Oroxylin_A (BioDeep_00000229878)

 

Secondary id: BioDeep_00000018715, BioDeep_00000269546, BioDeep_00000861850

PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl-

化学式: C16H12O5 (284.0684702)
中文名称: 千层纸素A
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(O)=CC2OC(C3C=CC=CC=3)=CC(=O)C=2C(O)=C1OC
InChI: InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3

描述信息

Oroxylin A is a dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-6. It has a role as an antineoplastic agent and an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It is a monomethoxyflavone and a dihydroxyflavone. It is a conjugate acid of an oroxylin A(1-).
Oroxylin A is a natural product found in Scutellaria likiangensis, Scutellaria amoena, and other organisms with data available.
Oroxylin A is an active flavonoid compound with strong anti-cancer effects.
Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis[1][2][3][4][5].
Oroxylin A is an active flavonoid compound with strong anti-cancer effects.

同义名列表

18 个代谢物同义名

4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl-; 5,7-dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one; 5,7-dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one; 5,7-Dihydroxy-6-methoxy-2-phenyl-chromen-4-one; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one; Baicalein 6-methyl ether;6-Methoxybaicalein; FLAVONE, 5,7-DIHYDROXY-6-METHOXY-; 5,7-dihydroxy-6-methoxyflavone; Oroxylin A, >=98\\% (HPLC); baicalein 6-methyl ether; 6-Methoxybaicalein; UNII-53K24Z586G; OROXYLIN A [MI]; 53K24Z586G; Oroxylin A; Oroxylia A; Oroxylin-A; Oroxylin



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

74 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaofei Chen, Ruili Ma, Weiguo Wu, Ran Gao, Yikang Shu, Mingxin Dong, Mengzhe Guo, Daoquan Tang, Danhua Li, Shuai Ji. Wighteone, a prenylated flavonoid from licorice, inhibits growth of SW480 colorectal cancer cells by allosteric inhibition of Akt. Journal of ethnopharmacology. 2024 Aug; 330(?):118195. doi: 10.1016/j.jep.2024.118195. [PMID: 38641080]
  • Shiyong Gao, Huixin Tan, Jian Gang. Inhibition of hepatocellular carcinoma cell proliferation through regulation of the Cell Cycle, AGE-RAGE, and Leptin signaling pathways by a compound formulation comprised of andrographolide, wogonin, and oroxylin A derived from Andrographis Paniculata(Burm.f.) Nees. Journal of ethnopharmacology. 2024 Jul; 329(?):118001. doi: 10.1016/j.jep.2024.118001. [PMID: 38467318]
  • Ting Wang, Zhao-Bo Wang, Chun-Miao Jiang, Yang Zhao, Li Tang, Xi-Mei Xiao, Jing Fu. Oroxylin A inhibits inflammatory cytokines in periodontitis via HO‑1. Molecular medicine reports. 2024 Jul; 30(1):. doi: 10.3892/mmr.2024.13249. [PMID: 38785151]
  • Yan Chen, Jiehuang Zheng, Lixia Mo, Fengsheng Chen, Ruopeng Li, Yiyuan Wang, Qinghe Liang, Ziye Chen, Wenqi Dai, Lishan Chen, Peiyu Yan, Hua Zhou, Xiaojuan Li. Oroxylin A suppresses breast cancer-induced osteoclastogenesis and osteolysis as a natural RON inhibitor. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155688. doi: 10.1016/j.phymed.2024.155688. [PMID: 38728920]
  • Peng-Xin Wang, Xiao-Nan Mu, Shu-Hong Huang, Kang Hu, Zhi-Gang Sun. Cellular and molecular mechanisms of oroxylin A in cancer therapy: Recent advances. European journal of pharmacology. 2024 Apr; 969(?):176452. doi: 10.1016/j.ejphar.2024.176452. [PMID: 38417609]
