Saponins (BioDeep_00000227124)
Main id: BioDeep_00000000051
human metabolite PANOMIX_OTCML-2023
代谢物信息卡片
(2S,3S,4S,5R,6R)-6-{[(3S,4S,6aR,6bS,8R,8aR,9R,10R,14bR)-9-(acetyloxy)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-{[(2Z)-2-methylbut-2-enoyl]oxy}-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-4-hydroxy-3,5-bis({[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})oxane-2-carboxylic acid
化学式: C55H86O24 (1130.5509)
中文名称: 七叶皂素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC=C(C)C(=O)OC1C(C2(C(CC1(C)C)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(C(O7)CO)O)O)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)CO)OC(=O)C
InChI: InChI=1S/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10-/t26?,27-,28-,29?,30?,31-,32+,33-,34-,35+,36+,37-,38-,39+,40+,41-,42+,43+,44+,47+,48+,49-,51+,52-,53-,54-,55+/m1/s1
描述信息
Saponins, also known as aescin or opino, is a member of the class of compounds known as triterpene saponins. Triterpene saponins are glycosylated derivatives of triterpene sapogenins. The sapogenin moiety backbone is usually based on the oleanane, ursane, taraxastane, bauerane, lanostane, lupeol, lupane, dammarane, cycloartane, friedelane, hopane, 9b,19-cyclo-lanostane, cycloartane, or cycloartanol skeleton. Saponins is practically insoluble (in water) and a weakly acidic compound (based on its pKa). Saponins can be found in a number of food items such as dandelion, soy bean, fenugreek, and carob, which makes saponins a potential biomarker for the consumption of these food products. Saponins are a class of chemical compounds found in particular abundance in various plant species. More specifically, they are amphipathic glycosides grouped phenomenologically by the soap-like foaming they produce when shaken in aqueous solutions, and structurally by having one or more hydrophilic glycoside moieties combined with a lipophilic triterpene derivative .
D002317 - Cardiovascular Agents
Escin, a natural compound of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent[1].
Escin, a natural compound of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent[1].
同义名列表
25 个代谢物同义名
(2S,3S,4S,5R,6R)-6-{[(3S,4S,6aR,6bS,8R,8aR,9R,10R,14bR)-9-(acetyloxy)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-{[(2Z)-2-methylbut-2-enoyl]oxy}-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-4-hydroxy-3,5-bis({[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})oxane-2-carboxylic acid; (2S,3S,4S,5R,6R)-6-{[(3S,4S,6ar,6BS,8R,8ar,9R,10R,14BR)-9-(acetyloxy)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-{[(2Z)-2-methylbut-2-enoyl]oxy}-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-4-hydroxy-3,5-bis({[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})oxane-2-carboxylate; (2S,3S,4S,5R,6R)-6-{[(3S,4S,6aR,6bS,8R,8aR,9R,10R,14bR)-9-(acetyloxy)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-{[(2Z)-2-methylbut-2-enoyl]oxy}-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy}-4-hydroxy-3,5-bis({[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})oxane-2-carboxylic acid; sankyo Brand OF escin; Madaus brand OF escin; biomo Brand OF escin; Flebostasin; opino Biomo; beta-Aescin; opino-Biomo; beta Aescin; beta-ESCIN; Opinobiomo; beta Escin; Fepalitan; Aescusan; Saponins; Feparil; Reparil; Eskuzan; Aescin; Escina; Escin; Opino; Aescin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Chandrashekhar Jori, Md Meraj Ansari, Anas Ahmad, Nemat Ali, Syed Shadab Raza, Rehan Khan. Biomaterial-based combinatorial approach of aescin-comprised zein-coated gelatin nanoparticles alleviates synovial inflammation in experimental inflammatory arthritis.
Nanoscale.
2024 Apr; 16(16):7965-7975. doi:
10.1039/d3nr06476j. [PMID: 38567436] - Freddy Armando Peñaranda Figueredo, Josefina Vicente, Andrea Alejandra Barquero, Carlos Alberto Bueno. Aesculus hippocastanum extract and the main bioactive constituent β-escin as antivirals agents against coronaviruses, including SARS-CoV-2.
Scientific reports.
2024 03; 14(1):6418. doi:
10.1038/s41598-024-56759-y. [PMID: 38494515] - Yunyu Wang, Xiuwei Han, Xinhuan Wan, Fengjv Niu, Changzheng Zhou. β-Escin: An Updated Review of Its Analysis, Pharmacology, Pharmacokinetics, and Toxicity.
The American journal of Chinese medicine.
2023 Oct; ?(?):1-26. doi:
10.1142/s0192415x23500908. [PMID: 37865870] - Wei Sun, Qinggang Yin, Huihua Wan, Ranran Gao, Chao Xiong, Chong Xie, Xiangxiao Meng, Yaolei Mi, Xiaotong Wang, Caixia Wang, Weiqiang Chen, Ziyan Xie, Zheyong Xue, Hui Yao, Peng Sun, Xuehua Xie, Zhigang Hu, David R Nelson, Zhichao Xu, Xinxiao Sun, Shilin Chen. Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis.
Nature communications.
2023 Oct; 14(1):6470. doi:
10.1038/s41467-023-42253-y. [PMID: 37833361] - Yuman Wang, Tianjiao Chu, Xianmei Pan, Yifei Bian, Jing Li. Escin ameliorates inflammation via inhibiting mechanical stretch and chemically induced Piezo1 activation in vascular endothelial cells.
European journal of pharmacology.
2023 Aug; 956(?):175951. doi:
10.1016/j.ejphar.2023.175951. [PMID: 37541373] - Chenyuan Li, Ziqi He, Feng Yao, Shichong Liao, Kai Sun, Shengrong Sun, Zhiyu Li, Zhong Wang. Role of Escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin.
