1-Dehydro-[10]-gingerdione (BioDeep_00000227045)

Main id: BioDeep_00000023294

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(1E)-1-(4-hydroxy-3-methoxyphenyl)tetradec-1-ene-3,5-dione

化学式: C21H30O4 (346.214398)
中文名称: 1-脱氢-10-姜酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1c(c(cc(c1)/C=C/C(=O)CC(=O)CCCCCCCCC)OC)O
InChI: InChI=1S/C21H30O4/c1-3-4-5-6-7-8-9-10-18(22)16-19(23)13-11-17-12-14-20(24)21(15-17)25-2/h11-15,24H,3-10,16H2,1-2H3/b13-11+

描述信息

1-dehydro-[10]-gingerdione belongs to hydroxycinnamic acids and derivatives class of compounds. Those are compounds containing an cinnamic acid (or a derivative thereof) where the benzene ring is hydroxylated. 1-dehydro-[10]-gingerdione is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). 1-dehydro-[10]-gingerdione can be found in ginger, which makes 1-dehydro-[10]-gingerdione a potential biomarker for the consumption of this food product.

同义名列表

4 个代谢物同义名

(1E)-1-(4-hydroxy-3-methoxyphenyl)tetradec-1-ene-3,5-dione; 1-Dehydro-[10]-gingerdione; 1-Dehydro-10-gingerdione; (10)-dehydrogingerdione



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

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WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Gehad M Elnagar, Mohamed M Elseweidy, Yasmin K Mahmoud, Nesreen M I M Elkomy, Ziyad M Althafar, Sultan F Alnomasy, Naif A Al-Gabri, Mohamed Shawky. 10-Dehydrogingerdione Attenuates Tramadol-Induced Nephrotoxicity by Modulating Renal Oxidative Stress, Inflammation and Apoptosis in Experimental Rats: Role of HO-1 Activation and TLR4/NF-κB/ERK Inhibition. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031384. [PMID: 35163308]
  • Nazanin Momeni Roudsari, Naser-Aldin Lashgari, Saeideh Momtaz, Basil Roufogalis, Amir Hossein Abdolghaffari, Amirhossein Sahebkar. Ginger: A complementary approach for management of cardiovascular diseases. BioFactors (Oxford, England). 2021 Nov; 47(6):933-951. doi: 10.1002/biof.1777. [PMID: 34388275]
  • Gehad M Elnagar, Mohamed M Elseweidy, Nesreen M I M Elkomy, Naif A Al-Gabri, Mohamed Shawky. 10-Dehydrogingerdione ameliorates renal endoplasmic reticulum/oxidative stress and apoptosis in alcoholic nephropathy induced in experimental rats. Life sciences. 2021 Aug; 279(?):119673. doi: 10.1016/j.lfs.2021.119673. [PMID: 34081991]
  • Mohamed M Elseweidy, Sahar E Elswefy, Nahla N Younis, Shaden Tarek. The modulation of PCSK-9 and GAGs by 10-dehydrogingerdione and pentoxifylline in hyperlipidemic rabbits. Natural product research. 2020 Aug; 34(16):2372-2377. doi: 10.1080/14786419.2018.1536134. [PMID: 30580599]
  • Mohamed M Elseweidy, Sahar E Elswefy, Nahla N Younis, Shaden Tarek. Contribution of aorta glycosaminoglycans and PCSK9 to hyperlipidemia in experimental rabbits: the role of 10-dehdrogingerdione as effective modulator. Molecular biology reports. 2019 Aug; 46(4):3921-3928. doi: 10.1007/s11033-019-04836-1. [PMID: 31049833]
  • Mohamed Mahmoud Elseweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Reham Raafat El-Zeiky, Naif A Al-Gabri. New Insight on a Combination of Policosanol and 10-Dehydrogingerdione Phytochemicals as Inhibitors for Platelet Activation Biomarkers and Atherogenicity Risk in Dyslipidemic Rabbits: Role of CETP and PCSK9 Inhibition. Applied biochemistry and biotechnology. 2018 Dec; 186(4):805-815. doi: 10.1007/s12010-018-2776-5. [PMID: 29740798]
  • Mohamed M Elseweidy, Mohamed S Zaghloul, Nahla N Younis. 10-DHGD ameliorates cisplatin-induced nephrotoxicity in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Oct; 83(?):241-246. doi: 10.1016/j.biopha.2016.06.032. [PMID: 27376779]
  • Mohamed Mahmoud El-Seweidy, Mervat El-Sayed Asker, Sameih Ibrahim Eldahmy, Hebatallah Husseini Atteia, Mohamed Ahmed Abdallah. Haemostatic risk factors in dyslipidemic rabbits: role of 10-dehydrogingerdione as a new hypolipemic agent. Journal of thrombosis and thrombolysis. 2015 Feb; 39(2):196-202. doi: 10.1007/s11239-014-1150-x. [PMID: 25388083]
  • Mohamed M Elseweidy, Fatma R Abdallah, Nahla N Younis, Sameih Aldohmy, Haitham M Kassem. 10-Dehydrogingerdione raises HDL-cholesterol through a CETP inhibition and wards off oxidation and inflammation in dyslipidemic rabbits. Atherosclerosis. 2013 Dec; 231(2):334-40. doi: 10.1016/j.atherosclerosis.2013.09.024. [PMID: 24267247]
  • Soon-Yong Choi, Gil-Soon Park, Sung Yoon Lee, Ji Yeon Kim, Young Kook Kim. The conformation and CETP inhibitory activity of [10]-dehydrogingerdione isolated from Zingiber officinale. Archives of pharmacal research. 2011 May; 34(5):727-31. doi: 10.1007/s12272-011-0505-5. [PMID: 21656357]