  • Chunmei Feng, Haiyan Zhang, Peiru Wang, Linglin Zhang, Xiaojing Liu, Guorong Yan, Yu Yan, Jin Yang, Jia Liu, Fei Tan, Xiuli Wang, Qingyu Zeng. Oroxylin A suppress LL-37 generated rosacea-like skin inflammation through the modulation of SIRT3-SOD2-NF-κB signaling pathway. International immunopharmacology. 2024 Mar; 129(?):111636. doi: 10.1016/j.intimp.2024.111636. [PMID: 38364746]
  • Tao Liu, Shan Zhu, Yi Yang, Wenxiao Qin, Zijing Wang, Zhiyue Zhao, Tao Liu, Xiang Wang, Tian Duan, Yang Liu, Yan Liu, Qingmei Xia, Han Zhang, Nan Li. Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Feb; 171(?):116110. doi: 10.1016/j.biopha.2023.116110. [PMID: 38198955]
  • Zhenhua Ni, Honghong Ma, Xiaodong Li, Liwei Zou, Zongjun Liu, Xiongbiao Wang, Hong Ma, Ling Yang. Wogonin alleviates BaP-induced DNA damage and oxidative stress in human airway epithelial cells by dual inhibiting CYP1A1 activity and expression. Environmental toxicology. 2023 Jul; ?(?):. doi: 10.1002/tox.23907. [PMID: 37515497]
  • Yansi Xian, Yunyuan Nong, Yijie Gao, Yuangang Su, Zhiqiang Lei, Haoyu Lian, Jianwen Cheng, Jiamin Liang, Xiaoliang Feng, Zhijuan Liu, Jinmin Zhao, Tongling Zhao, Zhiheng Su, Qian Liu, Fangming Song. UPLC/Q-TOF-MS-based metabolomics evaluate the efficacy of oroxylin A against postmenopausal osteoporosis. Biomedical chromatography : BMC. 2023 May; 37(5):e5609. doi: 10.1002/bmc.5609. [PMID: 36811170]
  • Wonjun Cho, Sung Woo Choi, Heeseung Oh, A M Abd El-Aty, Ahmet Hacimuftuoglu, Ji Hoon Jeong, Jin-Ho Song, Yong Kyoo Shin, Tae Woo Jung. Oroxylin-A alleviates hepatic lipid accumulation and apoptosis under hyperlipidemic conditions via AMPK/FGF21 signaling. Biochemical and biophysical research communications. 2023 Mar; 648(?):59-65. doi: 10.1016/j.bbrc.2023.01.090. [PMID: 36736092]
  • Ye-Ji Lee, Dong-Soon Im. Inhibitory Effect of Oroxylin A in a Mouse Model of Atopic Dermatitis. Inflammation. 2022 Dec; ?(?):. doi: 10.1007/s10753-022-01764-4. [PMID: 36456726]
  • Shan Zhu, Zhiyue Zhao, Wenxiao Qin, Tao Liu, Yi Yang, Zijing Wang, Hongfei Ma, Xiang Wang, Tao Liu, Dongli Qi, Pan Guo, JiaXin Pi, BaoCheng Tian, Han Zhang, Nan Li. The Nanostructured lipid carrier gel of Oroxylin A reduced UV-induced skin oxidative stress damage. Colloids and surfaces. B, Biointerfaces. 2022 Aug; 216(?):112578. doi: 10.1016/j.colsurfb.2022.112578. [PMID: 35636325]
  • Zhilan Qian, Jiahui Yu, Xinjie Chen, Yijia Kang, Yanna Ren, Qi Liu, Jian Lu, Qing Zhao, Menghao Cai. De Novo Production of Plant 4'-Deoxyflavones Baicalein and Oroxylin A from Ethanol in Crabtree-Negative Yeast. ACS synthetic biology. 2022 04; 11(4):1600-1612. doi: 10.1021/acssynbio.2c00026. [PMID: 35389625]
  • Yueying Bian, Mengqi Sun, Huili Chen, Guanghui Ren, Kejia Fu, Nan Yang, Mei Zhang, Nan Zhou, Yang Lu, Ning Li, Yongjie Zhang, Xijing Chen, Di Zhao. Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS. Xenobiotica; the fate of foreign compounds in biological systems. 2022 Feb; 52(2):165-176. doi: 10.1080/00498254.2021.2014080. [PMID: 35345974]
  • Jiapan Gao, Yuanyuan Ding, Yuejin Wang, Peida Liang, Liyang Zhang, Rui Liu. Oroxylin A is a severe acute respiratory syndrome coronavirus 2-spiked pseudotyped virus blocker obtained from Radix Scutellariae using angiotensin-converting enzyme II/cell membrane chromatography. Phytotherapy research : PTR. 2021 Jun; 35(6):3194-3204. doi: 10.1002/ptr.7030. [PMID: 33587321]