Apoptosis : an international journal on programmed cell death.
2023 May; ?(?):. doi:
10.1007/s10495-023-01849-x. [PMID: 37149513] - Hao Yu, Siru Yan, Meiyu Jin, Yunfei Wei, Lilei Zhao, Jiaqi Cheng, Lu Ding, Haihua Feng. Aescin can alleviate NAFLD through Keap1-Nrf2 by activating antioxidant and autophagy.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 May; 113(?):154746. doi:
10.1016/j.phymed.2023.154746. [PMID: 36905866] - Philippe Savarino, Emmanuel Colson, Julien André, Pascal Gerbaux. Horse Chestnut Saponins-Escins, Isoescins, Transescins, and Desacylescins.
Molecules (Basel, Switzerland).
2023 Feb; 28(5):. doi:
10.3390/molecules28052087. [PMID: 36903330] - Sunnatullo Fazliev, Khurshid Tursunov, Jamoliddin Razzokov, Avez Sharipov. Escin's Multifaceted Therapeutic Profile in Treatment and Post-Treatment of Various Cancers: A Comprehensive Review.
Biomolecules.
2023 Feb; 13(2):. doi:
10.3390/biom13020315. [PMID: 36830684] - Min Li, Shengguang Wang, Ce Zhang, Chenglin Chi, Rongxia Liu, Tian Wang, Fenghua Fu. Escin alleviates stress-induced intestinal dysfunction to protect brain injury by regulating the gut-brain axis in ischemic stroke rats.
International immunopharmacology.
2023 Feb; 115(?):109659. doi:
10.1016/j.intimp.2022.109659. [PMID: 36608442] - Min Li, Fang Wang, Ce Zhang, Min-An Li, Tian Wang, Yu-Chen Li, Feng-Hua Fu. Integrated systematic pharmacology analysis and experimental validation to reveal the mechanism of action of Semen aesculi on inflammatory bowel diseases.
Journal of ethnopharmacology.
2022 Nov; 298(?):115627. doi:
10.1016/j.jep.2022.115627. [PMID: 35985613] - I M Tucker, A Burley, R E Petkova, S L Hosking, J R P Webster, P X Li, K Ma, J Doutch, J Penfoldoo, R K Thomas. Self-assembly in escin-nonionic surfactant mixtures: From micelles to vesicles.
Journal of colloid and interface science.
2022 Nov; 626(?):305-313. doi:
10.1016/j.jcis.2022.06.122. [PMID: 35792461] - Q-H Zhang, X-Y Cui, D Wang, Y Jin, Y-X Guan. Anti-obesity effect of escin: a study on high-fat diet-induced obese mice.
European review for medical and pharmacological sciences.
2022 11; 26(21):7797-7812. doi:
10.26355/eurrev_202211_30129. [PMID: 36394728] - Jinxia Hou, Lanping Zhong, Jianming Liu, Fanglan Liu, Chunhua Xia. Interaction of the main active components in Shengmai formula mediated by organic anion transporter 1 (OAT1).
Journal of ethnopharmacology.
2022 Oct; 296(?):115515. doi:
10.1016/j.jep.2022.115515. [PMID: 35777609] - Hanfei Sun, Manman Wang, Tiantian Su, Paipai Guo, Yu Tai, Huijuan Cheng, Zhenduo Zhu, Chunru Jiang, Shangxue Yan, Wei Wei, Lingling Zhang, Qingtong Wang. Ziyuglycoside I attenuates collagen-induced arthritis through inhibiting plasma cell expansion.
Journal of ethnopharmacology.
2022 Aug; 294(?):115348. doi:
10.1016/j.jep.2022.115348. [PMID: 35533910] - Genbei Wang, Mengyao Yan, Ruijia Hao, Panpan Lv, Yu Wang, Shuli Man, Wenyuan Gao. Q-marker identification of Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz. in pulmonary metastasis of liver cancer mice.
Journal of ethnopharmacology.
2022 Jul; 293(?):115311. doi:
10.1016/j.jep.2022.115311. [PMID: 35461989] - Haiqin Wang, Xiaojuan Xiao, Zhenzhen Li, Saiqun Luo, Lei Hu, Hui Yi, Ruohong Xiang, Yu Zhu, Yanpeng Wang, Lin Zhu, Ling Xiao, Chongwen Dai, Abdul Aziz, Lingli Yuan, Yajuan Cui, Ruijuan Li, Fanjie Gong, Xifeng Liu, Long Liang, Hongling Peng, Hui Zhou, Jing Liu. Polyphyllin VII, a novel moesin inhibitor, suppresses cell growth and overcomes bortezomib resistance in multiple myeloma.
Cancer letters.
2022 07; 537(?):215647. doi:
10.1016/j.canlet.2022.215647. [PMID: 35306105] - Sinan Chen, Xinyan Liu, Haoan Zhao, Ni Cheng, Jing Sun, Wei Cao. Beneficial effects of Gynostemma pentaphyllum honey paste on obesity via counteracting oxidative stress and inflammation: An exploration of functional food developed from two independent foods rich in saponins and phenolics.
Food research international (Ottawa, Ont.).
2022 Jul; 157(?):111483. doi:
10.1016/j.foodres.2022.111483. [PMID: 35761708] - Man-Man Zhang, Guo-Ming Huo, Jie Cheng, Qiu-Ping Zhang, Na-Zhi Li, Min-Xia Guo, Qing Liu, Guang-Hui Xu, Ji-Xiao Zhu, Cheng-Fu Li, Feng Zhou, Li-Tao Yi. Gypenoside XVII, an Active Ingredient from Gynostemma Pentaphyllum, Inhibits C3aR-Associated Synaptic Pruning in Stressed Mice.
Nutrients.
