5364(17)30067-5. [PMID: 28629535]
  • Ying Mu, Zhaohui Xu, Xuanxuan Zhou, Huinan Zhang, Qian Yang, Yunlong Zhang, Yanhua Xie, Juan Kang, Feng Li, Siwang Wang. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside Attenuates Ischemia/Reperfusion-Induced Brain Injury in Rats by Promoting Angiogenesis. Planta medica. 2017 May; 83(8):676-683. doi: 10.1055/s-0042-120544. [PMID: 27894149]
  • Guang-Tong Chen, Min Yang, Bing-Bing Chen, Yan Song, Wei Zhang, Yan Zhang. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside exerted protective effects on diabetic nephropathy in mice with hyperglycemia induced by streptozotocin. Food & function. 2016 Nov; 7(11):4628-4636. doi: 10.1039/c6fo01319h. [PMID: 27747335]
  • Tao Chen, Yuan-Jian Yang, Yan-Kun Li, Jing Liu, Peng-Fei Wu, Fang Wang, Jian-Guo Chen, Li-Hong Long. Chronic administration tetrahydroxystilbene glucoside promotes hippocampal memory and synaptic plasticity and activates ERKs, CaMKII and SIRT1/miR-134 in vivo. Journal of ethnopharmacology. 2016 Aug; 190(?):74-82. doi: 10.1016/j.jep.2016.06.012. [PMID: 27275773]
  • Shuang Ling, Ju Duan, Rongzhen Ni, Jin-Wen Xu. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside Promotes Expression of the Longevity Gene Klotho. Oxidative medicine and cellular longevity. 2016; 2016(?):3128235. doi: 10.1155/2016/3128235. [PMID: 27885332]
  • Shuang Ling, Jin-Wen Xu. Biological Activities of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments. Oxidative medicine and cellular longevity. 2016; 2016(?):4973239. doi: 10.1155/2016/4973239. [PMID: 27413420]
  • Hong He, Songhai Wang, Jiyu Tian, Lei Chen, Wei Zhang, Junjie Zhao, Haifeng Tang, Xiaojun Zhang, Jianzong Chen. Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside in the MPTP-induced mouse model of Parkinson's disease: Involvement of reactive oxygen species-mediated JNK, P38 and mitochondrial pathways. European journal of pharmacology. 2015 Nov; 767(?):175-82. doi: 10.1016/j.ejphar.2015.10.023. [PMID: 26477638]
  • Ming-Thau Sheu, Hua-Jing Jhan, Chien-Ming Hsieh, Chien-Ju Wang, Hsiu-O Ho. Efficacy of antioxidants as a Complementary and Alternative Medicine (CAM) in combination with the chemotherapeutic agent doxorubicin. Integrative cancer therapies. 2015 Mar; 14(2):184-95. doi: 10.1177/1534735414564425. [PMID: 25542609]
  • Pei Lin, Jianmei Lu, Yanfang Wang, Wen Gu, Jie Yu, Ronghua Zhao. Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis. PloS one. 2015; 10(10):e0140346. doi: 10.1371/journal.pone.0140346. [PMID: 26474417]
  • Christian Büchter, Liang Zhao, Susannah Havermann, Sebastian Honnen, Gerhard Fritz, Peter Proksch, Wim Wätjen. TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxidative medicine and cellular longevity. 2015; 2015(?):124357. doi: 10.1155/2015/124357. [PMID: 26075030]
  • Jing Zhao, Shouzhu Xu, Fan Song, Lun Nian, Xuanxuan Zhou, Siwang Wang. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside protects human umbilical vein endothelial cells against lysophosphatidylcholine-induced apoptosis by upregulating superoxide dismutase and glutathione peroxidase. IUBMB life. 2014 Oct; 66(10):711-22. doi: 10.1002/iub.1321. [PMID: 25382724]
