Falcarindiol (BioDeep_00000229851)
Main id: BioDeep_00000407529
PANOMIX_OTCML-2023 Antitumor activity
代谢物信息卡片
1,9-Heptadecadiene-4,6-diyne-3,8-diol, [S-[R*,R*-(Z)]]-
化学式: C17H24O2 (260.17762039999997)
中文名称: 法卡林二醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=CC(O)C#CC#CC(O)C=CCCCCCCC
InChI: InChI=1S/C17H24O2/c1-3-5-6-7-8-9-10-14-17(19)15-12-11-13-16(18)4-2/h4,10,14,16-19H,2-3,5-9H2,1H3/b14-10-/t16-,17-/m0/s1
描述信息
Falcarindiol is an organic molecular entity. It has a role as a metabolite.
1,9-Heptadecadiene-4,6-diyne-3,8-diol is a natural product found in Peucedanum oreoselinum, Oplopanax horridus, and other organisms with data available.
Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties[1][2]. Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties[1][2]. Falcarindiol is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties[1][2]. Falcarindiol is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
同义名列表
15 个代谢物同义名
1,9-Heptadecadiene-4,6-diyne-3,8-diol, [S-[R*,R*-(Z)]]-; 1,9-Heptadecadiene-4,6-diyne-3,8-diol, (3S,8S,9Z)-; (3S,8S,9Z)-heptadeca-1,9-dien-4,6-diyne-3,8-diol; (3S,8S,9Z)-1,9-Heptadecadiene-4,6-diyne-3,8-diol; heptadeca-1,9-diene-4,6-diyne-3,8-diol; 1,9-Heptadecadiene-4,6-diyne-3,8-diol; Heptadeca-1,9-dien-4,6-diyne-3,8-diol; (Z)-Falcarindiol; (+)-Falcarindiol; UNII-8G3AW3GYU8; MEGxp0_000391; falcarindiol; ACon1_000065; falcalindiol; 8G3AW3GYU8
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:69236
- PubChem: 6436239
- ChEMBL: CHEMBL425677
- Wikipedia: Falcarindiol
- MeSH: falcarindiol
- ChemIDplus: 0055297875
- CAS: 55297-87-5
- MetaboLights: MTBLC69236
- medchemexpress: HY-N0364
- LOTUS: LTS0241354
- wikidata: Q105229101
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Likang Zhao, Changkai Li, Meng Zhang, Honglian Li, Shengli Ding, Xi Zhao, Lianjuan Yang, Jia Liu, Qing X Li, Risong Na. Design, Synthesis, and Antifungal Activity of Polyacetylenic Alcohol Derivatives and Stereoisomers against Phytopathogenic Fungi.
Journal of agricultural and food chemistry.
2023 Jun; ?(?):. doi:
10.1021/acs.jafc.3c00924. [PMID: 37261403] - Siyue Kan, Jingwen Tan, Qing Cai, Lulu An, Zhiqin Gao, Hong Yang, Siyu Liu, Risong Na, Lianjuan Yang. Synergistic activity of the combination of falcarindiol and itraconazole in vitro against dermatophytes.
Frontiers in cellular and infection microbiology.
2023; 13(?):1128000. doi:
10.3389/fcimb.2023.1128000. [PMID: 37207188] - Gokay Albayrak, Serdar Demir, Halil Koyu, Sura Baykan. Anticholinesterase Compounds from Endemic Prangos uechtritzii.
Chemistry & biodiversity.
2022 Nov; 19(11):e202200557. doi:
10.1002/cbdv.202200557. [PMID: 36201258] - Kyung-Ran Park, Hyun Hee Leem, Yoon-Ju Kwon, Il Keun Kwon, Jin Tae Hong, Hyung-Mun Yun. Falcarindiol Stimulates Apoptotic and Autophagic Cell Death to Attenuate Cell Proliferation, Cell Division, and Metastasis through the PI3K/AKT/mTOR/p70S6K Pathway in Human Oral Squamous Cell Carcinomas.
The American journal of Chinese medicine.
2022; 50(1):295-311. doi:
10.1142/s0192415x22500112. [PMID: 34931585] - Chaoyue Zhao, Hongda Zheng, Liman Zhou, Hongrui Ji, Lu Zhao, Wengong Yu, Qianhong Gong. Falcarindiol Isolated from Notopterygium incisum Inhibits the Quorum Sensing of Pseudomonas aeruginosa.
Molecules (Basel, Switzerland).
2021 Sep; 26(19):. doi:
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Journal of natural products.
2021 02; 84(2):230-238. doi:
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Journal of applied biomedicine.
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10.32725/jab.2021.013. [PMID: 34754259] - Mirta Resetar, Xin Liu, Sonja Herdlinger, Olaf Kunert, Eva-Maria Pferschy-Wenzig, Simone Latkolik, Theresa Steinacher, Daniela Schuster, Rudolf Bauer, Verena M Dirsch. Polyacetylenes from Oplopanax horridus and Panax ginseng: Relationship between Structure and PPARγ Activation.
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Journal of agricultural and food chemistry.
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Biological & pharmaceutical bulletin.
2011; 34(3):371-8. doi:
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