2022 Jun; 14(12):. doi:
10.3390/nu14122418. [PMID: 35745148] - Wei Ning, Xiaogang Liao, Xingyou Dong, Yangcai Wang, Xingliang Yang, Jie Xu, Shanhong Yi, Zhenxing Yang. Protective effect of astragaloside IV on cadmium-induced spermatogenesis microenvironment damage in rats.
Systems biology in reproductive medicine.
2022 Jun; 68(3):203-212. doi:
10.1080/19396368.2021.1983888. [PMID: 34711125] - Arafa I Hamed, Ridha Ben Said, Mohamed Ali Ben Aissa, Ibrahim Bayoumi Abdel-Farid, Bogdan Kontek, Mariusz Kowalczyk, Wieslaw Oleszek, Anna Stochmal, Ivona Kowalska, Beata Olas. Comprehensive polyoxypregnane glycosides report in Caralluma quadrangula using UPLC-ESI-Q-TOF and their antioxidant effects in human plasma.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jun; 150(?):112954. doi:
10.1016/j.biopha.2022.112954. [PMID: 35447547] - Akifumi Nagatomo, Naoki Inoue, Takuya Konno, Yin Xu, Chinatsu Sakamoto, Mayuko Sone, Aya Shibasaka, Osamu Muraoka, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yoshiaki Manse, Toshio Morikawa. Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.
Journal of natural medicines.
2022 Jun; 76(3):654-669. doi:
10.1007/s11418-022-01614-5. [PMID: 35292883] - Ruoyu Zhang, Qingfeng Zhai, Yuan Yu, Xuening Li, Fengxiang Zhang, Zhaohua Hou, Yuqing Cao, Jing Feng, Peng Xue. Safety assessment of crude saponins from Chenopodium quinoa willd. husks: 90-day oral toxicity and gut microbiota & metabonomics study in rats.
Food chemistry.
2022 May; 375(?):131655. doi:
10.1016/j.foodchem.2021.131655. [PMID: 34903398] - Jiafen Qian, Wenjun Chen, Jianmei Wu, Meina Lv, Shaojun Jiang, Zhiwei Zeng, Zongwei Fang, Mingrong Chen, Jinhua Zhang. Effects and Mechanism of Action of Panax notoginseng Saponins on the Pharmacokinetics of Warfarin.
European journal of drug metabolism and pharmacokinetics.
2022 May; 47(3):331-342. doi:
10.1007/s13318-022-00753-0. [PMID: 35138605] - Yuyan Fan, Hongyu Fan, Ping Li, Qingshan Liu, Lixia Huang, Yilun Zhou. Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis.
Bioengineered.
2022 05; 13(5):11517-11529. doi:
10.1080/21655979.2022.2068822. [PMID: 35510516] - Fang-Wei Zhong, Geng-Xi Li, Li Zeng. [Gynostemma pentaphyllum saponins alleviate non-alcoholic fatty liver disease in rats by regulating intestinal flora and short-chain fatty acid metabolism].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 May; 47(9):2500-2508. doi:
10.19540/j.cnki.cjcmm.20211208.401. [PMID: 35531697] - S P Piragauta, J L Higuita-Castro, N Arbeláez, A M Restrepo, R Archbold, W Quiñones, F Torres, F Echeverri, G Escobar, I D Vélez, A Montoya, S M Robledo. Utility of the combination of hederagenin glucoside saponins and chromane hydrazone in the topical treatment of canine cutaneous leishmaniasis. An observational study.
Parasitology research.
2022 May; 121(5):1419-1428. doi:
10.1007/s00436-022-07467-x. [PMID: 35179617] - Mustafa Cengiz, Hatice Mehtap Kutlu, Betül Peker Cengiz, Adnan Ayhancı. Escin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage.
Drug and chemical toxicology.
2022 May; 45(3):1180-1187. doi:
10.1080/01480545.2020.1810262. [PMID: 32838567] - Q Zou, X Wu, J Wang, D Xia, M Deng, Y Ding, Y Dai, S Zhao, T Chen. [Therapeutic effect of Panax notoginseng saponins combined with cyclophosphamide in mice bearing hepatocellular carcinoma H22 cell xenograft].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2022 Apr; 42(4):538-545. doi:
10.12122/j.issn.1673-4254.2022.04.09. [PMID: 35527489] - Peng Li, Mingkun Gao, Jiahuan Fu, Shaojia Yan, Yongfa Liu, Tahir Mahmood, Zengpeng Lv, Yuming Guo. Dietary soya saponin improves the lipid metabolism and intestinal health of laying hens.
Poultry science.
2022 Apr; 101(4):101663. doi:
10.1016/j.psj.2021.101663. [PMID: 35172236] - Keisuke Hagihara, Kazuto Nunomura, Bangzhong Lin, Megumi Fumimoto, Junko Watanabe, Yasuharu Mizuhara. Gosha-jinki-Gan (GJG) shows anti-aging effects through suppression of TNF-α production by Chikusetsusaponin V.
Gene.
2022 Mar; 815(?):146178. doi:
10.1016/j.gene.2021.146178. [PMID: 34995733] - Célia Cristina Malaguti Figueiredo, Amanda da Costa Gomes, Filipe Oliveira Granero, João Luiz Bronzel Junior, Luciana Pereira Silva, Valdecir Farias Ximenes, Regildo Márcio Gonçalves da Silva. Antiglycation and antioxidant activities of the crude extract and saponin fraction of Tribulus terrestris before and after microcapsule release.
Journal of integrative medicine.
2022 03; 20(2):153-162. doi:
10.1016/j.joim.2021.12.003. [PMID: 34996732] - Hongjiao Geng, Lidan Zhang, Cui Xin, Cheng Zhang, Yanming Xie. Xuesaitong oral preparation as adjuvant therapy for treating acute cerebral infarction: A systematic review and meta-analysis of randomized controlled trials.