  • Caiyu Li, Xue Wang, Yajuan Bi, Heshui Yu, Jing Wei, Yi Zhang, Lifeng Han, Youcai Zhang. Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy. Toxicological sciences : an official journal of the Society of Toxicology. 2020 06; 175(2):279-291. doi: 10.1093/toxsci/kfaa033. [PMID: 32159797]
  • Guanghui Ren, Huili Chen, Mei Zhang, Nan Yang, Hui Yang, Chuanru Xu, Jiaming Li, Chen Ning, Zhongjin Song, Shiyu Zhou, Siliang Zhang, Xiaoqian Wang, Yang Lu, Ning Li, Yongjie Zhang, Xijing Chen, Di Zhao. Determination of oroxylin A, oroxylin A 7-O-glucuronide, and oroxylin A sodium sulfonate in beagle dogs by using UHPLC MS/MS Application in a pharmacokinetic study. Journal of separation science. 2020 Jun; 43(12):2290-2300. doi: 10.1002/jssc.201901259. [PMID: 32187438]
  • Jun Kai, Xiang Yang, Zhimin Wang, Feixia Wang, Yan Jia, Shijun Wang, Shanzhong Tan, Anping Chen, Jiangjuan Shao, Feng Zhang, Zili Zhang, Shizhong Zheng. Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease. Free radical biology & medicine. 2020 06; 153(?):89-102. doi: 10.1016/j.freeradbiomed.2020.03.031. [PMID: 32289481]
  • Guanghui Ren, Huili Chen, Mei Zhang, Nan Yang, Hui Yang, Chuanru Xu, Jiaming Li, Chen Ning, Zhongjin Song, Shiyu Zhou, Yueying Bian, Yang Lu, Ning Li, Yongjie Zhang, Xijing Chen, Di Zhao. Pharmacokinetics, tissue distribution and excretion study of Oroxylin A, Oroxylin A 7-O-glucuronide and Oroxylin A sodium sulfonate in rats after administration of Oroxylin A. Fitoterapia. 2020 Apr; 142(?):104480. doi: 10.1016/j.fitote.2020.104480. [PMID: 31927013]
  • Jian-Jiang Shen, Xiao-Fei Zhu, Juan Xu, Zhi-Fei Wang, Wan-Jian Gu, Yun Chen. Oroxylin A exerts anticancer effects on human ovarian cancer cells via the PPARγ‑dependent reversal of the progesterone receptor membrane component 1/2 expression profile. Oncology reports. 2020 04; 43(4):1309-1318. doi: 10.3892/or.2020.7509. [PMID: 32323796]
  • Bei Yin, Yi-Ming Bi, Guan-Jie Fan, Ya-Qing Xia. Molecular Mechanism of the Effect of Huanglian Jiedu Decoction on Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking. Journal of diabetes research. 2020; 2020(?):5273914. doi: 10.1155/2020/5273914. [PMID: 33134394]
  • Liqian Xuan, Jiajun Zhang, Jianmei Ji, Jun Hu, Fu Li. Oroxylin A Exerts Its Antitumor Effects in Human Gallbladder Cancer via Inhibition of the PTEN/PI3K/AKT Signaling Pathway. Biological & pharmaceutical bulletin. 2020; 43(10):1511-1518. doi: 10.1248/bpb.b20-00262. [PMID: 32999161]
  • Zili Zhang, Mei Guo, Min Shen, Yujia Li, Shanzhong Tan, Jiangjuan Shao, Feng Zhang, Anping Chen, Shijun Wang, Shizhong Zheng. Oroxylin A regulates the turnover of lipid droplet via downregulating adipose triglyceride lipase (ATGL) in hepatic stellate cells. Life sciences. 2019 Dec; 238(?):116934. doi: 10.1016/j.lfs.2019.116934. [PMID: 31610205]
  • Mianli Bian, Jianlin He, Huanhuan Jin, Naqi Lian, Jiangjuan Shao, Qinglong Guo, Shijun Wang, Feng Zhang, Shizhong Zheng. Oroxylin A induces apoptosis of activated hepatic stellate cells through endoplasmic reticulum stress. Apoptosis : an international journal on programmed cell death. 2019 12; 24(11-12):905-920. doi: 10.1007/s10495-019-01568-2. [PMID: 31538267]
  • Jie Bai, Shengyu Zhao, Xiaoqing Fan, Yonghui Chen, Xiaowen Zou, Minwan Hu, Baolian Wang, Jing Jin, Xiaojian Wang, Jinping Hu, Dan Zhang, Yan Li. Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships. Toxicology and applied pharmacology. 2019 04; 369(?):49-59. doi: 10.1016/j.taap.2019.02.010. [PMID: 30790579]
