Harmalan (BioDeep_00000021703)

 

Secondary id: BioDeep_00000615919

human metabolite Endogenous


代谢物信息卡片


4,9-Dihydro-1-methyl-3H-pyrido[3,4-b]indole, 9ci

化学式: C12H12N2 (184.1000432)
中文名称:
谱图信息: 最多检出来源 Bos taurus(endogenous) 80%

分子结构信息

SMILES: CC1=NCCC2=C1NC1=C2C=CC=C1
InChI: InChI=1S/C12H12N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-5,14H,6-7H2,1H3

描述信息

Harmalan is found in fruits. Harmalan is an alkaloid from Elaeagnus angustifolia (Russian olive

同义名列表

9 个代谢物同义名

4,9-Dihydro-1-methyl-3H-pyrido[3,4-b]indole, 9ci; 3,4-Dihydro-1-methyl-2H-pyrido[3,4-b]indole; 4,9-Dihydro-1-methyl-3H-pyrido(3,4-b)indole; 1-Methyl-4,9-dihydro-3H-beta-carboline; 1-methyl-3H,4H,9H-pyrido[3,4-b]indole; 3,4-Dihydro-1-methyl-beta-carboline; 1-Methyl-3,4-dihydro-beta-carboline; Dihydroharman; Harmalan



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

60 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Joanna Kałużna-Czaplińska, Jagoda Jóźwik-Pruska, Andrea Axt. Chromatographic determination of harmalans in the urine of autistic children. Biomedical chromatography : BMC. 2017 Sep; 31(9):. doi: 10.1002/bmc.3951. [PMID: 28182283]
  • Horace T B Ho, Yongmei Pan, Zhiyi Cui, Haichuan Duan, Peter W Swaan, Joanne Wang. Molecular analysis and structure-activity relationship modeling of the substrate/inhibitor interaction site of plasma membrane monoamine transporter. The Journal of pharmacology and experimental therapeutics. 2011 Nov; 339(2):376-85. doi: 10.1124/jpet.111.184036. [PMID: 21816955]
  • Julien Fiot, Souleymane Sanon, Nadine Azas, Valérie Mahiou, Olivia Jansen, Luc Angenot, Guy Balansard, Evelyne Ollivier. Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae). Journal of ethnopharmacology. 2006 Jun; 106(2):173-8. doi: 10.1016/j.jep.2005.12.030. [PMID: 16443341]
  • R Susilo, H Rommelspacher. Formation of 1-methyl-beta-carbolines in rats from their possible carboxylic acid precursor. Naunyn-Schmiedeberg's archives of pharmacology. 1988 May; 337(5):566-71. doi: 10.1007/bf00182733. [PMID: 3412494]
  • R Susilo, H Damm, H Rommelspacher, G Höfle. Biotransformation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-1-carboxylic acid to harmalan, tetrahydroharman and harman in rats. Neuroscience letters. 1987 Oct; 81(3):325-30. doi: 10.1016/0304-3940(87)90404-6. [PMID: 3431747]
  • P Szylman, O S Better, C Chaimowitz, A Rosler. Role of hyperkalemia in the metabolic acidosis of isolated hypoaldosteronism. The New England journal of medicine. 1976 Feb; 294(7):361-5. doi: 10.1056/nejm197602122940703. [PMID: 1674]