Journal of ethnopharmacology.
2022 Mar; 285(?):114849. doi:
10.1016/j.jep.2021.114849. [PMID: 34800648] - Shuyao Wang, Xin Yu, Siyang Wu, Wei Yang, Yang Gao, Weihua Wang, Qiutao Wang, Mengmeng Wei, Mingying Zhu, Jiarui Wu, Zheng Yuan, Yingfei Li. Simultaneous determination of periplocin, periplocymarin, periplogenin, periplocoside M and periplocoside N of Cortex Periplocae in rat plasma and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2022 Mar; 36(3):e5283. doi:
10.1002/bmc.5283. [PMID: 34816469] - Yousra Abdel-Mottaleb, Howaida S Ali, Mohamed K El-Kherbetawy, Amany Y Elkazzaz, Mohamed H ElSayed, Amr Elshormilisy, Amira H Eltrawy, Sally Y Abed, Asma M Alshahrani, Abdullah A Hashish, Eman Saad Alamri, Sawsan A Zaitone. Saponin-rich extract of Tribulus terrestris alleviates systemic inflammation and insulin resistance in dietary obese female rats: Impact on adipokine/hormonal disturbances.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Mar; 147(?):112639. doi:
10.1016/j.biopha.2022.112639. [PMID: 35051859] - Junda Chen, Yu Zhang, Xiao Guan, Hongwei Cao, Lin Li, Jie Yu, Hanlin Liu. Characterization of Saponins from Differently Colored Quinoa Cultivars and Their In Vitro Gastrointestinal Digestion and Fermentation Properties.
Journal of agricultural and food chemistry.
2022 Feb; 70(6):1810-1818. doi:
10.1021/acs.jafc.1c06200. [PMID: 35119265] - Chenyang Zhang, Bin Zhang, Xuelian Zhang, Min Wang, Xiaobo Sun, Guibo Sun. Panax notoginseng Saponin Protects Against Diabetic Cardiomyopathy Through Lipid Metabolism Modulation.
Journal of the American Heart Association.
2022 02; 11(4):e023540. doi:
10.1161/jaha.121.023540. [PMID: 35112884] - Xiao-Chen Sun, Xiao Song, Fei Guo, Yao-Hui Yuan, Shu-Yue Wang, Shuai Wang, Kun-Lin Liu, Xi-Yu Lv, Bing Han, Chao Zhang, Jiang-Ting Liu. Terrestrosin D, a spirostanol saponin from Tribulus terrestris L. with potential hepatorenal toxicity.
Journal of ethnopharmacology.
2022 Jan; 283(?):114716. doi:
10.1016/j.jep.2021.114716. [PMID: 34626781] - Shuang Yuan, Yuanyuan Xu, Tao Yi, Hongjing Wang. The anti-tumor effect of OP-B on ovarian cancer in vitro and in vivo, and its mechanism: An investigation using network pharmacology-based analysis.
Journal of ethnopharmacology.
2022 Jan; 283(?):114706. doi:
10.1016/j.jep.2021.114706. [PMID: 34614446] - Hailun Jiang, Fang Xu, Li Zeng, Chenyang Li, Yan Chen, Linlin Wang, Zhuorong Li, Rui Liu. Saponins from Nigella glandulifera seeds attenuate collagen-induced rheumatoid arthritis in rats via the OPG/RANKL/NF-κB and Ang/Tie-2 pathways.
Journal of ethnopharmacology.
2022 Jan; 283(?):114714. doi:
10.1016/j.jep.2021.114714. [PMID: 34624452] - Dnyanesh Ranade, Rajender Jena, Shubham Sancheti, Vicky Deore, Vikas Dogar, Sunil Gairola. Rapid, high throughput protein estimation method for saponin and alhydrogel adjuvanted R21 VLP Malaria vaccine based on intrinsic fluorescence.
Vaccine.
2022 01; 40(4):601-611. doi:
10.1016/j.vaccine.2021.12.019. [PMID: 34933766] - Xin-Nan Wang, Wen-Rui Xia, Jian-Qun Liu, Fang-Yuan Sun, Zhu-Jun Zhong, Li-Fang Liu, Gui-Zhong Xin. Targeting tryptophan metabolism reveals Clematichinenoside AR alleviates triptolide-induced hepatotoxicity.
Journal of pharmaceutical and biomedical analysis.
2022 Jan; 208(?):114461. doi:
10.1016/j.jpba.2021.114461. [PMID: 34775190] - Meng Yang, Jieying Ding, Qingqiong Luo, Xu Chen, Fuxiang Chen. Improving the diagnostic efficacy of squamous cell carcinoma antigen for oral squamous cell carcinoma via saponin disruption of serum extracellular vesicles.
Clinica chimica acta; international journal of clinical chemistry.
2022 Jan; 525(?):40-45. doi:
10.1016/j.cca.2021.12.012. [PMID: 34921893] - Yujie Zhong, Ruilin Luo, Qi Liu, Jiachang Zhu, Min Lei, Xiaofei Liang, Xin Wang, Xiaoli Peng. Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2022 Jan; 159(?):112697. doi:
10.1016/j.fct.2021.112697. [PMID: 34826549] - Zhi-Yong Jiang, Fang-Quan Yu, Rui-Lan Gao, Yue-Min Kuang, Yan Zhu, Yue-Hua Chen, Lin-Jie Li, Gui-Fang Ouyang, Jing Hu, Xiao-Long Wu. Treatment of Chronic Aplastic Anemia with Chinese Patent Medicine Pai-Neng-Da Capsule () for Replacing Androgen Partially: A Clinical Multi-Center Study.
Chinese journal of integrative medicine.
