Corylin (BioDeep_00000229949)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


3- (2,2-Dimethyl-2H-1-benzopyran-6-yl) -7-hydroxy-4H-1-benzopyran-4-one

化学式: C20H16O4 (320.1048536)
中文名称: 补骨脂异黄酮, 榛仁球蛋白, 补骨脂宁, 补骨脂异黄酮
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 45.45%

分子结构信息

SMILES: c(c12)(ccc(C(C3=O)=COc(c4)c(ccc(O)4)3)c2)OC(C=C1)(C)C
InChI: InChI=1S/C20H16O4/c1-20(2)8-7-13-9-12(3-6-17(13)24-20)16-11-23-18-10-14(21)4-5-15(18)19(16)22/h3-11,21H,1-2H3

描述信息

Corylin is a natural product found in Ulex airensis, Erythrina sacleuxii, and other organisms with data available.
Corylin is an important bioactive compound isolated from psoralen; an antibiotic or anticancer compound.
Corylin is an important bioactive compound isolated from psoralen; an antibiotic or anticancer compound.

同义名列表

5 个代谢物同义名

Corylin; 3-(2,2-Dimethyl-2H-1-benzopyran-6-yl)-7-hydroxy-4H-1-benzopyran-4-one; 3-(2,2-dimethylchromen-6-yl)-7-hydroxychromen-4-one; 7-Hydroxy-2,2-dimethyl-2H,4H-3,6-bichromen-4-one; 3- (2,2-Dimethyl-2H-1-benzopyran-6-yl) -7-hydroxy-4H-1-benzopyran-4-one



