Loureirin B (BioDeep_00000229943)
Secondary id: BioDeep_00000230870
PANOMIX_OTCML-2023
代谢物信息卡片
Propan-1-one, 1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)-
化学式: C18H20O5 (316.13106700000003)
中文名称: 龙血素 B, 龙血素B
谱图信息:
最多检出来源 Anoectochilus roxburghii(viridiplantae) 87.5%
分子结构信息
SMILES: C1(O)C=CC(C(=O)CCC2C(OC)=CC(OC)=CC=2OC)=CC=1
InChI: InChI=1S/C18H20O5/c1-21-14-10-17(22-2)15(18(11-14)23-3)8-9-16(20)12-4-6-13(19)7-5-12/h4-7,10-11,19H,8-9H2,1-3H3
描述信息
Loureirin B is a natural product found in Garcinia dulcis with data available.
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10?μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10?μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10?μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 189670
- Metlin: METLIN52406
- LipidMAPS: LMPK12120604
- MeSH: loureirin B
- ChemIDplus: 0119425900
- CAS: 119425-90-0
- medchemexpress: HY-N1504
- PMhub: MS000099878
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wei-Yi Cheng, Xi-Xi Zeng, Ping Cheng, Jin-Xiang Zhang. Loureirin B ameliorates cholestatic liver fibrosis via AKT/mTOR/ATG7-mediated autophagy of hepatic stellate cells.
European journal of pharmacology.
2024 May; 971(?):176552. doi:
10.1016/j.ejphar.2024.176552. [PMID: 38580181] - Yan Zou, Qianru Zhao, Xu Zhang, Hui Yu, Yongsheng Zhou, Ziyi Li, Min Xiao, Qiu Xiang, Lirong Zhang, Wenyi Shi, Haobo Tao, Lvyi Chen, Bing Han, Shijin Yin. The immunosuppressive effects and mechanisms of loureirin B on collagen-induced arthritis in rats.
Frontiers in immunology.
2023; 14(?):1094649. doi:
10.3389/fimmu.2023.1094649. [PMID: 37168850] - Min Liu, Jian Feng Zhang, Wen Long Zhu, Huan Liu, Xiong Jia. Loureirin B protects against obesity via activation of adipose tissue ω3 PUFA-GPR120-UCP1 axis in mice.
Biochemical and biophysical research communications.
2022 12; 632(?):139-149. doi:
10.1016/j.bbrc.2022.09.096. [PMID: 36209582] - Jiahao Zhang, Liang Mo, Haoran Huang, Jiake Xu, Yinuo Fan, Weifeng Li, Haibin Wang, Chi Zhou, Hanjun Fang, Wei He, Zhenqiu Chen, Yuhao Liu. Loureirin B downregulates osteoclast differentiation of bone marrow macrophages by targeting the MAPK signaling pathway.
Scientific reports.
2022 08; 12(1):14382. doi:
10.1038/s41598-022-18287-5. [PMID: 35999378] - Mian Cheng, Zhen Yang, Ruichao Li, Gang Wu, Cuntai Zhang. Loureirin B alleviates cardiac fibrosis by suppressing Pin1/TGF-β1 signaling.
European journal of pharmacology.
2022 Mar; 918(?):174791. doi:
10.1016/j.ejphar.2022.174791. [PMID: 35093323] - Yanting Ding, Sijing Xia, Haowen Fang, Bing Niu, Qin Chen. Loureirin B attenuates insulin resistance in HepG2 cells by regulating gluconeogenesis signaling pathway.
European journal of pharmacology.
2021 Nov; 910(?):174481. doi:
10.1016/j.ejphar.2021.174481. [PMID: 34481876] - Yanting Ding, Sijing Xia, Han Zhang, Qin Chen, Bing Niu. Loureirin B activates GLP-1R and promotes insulin secretion in Ins-1 cells.
Journal of cellular and molecular medicine.
2021 01; 25(2):855-866. doi:
10.1111/jcmm.16138. [PMID: 33300675] - Song Cheng, Yi Rong, Minjie Ma, Xianguang Lin, Xiangming Liu, Chenhong Li, Xiaofei Yang, Su Chen. Modulation on tetrodotoxin-resistant sodium current of loureirin B in rat dorsal root ganglion neurons via cyclic AMP-dependent protein kinase A.
Journal of cellular biochemistry.