2022 Jan; 28(1):20-27. doi:
10.1007/s11655-021-3283-z. [PMID: 33837482] - Ziyu Li, Wei Yang, Yong Yang, Jianbo Wu, Pei Luo, Yong Liu. The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy.
Drug design, development and therapy.
2022; 16(?):647-664. doi:
10.2147/dddt.s346546. [PMID: 35308255] - Xu-Qin Du, Li-Peng Shi, Zhi-Wei Chen, Jin-Yuan Hu, Biao Zuo, Yu Xiong, Wen-Fu Cao. Astragaloside IV Ameliorates Isoprenaline-Induced Cardiac Fibrosis in Mice via Modulating Gut Microbiota and Fecal Metabolites.
Frontiers in cellular and infection microbiology.
2022; 12(?):836150. doi:
10.3389/fcimb.2022.836150. [PMID: 35656031] - He-Wei Qin, Qin-Sheng Zhang, Yan-Jie Li, Wen-Tao Li, Yuan Wang. [Molecular mechanism of astragaloside Ⅳ against atherosclerosis by regulating miR-17-5p and PCSK9/VLDLR signal pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Jan; 47(2):492-498. doi:
10.19540/j.cnki.cjcmm.20210918.701. [PMID: 35178994] - Yonghui Hu, Wangna Tang, Wenjie Liu, Zhibo Hu, Congqing Pan. Astragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease.
Drug design, development and therapy.
2022; 16(?):1605-1620. doi:
10.2147/dddt.s360346. [PMID: 35669284] - He Yang, Zuodong Liu, Xiangka Hu, Xiaojuan Liu, Liuming Gui, Zengxiaorui Cai, Chunmei Dai. Protective Effect of Panax Notoginseng Saponins on Apolipoprotein-E-deficient Atherosclerosis-prone Mice.
Current pharmaceutical design.
2022; 28(8):671-677. doi:
10.2174/1381612828666220128104636. [PMID: 35088656] - Zhongbo Shi, Junhao Jiang, Dezhang Zhao, Baogang Xie, Yan Li, Chao Yu. Effects of Astragaloside IV on the Pharmacokinetics of Metoprolol in Rats and its Mechanism.
Current drug metabolism.
2022; 23(2):131-136. doi:
10.2174/1389200223666220128143133. [PMID: 35088663] - Sheng-Yan Xu, Xiang-Dang Hu, Zong-Liang Yang, An Liu, Yong-Heng He, Hai-Yan Lu. [Effects of astragaloside Ⅳ on inflammatory response and percentage of peripheral blood Th17 cells in mice with ulcerative colitis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Jan; 47(2):469-475. doi:
10.19540/j.cnki.cjcmm.20210827.401. [PMID: 35178991] - Zhidong Hu, Jian-Ping Chen, Jin-Chuan Xu, Zhen-Yan Chen, Rong Qu, Ling Zhang, Wenrong Yao, Juan Wu, Heng Yang, Douglas B Lowrie, Yong Liu, Xiao-Yong Fan. A two-dose optimum for recombinant S1 protein-based COVID-19 vaccination.
Virology.
2022 01; 566(?):56-59. doi:
10.1016/j.virol.2021.11.011. [PMID: 34864488] - Peng Qiao, Baokun Zhang, Xueni Liu, Jie Xu, Xuehan Li. Effects of Escin on Oxidative Stress and Apoptosis of H9c2 Cells Induced by H2O2.
Disease markers.
2022; 2022(?):7765353. doi:
10.1155/2022/7765353. [PMID: 35126791] - Xiang Guo, Jinyu Ji, Jingkai Zhang, Xiaoqiang Hou, Xianyun Fu, Yanan Luo, Zhigang Mei, Zhitao Feng. Anti-inflammatory and osteoprotective effects of Chikusetsusaponin Ⅳa on rheumatoid arthritis via the JAK/STAT signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Dec; 93(?):153801. doi:
10.1016/j.phymed.2021.153801. [PMID: 34758437] - Qin Gong, Mulan Wang, Ya Jiang, Chengliang Zha, Dong Yu, Fan Lei, Yingying Luo, Yulin Feng, Shilin Yang, Jun Li, Lijun Du. The abrupt pathological deterioration of cisplatin-induced acute kidney injury: Emerging of a critical time point.
Pharmacology research & perspectives.
2021 12; 9(6):e00895. doi:
10.1002/prp2.895. [PMID: 34817124] - Cuiyun Huang, Shi Qiu, Xiangcheng Fan, Guangyang Jiao, Xun Zhou, Mei Sun, Nan Weng, Shouhong Gao, Xia Tao, Feng Zhang, Wansheng Chen. Evaluation of the effect of Shengxian Decoction on doxorubicin-induced chronic heart failure model rats and a multicomponent comparative pharmacokinetic study after oral administration in normal and model rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Dec; 144(?):112354. doi:
10.1016/j.biopha.2021.112354. [PMID: 34794233] - Qixia Liu, Xiaohui Chen, Min Kan, Jing Yang, Qian Gong, Rui Jin, Yulong Dai, Juan Jin, Hongmei Zang. Gypenoside XLIX loaded nanoparticles targeting therapy for renal fibrosis and its mechanism.
European journal of pharmacology.
2021 Nov; 910(?):174501. doi:
10.1016/j.ejphar.2021.174501. [PMID: 34529980] - Xin Huang, Min-Zhou Zhang, Bo Liu, Shi-Yu Ma, Xin Yin, Li-Heng Guo. Astragaloside IV Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction in Rats via IKK/NF-κB Pathway.
Chinese journal of integrative medicine.
2021 Nov; 27(11):825-831. doi:
10.1007/s11655-021-2869-9. [PMID: 34432200] - Yun-Fang Hao, Ting Luo, Zhong-Yu Lu, Chun-Yan Shen, Jian-Guo Jiang. Targets and underlying mechanisms related to the sedative and hypnotic activities of saponins from Rhodiola rosea L. (crassulaceae).