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nan Li, Tao Liu, Shan Zhu, Yi Yang, Zijing Wang, Zhiyue Zhao, Tao Liu, Xiang Wang, Wenxiao Qin, Yiqi Yan, Yang Liu, Qingmei Xia, Han Zhang. Corylin from Psoralea fructus (Psoralea corylifolia L.) protects against UV-induced skin aging by activating Nrf2 defense mechanisms. Phytotherapy research : PTR. 2022 Aug; 36(8):3276-3294. doi: 10.1002/ptr.7501. [PMID: 35821646]
  • Tong-Hong Wang, Wei-Che Tseng, Yann-Lii Leu, Chi-Yuan Chen, Wen-Chih Lee, Ying-Chih Chi, Shu-Fang Cheng, Chun-Yu Lai, Chen-Hsin Kuo, Shu-Ling Yang, Sien-Hung Yang, Jiann-Jong Shen, Chun-Hao Feng, Chih-Ching Wu, Tsong-Long Hwang, Chia-Jen Wang, Shu-Huei Wang, Chin-Chuan Chen. The flavonoid corylin exhibits lifespan extension properties in mouse. Nature communications. 2022 03; 13(1):1238. doi: 10.1038/s41467-022-28908-2. [PMID: 35264584]
  • Zi-Yu Chang, Hsuan-Miao Liu, Yann-Lii Leu, Chung-Hua Hsu, Tzung-Yan Lee. Modulation of Gut Microbiota Combined with Upregulation of Intestinal Tight Junction Explains Anti-Inflammatory Effect of Corylin on Colitis-Associated Cancer in Mice. International journal of molecular sciences. 2022 Feb; 23(5):. doi: 10.3390/ijms23052667. [PMID: 35269806]
  • Shourong Liu, Li Wang, Run Zhang. Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target. The Libyan journal of medicine. 2021 Dec; 16(1):1883224. doi: 10.1080/19932820.2021.1883224. [PMID: 33550958]
  • Zhiyue Zhao, Tao Liu, Shan Zhu, Yi Yang, Zijing Wang, Hongfei Ma, Xiang Wang, Tao Liu, Pan Guo, JiaXin Pi, Dongli Qi, BaoCheng Tian, Zhidong Liu, Nan Li. Development and evaluation studies of Corylin loaded nanostructured lipid carriers gel for topical treatment of UV-induced skin aging. Experimental gerontology. 2021 10; 153(?):111499. doi: 10.1016/j.exger.2021.111499. [PMID: 34329721]
  • Chin-Chuan Chen, Chen-Hsin Kuo, Yann-Lii Leu, Shu-Huei Wang. Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation. Pharmacological research. 2021 02; 164(?):105291. doi: 10.1016/j.phrs.2020.105291. [PMID: 33253817]
  • Zhi-Xing Zhou, Li Yang, Li-Yuan Cheng, Ying-Li Yu, Lei Song, Kun Zhou, Ying-Liang Wu, Yue Zhang. Simultaneous characterization of multiple Psoraleae Fructus bioactive compounds in rat plasma by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry for application in sex-related differences in pharmacokinetics. Journal of separation science. 2020 Jul; 43(14):2804-2816. doi: 10.1002/jssc.202000286. [PMID: 32384213]
  • Zu-Guo Zheng, Xin Zhang, Xiao-Xiao Liu, Xiu-Xiu Jin, Lunzhi Dai, Hui-Min Cheng, Dan Jing, Pyone Myat Thu, Mu Zhang, Hongyang Li, Jing Zhu, Chang Liu, Bin Xue, Yu Li, Ligong Chen, Cheng Peng, Weiliang Zhu, Lin Wang, Junli Liu, Hui-Jun Li, Ping Li, Xiaojun Xu. Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System. Theranostics. 2019; 9(20):5769-5783. doi: 10.7150/thno.36505. [PMID: 31534518]
  • Chin-Chuan Chen, Chi-Yuan Chen, Shir-Hwa Ueng, Chuen Hsueh, Chau-Ting Yeh, Jar-Yi Ho, Li-Fang Chou, Tong-Hong Wang. Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair. Cell death & disease. 2018 05; 9(5):543. doi: 10.1038/s41419-018-0575-0. [PMID: 29749376]
  • Chi-Yuan Chen, Chin-Chuan Chen, Tzong-Ming Shieh, Chuen Hsueh, Shu-Huei Wang, Yann-Lii Leu, Jang-Hau Lian, Tong-Hong Wang. Corylin Suppresses Hepatocellular Carcinoma Progression via the Inhibition of Epithelial-Mesenchymal Transition, Mediated by Long Noncoding RNA GAS5. International journal of molecular sciences. 2018 Jan; 19(2):. doi: 10.3390/ijms19020380. [PMID: 29382035]
  • Yung-Li Hung, Shih-Hua Fang, Shu-Chi Wang, Wei-Chung Cheng, Po-Len Liu, Chia-Cheng Su, Chi-Shuo Chen, Ming-Yii Huang, Kuo-Feng Hua, Kun-Hung Shen, Yu-Ting Wang, Katsuhiko Suzuki, Chia-Yang Li. Corylin protects LPS-induced sepsis and attenuates LPS-induced inflammatory response. Scientific reports. 2017 04; 7(?):46299. doi: 10.1038/srep46299. [PMID: 28397806]
  • Dong-Xue Sun, Guang-Bo Ge, Pei-Pei Dong, Yun-Feng Cao, Zhi-Wei Fu, Rui-Xue Ran, Xue Wu, Yan-Yan Zhang, Hui-Ming Hua, Zhenying Zhao, Zhong-Ze Fang. Inhibition behavior of fructus psoraleae's ingredients towards human carboxylesterase 1 (hCES1). Xenobiotica; the fate of foreign compounds in biological systems. 2016; 46(6):503-10. doi: 10.3109/00498254.2015.1091521. [PMID: 26560012]
  • Seung Woong Lee, Bo Ra Yun, Mi Hwa Kim, Chan Sun Park, Woo Song Lee, Hyun-Mee Oh, Mun-Chual Rho. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta medica. 2012 Jun; 78(9):903-6. doi: 10.1055/s-0031-1298482. [PMID: 22573369]
  • Rong-Li Qiu, Lin Li, Miao-Hua Zhu, Jia Liu. [Study on the chemical constituents of Psoralea corylifolia]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Aug; 34(8):1211-3. doi: . [PMID: 22233033]
  • Yi Wang, Chengtao Hong, Chenguang Zhou, Dongmei Xu, Hai-Bin Qu. Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):363052. doi: 10.1093/ecam/nen087. [PMID: 19131395]
  • Chae Sun Na, Seong Su Hong, Yun-Hyeok Choi, Yong Ho Lee, Sun Hee Hong, Ji-Youn Lim, Byeong Hoa Kang, So-Young Park, Dongho Lee. Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells. Archives of pharmacal research. 2010 Jul; 33(7):999-1003. doi: 10.1007/s12272-010-0704-5. [PMID: 20661708]
  • P S Khushboo, V M Jadhav, V J Kadam, N S Sathe. Psoralea corylifolia Linn.-'Kushtanashini'. Pharmacognosy reviews. 2010 Jan; 4(7):69-76. doi: 10.4103/0973-7847.65331. [PMID: 22228944]
  • Chun-Feng Qiao, Quan-Bin Han, Jing-Zheng Song, Shi-Fu Mo, Ling-Dong Kong, Hsiang-Fu Kung, Hong-Xi Xu. Chemical fingerprint and quantitative analysis of fructus psoraleae by high-performance liquid chromatography. Journal of separation science. 2007 Apr; 30(6):813-8. doi: 10.1002/jssc.200600339. [PMID: 17536725]
  • Youn-Chul Kim, Hyuncheol Oh, Beom Seok Kim, Tai-Hyun Kang, Eun-Kyoung Ko, Yu Mi Han, Bo Yeon Kim, Jong Seog Ahn. In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia. Planta medica. 2005 Jan; 71(1):87-9. doi: 10.1055/s-2005-837759. [PMID: 15678382]
  • Z Xiong, D Wang, Y Xu, F Li. Osteoblastic differentiation bioassay and its application to investigating the activity of fractions and compounds from Psoralea corylifolia L. Die Pharmazie. 2003 Dec; 58(12):925-8. doi: ". [PMID: 14703975]
  • D Wang, F Li, Z Jiang. Osteoblastic proliferation stimulating activity of Psoralea corylifolia extracts and two of its flavonoids. Planta medica. 2001 Nov; 67(8):748-9. doi: 10.1055/s-2001-18343. [PMID: 11731919]