  • Hui Liu, Rui-Xue Xu, Xiao-Shuang Zhang, Ting-Ting Zhu, Hong-Xiang Lou, Ai-Xia Cheng. The identification and functional characterization of three liverwort class I O-methyltransferases. Phytochemistry. 2019 Mar; 159(?):190-198. doi: 10.1016/j.phytochem.2018.12.001. [PMID: 30634081]
  • Yanqiu Gu, Xiaofei Chen, Rong Wang, Shaozhan Wang, Xiaoyu Wang, Leyi Zheng, Bin Zhang, Yifeng Chai, Zhenyu Zhu, Yongfang Yuan. Comparative two-dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix. Journal of pharmaceutical and biomedical analysis. 2019 Feb; 164(?):550-556. doi: 10.1016/j.jpba.2018.10.028. [PMID: 30458388]
  • XiaoHu Sun, Xinzhong Chang, Yunhua Wang, Boyang Xu, Xuchen Cao. Oroxylin A Suppresses the Cell Proliferation, Migration, and EMT via NF-κB Signaling Pathway in Human Breast Cancer Cells. BioMed research international. 2019; 2019(?):9241769. doi: 10.1155/2019/9241769. [PMID: 31341911]
  • Hui Li, Na Lu, Xiaoxuan Yu, Xiao Liu, Po Hu, Yu Zhu, Le Shen, Jingyan Xu, Zhiyu Li, Qinglong Guo, Hui Hui. Oroxylin A, a natural compound, mitigates the negative effects of TNFα-treated acute myelogenous leukemia cells. Carcinogenesis. 2018 10; 39(10):1292-1303. doi: 10.1093/carcin/bgy004. [PMID: 29346508]
  • Shuai-Cheng Wu, Xiu-Ling Chu, Jian-Qing Su, Zhen-Qiang Cui, Li-Yan Zhang, Zhen-Jiang Yu, Zong-Mei Wu, Meng-Lu Cai, Han-Xiao Li, Zi-Jie Zhang. Baicalin protects mice against Salmonella typhimurium infection via the modulation of both bacterial virulence and host response. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Sep; 48(?):21-31. doi: 10.1016/j.phymed.2018.04.063. [PMID: 30195877]
  • François Chassagne, Mohamed Haddad, Aurélien Amiel, Chiobouaphong Phakeovilay, Chanthanom Manithip, Geneviève Bourdy, Eric Deharo, Guillaume Marti. A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases. Fitoterapia. 2018 Jun; 127(?):226-236. doi: 10.1016/j.fitote.2018.02.021. [PMID: 29477305]
  • Huanhuan Jin, Naqi Lian, Mianli Bian, Chenxi Zhang, Xingran Chen, Jiangjuan Shao, Li Wu, Anping Chen, Qinglong Guo, Feng Zhang, Shizhong Zheng. Oroxylin A prevents alcohol-induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha. Chemico-biological interactions. 2018 Apr; 285(?):14-20. doi: 10.1016/j.cbi.2018.02.025. [PMID: 29476730]
  • Jing Jin, Shuo Chen, Dechuan Wang, Yuanjin Chen, Yuxu Wang, Min Guo, Changlin Zhou, Jie Dou. Oroxylin A suppresses influenza A virus replication correlating with neuraminidase inhibition and induction of IFNs. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jan; 97(?):385-394. doi: 10.1016/j.biopha.2017.10.140. [PMID: 29091888]
  • Tomofumi Shimizu, Nobuhiko Shibuya, Yuji Narukawa, Naohiro Oshima, Noriyasu Hada, Fumiyuki Kiuchi. Synergistic effect of baicalein, wogonin and oroxylin A mixture: multistep inhibition of the NF-κB signalling pathway contributes to an anti-inflammatory effect of Scutellaria root flavonoids. Journal of natural medicines. 2018 Jan; 72(1):181-191. doi: 10.1007/s11418-017-1129-y. [PMID: 28921127]
  • Ruiya Zhang, Yonglei Cui, Yan Wang, Xiangge Tian, Lu Zheng, HaiJian Cong, Bin Wu, Xiaokui Huo, Chao Wang, BaoJing Zhang, Xiaobo Wang, Zhonghui Yu. Catechol-O-Methyltransferase and UDP-Glucuronosyltransferases in the Metabolism of Baicalein in Different Species. European journal of drug metabolism and pharmacokinetics. 2017 Dec; 42(6):981-992. doi: 10.1007/s13318-017-0419-9. [PMID: 28536775]