2020 02; 121(2):1790-1800. doi:
10.1002/jcb.29414. [PMID: 31642099] - Qingqing Wang, Hanxiao Cai, Zhenxin Hu, Yanqing Wu, Xin Guo, Jiawei Li, Haoli Wang, Yani Liu, Yanlong Liu, Ling Xie, Ke Xu, Huazi Xu, Huacheng He, Hongyu Zhang, Jian Xiao. Loureirin B Promotes Axon Regeneration by Inhibiting Endoplasmic Reticulum Stress: Induced Mitochondrial Dysfunction and Regulating the Akt/GSK-3β Pathway after Spinal Cord Injury.
Journal of neurotrauma.
2019 06; 36(12):1949-1964. doi:
10.1089/neu.2018.5966. [PMID: 30543130] - Ying Wan, Yi Yu, Xinxin Pan, Xiaoqiang Mo, Weifan Gong, Xiangming Liu, Su Chen. Inhibition on acid-sensing ion channels and analgesic activities of flavonoids isolated from dragon's blood resin.
Phytotherapy research : PTR.
2019 Mar; 33(3):718-727. doi:
10.1002/ptr.6262. [PMID: 30618119] - Yuhao Liu, Chao Wang, Gang Wang, Youqiang Sun, Zhangrong Deng, Leilei Chen, Kai Chen, Jennifer Tickner, Jacob Kenny, Dezhi Song, Qingwen Zhang, Haibin Wang, Zhenqiu Chen, Chi Zhou, Wei He, Jiake Xu. Loureirin B suppresses RANKL-induced osteoclastogenesis and ovariectomized osteoporosis via attenuating NFATc1 and ROS activities.
Theranostics.
2019; 9(16):4648-4662. doi:
10.7150/thno.35414. [PMID: 31367247] - Su Chen, Ying Wan, Xiangming Liu, Xinxin Pan. Inhibitive effect of loureirin B plus capsaicin on tetrodotoxin-resistant sodium channel.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2018 12; 38(6):842-852. doi:
. [PMID: 32186131] - Yijie Sha, Yuelin Zhang, Jing Cao, Kai Qian, Bing Niu, Qin Chen. Loureirin B promotes insulin secretion through inhibition of KATP channel and influx of intracellular calcium.
Journal of cellular biochemistry.
2018 02; 119(2):2012-2021. doi:
10.1002/jcb.26362. [PMID: 28817206] - Jian-Peng Hu, Rong Zhang, Min Tang, Yu-Lian Li, Lin-Ting Xun, Zhi-Zhou Shi, Ying An, Ting Li, Zheng-Ji Song. Loureirin B inhibits the proliferation of hepatic stellate cells and the Wnt/β-catenin signaling pathway by regulating miR-148-3p.
Cellular & molecular biology letters.
2018; 23(?):35. doi:
10.1186/s11658-018-0098-9. [PMID: 30123297] - Jiachun Li, Dongpo Li, Youzhi Pan, Jun-Hua Hu, Wenzhe Huang, Zhen-Zhong Wang, Wei Xiao, Yu Wang. Simultaneous determination of ten bioactive constituents of Sanjie Zhentong Capsule in rat plasma by ultra-high-performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Jun; 1054(?):20-26. doi:
10.1016/j.jchromb.2017.03.001. [PMID: 28415020] - Yuelin Zhang, Yijie Sha, Kai Qian, Xu Chen, Qin Chen. Comparison of three methods for analyzing loureirin B and human serum albumin interaction using capillary electrophoresis.
Electrophoresis.
2017 04; 38(7):1038-1043. doi:
10.1002/elps.201600529. [PMID: 28059439] - Xiaoshuang Chen, Gaofeng Li, Shangfang Ma, Xujia Hu. A Rapid Centrifugation-Assisted Solid-Phase Extraction and Liquid Chromatography Method for Determination of Loureirin A and Loureirin B of Dragon's Blood Capsules in Rat Plasma and Urine After Oral Administration.
Journal of chromatographic science.
2015 Jul; 53(6):979-85. doi:
10.1093/chromsci/bmu209. [PMID: 25575508] - Xiaozhi Bai, Ting He, Jiaqi Liu, Yunchuan Wang, Lei Fan, Ke Tao, Jihong Shi, Chaowu Tang, Linlin Su, Dahai Hu. Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway.
Experimental dermatology.
2015 May; 24(5):355-60. doi:
10.1111/exd.12665. [PMID: 25683490] - Ting He, Xiaozhi Bai, Longlong Yang, Lei Fan, Yan Li, Linlin Su, Jianxin Gao, Shichao Han, Dahai Hu. Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β1-ERK/JNK Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2015; 37(2):666-76. doi:
10.1159/000430385. [PMID: 26344923] - Jin-Long Cui, Chun-Lan Wang, Shun-Xing Guo, Pei-Gen Xiao, Meng-Liang Wang. Stimulation of dragon's blood accumulation in Dracaena cambodiana via fungal inoculation.