Food & function.
2021 Nov; 12(21):10589-10601. doi:
10.1039/d1fo01178b. [PMID: 34585202] - Meina Gao, Hui Li, Chenghao Ye, Kaixian Chen, Hualiang Jiang, Kunqian Yu. Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study.
Biomolecules.
2021 10; 11(11):. doi:
10.3390/biom11111586. [PMID: 34827585] - Geng-Ruei Chang, Wei-Li Lin, Tzu-Chun Lin, Huei-Jyuan Liao, Yu-Wen Lu. The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice.
International journal of molecular sciences.
2021 Oct; 22(21):. doi:
10.3390/ijms222111383. [PMID: 34768813] - Fen Liu, Meng Feng, Julin Xing, Xinxin Zhou. Timosaponin alleviates oxidative stress in rats with high fat diet-induced obesity via activating Nrf2/HO-1 and inhibiting the NF-κB pathway.
European journal of pharmacology.
2021 Oct; 909(?):174377. doi:
10.1016/j.ejphar.2021.174377. [PMID: 34302815] - Yuqing Sun, Xin Zhang, Xiaofan Shen, Shuo Wang, Qi Wang, Xiuwei Yang. Computational and experimental characterization of isomers of escin-induced renal cytotoxicity by inhibiting heat shock proteins.
European journal of pharmacology.
2021 Oct; 908(?):174372. doi:
10.1016/j.ejphar.2021.174372. [PMID: 34324856] - Qun Yu, Liuping Fan. Improving the bioactive ingredients and functions of asparagus from efficient to emerging processing technologies: A review.
Food chemistry.
2021 Oct; 358(?):129903. doi:
10.1016/j.foodchem.2021.129903. [PMID: 33933971] - Qingqing Li, Yansong Zhang, Yufang Yang, Songqing Huang, Xiaoqin Zou, Congying Wei, Taolin Liang, Xiaobin Zhong. Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Oct; 142(?):111965. doi:
10.1016/j.biopha.2021.111965. [PMID: 34385105] - Xiao Song, Yaohui Yuan, Shuyue Wang, Xiaochen Sun, Chao Zhang, Peng Gao, Lei Shi. Pharmacokinetic comparisons of six steroid saponins in rat plasma following oral administration of crude and stir-fried Fructus Tribuli extracts by UHPLC-MS/MS.
Biomedical chromatography : BMC.
2021 Oct; 35(10):e5151. doi:
10.1002/bmc.5151. [PMID: 33939847] - Tao Yao, Lei Zhang, Ye Fu, Lina Yao, Chengjie Zhou, Guozhong Chen. Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition.
Molecular and cellular biology.
2021 09; 41(10):e0033221. doi:
10.1128/mcb.00332-21. [PMID: 34309413] - Matthew J Gorman, Nita Patel, Mimi Guebre-Xabier, Alex L Zhu, Caroline Atyeo, Krista M Pullen, Carolin Loos, Yenny Goez-Gazi, Ricardo Carrion, Jing-Hui Tian, Dansu Yuan, Kathryn A Bowman, Bin Zhou, Sonia Maciejewski, Marisa E McGrath, James Logue, Matthew B Frieman, David Montefiori, Colin Mann, Sharon Schendel, Fatima Amanat, Florian Krammer, Erica Ollmann Saphire, Douglas A Lauffenburger, Ann M Greene, Alyse D Portnoff, Michael J Massare, Larry Ellingsworth, Gregory Glenn, Gale Smith, Galit Alter. Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination.
Cell reports. Medicine.
2021 09; 2(9):100405. doi:
10.1016/j.xcrm.2021.100405. [PMID: 34485950] - Fredrick Nwude Eze, Titilope John Jayeoye. Chromolaena odorata (Siam weed): A natural reservoir of bioactive compounds with potent anti-fibrillogenic, antioxidative, and cytocompatible properties.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Sep; 141(?):111811. doi:
10.1016/j.biopha.2021.111811. [PMID: 34153847] - Ling Feng, Xiao-Jun Wu, Tian Cao, Bo Wu. The efficacy and safety of Xuesaitong injection combined with western medicines in the treatment of ischemic stroke: an updated systematic review and meta-analysis.
Annals of palliative medicine.
2021 Sep; 10(9):9523-9534. doi:
10.21037/apm-21-1828. [PMID: 34628878] - Liang Pei, Linxi He. Hepatoprotective effect of anemoside B4 against sepsis-induced acute liver injury through modulating the mTOR/p70S6K-mediated autophagy.
Chemico-biological interactions.
2021 Aug; 345(?):109534. doi:
10.1016/j.cbi.2021.109534. [PMID: 34051206] - Kamila Misiakiewicz-Has, Dominika Maciejewska-Markiewicz, Sylwia Rzeszotek, Anna Pilutin, Agnieszka Kolasa, Paweł Szumilas, Ewa Stachowska, Barbara Wiszniewska. The Obscure Effect of Tribulus terrestris Saponins Plus Inulin on Liver Morphology, Liver Fatty Acids, Plasma Glucose, and Lipid Profile in SD Rats with and without Induced Type 2 Diabetes Mellitus.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22168680. [PMID: 34445384] - Jie Tang, Mengge Shi, Yan Xu, Zhengcai Ju, Huida Guan, Jun Lin, Gan Li, Han Han, Tong Zhang. Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Aug; 1179(?):122827. doi:
10.1016/j.jchromb.2021.122827. [PMID: 34147874] - Hui Feng, Xiaoyun Zhu, Yang Tang, Shouqiang Fu, Bingtan Kong, Ximing Liu. Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome‑mediated inflammation.
International journal of molecular medicine.