  • Minting Chen, Suying Wei, Chaohua Luo, Feilong Chen, Shuai Song, Qun Shen, Zhixian Mo, Fenghuan Wei. Simultaneous determination of wogonin, oroxylin a, schisandrin, paeoniflorin and emodin in rat serum by HPLC-MS/MS and application to pharmacokinetic studies. Biomedical chromatography : BMC. 2017 Oct; 31(10):. doi: 10.1002/bmc.3966. [PMID: 28236316]
  • Sophia Yui Kau Fong, Chenrui Li, Yiu Cheong Ho, Rui Li, Qian Wang, Yin Cheong Wong, Hong Xue, Zhong Zuo. Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice. Molecular pharmaceutics. 2017 09; 14(9):2908-2916. doi: 10.1021/acs.molpharmaceut.7b00029. [PMID: 28426226]
  • Ting Ni, Zihao He, Yuanyuan Dai, Jingyue Yao, Qinglong Guo, Libin Wei. Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1α-modulated fatty acid metabolism. Cell death & disease. 2017 06; 8(6):e2865. doi: 10.1038/cddis.2017.261. [PMID: 28594405]
  • Qinghe Han, Haiyu Wang, Chong Xiao, Ben-Dong Fu, Chong-Tao Du. Oroxylin A inhibits H2O2-induced oxidative stress in PC12 cells. Natural product research. 2017 Jun; 31(11):1339-1342. doi: 10.1080/14786419.2016.1244193. [PMID: 27820974]
  • Priyanka Mangal, Pragyanshu Khare, Sneha Jagtap, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Kamlesh Kumar Bhutani. Screening of six Ayurvedic medicinal plants for anti-obesity potential: An investigation on bioactive constituents from Oroxylum indicum (L.) Kurz bark. Journal of ethnopharmacology. 2017 Feb; 197(?):138-146. doi: 10.1016/j.jep.2016.07.070. [PMID: 27469197]
  • Rong-Xiu Liu, Guo-Hu Song, Pei-Gen Wu, Xue-Wen Zhang, Hui-Juan Hu, Jia Liu, Xiao-Su Miao, Zhi-Yan Hou, Wen-Quan Wang, Sheng-Li Wei. Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis. Chinese journal of natural medicines. 2017 Feb; 15(2):152-160. doi: 10.1016/s1875-5364(17)30030-4. [PMID: 28284428]
  • Pauline Cho, Guangsen Shi, Maurice Yap, Maureen V Boost. Effects of Lead Phytochemicals of Radix Scutellariae on Acanthamoeba. Investigative ophthalmology & visual science. 2016 12; 57(15):6591-6595. doi: 10.1167/iovs.16-20533. [PMID: 27918833]
  • Yu-Ling Wang, Ju-Mei Gao, Li-Zhi Xing. Therapeutic potential of Oroxylin A in rheumatoid arthritis. International immunopharmacology. 2016 Nov; 40(?):294-299. doi: 10.1016/j.intimp.2016.09.006. [PMID: 27643663]
  • Lian Huang, Hiroyuki Fuchino, Nobuo Kawahara, Yuji Narukawa, Noriyasu Hada, Fumiyuki Kiuchi. Application of a new method, orthogonal projection to latent structure (OPLS) combined with principal component analysis (PCA), to screening of prostaglandin E2 production inhibitory flavonoids in Scutellaria Root. Journal of natural medicines. 2016 Oct; 70(4):731-9. doi: 10.1007/s11418-016-1004-2. [PMID: 27164908]
  • De-Gang Zhou, Bao-Zhong Diao, Wen Zhou, Jia-Long Feng. Oroxylin A Inhibits Allergic Airway Inflammation in Ovalbumin (OVA)-Induced Asthma Murine Model. Inflammation. 2016 Apr; 39(2):867-72. doi: 10.1007/s10753-016-0317-3. [PMID: 26895180]
  • Bo-Eun Kwon, Jae-Hyoung Song, Hyuk-Hwan Song, Ju Won Kang, Sam Noh Hwang, Ki-Jong Rhee, Aeri Shim, Eun-Hye Hong, Yeon-Jeong Kim, Sang-Min Jeon, Sun-Young Chang, Dong-Eun Kim, Sungchan Cho, Hyun-Jeong Ko. Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice. PloS one. 2016; 11(5):e0155784. doi: 10.1371/journal.pone.0155784. [PMID: 27195463]