  • Wei Zhao, Wanxia Xia, Jiewen Li, Shujing Sheng, Lei Lei, Shujing Zhao. Transcriptome profiling and digital gene expression analysis of Fallopia multiflora to discover putative genes involved in the biosynthesis of 2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside. Gene. 2014 Aug; 547(1):126-35. doi: 10.1016/j.gene.2014.06.041. [PMID: 24967942]
  • Xiao-Ping Yang, Tao-Yan Liu, Xiao-Yan Qin, Long-Chuan Yu. Potential protection of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside against staurosporine-induced toxicity on cultured rat hippocampus neurons. Neuroscience letters. 2014 Jul; 576(?):79-83. doi: 10.1016/j.neulet.2014.05.045. [PMID: 24887581]
  • Wangen Wang, Yanran He, Pei Lin, Yunfei Li, Ruifen Sun, Wen Gu, Jie Yu, Ronghua Zhao. In vitro effects of active components of Polygonum Multiflorum Radix on enzymes involved in the lipid metabolism. Journal of ethnopharmacology. 2014 May; 153(3):763-70. doi: 10.1016/j.jep.2014.03.042. [PMID: 24680992]
  • Xiao Le Xu, Qiu Yan Zhu, Cheng Zhao, Fei Wang, Zhong Yin Zhou, Ya E Hu, Wei Zhang. The effect of 2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside on pressure overload-induced cardiac remodeling in rats and its possible mechanism. Planta medica. 2014 Feb; 80(2-3):130-8. doi: 10.1055/s-0033-1360198. [PMID: 24431015]
  • Lingling Zhang, LinHong Huang, Liangwei Chen, Dingjun Hao, Jianzong Chen. Neuroprotection by tetrahydroxystilbene glucoside in the MPTP mouse model of Parkinson's disease. Toxicology letters. 2013 Oct; 222(2):155-63. doi: 10.1016/j.toxlet.2013.07.020. [PMID: 23911879]
  • Chao Huang, Yuzhe Wang, Jia Wang, Wenjuan Yao, Xiangfan Chen, Wei Zhang. TSG (2,3,4' ,5-tetrahydroxystilbene 2-O-β-D-glucoside) suppresses induction of pro-inflammatory factors by attenuating the binding activity of nuclear factor-κB in microglia. Journal of neuroinflammation. 2013 Oct; 10(?):129. doi: 10.1186/1742-2094-10-129. [PMID: 24144353]
  • Pei-Lun Hsu, Lin-Yea Horng, Kang-Yung Peng, Chia-Ling Wu, Hui-Ching Sung, Rong-Tsun Wu. Activation of mitochondrial function and Hb expression in non-haematopoietic cells by an EPO inducer ameliorates ischaemic diseases in mice. British journal of pharmacology. 2013 Aug; 169(7):1461-76. doi: 10.1111/bph.12197. [PMID: 23530756]
  • Ling Zhang, Wen-Fang Ma, Jin Li, Jun He, Peng Zhang, Fang Zheng, Bo-Li Zhang, Xiu-Mei Gao, Yan-Xu Chang. Influence of processing on pharmacokinetic of typical constituents in radix polygoni multiflori after oral administration by LC-ESI-MS/MS. Journal of ethnopharmacology. 2013 Jun; 148(1):246-53. doi: 10.1016/j.jep.2013.04.020. [PMID: 23608243]
  • Ying-Yong Zhao, Li Zhang, Ya-Long Feng, Dan-Qian Chen, Zhi-Hui Xi, Xiao Du, Xu Bai, Rui-Chao Lin. Pharmacokinetics of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside in rat using ultra-performance LC-quadrupole TOF-MS. Journal of separation science. 2013 Mar; 36(5):863-71. doi: 10.1002/jssc.201200668. [PMID: 23371758]
  • Xin Han, Shuang Ling, Woting Gan, Li Sun, Ju Duan, Jin-Wen Xu. 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation. Atherosclerosis. 2012 Nov; 225(1):76-82. doi: 10.1016/j.atherosclerosis.2012.08.011. [PMID: 22981429]