2021 Aug; 48(2):. doi:
10.3892/ijmm.2021.4996. [PMID: 34278447] - Qiu-Yu Li, Li-Hua Bian, Xiao-Mei Wang, Zi-Wei Yao, Jia-Yuan Li, Guo-Hui Wan, Xiao-Jia Wei, Jin-Feng Liu, Jia-He Yu, Zhong-Xian Jin, Chun-Guo Wang, Jin-Li Shi. [Spectrum-effect relationship of hemostatic effects of Notoginseng Radix et Rhizoma with different commodity specifications].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 Aug; 46(16):4157-4166. doi:
10.19540/j.cnki.cjcmm.20210331.203. [PMID: 34467728] - Rupesh Chikhale, Saurabh K Sinha, Manish Wanjari, Nilambari S Gurav, Muniappan Ayyanar, Satyendra Prasad, Pukar Khanal, Yadu Nandan Dey, Rajesh B Patil, Shailendra S Gurav. Computational assessment of saikosaponins as adjuvant treatment for COVID-19: molecular docking, dynamics, and network pharmacology analysis.
Molecular diversity.
2021 Aug; 25(3):1889-1904. doi:
10.1007/s11030-021-10183-w. [PMID: 33492566] - Mao-Sen Zeng, Wen-Di Yu, Hui-Xian Wang, Jin-Yuan Liu, Pei-Ping Xu. A potential antiviral activity of Esculentoside A against binding interactions of SARS-COV-2 spike protein and angiotensin converting enzyme 2 (ACE2).
International journal of biological macromolecules.
2021 Jul; 183(?):2248-2261. doi:
10.1016/j.ijbiomac.2021.06.017. [PMID: 34111482] - Wei Wang, Yuqi Fan, Xuhua Huang, Li Li, Songrui Wang, Zixiang Xue, Huizi Ouyang, Jun He. Metabolomics study on the periplocin-induced cardiotoxicity and the compatibility of periplocin and Panax notoginseng saponins in reducing cardiotoxicity in rats by GC-MS.
Journal of separation science.
2021 Jul; 44(14):2785-2797. doi:
10.1002/jssc.202001262. [PMID: 33961332] - Fei Xiong, Zhongdaixi Zheng, Lingyu Xiao, Chuhong Su, Junbin Chen, Xiangfu Gu, Jiaqi Tang, Yue Zhao, Huiyu Luo, Longying Zha. Soyasaponin A2 Alleviates Steatohepatitis Possibly through Regulating Bile Acids and Gut Microbiota in the Methionine and Choline-Deficient (MCD) Diet-induced Nonalcoholic Steatohepatitis (NASH) Mice.
Molecular nutrition & food research.
2021 07; 65(14):e2100067. doi:
10.1002/mnfr.202100067. [PMID: 34047448] - Zhiyong Du, Yingyuan Lu, Jiaxu Sun, Kun Chang, Mengqiu Lu, Meng Fang, Xiangrui Zeng, Wenxin Zhang, Jinyang Song, Xiaoyu Guo, Pengfei Tu, Yong Jiang. Pharmacokinetics/pharmacometabolomics-pharmacodynamics reveals the synergistic mechanism of a multicomponent herbal formula, Baoyuan decoction against cardiac hypertrophy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jul; 139(?):111665. doi:
10.1016/j.biopha.2021.111665. [PMID: 34243607] - Jun Fu, Huan Wu, Hong Wu, Ran Deng, Minghui Sun. Deciphering the metabolic profile and pharmacological mechanisms of Achyranthes bidentata blume saponins using ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry coupled with network pharmacology-based investigation.
Journal of ethnopharmacology.
2021 Jun; 274(?):114067. doi:
10.1016/j.jep.2021.114067. [PMID: 33771642] - Genbei Wang, Ruijia Hao, Yu Liu, Yu Wang, Shuli Man, Wenyuan Gao. Tissue distribution, metabolism and absorption of Rhizoma Paridis Saponins in the rats.
Journal of ethnopharmacology.
2021 Jun; 273(?):114038. doi:
10.1016/j.jep.2021.114038. [PMID: 33746004] - El Mabrouki Hakim, K V Sivak, I E Kaukhova. Evaluation of the diuretic effect of crude ethanol and saponin-rich extracts of Herniaria glabra L. in rats.
Journal of ethnopharmacology.
2021 Jun; 273(?):113942. doi:
10.1016/j.jep.2021.113942. [PMID: 33610714] - Ye Zhang, Chun-Jing Yang, Qi Meng, Lei Zhang, Li Liu, Xu Zhang, Dan Yan. [Effect of intestinal flora changes on pharmacokinetics of astragaloside Ⅳ].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 Jun; 46(12):3144-3149. doi:
10.19540/j.cnki.cjcmm.20210301.201. [PMID: 34467706] - Yunfeng Zhu, Yong Su, Jie Zhang, Yanhua Zhang, Yan Li, Yuli Han, Xianan Dong, Weizu Li, Weiping Li. Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy.
Molecular medicine reports.
2021 06; 23(6):. doi:
10.3892/mmr.2021.12076. [PMID: 33846768] - Genbei Wang, Ruijia Hao, Chen Luo, Yu Wang, Shuli Man, Wenyuan Gao. Pharmacokinetics profiles of polyphyllin II and polyphyllin VII in rats by liquid chromatography with tandem mass spectrometry.
Biomedical chromatography : BMC.
2021 Jun; 35(6):e5083. doi:
10.1002/bmc.5083. [PMID: 33544400] - Ayman Saber Mohamed, Shimaa Anter Mahmoud, Amel Mahmoud Soliman, Sohair Ramadan Fahmy. Antitumor activity of saponin isolated from the sea cucumber, holothuria arenicola against ehrlich ascites carcinoma cells in swiss albino mice.