  • Haiying Huang, Xiaoyu Zhang, Jingyuan Li. Protective effect of oroxylin A against lipopolysaccharide and/or D-galactosamine-induced acute liver injury in mice. The Journal of surgical research. 2015 May; 195(2):522-8. doi: 10.1016/j.jss.2015.01.047. [PMID: 25818981]
  • Kai Zhao, Yuxin Zhou, Chen Qiao, Ting Ni, Zhiyu Li, Xiaotang Wang, Qinglong Guo, Na Lu, Libin Wei. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. Journal of hematology & oncology. 2015 Apr; 8(?):41. doi: 10.1186/s13045-015-0137-1. [PMID: 25902914]
  • L Wei, Y Zhou, C Qiao, T Ni, Z Li, Q You, Q Guo, N Lu. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell death & disease. 2015 Apr; 6(?):e1714. doi: 10.1038/cddis.2015.86. [PMID: 25855962]
  • X Li, H Miao, Y Zhang, W Li, Z Li, Y Zhou, L Zhao, Q Guo. Bone marrow microenvironment confers imatinib resistance to chronic myelogenous leukemia and oroxylin A reverses the resistance by suppressing Stat3 pathway. Archives of toxicology. 2015 Jan; 89(1):121-36. doi: 10.1007/s00204-014-1226-6. [PMID: 24671465]
  • Jyotsna Singh, Poonam Kakkar. Oroxylin A, a constituent of Oroxylum indicum inhibits adipogenesis and induces apoptosis in 3T3-L1 cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Oct; 21(12):1733-41. doi: 10.1016/j.phymed.2014.08.014. [PMID: 25442284]
  • Tao Li, Yi-Wei Wang, Yan-Li Wang, Dong Zhang, Hui-Hui Zhang, Li Chen, Shuai-Xing Zhuang, Zhong-Ming Zhou, Wei-Peng Yang. [Pharmacokinetics and pharmacodynamics of huangqin tang in febrile rats]. Yao xue xue bao = Acta pharmaceutica Sinica. 2014 Oct; 49(10):1418-25. doi: . [PMID: 25577872]
  • Sophia Yui Kau Fong, Yin Cheong Wong, Zhong Zuo. Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2014 Aug; 97(?):9-23. doi: 10.1016/j.jpba.2014.03.033. [PMID: 24803030]
  • Chenrui Li, Sophia Yui Kau Fong, Qibing Mei, Ge Lin, Zhong Zuo. Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact. Pharmaceutical biology. 2014 Mar; 52(3):291-7. doi: 10.3109/13880209.2013.834366. [PMID: 24102566]
  • Tao Li, Yi-Wei Wang, Yan-Li Wang, Ri-Xin Liang, Dong Zhang, Hui-Hui Zhang, Li Chen, Zhong-Ming Zhou, Wei-Peng Yang. [LC-MS quantification and pharmacokinetics of the multi-constituents of Huangqin Tang in rat plasma after different single oral doses]. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Jun; 48(6):917-24. doi: . [PMID: 23984529]
  • Libin Wei, Qinsheng Dai, Yuxin Zhou, Meijuan Zou, Zhiyu Li, Na Lu, Qinglong Guo. Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II. Biochimica et biophysica acta. 2013 Jun; 1830(6):3835-45. doi: 10.1016/j.bbagen.2013.03.009. [PMID: 23500080]
  • Litao Zhu, Li Zhao, Hu Wang, Yu Wang, Di Pan, Jing Yao, Zhiyu Li, Guanzhong Wu, Qinglong Guo. Oroxylin A reverses P-glycoprotein-mediated multidrug resistance of MCF7/ADR cells by G2/M arrest. Toxicology letters. 2013 May; 219(2):107-15. doi: 10.1016/j.toxlet.2013.01.019. [PMID: 23470866]
  • L Wei, Y Zhou, Q Dai, C Qiao, L Zhao, H Hui, N Lu, Q-L Guo. Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma. Cell death & disease. 2013 Apr; 4(?):e601. doi: 10.1038/cddis.2013.131. [PMID: 23598413]
  • Hong Wang, Ying Guo, Xin Zhao, Huiying Li, Guanwei Fan, Haoping Mao, Lin Miao, Xiumei Gao. An estrogen receptor dependent mechanism of Oroxylin A in the repression of inflammatory response. PloS one. 2013; 8(7):e69555. doi: 10.1371/journal.pone.0069555. [PMID: 23922737]