  • Li Shao, Shu-Jin Zhao, Tang-Bing Cui, Zhong-Yu Liu, Wei Zhao. 2,3,5,4'- tetrahydroxystilbene-2-O-β-D-glycoside biosynthesis by suspension cells cultures of Polygonum multiflorum Thunb and production enhancement by methyl jasmonate and salicylic acid. Molecules (Basel, Switzerland). 2012 Feb; 17(2):2240-7. doi: 10.3390/molecules17022240. [PMID: 22357320]
  • Guiyuan Lv, Hui Gu, Suhong Chen, Zhaohuan Lou, Letian Shan. Pharmacokinetic profile of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside in mice after oral administration of Polygonum multiflorum extract. Drug development and industrial pharmacy. 2012 Feb; 38(2):248-55. doi: 10.3109/03639045.2011.597763. [PMID: 21892876]
  • Cheng Zeng, Jun-Hua Xiao, Mu-Jun Chang, Jia-Ling Wang. Beneficial effects of THSG on acetic acid-induced experimental colitis: involvement of upregulation of PPAR-γ and inhibition of the Nf-Κb inflammatory pathway. Molecules (Basel, Switzerland). 2011 Oct; 16(10):8552-68. doi: 10.3390/molecules16108552. [PMID: 21993246]
  • Zhi-Tao Liang, Yi-Xiao Shi, Hu-Biao Chen, Zhong-Zhen Zhao. Histochemical analysis of the root tuber of Polygonum multiflorum Thunb. (Fam. Polygonaceae). Microscopy research and technique. 2011 Jun; 74(6):488-95. doi: 10.1002/jemt.20936. [PMID: 20945465]
  • Xiao-liang Ren, Gui-fang Wang, Meng Wang, Hui-zi Ou-Yang, Ai-di Qi. Kinetics and mechanism of 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glycoside (THSG) degradation in aqueous solutions. Journal of pharmaceutical and biomedical analysis. 2011 Apr; 55(1):211-5. doi: 10.1016/j.jpba.2010.12.026. [PMID: 21282026]
  • Rong Qin, Xiaobing Li, Gang Li, Lizhen Tao, Yan Li, Jing Sun, Xiaogang Kang, Jianzong Chen. Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP+: the involvement of PI3K/Akt pathway activation. Toxicology letters. 2011 Apr; 202(1):1-7. doi: 10.1016/j.toxlet.2011.01.001. [PMID: 21237255]
  • Ting Wang, Yuan-Jian Yang, Peng-Fei Wu, Wei Wang, Zhuang-Li Hu, Li-Hong Long, Na Xie, Hui Fu, Fang Wang, Jian-Guo Chen. Tetrahydroxystilbene glucoside, a plant-derived cognitive enhancer, promotes hippocampal synaptic plasticity. European journal of pharmacology. 2011 Jan; 650(1):206-14. doi: 10.1016/j.ejphar.2010.10.002. [PMID: 20951128]
  • Cairong Li, Fei Cai, Yinqiao Yang, Xinyuan Zhao, Chun Wang, Juan Li, Yanlong Jia, Jing Tang, Qing Liu. Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-β1 pathway. European journal of pharmacology. 2010 Dec; 649(1-3):382-9. doi: 10.1016/j.ejphar.2010.09.004. [PMID: 20854812]
  • Hong-Wei Lin, Ming-Xue Sun, Yun-Hua Wang, Liu-Meng Yang, Ying-Ruo Yang, Ning Huang, Li-Jiang Xuan, Ya-Ming Xu, Dong-Lu Bai, Yong-Tang Zheng, Kai Xiao. Anti-HIV activities of the compounds isolated from Polygonum cuspidatum and Polygonum multiflorum. Planta medica. 2010 Jun; 76(9):889-92. doi: 10.1055/s-0029-1240796. [PMID: 20112182]
  • Lifen Cai, Guoyue Zhong, Qian Zhang, Xianyou Qu. [Determination of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside and anthraquinon simultaneously in Polygonum multiflori of different growing stage and gathering periods by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 May; 35(10):1221-5. doi: 10.4268/cjcmm20101001. [PMID: 20707185]
