Harmalan (BioDeep_00000021703)

human metabolite Endogenous

代谢物信息卡片

4,9-Dihydro-1-methyl-3H-pyrido[3,4-b]indole, 9ci

化学式: C12H12N2 (184.1)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(endogenous) 2.51%

分子结构信息

SMILES: CC1=NCCC2=C1NC1=C2C=CC=C1
InChI: InChI=1S/C12H12N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-5,14H,6-7H2,1H3

描述信息

Harmalan is found in fruits. Harmalan is an alkaloid from Elaeagnus angustifolia (Russian olive

同义名列表

9 个代谢物同义名

4,9-Dihydro-1-methyl-3H-pyrido[3,4-b]indole, 9ci; 3,4-Dihydro-1-methyl-2H-pyrido[3,4-b]indole; 4,9-Dihydro-1-methyl-3H-pyrido(3,4-b)indole; 1-Methyl-4,9-dihydro-3H-beta-carboline; 1-methyl-3H,4H,9H-pyrido[3,4-b]indole; 3,4-Dihydro-1-methyl-beta-carboline; 1-Methyl-3,4-dihydro-beta-carboline; Dihydroharman; Harmalan

数据库引用编号

11 个数据库交叉引用编号

ChEBI: CHEBI:168077
PubChem: 160510
HMDB: HMDB0029834
ChEMBL: CHEMBL295234
KNApSAcK: C00054103
foodb: FDB001049
chemspider: 10309487
CAS: 525-41-7
PMhub: MS000069095
LOTUS: LTS0027115
wikidata: Q104667271

分类词条

Harmala alkaloids

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

60 个相关的物种来源信息

127177 - Acraea andromacha: 10.1016/S0021-9673(01)91507-9
171929 - Anacardium occidentale: 10.1002/(SICI)1099-1565(199909/10)10:5<247::AID-PCA465>3.0.CO;2-9
4615 - Ananas comosus: 10.1002/(SICI)1099-1565(199909/10)10:5<247::AID-PCA465>3.0.CO;2-9
184783 - Areca catechu: 10.1002/(SICI)1099-1565(199909/10)10:5<247::AID-PCA465>3.0.CO;2-9
140793 - Carex brevicollis: 10.2307/4117899
88193 - Cephalanthus natalensis: 10.1021/NP50020A008
4744 - Commelina communis: 10.1007/BF02974058
2138266 - Costaticella bicuspis: 10.1021/NP50051A026
82528 - Crocus sativus: 10.1021/NP0302854
316785 - Croton heliotropiifolius: 10.1080/13880200490505618
36777 - Elaeagnus angustifolia: 10.1007/BF00563479
38851 - Gentiana lutea: 10.1002/(SICI)1099-1565(199909/10)10:5<247::AID-PCA465>3.0.CO;2-9
493990 - Grewia bicolor: 10.1016/0378-8741(86)90109-1
578546 - Guiera senegalensis: 10.1002/PTR.1025
33416 - Heliconius: 10.1016/S0021-9673(01)91507-9
9606 - Homo sapiens: -
51240 - Juglans regia: 10.1002/(SICI)1099-1565(199909/10)10:5<247::AID-PCA465>3.0.CO;2-9
1750996 - Kopsia griffithii:
371154 - Mitragyna hirsuta: 10.1021/NP50020A008
4097 - Nicotiana tabacum: 10.1016/S0031-9422(00)82825-3
1817 - Nocardia: 10.1271/BBB1961.51.921
367364 - Ophiorrhiza kuroiwae: 10.1002/CHIN.200612187
489897 - Ophiorrhiza liukiuensis: 10.1002/CHIN.200612187
4054 - Panax ginseng: 10.1007/BF02884768
159424 - Passiflora actinia: 10.1076/PHBI.41.2.100.14244
159422 - Passiflora alata:
197923 - Passiflora amethystina: 10.1076/PHBI.41.2.100.14244
1341340 - Passiflora boenderi: 10.1076/PHBI.41.2.100.14244
159428 - Passiflora caerulea: 10.1076/PHBI.41.2.100.14244
378231 - Passiflora citrina: 10.1076/PHBI.41.2.100.14244
78168 - Passiflora edulis: 10.1076/PHBI.41.2.100.14244
159421 - Passiflora foetida: 10.1076/PHBI.41.2.100.14244
338812 - Passiflora guatemalensis: 10.1076/PHBI.41.2.100.14244
159425 - Passiflora incarnata:
237858 - Passiflora jorullensis: 10.1076/PHBI.41.2.100.14244
231178 - Passiflora macrophylla: 10.1076/PHBI.41.2.100.14244
196581 - Passiflora menispermifolia: 10.1076/PHBI.41.2.100.14244
231179 - Passiflora multiflora: 10.1076/PHBI.41.2.100.14244
237874 - Passiflora perfoliata: 10.1076/PHBI.41.2.100.14244
159431 - Passiflora rubra: 10.1076/PHBI.41.2.100.14244
231183 - Passiflora sexflora: 10.1076/PHBI.41.2.100.14244
196688 - Passiflora tripartita var. mollissima: 10.1076/PHBI.41.2.100.14244
1822416 - Passiflora tucumanensis: 10.1076/PHBI.41.2.100.14244
231184 - Passiflora xiikzodz: 10.1076/PHBI.41.2.100.14244
43879 - Peganum harmala: 10.1104/PP.69.2.400
199225 - Pinellia ternata: 10.1002/(SICI)1099-1565(199909/10)10:5<247::AID-PCA465>3.0.CO;2-9
355332 - Polygala tenuifolia:
3755 - Prunus dulcis: 10.1002/(SICI)1099-1565(199909/10)10:5<247::AID-PCA465>3.0.CO;2-9
3893 - Pueraria montana var. lobata: 10.1002/(SICI)1099-1565(199909/10)10:5<247::AID-PCA465>3.0.CO;2-9
148305 - Pyricularia grisea: 10.1007/BF00636558
318829 - Pyricularia oryzae: 10.1007/BF00636558
478094 - Rauvolfia sumatrana: 10.1248/CPB.42.1427
1827580 - Streptomyces nigra: 10.3389/FMICB.2018.01587
1040892 - Strychnos johnsonii: 10.1016/S0031-9422(00)83601-8
992791 - Strychnos usambarensis: 10.1002/(SICI)1099-1565(199803/04)9:2<63::AID-PCA388>3.0.CO;2-9
2291169 - Symplocos lucida: 10.1021/NP0101189
1340885 - Symplocos racemosa: 10.1021/NP0101189
210366 - Symplocos setchuensis: 10.1021/NP0101189
2945534 - Symplocos theifolia: 10.1021/NP0101189
210369 - Tribulus terrestris:

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表

文献列表

Joanna Kałużna-Czaplińska, Jagoda Jóźwik-Pruska, Andrea Axt. Chromatographic determination of harmalans in the urine of autistic children. Biomedical chromatography : BMC. 2017 Sep; 31(9):. doi: 10.1002/bmc.3951. [PMID: 28182283]
Horace T B Ho, Yongmei Pan, Zhiyi Cui, Haichuan Duan, Peter W Swaan, Joanne Wang. Molecular analysis and structure-activity relationship modeling of the substrate/inhibitor interaction site of plasma membrane monoamine transporter. The Journal of pharmacology and experimental therapeutics. 2011 Nov; 339(2):376-85. doi: 10.1124/jpet.111.184036. [PMID: 21816955]
Julien Fiot, Souleymane Sanon, Nadine Azas, Valérie Mahiou, Olivia Jansen, Luc Angenot, Guy Balansard, Evelyne Ollivier. Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae). Journal of ethnopharmacology. 2006 Jun; 106(2):173-8. doi: 10.1016/j.jep.2005.12.030. [PMID: 16443341]
R Susilo, H Rommelspacher. Formation of 1-methyl-beta-carbolines in rats from their possible carboxylic acid precursor. Naunyn-Schmiedeberg's archives of pharmacology. 1988 May; 337(5):566-71. doi: 10.1007/bf00182733. [PMID: 3412494]
R Susilo, H Damm, H Rommelspacher, G Höfle. Biotransformation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-1-carboxylic acid to harmalan, tetrahydroharman and harman in rats. Neuroscience letters. 1987 Oct; 81(3):325-30. doi: 10.1016/0304-3940(87)90404-6. [PMID: 3431747]
P Szylman, O S Better, C Chaimowitz, A Rosler. Role of hyperkalemia in the metabolic acidosis of isolated hypoaldosteronism. The New England journal of medicine. 1976 Feb; 294(7):361-5. doi: 10.1056/nejm197602122940703. [PMID: 1674]