  • Seo Young Yoon, Ike dela Peña, Sung Mok Kim, Tae Sun Woo, Chan Young Shin, Kun Ho Son, Haeil Park, Yong Soo Lee, Jong Hoon Ryu, Mingli Jin, Kyeong-Man Kim, Jae Hoon Cheong. Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro. Archives of pharmacal research. 2013 Jan; 36(1):134-40. doi: 10.1007/s12272-013-0009-6. [PMID: 23371806]
  • Runzhi Zhu, Guofang Zeng, Yinqin Chen, Qingyu Zhang, Bin Liu, Jie Liu, Hege Chen, Mingyi Li. Oroxylin A accelerates liver regeneration in CCl₄-induced acute liver injury mice. PloS one. 2013; 8(8):e71612. doi: 10.1371/journal.pone.0071612. [PMID: 23951204]
  • Ling Tong, Meixu Wan, Lihua Zhang, Yonghong Zhu, He Sun, Kaishun Bi. Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2012 Nov; 70(?):6-12. doi: 10.1016/j.jpba.2012.03.051. [PMID: 22703838]
  • Hong Wang, Jing-Tian Qu, Xin Zhao, Ying Guo, Hao-Ping Mao. [Vasodilator effect of oroxylin A on thoracic aorta isolated from rats]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2012 Aug; 10(8):880-5. doi: 10.3736/jcim20120808. [PMID: 22883404]
  • Qing-Yi Lu, Lifeng Zhang, Aune Moro, Monica C Chen, Diane M Harris, Guido Eibl, Vay-Liang W Go. Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts. Pancreas. 2012 May; 41(4):571-6. doi: 10.1097/mpa.0b013e318232e130. [PMID: 22158070]
  • Zhijian Lu, Na Lu, Chenglin Li, Fanni Li, Kai Zhao, Biqi Lin, Qinglong Guo. Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway. Toxicology letters. 2012 Mar; 209(3):211-20. doi: 10.1016/j.toxlet.2011.12.022. [PMID: 22245252]
  • Tzu-Ling Tseng, Mei-Fang Chen, Ming-Jen Tsai, Yung-Hsiang Hsu, Chin-Piao Chen, Tony J F Lee. Oroxylin-A rescues LPS-induced acute lung injury via regulation of NF-κB signaling pathway in rodents. PloS one. 2012; 7(10):e47403. doi: 10.1371/journal.pone.0047403. [PMID: 23071799]
  • Chenrui Li, Li Zhang, Ge Lin, Zhong Zuo. Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product. Journal of pharmaceutical and biomedical analysis. 2011 Mar; 54(4):750-8. doi: 10.1016/j.jpba.2010.10.005. [PMID: 21051171]
  • G Suresh Kumar, Ashok K Tiwari, V Rama Subba Rao, K Rajendra Prasad, A Zehra Ali, K Suresh Babu. Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and α-glucosidase inhibitors. Journal of Asian natural products research. 2010 Nov; 12(11):978-84. doi: 10.1080/10286020.2010.511190. [PMID: 21061220]
  • Hien-trung Trinh, Eun-ha Joh, Ho-young Kwak, Nam-in Baek, Dong-hyun Kim. Anti-pruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice. Acta pharmacologica Sinica. 2010 Jun; 31(6):718-24. doi: 10.1038/aps.2010.42. [PMID: 20453872]
  • T Hari Babu, K Manjulatha, G Suresh Kumar, A Hymavathi, Ashok K Tiwari, Muraleedhar Purohit, J Madhusudana Rao, K Suresh Babu. Gastroprotective flavonoid constituents from Oroxylum indicum Vent. Bioorganic & medicinal chemistry letters. 2010 Jan; 20(1):117-20. doi: 10.1016/j.bmcl.2009.11.024. [PMID: 19948405]
  • Jing Li, Yuanqing Ding, Xing-Cong Li, Daneel Ferreira, Shabana Khan, Troy Smillie, Ikhlas A Khan. Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. Journal of natural products. 2009 Jun; 72(6):983-7. doi: 10.1021/np900068t. [PMID: 19555121]
  • Huey-Chuan Shih, Chun-Sen Hsu, Ling-Ling Yang. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. Journal of biomedical science. 2009 Mar; 16(?):27. doi: 10.1186/1423-0127-16-27. [PMID: 19272127]