  • Shao-hui Zhang, Wen-quan Wang, Jia-ling Wang. Protective effect of tetrahydroxystilbene glucoside on cardiotoxicity induced by doxorubicin in vitro and in vivo. Acta pharmacologica Sinica. 2009 Nov; 30(11):1479-87. doi: 10.1038/aps.2009.144. [PMID: 19890356]
  • Wei Zhang, Xiao-Le Xu, Yu-Qin Wang, Chun-Hua Wang, Wei-Zhong Zhu. Effects of 2,3,4',5-tetrahydroxystilbene 2-O-beta-D-glucoside on vascular endothelial dysfunction in atherogenic-diet rats. Planta medica. 2009 Sep; 75(11):1209-14. doi: 10.1055/s-0029-1185540. [PMID: 19350477]
  • Xiao-Le Xu, Feng Li, Chun-Hua Wang, Yan Shen, Wei Zhang. [The expression of matrix metalloproteinase-2,9 on atherosclerosis in experimental rats by treatment of 2,3,4',5-tetrahydroxystilbene -2-0-beta-D glucoside]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2009 Feb; 25(1):91-5. doi: NULL. [PMID: 21186625]
  • Zhen Wen, Bo Liu, Zong-Kun Zheng, Xin-Kui You, Yi-Tao Pu, Zhi Dang. [Harmful elements removal from Polygonum multiflorum by supercritical CO2 extraction]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2008 Oct; 31(10):1567-71. doi: ". [PMID: 19230419]
  • Shuyu Guan, Weiwei Su, Ning Wang, Peibo Li, Yonggang Wang. A potent tyrosinase activator from Radix Polygoni multiflori and its melanogenesis stimulatory effect in B16 melanoma cells. Phytotherapy research : PTR. 2008 May; 22(5):660-3. doi: 10.1002/ptr.2358. [PMID: 18389468]
  • Wei Zhang, Chun-Hua Wang, Feng Li, Wei-Zhong Zhu. 2,3,4',5-Tetrahydroxystilbene-2-O-beta-D-glucoside suppresses matrix metalloproteinase expression and inflammation in atherosclerotic rats. Clinical and experimental pharmacology & physiology. 2008 Mar; 35(3):310-6. doi: 10.1111/j.1440-1681.2007.04824.x. [PMID: 17973930]
  • Hui Ming Ge, Bo Huang, Shu Hua Tan, Da Hua Shi, Yong Chun Song, Ren Xiang Tan. Bioactive oligostilbenoids from the stem bark of Hopea exalata. Journal of natural products. 2006 Dec; 69(12):1800-2. doi: 10.1021/np060242y. [PMID: 17190464]
  • Wei Wang, Dan-qiao Wang. [Progress of study on brain protective effect and mechanism of Polygonum multiflorum]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2005 Oct; 25(10):955-9. doi: ". [PMID: 16313126]
  • Hong-qing Wei, Er-bao Liu, Rong-fang Ren, Xiu-li Zhao, Xiao-xia Li, Feng-xian Jiang. [Determination of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside in the traditional Chinese preparation by high performance liquid chromatography with chemiluminescence detection]. Guang pu xue yu guang pu fen xi = Guang pu. 2005 Jun; 25(6):844-7. doi: ". [PMID: 16201354]
  • Hai-bo Bai, Jian-fei Wang, Juan Long. [Study on optimizing extraction process of root of Polygonum multiflorum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2004 Mar; 29(3):219-21. doi: ". [PMID: 15706843]
  • J N Grech, Q Li, B D Roufogalis, C C Duck. Novel Ca(2+)-ATPase inhibitors from the dried root tubers of Polygonum Multiflorum. Journal of natural products. 1994 Dec; 57(12):1682-7. doi: 10.1021/np50114a010. [PMID: 7714535]