Natural product research.
2021 Jun; 35(11):1928-1932. doi:
10.1080/14786419.2019.1644633. [PMID: 31343268] - Miaomiao Liu, Bin Zheng, Panpan Liu, Jianping Zhang, Xi Chu, Chunhui Dong, Jing Shi, Yingran Liang, Li Chu, Yanshuang Liu, Xue Han. Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury.
Molecular medicine reports.
2021 06; 23(6):. doi:
10.3892/mmr.2021.12077. [PMID: 33846815] - Tao He, Chuanxin Liu, Mengyu Li, Mingshuang Wang, Ning Liu, Dan Zhang, Shuang Han, Wenxian Li, Shilin Chen, Ruijuan Yuan, Jianmei Huang. Integrating non-targeted metabolomics and toxicology networks to study the mechanism of Esculentoside A-induced hepatotoxicity in rats.
Journal of biochemical and molecular toxicology.
2021 Jun; 35(6):1-15. doi:
10.1002/jbt.22761. [PMID: 33788351] - Song Yang, Ting Hu, He Liu, Ya-Li Lv, Wen Zhang, Han Li, Lingling Xuan, Li-Li Gong, Li-Hong Liu. Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jun; 138(?):111441. doi:
10.1016/j.biopha.2021.111441. [PMID: 33652261] - Saurabh K Sinha, Anshul Shakya, Satyendra K Prasad, Shashikant Singh, Nilambari S Gurav, Rupali S Prasad, Shailendra S Gurav. An in-silico evaluation of different Saikosaponins for their potency against SARS-CoV-2 using NSP15 and fusion spike glycoprotein as targets.
Journal of biomolecular structure & dynamics.
2021 Jun; 39(9):3244-3255. doi:
10.1080/07391102.2020.1762741. [PMID: 32345124] - Amiya Das, Deepti Pandita, Gaurav Kumar Jain, Pallavi Agarwal, Ajmer Singh Grewal, Roop K Khar, Viney Lather. Role of phytoconstituents in the management of COVID-19.
Chemico-biological interactions.
2021 May; 341(?):109449. doi:
10.1016/j.cbi.2021.109449. [PMID: 33798507] - Wen-Ya Gao, Nan Si, Ming-Li Li, Xin-Ru Gu, Yan Zhang, Yan-Yan Zhou, Hong-Jie Wang, Xiao-Lu Wei, Bao-Lin Bian, Hai-Yu Zhao. The integrated study on the chemical profiling and in vivo course to explore the bioactive constituents and potential targets of Chinese classical formula Qingxin Lianzi Yin Decoction by UHPLC-MS and network pharmacology approaches.
Journal of ethnopharmacology.
2021 May; 272(?):113917. doi:
10.1016/j.jep.2021.113917. [PMID: 33609729] - Mehreen S Datoo, Magloire H Natama, Athanase Somé, Ousmane Traoré, Toussaint Rouamba, Duncan Bellamy, Prisca Yameogo, Daniel Valia, Moubarak Tegneri, Florence Ouedraogo, Rachidatou Soma, Seydou Sawadogo, Faizatou Sorgho, Karim Derra, Eli Rouamba, Benedict Orindi, Fernando Ramos Lopez, Amy Flaxman, Federica Cappuccini, Reshma Kailath, Sean Elias, Ekta Mukhopadhyay, Andres Noe, Matthew Cairns, Alison Lawrie, Rachel Roberts, Innocent Valéa, Hermann Sorgho, Nicola Williams, Gregory Glenn, Louis Fries, Jenny Reimer, Katie J Ewer, Umesh Shaligram, Adrian V S Hill, Halidou Tinto. Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial.
Lancet (London, England).
2021 05; 397(10287):1809-1818. doi:
10.1016/s0140-6736(21)00943-0. [PMID: 33964223] - Arshid Yousefi Avarvand, Zahra Meshkat, Farzad Khademi, Mohsen Tafaghodi. Immunogenicity of HspX/EsxS fusion protein of Mycobacterium tuberculosis along with ISCOMATRIX and PLUSCOM nano-adjuvants after subcutaneous administration in animal model.
Microbial pathogenesis.
2021 May; 154(?):104842. doi:
10.1016/j.micpath.2021.104842. [PMID: 33762199] - Tai Young Kim, Sangeun Jeon, Youngho Jang, Lizaveta Gotina, Joungha Won, Yeon Ha Ju, Sunpil Kim, Minwoo Wendy Jang, Woojin Won, Mingu Gordon Park, Ae Nim Pae, Sunkyu Han, Seungtaek Kim, C Justin Lee. Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion.
Experimental & molecular medicine.
2021 05; 53(5):956-972. doi:
10.1038/s12276-021-00624-9. [PMID: 34035463] - Qin Yang, Hong-Mei Zang, Tian Xing, Shao-Fei Zhang, Chao Li, Yao Zhang, Yu-Hang Dong, Xiao-Wei Hu, Ju-Tao Yu, Jia-Gen Wen, Juan Jin, Jun Li, Ren Zhao, Tao-Tao Ma, Xiao-Ming Meng. Gypenoside XLIX protects against acute kidney injury by suppressing IGFBP7/IGF1R-mediated programmed cell death and inflammation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 May; 85(?):153541. doi:
10.1016/j.phymed.2021.153541. [PMID: 33773190] - Chen-Xue Li, Jun Liang, Yan Song, Jun-Hong Chai, Hai-Xue Kuang, Yong-Gang Xia. Structural characterization of the metabolites of orally ingested hederasaponin B, a natural saponin that is isolated from Acanthopanax senticosus leaves by liquid chromatography-mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2021 Apr; 197(?):113929. doi:
10.1016/j.jpba.2021.113929. [PMID: 33618133]