  • Dong Hyun Kim, Sunho Kim, Su Jin Jeon, Kun Ho Son, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Kwang Ho Ko, Jong Hoon Ryu. The effects of acute and repeated oroxylin A treatments on Abeta(25-35)-induced memory impairment in mice. Neuropharmacology. 2008 Oct; 55(5):639-47. doi: 10.1016/j.neuropharm.2008.05.019. [PMID: 18620712]
  • Zhao-Tang Ma, Xiu-Wei Yang. [Studies on ethyl acetate soluble constituents of Huanglian Jiedutang]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Sep; 33(18):2080-6. doi: . [PMID: 19160789]
  • Tomohisa Hattori, Chiharu Sadakane, Junichi Koseki, Yoshio Kase, Shuichi Takeda. Saireito probably prevents mesangial cell proliferation in HIGA mice via PDGF-BB tyrosine kinase inhibition. Clinical and experimental nephrology. 2007 Dec; 11(4):275-282. doi: 10.1007/s10157-007-0493-4. [PMID: 18085387]
  • Jih-Jung Chen, Hsinn-Hsing Lee, Cheng-Dean Shih, Chang-Hui Liao, Ih-Sheng Chen, Tsung-Hsien Chou. New dihydrochalcones and anti-platelet aggregation constituents from the leaves of Muntingia calabura. Planta medica. 2007 Jun; 73(6):572-7. doi: 10.1055/s-2007-967196. [PMID: 17516329]
  • Dong Hyun Kim, Su Jin Jeon, Kun Ho Son, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jong-Ju Lee, Young-Wuk Cho, Jae Hoon Cheong, Kwang Ho Ko, Jong Hoon Ryu. The ameliorating effect of oroxylin A on scopolamine-induced memory impairment in mice. Neurobiology of learning and memory. 2007 May; 87(4):536-46. doi: 10.1016/j.nlm.2006.11.005. [PMID: 17196405]
  • Young Hoon Kim, Dong Won Jeong, Yoon-Cheol Kim, Dong Hwan Sohn, Eun-Seok Park, Hye Suk Lee. Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats. Archives of pharmacal research. 2007 Feb; 30(2):260-5. doi: 10.1007/bf02977703. [PMID: 17366750]
  • Young Hoon Kim, Dong Won Jeong, In Bok Paek, Hye Young Ji, Youn-Chul Kim, Dong Hwan Sohn, Hye Suk Lee. Liquid chromatography with tandem mass spectrometry for the simultaneous determination of baicalein, baicalin, oroxylin A and wogonin in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Dec; 844(2):261-7. doi: 10.1016/j.jchromb.2006.07.021. [PMID: 16893689]
  • Wen-Hsin Huang, An-Rong Lee, Ching-Huey Yang. Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI. Bioscience, biotechnology, and biochemistry. 2006 Oct; 70(10):2371-80. doi: 10.1271/bbb.50698. [PMID: 17031041]
  • Hua-Bin Li, Feng Chen. Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography. Journal of chromatography. A. 2005 May; 1074(1-2):107-10. doi: 10.1016/j.chroma.2005.03.088. [PMID: 15941045]
  • Shuang-Cheng Ma, Jiang Du, Paul Pui-Hay But, Xue-Long Deng, Yong-Wen Zhang, Vincent Eng-Choon Ooi, Hong-Xi Xu, Spencer Hon-Sun Lee, Song Fong Lee. Antiviral Chinese medicinal herbs against respiratory syncytial virus. Journal of ethnopharmacology. 2002 Feb; 79(2):205-11. doi: 10.1016/s0378-8741(01)00389-0. [PMID: 11801383]
  • Y Chen, L Yang, T J Lee. Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation. Biochemical pharmacology. 2000 Jun; 59(11):1445-57. doi: 10.1016/s0006-2952(00)00255-0. [PMID: 10751555]
  • A B Pomilio, C A Buschi, C N Tomes, A A Viale. Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana. Journal of ethnopharmacology. 1992 Apr; 36(2):155-61. doi: 10.1016/0378-8741(92)90016-k. [PMID: 1608273]