Fitoterapia.
2013 Jun; 87(?):31-6. doi:
10.1016/j.fitote.2013.03.012. [PMID: 23518260] - Haiyan Zhao, Zilin Chen. An HPLC-ESI-MS method for analysis of loureirin A and B in dragon's blood and application in pharmacokinetics and tissue distribution in rats.
Fitoterapia.
2013 Apr; 86(?):149-58. doi:
10.1016/j.fitote.2013.02.012. [PMID: 23458829] - Li-Si Wei, Su Chen, Xian-Ju Huang, Jing Yao, Xiang-Ming Liu. Material basis for inhibition of dragon's blood on capsaicin-induced TRPV1 receptor currents in rat dorsal root ganglion neurons.
European journal of pharmacology.
2013 Feb; 702(1-3):275-84. doi:
10.1016/j.ejphar.2013.01.052. [PMID: 23399763] - Xueying Yang, Xufang Hu, Fei Li, Xinghong Wang, Qiue Cao. [Determination of loureirin A and loureirin B in dragon's blood by capillary zone electrophoresis].
Se pu = Chinese journal of chromatography.
2012 May; 30(5):501-6. doi:
10.3724/sp.j.1123.2011.12006. [PMID: 22934414] - Yun Li, Wei Xiao, Jianping Qin, Ying Guo, Qianqian Zhu. [Simultaneous determination of five active components in resina draconis and its extract by HPLC].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2012 Apr; 37(7):929-33. doi:
. [PMID: 22792791] - Yushi Zhang, Yongzhi Li, Bo Chen, Yulin Deng, Yujuan Li. Simultaneous quantification of loureirin A and loureirin B in rat urine, feces, and bile by HPLC-MS/MS method and its application to excretion study.
Analytical and bioanalytical chemistry.
2011 May; 400(4):1181-7. doi:
10.1007/s00216-011-4868-8. [PMID: 21431828] - Xing-Hong Wang, Changhe Zhang, Ling-Ling Yang, José Gomes-Laranjo. Production of dragon's blood in Dracaena cochinchinensis plants by inoculation of Fusarium proliferatum.
Plant science : an international journal of experimental plant biology.
2011 Feb; 180(2):292-9. doi:
10.1016/j.plantsci.2010.09.007. [PMID: 21421373] - Yujuan Li, Yongzhi Li, Zhezhe Yang, Nian Xin, Yulin Deng. A sensitive LC-MS/MS method to quantify loureirin B in rat plasma with application to preclinical pharmacokinetic studies.
Journal of pharmaceutical and biomedical analysis.
2009 Dec; 50(5):983-6. doi:
10.1016/j.jpba.2009.07.003. [PMID: 19660887] - Yi-Ning Yang, Jue-Xu Chen, Xue-Yan Pang, Susumu Terakawa, Xu Chen, Yong-Hua Ji, Ke-Lan Yong. Slow rise of intracellular Ca(2+) concentration in rat primary sensory neurons triggered by loureirin B.
Sheng li xue bao : [Acta physiologica Sinica].
2009 Apr; 61(2):115-20. doi:
". [PMID: 19377821] - Min Guo, Su Chen, Xiangming Liu. Material basis for inhibition of Dragon's Blood on evoked discharges of wide dynamic range neurons in spinal dorsal horn of rats.
Science in China. Series C, Life sciences.
2008 Nov; 51(11):1025-38. doi:
10.1007/s11427-008-0133-6. [PMID: 18989646] - Su Chen, Xiangming Liu. [A computer simulation research for the effects of dragon's blood and its component loureirin B on sodium channel in dorsal root ganglion cells].
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi.
2006 Dec; 23(6):1172-6. doi:
". [PMID: 17228702] - Xiangming Liu, Su Chen, Yuxia Zhang, Fan Zhang. Modulation of dragon's blood on tetrodotoxin-resistant sodium currents in dorsal root ganglion neurons and identification of its material basis for efficacy.
Science in China. Series C, Life sciences.
2006 Jun; 49(3):274-85. doi:
10.1007/s11427-006-0274-4. [PMID: 16856497] - Liu Xiangming, Chen Su, Yin Shijin, Mei Zhinan. Effects of dragon's blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons.
Science in China. Series C, Life sciences.
2004 Aug; 47(4):340-8. doi:
10.1360/03yc0146. [PMID: 15493475] - C D Gerson, N Cohen. Folic acid absorption in regional enteritis.
The American journal of clinical nutrition.
1976 Feb; 29(2):182-6. doi:
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International journal of fertility.
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